MWPC 위치검출기의 X-선 천체물리학에의 응용

남욱원,최철성,문신행,강희동 경북대학교 센서기술연구소 1990 센서技術學術大會論文集 Vol.1 No.1

1983 년경 국내에서도 과학탐사 로케트와 인공위성이 발사될 예정에 있으며 이에 따라 X-선 천체물리학을 위한 방사선 센서의 국내 개발이 시급히 요청되는 바이다. 따라서 현재 방사선계측에 많이 이용되고 있는 방사선 센서들 중 국내에서 개발되어온 MWPC위치검출기를 소개하고 인공위성 혹은 과학탐사로케트에 탑재되어 X-선 천체물리학연구에 이용될 경우 연구 개발되어 나가야 할 방향을 제시하고자 한다. Domestic sounding rocket and scientific satellite are scheduled to launch around 1993. The development of radiation sensor is required to observe X-rays coming from celestial bodies by the use of those space vehicleS. In this study we introduce the multi-wire position sensitive detector and the future works of onboard detector for X-ray astrophysics.

40세 이하 관상동맥 질환자에서 장기적 임상 관찰

이승욱,정명호,박종철,박형욱,조상희,김원,김계훈,이상현,강경태,조장현,김남호,김건형,안영근,조정관,박종춘,강정채 全南大醫大 2001 전남의대학술지 Vol.37 No.2

실내사무환경의 환경성담배연기(ETS)의 지표물질에 관한 연구

하권철,백남원,박동욱,윤충식,김원,최상준,박지영,최인자,김신범,강태선 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.2

The purpose of this research is to evaluate indoor office environment using the concentrations of nicotine, 3-enthenyl-pyridine(3-EP), and respirable suspended particulate(RSP), which are indicators for environmental tobacco smoke(ETS) and the correlations between indicators and environmental conditions(smoking density, smoking index). The mean air charge per hour (ACH) in smoking rooms was 10.4 and most of the smoking rooms showed non-compliance withe ASHRAE standard value except only one smoking rooms. The concentrations of RSP, 3-EP, nicotine showed log=normal distributions, and became different statistically depending on smoking condition(p〈0.01). The geometric mean concentration of RSP in smoking room was 441.7 ug/㎡ that is far exceeded environmental standard(150 ug/㎡). This implies that fine particulate in smoking room should be carefully controlled considering smoking density and ventilation fate. The mean concentrations of nicotine and 3-EP were 93.4 ug/㎥, respectively. The correlation coefficients between RSP and SI, 3-EP and SI, and Nicotine and SI were 0.67, 0.84 and 0.74, respectively. The correlation coefficient between nicotine and 3-EP, nicotine and RSP, and RSP and 3-EP were 0.76,0.78 and 0.57 respectively.

한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.

cDNA Cloning and Developmental Expression of Hemolin in Bombyx mandarina

Kang Min Uk,Kim Kyung-A,Lee Jin Sung,Kim Nam Soon,Kang Seok-Woo,Nho Si-kab Korean Society of Sericultural Science 2005 International Journal of Industrial Entomology Vol.10 No.2

In this study, we describe the Bombyx mandarina hemolin cDNA. A sequence analysis of cDNA revealed a single open reading frame (ORF) of 1233 nucleotides. The deduced 410 amino acid sequence of B. mandarina hemolin contains 4 imunoglobulin (Ig) C-2 type domains. B. mandarina hemolin cDNA showed the highest sequence homology to known those of B. mori. The developmental profile in terms of expression level of hemolin mRNA was determined in the absence of a bacterial challenge. Hemolin mRNA was detected only in mid-gut, but not in hemocytes, fat body, testis, and silkglands. Hemolin mRNA in mid-gut was not detected until the spinning stage of the last instar larva, however, lit dramatically increased at the beginning of spinning and gradually decreased until pupal stage.

[Free Paper] A Case-control Stduy of Single-Port Versus Conventional Laparoscopic Cholecystectomy in Gallbladder Polyp

Nam Uk Kang,Young Hoon Kim,Ghap Joong Jung,Hong Jo Choi,Young Hoon Roh 대한외과학회 2011 대한외과학회 학술대회 초록집 Vol.2011 No.11

cDNA Cloning and Developmental Expression of Hemolin in Bombyx mandarina

( Min Uk Kang ),( Kyung A Kim ),( Jin Sung Lee ),( Nam Soon Kim ),( Seok Woo Kang ),( Si Kab Nho ) 한국잠사학회 2005 International Journal of Industrial Entomology Vol.10 No.2

Bombyx mandarina, Hemolin, Imunoglobulin, Developmental profile, Spinning stage In this study, we describe the Bombyx mandarina hemolin cDNA. A sequence analysis of cDNA revealed a single open reading frame (ORF) of 1233 nucleotides. The deduced 410 amino acid sequence of B. mandarina hemolin contains 4 imunoglobulin (Ig) C-2 type domains. B. mandarina hemolin cDNA showed the highest sequence homology to known those of B. mori. The developmental profile in terms of expression level of hemolin mRNA was determined in the absence of a bacterial challenge. Hemolin mRNA was detected only in mid-gut, but not in hemocytes, fat body, testis, and silkglands. Hemolin mRNA in mid-gut was not detected until the spinning stage of the last instar larva, however, lit dramatically increased at the beginning of spinning and gradually decreased until pupal stage.

조기 유방암 환자에서 감시 림프절 내 면역조직화학적 발현양상

강남욱 ( Nam Uk Kang ),조세헌 ( Se Heon Cho ),이미리 ( Mi Ri Lee ),김대철 ( Dae Cheol Kim ),김수진 ( Su Jin Kim ),이진화 ( Jin Hwa Lee ),이근철 ( Keon Cheol Lee ),권혁찬 ( Hyuk Chan Kwan ),이형식 ( Hyung Sik Lee ) 대한임상종양학회 2010 Korean Journal of Clinical Oncology Vol.6 No.1

서론 : 감시 림프절은 유방암에서 림프관을 통해 가장 먼저 전이가 일어나는 첫 번째 액와부 림프절이다. 유방암 환자에서 감시림프절의 전이 상태는 환자의 무병 생존률 및 전체 생존률을 결정하는 가장 중요한 예후 인자이다. 최근 원발 유방암의 침윤성면역 세포의 면역조직 화학 분포에 관하여는 잘 알려지지 않아 유방암의 수술 후 예후 예측 인자 및 지표로 임상 경과를 예측하고자 한다. 대상 및 방법 : 2000년 1월부터 2003년 12월까지 OOO 의료원 외과에서 유방암으로 수술 받은 환자로 149개의 전이가 없는 감시 림프절을 보인 최종 조직 검사에서 조기 유방암(early breast cancer)(T1-T2/N0/M0)으로 확진한 41명의 환자를 대상으로 5년간 추적 관찰하였다. 감시 림프절의 CD4 양성 T 세포, CD8 양성 T 세포 및 CD1a양성 수지상 세포의 분포 양상과 원발 종양의 크기 및 병리학적 결과 및 조직등급 핵등급과 유방암의 재발 및 전이, 전체 생존률에 관하여 조사하였다. 결과 : 감시 림프절의 면역조직화학적 발현양상과 원발암의 ER, PR, C-erb B2 는 인과 관계가 없었으며 임상 경과와도 인과관계가 없었다. CD4, CD8 양성 T 세포 및 CD1a양성 수지상 세포의 분포와 상관없이 5년간의 추적 관찰 기간 동안 부분의 환자가 생존하였으나 통계학적인 의미를 찾을 수 없었다. 그러나 종양의 크기가 증가할 수록 CD1a 및 CD8 발현 세포는 증가하였다(pvalue=0.01/0.03). 결론 : 유방암의 원발 종양 크기와 감시 림프절의 CD1a 및 CD8발현 양상은 상관 관계가 있으며, 원발 종양은 림프절의 면역 활동성에 영향을 준다고 생각된다. 향후 유방암 수술 이후의 지속적인 장기간 추적 관찰 및 후향적 연구가 진행되어야 할 것이다. Purpose : Sentinel lymph node (SLN) biopsy allows to identify the first lymph node into which a primary tumor drains. In breast cancer, identification of tumor cells in SLNs is one of the strong predictor of disease-free and overall survival for breast cancer patients. Its immunologic nature has been identified or established, and would provide us useful prognostic or predictable information on clinical outcome. Meterial and Methods : We performed immunohistochemical analysis of 149 SLN from 41 early breast cancers (T1/T2 and N0) between 2000 and 2003 at OOO University for 5 years. They had followed to determine immunoprofile alterations of CD4 helper, CD8 cytotoxic T cell and CD1a dendritic cell population whether they can predict distant metastasis or disease-free survival. Classical prognostic factors-tumor size, pathologic diagnosis, histological grade and nuclear grade were compared. Results : Immunohistocheminal expression of SLN appear independent of ER and PR, C-erbB2. Immunoprofile changes and clinical manifestation represent independent processes. Although more patients were alive at the 5- year time point in the group with higher CD4 helper, CD8 cytotoxic T cell and CD1a dendritic cell population, this failed to reach statistical significance at the p= 0.05 level. The larger the tumor size is, the more the expression of CD1a, CD8 in SLN is increased(p-value =0.01/0.03). Conclusion : The expression of CD1 and CD8 correlatated primary tumor size of breast cancer. These finding demomstrate that immune-activity of primary tumor influence tumor-draining lymph node. Analysis for long term follow-up post surgery is required to investigate the association further.

The Effect of Choline Acetyltransferase Genotype on Donepezil Treatment Response in Patients with Alzheimer’s Disease

Lee, Kang Uk,Lee, Jung Hie,Lee, Dong Young,Youn, Jong Chul,Kim, Jeong Lan,Moon, Seok Woo,Kim, Bong-Jo,Ryu, Seung-Ho,Kim, Moon Doo,Lee, Chang-Uk,Lee, Nam-Jin,Chang, Sung Man,Kim, Young Hoon,Kim, Do Hoo Korean College of Neuropsychopharmacology 2015 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.13 No.2

<P><B>Objective</B></P><P>We examined the difference in responses to donepezil between carriers and non-carriers of the A allele at the +4 position of the choline acetyltransferase (ChAT) gene in Koreans.</P><P><B>Methods</B></P><P>Patients who met the criteria for probable Alzheimer’s disease (AD) (n=199) were recruited. Among these, 145 completed the 12-week follow-up evaluation and 135 completed the 26-week scheduled course. Differences and changes in the Korean version of the mini-mental state examination (MMSE-KC) score, Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Assessment Battery (CERAD-K[N]) wordlist subtest score (WSS), CERAD-K(N) total score (TS), and the Korean version of geriatric depression scale (GDS-K) score between baseline and 12 weeks or 26 weeks were assessed by the Student’s <I>t</I>-test.</P><P><B>Results</B></P><P>At 12 weeks, the changes in the MMSE-KC score, CERAD-K(N) WSS, and CERAD-K(N) TS from baseline were not significant between ChAT A allele carriers and non-carriers; however, at 26 weeks, these changes were significantly larger in ChAT A allele carriers than in non-carriers (<I>p</I>=0.02 for MMSE-KC and <I>p</I>=0.03 for CERAD-K(N) WSS respectively).</P><P><B>Conclusion</B></P><P>Our findings in this study suggested that presence of the A allele at the +4 position of ChAT might positively influence the treatment effect of donepezil in the early stages of AD in Koreans.</P>

진로탄력성에 관한 연구동향 고찰

강남욱(Kang, Nam-Uk),김장회(Kim, Jang-Hoi) 경성대학교 인문과학연구소 2016 인문학논총 Vol.41 No.-

본 연구는 최근 진로 영역에서 심리적 요인의 하나로 주목되고 있는 ‘진로탄력성(career resilience)’과 진로와의 관련 연구의 필요성에 주목하고 진로탄력성에 관한 기존의 연구동향을 살펴봄으로써 진로 교육의 실제와 연구에 기초 자료를 제공하고자 시도되었다. 연구 결과, 탄력성의 진로 관련 연구는 2005년부터 이루어지기 시작하여 2015년 8월까지 총 53편의 논문이 발표되었으며 71개의 진로 관련 변인이 분석되었다. 71개의 변인들을 8개의 진로 범주 영역으로 분류하여 고찰한 결과, 진로인식(59.2%), 진로결정(19.7%), 진로준비(7.0%) 순으로 분석되었다. 진로변인별로는 진로성숙(39.4%), 진로장벽(12.6%), 진로결정, 자기효능감(11.2%) 순으로 나타났다. 이러한 결과를 바탕으로 본 연구의 진로 상담에서의 함의 및 진로탄력성의 연구 가능성과 방향 등에 대한 논의가 제시되었다. This study tried to provide baseline data on career education and research through taking a look at prior studies on career resilience which paid attention to the necessity of related research with career and career resilience that are noticing recently as one of the psychological attributes in career areas. According to the analysis results, career related study of resilience started from 2005 to 2015, total 53 theses published and 71 career related variables are analyzed during the period. The 71 variables are analyzed by categorized 8 career areas, and the orders of analyzed results were career perception(59.2%), career decision(19.7%), and career preparation(7%). The orders of career factors were career muturity(39.4%), career barriers(12.6%), career decision self-efficacy(11.2%). Based on these results, discussions on implication of career counseling, the possibility of career resilience study, and its direction were suggested.