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( Mun Hyuk Seong ),( Ho Kil ),( Jong Yeop Kim ),( Sang Soo Lee ),( Eun Sun Jang ),( Jin Wook Kim ),( Sook Hyang Jeong ),( Young Seok Kim ),( Si Hyun Bae ),( Youn Jae Lee ),( Han Chu Lee ),( Hae Sun Yu 대한간학회 2013 Clinical and Molecular Hepatology(대한간학회지) Vol.19 No.1
Background/Aims: The distribution of hepatitis C virus (HCV) genotypes varies geographically. In Korea, genotypes 1 and 2 comprise more than 90% of HCV infections, while genotype 6 is very rare. This study compared the clinical and epidemiological characteristics of patients with genotype 6 HCV infection with those infected with HCV genotypes 1 and 2. Methods: This was a prospective, multicenter HCV cohort study that enrolled 1,173 adult patients, of which 930 underwent HCV genotype analysis, and only 9 (1.0%) were found to be infected with genotype 6 HCV. The clinical and epidemiological parameters of the genotypes were compared. Results: The patients with genotype 6 HCV had a mean age of 41.5 years, 77.8% were male, and they had no distinct laboratory features. A sustained virologic response (SVR) was observed in four (67%) of six patients who received antiviral therapy. Risk factors such as the presence of a tattoo (n=6, 66.7%), more than three sexual partners (n=3, 33.3%), and injection drug use (n=3, 33.3%) were more common among genotype 6 patients than among genotypes 1 or 2. Conclusions: The epidemiology and treatment response of patients infected with genotype 6 HCV differed significantly from those with genotypes 1 or 2, warranting continuous monitoring. (Clin Mol Hepatol 2013;19:45-50)
( Mun Hyuk Seong ),( Ho Kil ),( Jong Yeop Kim ),( Sang Soo Lee ),( Sook Hyang Jeong ),( Young Seok Kim ),( Si Hyun Bae ),( Youn Jae Lee ),( Han Chu Lee ),( Hae Sun Yun ),( Byung Hak Kang ),( Kisang Ki 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: Hepatitis C virus (HCV) infection is attributable to about 15% of cause of chronic liver disease in Korea. We aimed to study the epidemiological and clinical features of a prospective, multicenter cohort of HCV infection in Korea. Methods: A total 1,173 adult patients showing positive results for anti-HCV were prospectively enrolled and offered to complete the questionnaire survey on the risk factors of HCV infection from January 2007 to December 2011 at 5 university hospitals. Predefined demographic, clinical, and virological variables were collected and analysed. Results: The 1,173 subjects of the HCV cohort showed that mean age of 55.4 years, and male proportion of 48.3%, and diagnostic category of acute hepatitis (n=64, 5.5%), past infection (n=54, 4.6%), chronic hepatitis (n=772, 65.8%), liver cirrhosis (n=183, 15.6%), and hepatocellular carcinoma (n=100, 8.5%). The HCV genotypes were distributed into 5 types: genotype 1 (n=489, 52.4%), genotype 2 (n=421, 45.1%, genotype 3 (n=7, 0.8%), genotype 4 (n=2, 0.2%), and genotype 6 (n=9, 1.0%) with mixed genotypes (n=5, 0.5%). Hepatitis B virus coinfection rate was 3.5%. Liver biopsy was undertaken in (n=298, 20.0%), and the antiviral therapy against HCV had been undertaken in 42.8%. The risk factors were found as below: blood transfusion before 1995 (55.9%), needle stick injury (7.4%), acupuncture (82.5%), tattooing (36.0%), piercing (35.0%), intravenous drug abuse (IVDU) (5.0%), multiple sex partners more than 3 (21.0%), living with HCV-infected person (2.6%). Interestingly, patients living in Busan area showed higher frequency of IVDU (10.3%) compared to those in Capital area (4.5%).
( Mun Hyuk Seong ),( Ho Kil ),( Jong Yeop Kim ),( Sang Soo Lee ),( Sook Hyang Jeong ),( Young Seok Kim ),( Si Hyun Bae ),( Youn Jae Lee ),( Han Chu Lee ),( Hae Sun Yun ),( Byung Hak Kang ),( Ki Sang K 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: Hepatitis C virus (HCV) infection is attributable to about 15% of cause of chronic liver disease in Korea. We aimed to study the epidemiological and clinical features of a prospective, multicenter cohort of HCV infection in Korea. Methods: A total 1,173 adult patients showing positive results for anti-HCV were prospectively enrolled and offered to complete the questionnaire survey on the risk factors of HCV infection from January 2007 to December 2011 at 5 university hospitals. Predefined demographic, clinical, and virological variables were collected and analysed. Results: The 1,173 subjects of the HCV cohort showed that mean age of 55.4 years, and male proportion of 48.3%, and diagnostic category of acute hepatitis (n=64, 5.5%), past infection (n=54, 4.6%), chronic hepatitis (n=772, 65.8%), liver cirrhosis (n=183, 15.6%), and hepatocellular carcinoma (n=100, 8.5%). The HCV genotypes were distributed into 5 types: genotype 1 (n=489, 52.4%), genotype 2 (n=421, 45.1%, genotype 3 (n=7, 0.8%), genotype 4 (n=2, 0.2%), and genotype 6 (n=9, 1.0%) with mixed genotypes (n=5, 0.5%). Hepatitis B virus coinfection rate was 3.5%. Liver biopsy was undertaken in (n=298, 20.0%), and the antiviral therapy against HCV had been undertaken in 42.8%. The risk factors were found as below: blood transfusion before 1995 (55.9%), needle stick injury (7.4%), acupuncture (82.5%), tattooing (36.0%), piercing (35.0%), intravenous drug abuse (IVDU) (5.0%), multiple sex partners more than 3 (21.0%), living with HCV-infected person (2.6%). Interestingly, patients living in Busan area showed higher frequency of IVDU (10.3%) compared to those in Capital area (4.5%).
성문혁 ( Mun Hyuk Seong ),김성무 ( Sung Moo Kim ),유숙희 ( Suk Hee Yoo ),박우리 ( Woo Ri Park ),안진영 ( Jin Young An ),최강현 ( Kang Hyeon Choe ),이기만 ( Ki Man Lee ),김시욱 ( Si Wook Kim ) 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.70 No.3
Cholethorax is a bilious pleural effusion caused by a pleurobiliary fistula or leakage of bile into the pleural space. Most cases of cholethorax arise from a complication of abdominal trauma, hepatobiliary infection, or invasive procedures or surgery of hepatobiliary system. However, we experienced a case of a patient with cholethorax of unknown origin. There was no evidence of pleurobiliary fistula or leakage of bile from the hepatobiliary system although we examined the patient with various diagnostic tools including chest and abdominal computed tomography, endoscopic retrograde cholangiopancreatography, tubography, bronchofiberscopy, hepatobiliary scintigraphy and video-assisted thoracoscopic surgery. Herein we report a case of cholethorax for which the specific cause was not identified. The patient was improved by percutaneous drainage of pleural bile.
Mun, Se Hwan,Kim, Jie Wan,Nah, Seong Su,Ko, Na Young,Lee, Jun Ho,Kim, Ju Dong,Kim, Do Kyun,Kim, Hyuk Soon,Choi, Ji Da,Kim, Soo Hyun,Lee, Chang Keun,Park, Seung Hwa,Kim, Bo Kyung,Kim, Hyung Sik,Kim, Yo Wiley Subscription Services, Inc., A Wiley Company 2009 Vol.60 No.3
<B>Objective</B><P>Interleukin-32 (IL-32) is a recently discovered cytokine that appears to play a critical role in human rheumatoid arthritis (RA). It is highly expressed in synovium and fibroblast-like synoviocytes (FLS) from RA patients, but not in patients with osteoarthritis (OA). This study was undertaken to assess IL-32 levels in RA synovial fluid (SF) and to investigate the secretion and regulation of IL-32 in RA FLS.</P><B>Methods</B><P>FLS and SF were obtained from the joints of RA patients. The secretion and expression of IL-32 and activation of signaling molecules were examined by enzyme-linked immunosorbent assay, immunoblotting, immunoprecipitation, reverse transcriptase–polymerase chain reaction, and small interfering RNA (siRNA) transfection.</P><B>Results</B><P>IL-32 levels were high in RA SF compared with OA SF. Furthermore, RA FLS expressed and secreted IL-32 when stimulated with tumor necrosis factor α (TNFα). TNFα-induced expression of IL-32 was significantly suppressed, in a dose-dependent manner, by inhibitors of Syk, protein kinase Cδ (PKCδ), and JNK and by knockdown of these kinases and c-Jun with siRNA. We also observed that PKCδ mediated the activation of JNK and c-Jun, and experiments using specific inhibitors and siRNA demonstrated that Syk was the upstream kinase for the activation of PKCδ.</P><B>Conclusion</B><P>The present findings suggest that IL-32 may be a newly identified prognostic biomarker in RA, thereby adding valuable knowledge to the understanding of this disease. The results also demonstrate that the production of IL-32 in RA FLS is regulated by Syk/PKCδ-mediated signaling events.</P>
Impact of calcineurin inhibitors on rat glioma cells viability
Seong, Jeong Hun,Park, Woo Yeong,Paek, Jin Hyuk,Park, Sung Bae,Han, Seungyeup,Mun, Kyo-Cheol,Jin, Kyubok Yeungnam University College of Medicine 2019 Yeungnam University Journal of Medicine Vol.36 No.2
Background: Although kidney transplantation outcomes have improved dramatically after using calcineurin inhibitors (CNIs), CNI toxicity continues to be reported and the mechanism remains uncertain. Here, we investigated the neurotoxicity of CNIs by focusing on the viability of glioma cells. Methods: Glioma cells were treated with several concentrations of CNIs for 24 hours at $37^{\circ}C$ and their cell viability was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Results: Exposure to 0, 0.25, 0.5, 2.5, 5.0, and 10.0 mM concentrations respectively showed 100%, 64.3%, 61.3%, 68.1%, 62.4%, and 68.6% cell viability for cyclosporine and 100%, 38.6%, 40.8%, 43.7%, 37.8%, and 43.0% for tacrolimus. The direct toxic effect of tacrolimus on glioma cell viability was stronger than that of cyclosporine at the same concentration. Conclusion: CNIs can cause neurological side effects by directly exerting cytotoxic effects on brain cells. Therefore, we should carefully monitor the neurologic symptoms and level of CNIs in kidney transplant patients.
Jungho Mun,Young Uk Jeong,Byung Cheol Lee,Hyuk Jin Cha,Ji Young Lee,Kitae Lee,Kwon-hae Yea,Pil Dong Ahn,Seong Hee Park,Yong Ho Cha,Yong Woo Lee 한국물리학회 2007 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.51 No.I
Terahertz (THz) pulses from solid targets, such as an aluminum (Al) and a strong polyester film (Mylar), irradiated by ultra-intense laser pulses were measured by using a liquid-helium-cooled Ge:Ga detector. The irradiating intensity of the Ti:Sapphire laser was more than 10$^{18}$ W/cm$^2$. The typical pulse energy and pulse duration on the target were 200 mJ and 30 fs, respectively. To prevent ultraviolet (UV), visible, and near-infrared (NIR) radiation from being measured by the detector, we used polyethylene (PE) plates and indium-tin-oxide (ITO) films as selective windows and mirrors for the THz radiation. The reflectivity of the ITO film for THz radiation is 10 times higher than that for visible and NIR radiations. The THz wave radiated from a laser-induced plasma has a linear component of the polarization, which may be explained by linear mode conversion from a laser wakefield. This intense and wide-band radiation is expected to be a useful source for various THz applications, as well as for real-time diagnostics for a plasma in which particles are accelerating.