스테로이드 치료 후 회복기의 규칙적인 운동이 쥐의 스테로이드 유발성 위축 뒷다리근에 미치는 영향

최명애,변영순,황애란,김희승,홍해숙,최스미,서화숙,이경숙,박미정,신기수,안경주,이윤경,임지회 대한기초간호자연과학회 2002 Journal of korean biological nursing science Vol.4 No.1

This study was conducted to determine whether low intensity regular exercise following steroid treatment could attenuate steroid-induced muscle atrophy. Thirty-eight Sprague-Dawley rats weighing 165~175g were divided into six groups;control group(C), dexamethasone administration group(D), sedentary after normal saline administration group(C+Se), exercise after normal saline administration group(C+Ex), sedentary group after dexamethasone administration(D+Se), exercise group after dexamethasone administration(D+Ex). Either dexamethasone(5mg/kg) or normal saline was injected for 7days accordingly. Exercise was started at 10m/min on the 10?grade treadmill and gradually increased up to 15m/min by the 7th day for 60minutes/day(20min×3). The data were analyzed by Kruskal-Wallis test and Mann-Whitney U test using the SPSS WIN 9.0 program. Body weight, muscle weight and myofibrillar protein content of both plantaris and gastrocnemius, Type I, II muscle fiber cross-sectional area of plantaris, and Type II muscle fiber cross-sectional area of gastrocnemis in D group were significantly lower than those of C group(p<.05) respectively. Hindlimb muscle weight, myofibrillar protein content of both plantaris and gastrocnemius, Type I muscle fiber cross-sectional area of soleus and Type I, II muscle fiber cross-sectional area of plantaris in D+Ex group tended to increase compared to those of D+Se group. Myofibrillar protein content of both plantaris and gastrocnemius, Type I muscle fiber cross-sectional area of plantaris in D+Ex group tended to increase compared to those of C+Se group. Based on these results, it is suggested that regular low-intensity exercise during recovery period after steroid treatment might facilitate the recovery from steroid-induced muscle atrophy.

기초간호자연과학의 인체구조와 기능 내용별 필요도에 대한 연구

최명애,변영순,서영숙,황애란,김희승,홍해숙,박미정,최스미,이경숙,서화숙,신기수 대한기초간호자연과학회 1999 Journal of korean biological nursing science Vol.1 No.1

The purpose of this study was to define the content of requisite human structure and function knowledge needed for clinical knowledge of nursing practice. Subjects of human structure and function were divided into 10 units, and each unit was further divided into 21 subunits, resulting in a total of 90 items. Contents of knowledge of human structure and function were constructed from syllabus of basic nursing subjects in 4 college of nursing, and textbooks published by nurse scholars prepared with basic nursing sciences. The degree of need of 90 items was measured with a 4 point scale. The subjects of this study were college graduated 136 nurses from seven university hospitals in Seoul and three university hospitals located in Chonnam Province, Kyungbook Province, and Inchon. They have been working at internal medicine ward, surgical ward, intensive care unit, obstetrics and gynecology ward, pediatrics ward, opthalmology ward, ear, nose, and throat ward, emergency room, rehabilitation ward, cancer ward, hospice ward, and their working period was mostly under 5 years. The results were as follows : 1. The highest scored items of human structure and function knowledge necessary for nursing practice were electrolyte balance, blood clotting mechanism and anticoagulation mechanism, hematopoietic function, body fluid balance, function of plasma, and anatomical terminology in the order of importance. The lowest scored items of human structure and function knowledge necessary for nursing practice was sexual factors of genetic mutation. 2. The highest order of need according to unit was membrane transport in the living unit, anatomical terminology in movement and exercise unit, mechanism of hormone function in regulation and integration unit, component and function of blood in oxygenation function unit, structure and function of digestive system in digestive and energy metabolism unit, temperature regulation in temperature regulation unit electrolyte balance in body fluid and electrolyte unit, concept of immunity in body resistance unit, and genetics terminology in genetics unit. The highest order of importance according to subunit was membrane transportation in cell subunit, classification of tissues in tissue unit, function of skin and skin in skin subunit, anatomical derivatives of the skeleton subunit, classification of joints in joint subunit, an effect of exercise on muscles in muscle subunit, function of brain in nervous system subunit, special sense in sensory subunit mechanism of hormone function in endocrine subunit, structure and function of female reproductive system in reproductive system unit, structure and function of blood in blood unit, structure of heart, electrical and mechanical function in cardiovascular system unit, structure of respiratory system in respiratory system subunit, structure and function of digestive system in digestive system subunit, hormonal regulation of metabolism in nutrition and metabolism subunit, function of kidney in urologic system subunit, electolyte balance in body fluid, electolyte and acid-base balance subunit. 3. The common content of human structure and function knowledge need for all clinical areas in nursing was structure and function of blood, hematopoietic function, function of plasm, coagulation mechanism and anticoagulation mechanism, body fluid, electrolyte balance, and acid-base balance. However, the degree of need of each human structure and function knowledge was different depending on clinical areas. 4. Significant differences in human structure and function knowledge necessary for nursing practice such as skin and derivatives of the skin, growth and development of bone, classification of joint, classification of muscle, structure of muscle, function of muscle, function of spinal cord, peripheral nerve, structure and function of pancrease, component and function of blood, function of plasma, structure and function of blood, hemodynamics, respiratory dynamics, gas transport, regulation of respiration, chemical digestion of foods, absorption of foods, characteristics of nutrients, metabolism and hormonal regulation, body energy balance were demonstrated according to the duration of work. 5. Significant differences in human structure and function knowledge necessary for nursing practice such as classification of tissue, classification of muscles, function of muscles, muscle metabolism, classification of skeletal muscles, classification of nervous system, neurotransmitters, mechanism of hormone function, pituitary and pituitary hormone, structure and function of male reproductive organ, structure and function of female reproductive organ, component and function of blood, function of plasma, coagulation mechanism and anticoagulation mechanism, gas exchange, gas transport, regulation of respiration, characteristics of nutrients, energy balance, function of kidney, concept of immunity, classification and function of immunity were shown according to the work area. Based on these findings, all the 90 items constructed by Korean Academic Society of Basic Nursing Science should be included as contents of human structure and function knowledge.

기초간호자연과학의 병태생리학, 병원미생물, 약물의 기전과 효과 내용별 필요도에 대한 연구

최명애,변영순,서영숙,황애란,김희승,홍해숙,박미정,최스미,이경숙,서화숙,신기수 대한기초간호자연과학회 2000 Journal of korean biological nursing science Vol.2 No.1

The purpose of this study was to define the content of the requisite knowledge of pathophysiology, clinical microbiology, and mechanisms and effects of drugs needed for clinical knowledge for nursing practice. Contents of knowledge on pathological physiology, clinical microbiology, and mechanisms and effects of drugs were constructed from syllabus of basic nursing subjects in 4 colleges of nursing, and textbooks. The degree of need of 72 items was measured with a 4 point scale. The subjects of this study were college-graduated 136 nurses from seven university hospitals in Seoul and three in Chonnam Province, Kyungbook Province, and Inchon. They have been working at internal medicine ward, surgical ward, intensive care unit, obstetrics and gynecology ward, pediatrics ward, opthalmology ward, ear, nose, and throat ward, emergency room, rehabilitation ward, cancer ward, and hospice ward. The results were as follows : 1. The highest scored items of the knowledge of pathophysiology, clinical microbiology, and mechanisms and effects of drugs necessary for nursing practice were side effects of drugs, anticoagulants, mechanisms of drugs, antihypertensive drugs, tolerance and addiction of drugs, interactions among drugs, hospital infection in the order of importance. The lowest scored item was structure of microrganisms. 2. The highest order of need according to unit was repair in tissue injury unit, definition·etiology·classification of inflammation in inflammation unit, trasplantation and immunologic response in alterations in immunity unit, thrombus and thrombosis in disorders of cardiovascular function unit, gene disorders in genetic disorders unit, hospital infection in infection unit, virus in microrganisms unit, side reactions of drugs in introduction unit, anticonvulsants in drugs for central nervous system unit, local anesthesia in anesthesia unit, anticoagulants in drugs for cardiovascular system unit, anti-inflammatory drugs in antibiotics unit, anti-ulcer drugs in drugs for digestive system unit, and bronchodilators in drugs for respiratory system unit. 3. The common content of the knowledge of pathophysiology, clinical microbiology, and mechanisms and effects of drugs needed for all clinical areas in nursing were side effects of drugs, anticoagulants, interactions among drugs, and hospital infection. However, the degree of need of each pathological physiology, clinical microbiology, and mechanisms and effects of drugs was different depending on clinical areas. 4. Significant differences in the knowledge of pathophysiology, clinical microbiology, and mechanisms and effects of drugs necessary for nursing practice such as tissue changes due to injurious stimuli, degenerative changes of tissue, alterations in metabolism of carbohydrates, ischemia, hyperemia and congestion, hospital infection, structure of microorganism, classification of microorganism, bacteria, virus, antidepressants, antipsychotic drugs, antiemetic drugs, antiparkinsonism drugs, antianxiety drugs, antibiotics, tuberculostatics, antiviral drugs, antifungal drugs, parasiticides, antiulcer drugs, antidiarrheais, and anti constipation drugs were shown according to the work area. 5. Significant differences in the knowledge of pathophysiology, clinical microbiology, and mechanisms and effects of drugs necessary for nursing practice such as transplantation and immunologic response, alterations in the metabolism of uric acid, structure of microorganism, classification of microorganism, immunosuppresants, drugs for congestive heart failure were demonstrated according to the duration of work. Based on these findings, all the 72 items constructed by Korean Academic Society of Basic Nursing Science should be included as contents of the knowledge of pathophysiology, clinical microbiology. and mechanisms and effects of drugs

Apoliporotein E2 & E4 Alleles Influence on the Distribution of the Human Plasma Lipid Profiles in Normolipidemic Korean Women

Lee,Myoung Sook (이명숙) 한국영양학회 1996 Journal of Nutrition and Health Vol.29 No.6

이상치아 발생빈도에 관한 통계학적 연구

이명숙,이종갑 大韓小兒齒科學會 1985 大韓小兒齒科學會誌 Vol.12 No.1

This study was designed to find out the prevalence of dental anomalies. The clinical and roentgenographic examination was undertaken of 1,477 children at age from 2 to 13 years and statistic analysis was made. The results were as follows: 1. Among the examined patients, 308 patients showed dental anomalies. The prevalences of individual dental anomalies were as follows; congenitally missing teeth; 7.92%, supernumerary teeth; 7.58%, fused and geminated teeth; 3.39%, anomalies of crown shape; 2.57%, taurodontism; 1.76%, dens invaginatus: 0.34%, dilacerated teeth; 0.41%, malposed teeth; 0.41%, amelogenesis imperfecta and dentinogenesis imperfecta; 0.20%. 2. Between the groups with individual dental anomalies, what showed significant correlation were as follows; Between age and dens invaginatus was positive weak correlation, congenitally missing teeth and supernumerary teeth was negative weak correlation. And the correlation coefficiencies between male and female showed differences. 3. The sexual differences of the individual dental anomalies appeared in congenitally missing teeth, supernumerary teethh and taurodontism. While the congenitally missing teeth and taurodontism showed greater rate of prevalence in female, supernumerary teeth in male. 4. In congenitally missing teeth, the mandibular deciduous lateral incisor showed the highest rate of the prevalence in deciduous dentition, while mandibular lateral incisor in permanent dentition. 5. Most supernumerary teeth were mesiodens of median area in maxilla and showed no statistical difference between right and left side. Generally, the eruption pattern of that teeth was normal posiiton and unerupted state. 6. In the case with deciduous fused teeth, the prevalence of succeeding permanent congenitally missing teeth was 47.06%, while that of succeeding permanent fused teeth was 5.80%. And the highest rate of the prevalence appeared in fusion of mandibular right deciduous lateral incisor and canine. Also, in mandible and right side, appeared greater rate of prevalence.

산딸나무 열매로부터 저밀도 지질 단백질(LDL) 산화 역제물질의 분리

이대영,송명종,김민정,정낙훈,정태숙,이윤형,백남인 경희대학교식량자원개발연구소 2007 硏究論文集 Vol.26 No.1

산딸나무 열매를 100% MeOH로 추출하고, 얻어진 추출물을 EtOAc, n-BuOH 및 물로 용매 분획 하였다. 이 중 EtOAc 분획으로부터 silica gel과 octadecyl silica gel(ODS) column chromatography를 반복하여 1종의 lignan 화합물을 분리, 정제하였다. 화합물의 화학구조는 NMR, Ms 및 IR 등의 스펙트럼 데이터를 해석하여, (+)-pinoresinol (1) 로 동정하였다. 이 화합물은 산딸나무에서 처음 분리되었다. LDL-항산화활성 억제활성이 20㎍/mL 처리농도에서 85.1±1.3%로 나타났다. (+)-Pinoresinol was isolated from the EtOAc fraction of methanol extracts of the fruits of Cornus kousa Burg. The chemical structures of (+)-pinoresinol was determined by spectroscopy method, as well as 1D- and 2D-NMR (^(1)H-^(1)H COSY, HSQC and HMBC) spectroscopy. This compound was the first to be isolated from C. kousa Burg. Also, (+)-pinoresinol inhibited LDL-oxidation with the inhibitory activity of 85.1±1.3% at a concentration of 20 ㎍/mL.

대학생 복식 현상에 나타난 상징성 연구

이성희,유지현,한명숙 服飾文化學會 1994 服飾文化硏究 Vol.2 No.1

The purpose of this study was to analyze the classification and meaning of symbols, of the clothes of the college students by sex-roll theory and identity theory. The clothes analyzed in this study were collected by photographs which were taken in the campus (240 out of 1,000 pictures) of the several colleges and universities in Seoul form fall in 1993 to summer in 1994. The results were as follows: 1. Analysis as a symbol of sexuality. The phenomenon of the visual inconsistency and consistency of sexual image in dress were showed simultaneously. The clothes of male students were generally becoming feminine style in materials and colors of clothes. These suggested that sex-roll theory be applied to their clothes. 2. Analysis as symbols of identification or individuality. The identification of shoes, bags, accessories, and hair styles were prominent than that of clothes. When it was analyzed as a symbol of individuality, the college students seemed to act as fashion leaders, who accepted new fashions and tried them on first. Theses suggested that Erikson's theory on identity be applied to their clothes. 3. Analysis as a symbol of emblem. The dissimilarities of between the college students and other groups in the same generation were bright and casual attire with files, books, and sack. 4. Analysis as a symbol of campus ceremony. The clothes of college students on campus ceremonies were more casual and flexible than those of other groups in the same generation. It was known that the symbols showed above were reflected on their clothes as "one's expressions" which are sex-roll, identity, and characteristics of college students.

발달장애 아동의 인지적·사회적 놀이에 관한 선행 연구 고찰

이명숙 국립특수교육원 2000 특수교육연구 Vol.7 No.-

본 연구는 통합교육의 흐름에 맞추어 장애아동들이 일반아동들과 가장 쉽고 빠르게 접근하며 어울림으로써 진정한 통합을 이루어낼 수 있는 방법으로 놀이의 중요성을 인식하고 발달장애 아동의 인지적, 사회적 놀이의 특성과 놀이에 개입했을 때의 효과 등을 근래 보고된 연구들을 통해 고찰해보았다. 그 결과 1980년 이후의 양적으로나 질적으로 진보된 연구들은 장애아동의 인지적, 사회적 놀이와 인지적, 사회적 발달과는 밀접한 관련이 있으며, 자연스러운 놀이장면을 통해 발달의 정도를 가늠할 수 있음은 물론, 장애를 진단, 평가하는 과정에서도 유용하게 사용되리라는 것을 보여주고 있다. 또한 발달장애 아동의 놀이를 지도하거나 개입함으로써 놀이를 가르칠 수 있었고 그 향상을 가져왔으며, 통합 상황에서 일반아동들과 함께 어울려 놀 수 있음을 시사하고 있다. Children's play has recently received much attention and its importance also has been increasingly emphasized in the field of research. Not only has it a great influence on cognitive and social development of children but also it provides children with opportunities to interact with objects, peers, and adults so that children can learn adequate social behaviors. As such, it becomes more important when it comes to the handicapped children who are retarded in many respects than normal children. The current study reviewed the recent literature on the developmentally delayed children's cognitive and social play, keeping in the mind the importance of play. In fact, the handicapped children, though play, can interact and play with normal children, thereby reaching integration more easily. The review reveals that play not only has a great importance on children's development but also has close relations with cognitive and social development of the handicapped children. Therefore, it is possible to make an assessment, diagnosis of evaluation of the degrees of development by watching them playing in the fields. In addition, the review implies not only that you can teach and develop play of children but also that the handicapped children may play well with normal children in the integrated situation.

냉수 가글링과 젖은 거즈를 이용한 구강간호가 비강수술 환자의 갈증 및 구강상태에 미치는 효과 비교

이인선,심명숙,나은희,강재연,김지혜,황민영,윤계숙,성영희 병원간호사회 2006 임상간호연구 Vol.11 No.2

Purpose: This study researched the comparison of oral care methods between the wet gauze and the water gargling for nasal surgery patients. It executed to find out more effective method to relieve thirst. Method: We divided two groups; the wet gauze and the cold water garaling. We assessed patient's oral cavity state and sebjective oral dryness for three times; firstly before the intervention, secondly 15 minutes after 1st intervention and thirdly 15 minutes afrer 2nd intervention. Result: As the intervention, there was no difference on oral condition subhectvely, but there was a difference on thirsty reduction objectively. As the aral dryness has relieved through both methods. It showed the repeated gargling helps more to relieve oral dryness effectively than the wet gauge. At PACU, post nasal surgery patient's oral dryness was decreased with gauze more than two times, patient's oral dryness was relieved. Whereas the dryness was relieved after applying the cold water gargling for just one time. Conclusion: The water gargling is more effective intervention than the wet gauze. Especially, oral dryness was improved in the section of objetive oral assessment index.

DANSYL, BANSYL 및 DABSYL Chlorides의 가용매분해 반응에서의 용매화거동

李鍾八,成大東,金明淑 東亞大學校 1994 東亞論叢 Vol.31 No.1

The bimolecular nucleophilic substitution reactions of DABSYL and BANSYL chlorides have investigated by kinetic method and discussed with solvent dynamics that has been proved by means of laser flash photolysis. The results are as follows, 1. The rate constants of nucleophilic substitution reaction of BANSYL chloride show higher than those of DABSYL chloride in MeOH-MeNO2 binary solvent mixtures. The reactions proceed through an orbital-controlled reaction mechanism. 2. The phenomena of rate maxima show at 70% (v/v) content of MeOH in the solvolyses of DABSYL chloride and BANSYL chloride. The rate maximum is caused by the sum of the hydrogen bond donor acidity(α) and the polarity-polarizability parameter of solvent(π') as shown in the specific solvent effect as a general isodielectric solvent systems. 3. The laser flash photolyses of DABSYL chloride and BANSYL chloride are observed the fluorescent emission spectra which are generated by exciting of the two molecules. 4. The recovery life times of BANSYL chloride and DABSYL chloride are detected similar and the values of τ1 and τ2 are shown as shortest. 5. Rearrangement of the substrates in the content of 60% (v/v) of MeOH is depending on the rotation of the substrates on the surface of solvents by analysis of the rearrangement time.