울금(鬱金)에서 분리된 demethoxycurcumin이 백서의 혈관재협착에 미치는 효과

길인호,정명수,신창호,배현옥,정헌택,이기남,Kil, In-Ho,Chong, Myong-Soo,Shin, Chang-Ho,Pae, Hyun-Ock,Chung, Hun-Taeg,Lee, Ki-Nam 대한예방한의학회 2008 대한예방한의학회지 Vol.12 No.3

The pathobiologic process of arterial stenosis following balloon angioplasty continues to be an enigmatic problem in clinical settings. This study investigates the ability of demethoxycurcumin, a curcuminoid isolated from Radix Curcumae, to attenuate balloon injury-induced neointima(NI) formation in the rat carotid artery. It was found that demethoxycurcumin induced inducible heme oxygenase(HO-1) expression and inhibited dose-dependently cellular proliferation in rat vascular smooth muscle cells. Perivascular application of demethoxycurcumin immediately following injury significantly reduced NI area and NI thickness 2 weeks post-injury. Interestingly, treatment with tin-protoporphyrin IX, a HO inhibitor, reversed the effects of demethoxycurcumin on NI formation. These results implicate demethoxycurcumin as a potent new therapeutic agent that is capable of reducing post-angioplasty arterial stenosis through induction of the HO-1 expression.

청소년에서 폭력에의 노출과 관련된 정신의학적 증상

김동기,이호분,민성길,송동호,육기환,전여숙 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.2

서울 시내 중학생 1345명을 대상으로 폭력에 노출되는 정도와 이와 연관된 정신의학적 증상을 알아보고자 하였다. 이를 위해 자기보고식 설문지를 사용하였는데. 설문지의 내용은 사회인구학적 자료와 집. 학교, 동네에서 폭력을 당하거나 목격했는지를 묻는 문항과 폭력에 의한 정신의학적 증상의 정도를 묻는 TSC(trauma symptom checklist)로 구성되었으며, 그 결과는 다음과 같다. 1) 전체 학생 중 45%가 폭력에 노출된 경험이 있었으며. 남자가 여자보다 많았다 (p<0.025). 집에서 구타 당한 경험은 여학생이 22.8%로 남학생보다 유의하게 높았다 (p<0.001). 학교. 동네에서 구타당한 경험은 남학생이 각각 22.1%. 10.1%로서 여학생보다 유의하게 높았다. 2) TSC를 요인 분석한 결과 불안-우울, PTSD, 해리, 분노 증상으로 나뉘었다. TSC는 폭력 경험 변인들과 상관 관계를 나타냈다. 다중 회귀분석을 실시한 결과 TSC와 연관된 폭력 노출 변인은 일생 동안의 폭력 노출(R²=0.18). 최근의 성폭력 경험(R²=7.12). 최근 집에서의 폭력 경험(R²=0.08), 최근 학교에서의 폭력 경험(R²=0.08), 최근 집에서의 폭력 목격(R²=0.07). 모든 종류의 폭력 노출(R²=0.29)로 나타났다. 3) TSC와 유의하게 연관된 사회인구학적 변인은 여성, 물질 남용의 가족력이 있는 경우, 술이나 담배 약물 남용을 하는 청소년인 것으로 나타났다. 따라서 청소년 폭력에의 희생자에 대한 정신의학적 개입에는 이러한 위험인자에 대한 고려가 필요하리라고 본다. In this research, we examined the frequency of exposure to violence in the home, school and neighborhood among middle school students as well as its related psychiatric symptoms. A total of 1,345 students from 5 middle schools in Seoul participated in this study : 670 were male,675 were female. We administered self-reported questionaires including discriptions of exposure to violence and a trauma symptom checklist(TSC)(Singer 1995). 1) The total frequency of exposure to any type of violence was 45% in our sample. The frequency of girls' being hit in home was 22.8%, which was significantly higher than it was for boys(p<0.001). The frequency of boys' exposure to violence in school and in the neighbor-hood was 22.1% and 10.1% respectively, which was higher than it was for girls(p <0.005). 2) In factor analysis of TSC, 4 factors were identified. TSC including depression-anxity, PTSD, dissociation and anger was correlated with violence exposure variables. Multiple regression analysis revealed that TSC is related with violence victimization in life(R2=0.18), sexual assault(R2= 0.12), recent victimization in the home(R2= 0.08), recent witness to violencein the home(R2=0.07), recent victimization in school(R2=0.08) and all violence exposures(R2=0.29). 3) Among the demographic variables, sex, parental alcohol problem and student alcohol-smoking-drug problems influenced the TSC(p <0.005). TSC could be result of witness to violence as well as violence victimization. And the risk factors for violence-related psychiatric symptoms were mainly seen in females, who have parents with alcohol problems or who themselves have alcohol-smoking-substance problems. So intervention programs for violence victims should be focused on the these high risk group.

Mirizzi 증후군의 변형된 분류와 치료

김형철,강길호,채만규,김성용,백무준,이문수,박상흠,이문호,김창호,송옥평,조무식,박희주 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

Purpose : The Mirizzi syndrome is relatively rare and preoperative diagnosis of this disease is difficult. In 1978, Morelli suggested the subclassification of the Mirizzi syndrome into acute or chronic form. We experienced 5 cases of acute form. We analysed clinical features, preoperative radiologic findings and operative findings of 18 cases including acute forms which were diagnosed as Mirizzi syndrome and should suggest the modified classification of Mirizzi syndrome for choice of appropriate treatment. Method : From January 1995 to December 1998, 18 cases, of which 8 cases were diagnosed at Soonchunhyang University Chunan Hospital, and 10 cases were reported in the Korean Journal were retrospectively analysed with regard to clinical features, preoperative radiologic findings and operative findings. According to the clinical features, whole cases were divided into type Ⅰ(acute form) and type Ⅱ(chronic form) and then each type of cases were subclassified according to preoperative radiologic findings and operative findings. Results : Of 18 cases there were 5 cases in type Ⅰ(27.8%), 13 cases in type Ⅱ(72.2%). Type Ⅱb was most common. Type Ⅰa cases were treated only with cholecystectomy. We applied cholecystectomy, T-tube choledochostomy and patch technique in type Ⅰb and thpe Ⅰc cases. Cholectystectomies including removal of gallstones and internal drainage procedures were done in type Ⅱ chronic forms. Conclusion : The acute form(Type Ⅰ) of Mirizzi syndrome was suggested by Morelli might be subclassified into typeⅠa,Ⅰb and Ⅰc following the presence of the necrotic defect in common hepatic duct. Through the modified classification of Mirizzi syndrome based on clinical feature, preoperative radiologic findings and operative findings, we can choice appropriate treatment.

염증성 피부질환 개선 기능 소재로서 둥근전복(Haliotis discus) 유래 항균펩타이드 Ab4-7의 항염증 효과

최수철 ( Soo-cheol Choi ),서정길 ( Jung-kil Seo ),황준호 ( Joon-ho Hwang ),이기영 ( Ki-young Lee ),이인아 ( In-ah Lee ) 대한화장품학회 2020 대한화장품학회지 Vol.46 No.2

서해안에 서식하는 해양생물인 전복은 항산화 및 항염증 효과가 있으며, 항생제 개발 및 화장품 원료 등 다양한 산업에 활용될 수 있는 잠재력을 가진 자원이다. 본 연구에서 우리는 서해안의 다양한 해양 생물중에서 전복을 선택하였으며, 전복에서 분리한 항균펩타이드(AMP)를 이용하여 항균펩타이드 유도체인 Ab4-7를 규명하고 생리활성을 연구하였다. Ab4-7의 항염증 효능을 확인하기 위해 염증이 유도된 RAW 264.7에 Ab4-7을 처리한 결과, 염증성 사이토카인, TLR4, TNF-α, IL-1β, COX-2, iNOS 등을 억제하고 항산화와 관련된 유전인자인 HO-1의 mRNA 발현을 증가시켰다. Ab4-7의 강력한 항산화 및 항염증 효과를 바탕으로, 염증이 유도된 RAW 264.7 세포에서 Ab4-7이 extrocellular matrix metalloproteinase (ECM) 분해에 관여하여 다양한 염증성 피부질환을 유도하는 유전자인 matrix metalloproteinase (MMPs)를 조절하는 효과를 RT-PCR을 통해 확인하였다. Ab4-7은 강력한 항염증 및 항산화 효과를 가지고 있으며, 항염증 및 항산화 효과를 통한 MMPs 관련 유전인자 조절을 통해 다양한 염증성 피부질환 치료제의 기능성 재료로 활용될 수 있다고 사료된다. Abalone, a marine organism inhabiting the west coast of Korea, has antioxidant and anti-inflammatory effects, and is a resource with potential to be used in various industries such as antibiotic development and cosmetic raw materials. In this study, we chose abalone among various marine lives on the west coast. Antibacterial peptide (AMP) was separated from abalone and its derivative Ab4-7 was identified and its physiological activity was studied. The treatment of Ab4-7 in inflammatory RAW 264.7 to check the anti-inflammatory efficacy nhibited inflammatory cytokines, TLR4, TNF-α, IL-1β, COX-2, and iNOS and increased mRNA manifestation of HO-1, genes related to antioxidants. Based on the strong antioxidant and anti-inflammatory effects of Ab4-7, the effects of Ab4-7 in the inflammatory RAW 264.7 cells were identified through RT-PCR, which regulates the gene Matrix Metalloproteinase (MMPs) that induces a variety of inflammatory skin diseases by engaging in the decomposition of the extrocellular matrix metalloproteinase (ECM). Taken together, it is concluded that Ab4-7 has a powerful anti-inflammatory and antioxidant effect and can be used as a functional material for various inflammatory skin disease treatments by controlling the genes associated with matrix metalloproteinase (MMPs).

양방향 10MDSL을 위한 VDSL 시스템의 주파수할당 계획

길정수,권호열 江原大學校 産業技術硏究所 2002 産業技術硏究 Vol.22 No.B

In this paper, we discussed an effective VDSL frequency plan for symmetric 10MDSL service. The frequency plan 998 and plan 997 for asymmetric VDSL services have been not optimally designed for 10MDSL services. To obtain the reaches and data rates of 10MDSL, we proposed two frequency allocation schemes : Static method and dynamic method. We can select frequency bands with their fixed boundaries in static method while with their variable boundaries in dynamic method. To show the effectiveness of our proposed methods, we performed some simulations about plan 997 and plan 998, new static method, and new dynamic method, According to the simulation results, the proposed dynamic method can provide the best data rates and reaches for 10 Mbps symmetric VDSL services.

Heart Rate Variability 신호의 시간 및 주파수 영역 분석

길정수,권호열 江原大學校 産業技術硏究所 2002 産業技術硏究 Vol.22 No.B

Autonomic nervous system play an important role of keeping our health as balancing homeostasis. But the abnormality of these abilities makes our presence be feeble. To obtain these information of body which helps for us to decide whether one is healthy or not, based on the study of Heart Rate Variability. In this paper, we presented HRV model and its processing steps to extract some information of human body, After that, some experimental results are presented in time-domain and frequency-domain.

높은 지향성을 갖는 Air Line 결합기 설계

길준범,이성원,최영호,박종임,안달,박준석 호서대학교 반도체제조장비국산화연구센터 2000 학술대회 자료집 Vol.2000 No.1

본 논문에서는, 일반적인 스트립 구조의 결합기가 갖는 문제 즉, 높은 온도에서 나쁜 특성을 보이는 문제점을 극복하고자 Air Line Type의 결합기를 구현하였다. 또한 이 결합기는 24dB이상의 지향성을 가지고 있다. 해석을 위해 짝수 모드와 홀수 모드 해석법을 사용하였고, EM-Simulation으로 확인한 특성과 실제 제작된 20dB, 30dB Cellular 대역(800∼900MHz) Air Line 결합기의 결고 특성은 좋은 일치를 보여주고 있다. 또한 최대 장점인 온도 특성은 온도 데이터를 통하여 온도에 강한 특성을 보임을 알 수 있다.

英語 子音 習得에서의 國語障碍

趙佶鎬 혜전대학 1985 論文集 Vol.3 No.-

This paper deals with the native-language interference of Korean native speakers in acquiring English consonants. The main object of this paper, is to examine the native-language interference of Korean native speakers through the contrastive analysis of Korean and English consonants and to suggest the basic ways of surmounting the interference. The interference in Koreans' acquiring English phonemes is mainly in consongnts more than in vowels which are universal in most languages. In this paper, the consonants of Korean and English have been analyzed and compared with each other, and then the interference factors have been predicted from the comparison of the two languages. They are as follows: 1. Interference resulting from the differences of the phonemic presence 2. Interference resulting from the differences of the distinctive features 3. Interference resulting from the transfer of Korean assimilation rules This paper suggests some ways of surmounting the interferences. And this paper is expected to be helpful in understanding the differences between the Korean and English consonants, and in surmounting the interferences.

탄성 접촉 문제의 해석에 관한 연구(Ⅰ)

우호길 忠南大學校 産業技術硏究所 1988 산업기술연구논문집 Vol.3 No.1

A boundary element methed for solving problems of elastic bodies in contact is described. The method is successfully applied to some frictionless contact problems and the results are compared to other numerical and analytical solution to demonstrate the accuracy of the boundary element method.

근접센서를 이용한 자동 두께 측정 시스템

주해호,박현제,정길도,이재원 嶺南大學校 工業技術硏究所 1994 工業技術硏究所論文集 Vol.22 No.2

This paper describes the automatic thickness measurement of the surface grinder for a grinding wheel by application of a proximity sensor, a limit switch, and PLC. The control system is designed to provide feeding a workpiece on the turn-table and pressing it by the upper disk automatically. In the process, the automation of checking the thickness of a grinding wheel is most important. In order to measure the relative displacement, the proximity sensors were employed and the sensitivities of the sensors were investicated and discussed the superiority. It has been shown by model experiment that the automation system of the surface grinder is performed satisfactory.