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삼상 순환유동층의 상승관에서 연속 액상의 축방향 혼합특성
유명선,손성모,강석환,강용,김상돈 한국공업화학회 2004 공업화학 Vol.15 No.1
직경이 0.102 m이고 높이가 3.5 m인 기체-액체-고체 순환 유동층의 상승관에서 액상의 축방향 혼합특성을 고찰하였다. 기체유속(0.01~0.07 ㎧), 액체유속(0.25~0.31 ㎧) 그리고 고체순환속도(2~8 ㎏/㎡s)를 실험변수로 선정하였으며 이들 변수들이 액상의 축방향 분산계수에 미치는 영향을 고찰하였다. 축방향의 추적자 농도분포로부터 분산모델을 사용하여 액상의 축방향 분산계수를 구하였다. 액상의 축방향 분산계수는 기체유속과 고체순환속도가 증가함에 따라서 증가하였으나 액체의 유속의 증가에 따라서는 약간 감소하였다. 또한, 액상의 축방향 분산계수는 등방성 난류 모델을 적용한 무차원군으로 표현되는 상관식으로 나타낼 수 있었다. Characteristics of liquid dispersion in the axial direction were investigated in the riser of a three-phase circulating fluidized bed whose diameter is 0.102 m and 3.5 m in height. Effects of gas (0.01-0.07 m/sl and liquid (0.25-0.31./s) velocities and the circulation rate of solids (2∼8 kg/m^(2)s) on the dispersion coefficient of the continuous liquid phase in the axial direction were determined. A dispersion model was employed to obtain the axial dispersion coefficient of the liquid phase from the radial concentration profiles of tracer with variations of axial position. The axial dispersion coefficient of the liquid phase increased with increasing gas velocity or solid circulation rate, however, decreased slightly with increasing liquid velocity in the riser bed. The axial dispersion coefficient of the liquid phase was well correlated in terms of dimensionless groups based on the isotropic turbulence theory.
Hepatic lipase 유전자 promoter의 G-250A 다형성과 대사증후군간의 관련성
김명철,이명숙,유병철,이용환 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2
Background and Objectives: The -250G to A polymorphism of the hepatic lipase gene (LIPC) has been associated with lowered hepatic lipase activity, dyslipidemia, and diabetes. The aims of this study were to elucidate the relationship of the G-250A polymorphism of LIPC with metabolic syndrome in Koreans. Methods: A total of 943 health screen examinees were enrolled in this study who were examined in Kosin University Gospel Hospital from December 2004 to February 2006. The height, weight, body mass index, body fat mass, visceral fat mass, waist circumference, and systolic and diastolic blood pressure of the subjects were examined and fasting blood glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride were measured by sampling in venous blood. The metabolic syndrome was defined as the presence of three or more of the following : waist circumference men≥90 cm, women≥80 cm, blood pressure≥130/85 mmHg, fasting glucose≥110 mg/dL, HDL cholesterol men<40 mg/dL, women<50 mg/dL, triglyceride≥150 mg/dL. The blood pressure, fasting glucose, HDL cholesterol, triglyceride were evaluated by using the criteria of NECP ATP Ⅲ and waist circumference was assessed by using the criteria of WHO Asia-Western Pacific. The genotype at position -250 of the hepatic lipase promoter was determined by single base extension and electrophoresis. Results: The observed frequencies of the -250G to A polymorphism of LIPC were 49.8% for the metabolic syndrome, 51.4% for the control group and 50.9% in total subjects. The frequency of the A allele was 36% in total subjects. Concentration of triglyceride was significantly higher in subjects with GA and AA genotypes in women.. Conclusion: The -250A allele frequency was 36% in Koreans and the -250G to A polymorphism of LIPC seems to significantly influence to plasma triglyceride levels in women.
백병준,유명상,신재민,김효진,박훈,김장묵,오천환 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.2
Background and Objectives : Paranasal sinus cancer is rare when compared with cancers of other sites. Because paranasal sinus is anatomically located adjacent to the orbit and skull base, it is difficult to remove the tumor completely with tumor free margin in advanced paranasal sinus cancer. This report was conducted to investigate clinical characteristics, histologic type and treatment outcome of paranasal sinus cancer. Material and Methods : Twenty-six cases with paranasal sinus cancer diagnosed at the Department of otolaryngology-Head and Neck Surgery, Soonchunhyang Cheonan Hospital from January 1991 to September 2000 were studied by chart review, telephone interview and letters retrospectively. Results : The male to female ratio was 4.2 : 1. Most patients were 6th and 7th decade. The maxillary sinus was the most commonly affected site(61.5%), followed by the ethmoid sinus(34.6%). The most common histologic type of malignancy was squamous cell carcinoma(57.6%), followed by adenocarcinoma(19.2%). Most patients presented with T_(3)/T_(4) or locally advanced disease, N_(0)(91.3%), and M_(0)(100%) Sixtynine pertcent of this study group underwent sugery as part of a mutimodality curative treatment plan or alone as curative treatment. Eighteen patients(69.2%) developed recurrent disease at a median time of 278 days after initial treatment. Kaplan-Meier analysis revealed the 5-year disease specific survival was 34.6%. Conclusion : Most patients with paranasal sinus cancer presented with locally advanced disease. Adanced T stage was highly predictive of poor prognosis. Recurrence rate was high and mostly occured within the second year after treatment.
폴록사머 및 프로필렌글리콜을 이용한 클로트리마졸 고형 좌제의 물리화학적 특성
현경희,오유경,김정애,공경환,김지현,양준호,배명수,김호동,이종달,장현욱,용철순,최한곤 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.2
To develop a clotrimazole-loaded solid suppository with poloxamer and propylene glycol, the melting points of various formulations composed of poloxamer 188 (P 188) and propylene glycol were investigated. The dissolution study of clotrimazole delivered by the suppository composed of P 188 and propylene glycol was performed. The mixtures composed of P 188 and propylene glycol were homogeneous. Propylene glycol affected the melting points of poloxamer mixtures. In particular, the mixture [P 188/propylene glycol (70/30%)] with the melting point of about 32°C was a solid form at room temperature and instantly melted at physiological temperature. Furthermore, propylene glycol affected greatly the dissolution rates of clotrimazole from the suppository. Dissolution mechanism analysis showed the dissolution of clotrimazole was proportional to the time. Our results indicated that the solid suppository with P 188 and propylene glycol would be a candidate of rectal dosage form for clotrimazole.
Wee, Yu-Mee,Lim, Dong-Gyun,Kim, Yang-Hee,Kim, Jin-Hee,Kim, Song-Cheol,Yu, Eunsil,Park, Myung-Ok,Choi, Monica Young,Park, Youn-Hee,Jang, Hyuk-Jai,Cho, Eun-Young,Cho, Myung-Hwan,Han, Duck-Jong SAGE Publications 2008 CELL TRANSPLANTATION Vol.17 No.10
<P>The necessity to transplant islet tissue without the need for immunosuppressant therapy has led to the development of materials for immune modulation. Pegylation makes islets antigenically silent, protecting them from the adsorption of foreign protein and thus avoiding immune injury. The aim of this study is to determine whether pegylation of islets prolongs islet survival and function both during tissue culture and posttransplantation. We used cyanuric chloride-activated methoxy-polyethylene glycol for cell surface modification. To detect the pegylation effect on splenocytes, we measured antibody binding inhibition and abrogation of lymphocyte proliferation. To detect the pegylation effect on islet grafts, we performed rodent islet transplantation. Islet viability and function were maintained after pegylation. Pegylated islets showed a 90% decrease in antibody binding and decreased lymphocyte proliferation in a mixed lymphocyte culture. However, when pegylated islets were transplanted, no prolongation of graft survival was observed. When a subtherapeutic dose of immunosuppressant was given at the time of transplantation of pegylated islets, islet graft survival was significantly prolonged. In addition, when rats were sensitized with donor splenocytes, graft survival was prolonged by pegylation. We observed that pegylation of islets, combined with a subtherapeutic dose of immunosuppressant, protects the graft from rejection. Prolonged graft survival in sensitized recipients showed that pegylation of islets shifted the pattern of rejection from an acute humoral response to a less aggressive cellular alloresponse.</P>
( Yu Jin Kim ),( Seong Hyun Shin ),( Jeong Woong Park ),( Sun Young Kyung ),( Shin Myung Kang ),( Sang Pyo Lee ),( Yon Mi Sung ),( Yoon Kyung Kim ),( Sung Hwan Jeong ) 대한결핵 및 호흡기학회 2014 Tuberculosis and Respiratory Diseases Vol.77 No.1
Background: Combined pulmonary fibrosis and emphysema (CPFE) have different pulmonary function tests (PFTs) and outcomes than idiopathic pulmonary fibrosis (IPF). The intention of this study was to identify unknown differences between CPFE and IPF by a retrospective comparison of clinical data including baseline and annual changes in pulmonary function, comorbidities, laboratory findings, clinical characteristics and cause of hospitalization. Methods: This study retrospectively enrolled patients with CPFE and IPF who had undergone PFTs once or several times per year during a follow-up period of three years. Baseline clinical characteristics and the annual changes in the pulmonary function during the follow-up period were compared between 26 with CPFE and 42 patients with IPF. Results: The baseline ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC%) in patients with CPFE was lower than that in patients with IPF (78.6±1.7 vs. 82.9±1.1, p=0.041). The annual decrease in FEV1/FVC in the CPFE was significantly higher than in the IPF. The annual decreases in diffusion capacity of carbon monoxide and FVC showed no significant differences between the two groups. The symptom durations of cough and sputum were in the CPFE significantly lower than in the IPF. The serum erythrocyte sedimentation rate level at the acute stage was significantly higher than in the IPF. There were no significant differences in the hospitalization rate and pneumonia was the most common cause of hospitalization in both study groups. Conclusion: The annual decrease of FEV1/FVC was in patients with CPFE significantly higher than in the patients with IPF.