The Evolving Policy Debate on Border Closure in Korea

Su-Jin Kang,Jihyun Moon,Heewon Kang,Heekyoung Nam,Sangwoo Tak,Sung-Il Cho 대한예방의학회 2020 Journal of Preventive Medicine and Public Health Vol.53 No.5

302 Copyright © 2020 The Korean Society for Preventive Medicine J Prev Med Public Health 2020;53:302-306 • https://doi.org/10.3961/jpmph.20.213 The Evolving Policy Debate on Border Closure in Korea SuJin Kang1, Jihyun Moon2, Heewon Kang1, Heekyoung Nam3, Sangwoo Tak1, Sung-il Cho1,3 1Institute of Health and Environment, Seoul National University, Seoul, Korea; 2Samsung Advanced Institute of Health Science and Technology, Sungkyunkwan University, Seoul, Korea; 3Department of Public Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Korea Brief Report Objectives: In this paper, we aimed to investigate the evolving debate over border closure in Korea during the coronavirus disease 2019 (COVID-19) pandemic, to address the main themes associated with border closure, and to discuss the factors that need to be considered when making such decisions. Methods: We collated and reviewed previously conducted review studies on border closures during infectious disease outbreaks to derive relevant themes and factors. Results: According to our systematic review on border closures and travel restrictions, the effects of such containment efforts are limited. We suggest considering the following factors when determining whether to impose border closure measures: (1) disease characteristics, (2) timeliness of implementation, (3) transmission delay and the basic reproduction number, (4) globalization and pandemics, and (5) social and economic costs. Conclusions: Our assessment indicates that the effects of border closures are at best temporary and limited. Alternative measures must be contemplated and implemented to suppress the spread of COVID-19 in particular and infectious diseases more broadly.

고위험군 가와사끼병에서 스테로이드 추가 요법의 효과

강선미,문은경,인수미,길홍량 대한소아과학회 2002 小兒科 Vol.45 No.12

연안산 패류를 이용한 조미소재의 가공 및 정미성분

문정호,강수태,김종태,오광수 경상대학교 해양산업연구소 2002 해양산업연구소보 Vol.15 No.-

고부가가치를 창출할 수 있는 새로운 식품가공용 풍미조미소계의 개발과 품질의 개선, 그리고 연안에서 생산되는 수산자원의 유효이용이라는 관점에서, 고부가 활용도가 거의 없는 바지락을 원료로 하여 고부가가치의 풍미계 조미소재 및 수프 소재로서 활용될 수 있는 유용 조미소재의 최적 가공조건을 구명하였고, 이의 정미성분을 분석하였다. 바지락 2단 효소분해 조미소재는 최적 가공공정은 다음과 같다. 시료 바지락을 chopper로써 세절한 다음 약 3배량의 물을 가하고, 98℃에서 5분간 자숙하여 자가소화효소를 불활성화시킨 후, 시료액의 pH를 8.0으로 조정하고 여기에 활성이 비교적 약한 내알칼리성 단백분해효소 가하여 교반하면서 55℃에서 4시간 동안 가수분해시킨다. 이어 자숙 처리하여 효소를 불활성화시킨 후 다시 pH를 6.0으로 조정하고, 여기에 exopeptidase 형의 중성 단백분해효소를 가한 다음 45℃에서 교반하면서 4시간 동안 가수분해시키고, 효소를 불활성화시킨 후 원심분리하여 상등액을 취함으로서 효소분해 조미소재를 얻을 수 있었다. 열수추출법, 자가소화법 및 2단효소분해법으로 바지락 조미소재를 조제하고, 각 조미소재의 특성을 서로 비교 검토한 결과, 바지락 열수 및 가압추출 조미소재에서는 대체로 감칠맛이 났으나 맛의 강도가 약하였고 패류취가 감지되었다. 바지락 2단 효소분해 조미소재는 감칠맛과 맛의 조화력이 월등히 강하였고, 특히 투명도 상승 등 조미소재의 물리적, 관능적 품질이 현저히 개선되었다. 바지락 열수 및 가압추출 조미소재, 2단효소분해 조미소재의 유리아미노산 총량은 각각 1,352.1 mg/100g, 1,174.1 mg/100g 및 2,122.4 mg/100g이었고, glutamic acid, glycine, alanine, tyrosine, phonylalanine, arginine 등이 주요 유리아미노산으로 추출방법에 따라 아미노산의 농도변화가 켰다. Betaine 함량은 116.O~845.0 mg/100g으로 열수추출이나 가압추출에 비해 효소분해 조미소재의 함량이 월등히 많았으며, 타 정미성분과도 함량을 비교해 볼 때 바지락 조미소재의 주된 정미성분일 것으로 추정되었다. 무기이온으로서 P, Na, K 및 Cl의 함량이 많았으며, 열수나 가압추출 조미소재에 비해 효소분해 조미소재 쪽이 함량이 훨씬 많았다. To develop natural flavoring substances, optimal two stage enzyme hydrolysis conditions and flavour compounds for short-neck clam enzyme hydrolysates were examined. The optimal enzyme hydrolysis conditions for two stage enzyme hydrolysate(TSEH) of short-neck clam were revealed in temperature at 55℃ for 4 hours digestion with alcalase at the 1st stage and 4 hours digestion at 45℃ with exopeptidase type neutrase at the 2nd stage. From the results in quality tests of hot-water extracts, steam extracts and 4 kinds of enzyme hydrolysates, TSEH processing method was superior to other methods on the aspects of yield, nitrogen contents, taste such as umami intensity and inhibition of off-flavor formation, and transparency of extract. And the flavor constituents and functionality of short-neck clam were also examined as affected by two stage enzyme hydrolysis. Total free amino acid contents in hot-water extract steam extract and TSEH of short-neck clam were 1,352.1 mg%, 1,174.1 mg% and 2,122.4 mg%, respectively. Major free amino acids in TSEH were glutamic acid, glycine, alanine, tyrosine, phenylalanine, arginine. As for nucleotides and other bases, betaine, TMAO and creatinine were principal components in TSEH. And the major inorganic ions in TSEH were Na, K, p and Cl

大田地域 一部女性의 膣트리코모나스感染에 關한 調査硏究

姜文洙,李英河,羅榮彦,辛大煥 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.1

Studies on Trichomonas vaginalis in 180 obstetics and gynecologic out-patient and 217 prosititues were carried out at Daejeon areas during August to September, 1988. All the vaginal specimens were cultured on las’s casein hydrolysate-serum at 37.5℃ for 10 days. The results are summarized as follows: 1. The prevalence of Trichomonas vaginalis was 13.9% in total examined group. 2. The prevalence of Trichomonas vaginalis was 7.8% in 180 obsterics and gynecologic out-patients and 18.9% in 217 prostitutes. 3. According to age group, the prevalence of obstetrics and gynecologic patients were 10.7%(0―29 age group in years), 9.1% (40―49 age group in years), 5.6% (30―39 age group in years) and 5.3% (over 50 age group in years). 4. According to age group, the prevalence of obstetrics and gynecologic patients were 25.3% (0―29 age group in years), 25.0% (40―49 age group in years) and 11.4% (30―39 age group in years). 5. The most affected age group of Trichomonas vaginalis was 20―29 age group in obstetics and gynecologic out-patients and prostitutes.

삼척시 원덕읍 주민을 대상으로 한 류마티스 관절염 및 종양 진단

문수인,이도영,강진석 남서울대학교 2012 남서울대학교 논문집 Vol.18 No.1

Diagnosis of rheumatoid arthritis and cancer requires specific proteins as antigens and it has been developed by using a rapid detection kit and latex agglutination which identify circulating antibodies in the blood sera. In this study conducted by Namseoul University Health Medicine Care Service in October 2010, with the residents in Wondeok-eup, Samcheok city, Kangwon-do, the rapid diagnosis of the rheumatoid arthritis and cancer was performed by analyzing patients' blood sera. Rheumatoid arthritis and cancer were diagnosed in 3 and 1 patients, respectively in a total of twenty-six persons. In the rapid diagnosis of rheumatoid arthritis using by latex agglutination, there were one positive case of C-reactive protein (CRP), one positive case of Rheumatoid factor (RF) and one positive case of both CRP and RF detected. In the rapid diagnosis of cancer, one positive case of prostate specific antigen (PSA) was observed. Key Words : Diagnosis, Kit, Rheumatoid arthritis, Cancer

가토에서 관절원판을 전방변위시킨 후 두개하악관절의 조직병리학적 변화

김문수,여환호,김수관,강태호,박정열,장현석 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.5

To investigate the histopathologic changes of the rabbit craniomandibular joint (CMJ), anterior disc displacement (ADD) was surgically induced. Of 15 rabbits, 9 were classified as experimental group, 3 as control of group, and 3 as sham-operation group, respectively The experimental group (9 rabbit) was subdivided into 6 weeks, 12 weeks, and 20 weeks group, respectively 3 rabbits. In experimental group, the disc was displaced anteriorly at the right side(operation side) and left CMJ was not operated(non-operation side). Both CMJs were harvested at 6, 12, and 20 weeks following surgery in experimental group. The CMJ was harvested at 6 weeks following surgery in sham-operation group. The specimens were examined under light microscope after hematoxylineosin and verhoeff staining. The obtained results were as follows: 1.In midsagittal view of control and sham-operation group, there were no degenerative and hyperplastic changes in the CMJ including articular disc, mandibular condyle, and temporal fossa. 2.Disc was shortened anterior-posteriorly and deformed of biconcave shape in all experimental group. In 20 week experimental group, intermediate zone of disc width was almost same as the width of posterior band of disc. 3.Soft tissue hyperplasia at the posterior attachment area of the disc and condylar hyperplasia were seen in the all experimental groups, but the degree of the hyperplasia was greater at 12, 20 weeks than at 6 weeks. 4.The number of elastic fiber in the disc proper was decreased and the direction and morphology was chanced in all experimental groups compared with those of control of groups. 5.Fatty degeneration was shown in non-operation side of 20 weeks experimental group. These results suggest that induced ADD in craniomandibular joint of rabbits could lead to a reparative and degenerative changes of the affected joint similar to those described for osteoarthrosis and osteoarthritis in human.

지대별 가시오갈피의 광합성 반응

이강세,현동윤,박문수,김선 군산대학교 기초과학연구소 2000 基礎科學硏究 Vol.15 No.-

We determined the most adapted area as measured leaf function and chlorophyⅡfluorescence with a long-term on leaflets of Kasiogalpi (Eleutherococcus senticosus Mas) plants grown in Iksan, Changge and Mt. Chiri. 1. In area of Iksan and Changge, during the day, rate of CO2 assimilation was highest at ante meridiem, and it was not coincide with transpiration. But transpiration was generally coincide with highest light intensity and leaf temperature. When compared CO2 assimilation at each area, Changge showed highly pronounced diurnal fluctuation throughout season, but Mt. Chiri remaining low level without obvious fluctuation during the day. 2. The time-course of PAR (photon active radiation) and leaf temperature at each area was observed differently. Among areas, it showed substantially higher at Iksan than at relatively high attitude area (Mt. Chiri). 3. ChlorophyⅡ fluorescence, i.e., Fo, Fm and Fv/Fm were not different in compared Iksan with Changge. But at Mt. Chiri, it was higher than at any other areas.

β-agarase를 생산하는 해양균의 분리 및 효소 특성연구

김문수,김도만,박혜영,강미화,천종훈 전남대학교 촉매연구소 2000 觸媒硏究 論文集 Vol.21 No.-

An agar degrading bacteria was isolated from the south ocean of Korea and was identified as Aeromonas sp. This strain produced the amount of agarase (1.4U/ml) with agar as a carbon source and casamino acid as a nitrogen source. The optimum concentration of NaCl for both cell growth and enzyme activity was 2.5%. The agarase was purified by DEAE-cellulose and hydroxyapatite column chro-matograpy. The purified agarase showed a single protein band upon sodium dodecyl sulfate-polyacrylamide gel electrophoresis(SDS-PAGE) and its molecular weight was estimated to be 50 KDa. The optimal temperature and pH for the enzyme activity were 28℃ and 7.2, respectively. The agarase was stable at pH 6.5 - 8 and 22 - 37℃. The agarase activity was notably inhibited by EDTA, Mn2+, Hg2+, Fe2+ and slightly activated by Na+ and Ba2+.

연속식 오존처리공정을 이용한 낙동강 상수원수의 정수처리 효과

임영성,강관호,이홍재,서동철,박문수,허종수,조주식 한국환경농학회 2002 한국환경농학회지 Vol.21 No.3

낙동강 상수원수를 대상으로 연속적 오존처리에서 오존주업농도에 따른 유기물 분해 특성을 조사하기 위하여 오존처리에 의한 DOC성분변화, UV254/DOC의 변화와 소비오존에 따른 DOC 제거효율을 조사한 결과는 다음과 같다. 유입원수의 수질변화에 따라 다소 차이는 있었으나 전반적으로 오존주입농도가 증가할수록 DOC 처리효율도 증가되었다. 오존처리에 따른 DOC 성분변화는 전오존을 3 mg/L농도로 처리시 TDOC, ADOC, A&BDOC 및 NRDOC는 각각0.6, 0.2, 0.1 및 1.0 mg/L 정도 오존처리에 의하여 감소되었으나 BDOC는 0.8 mg/L 증가하였다. UV254/DOC의 분율은 오존주입농도를 1, 3 및 5 mg/L 처리하였을 때 전오존의 경우는 각각 0.048, 0.044 및 0.037 이였고, 후오존의 경우는 각각 0.018, 0.015 및 0.012로 나타나 오존주입농도가 증가할수록 감소하는 경향을 보였다. 초기 DOC mg당 소비되는 오존량에 대한 DOC 제거율은 전오존과 후오존처리의 초기 DOC에 대한 소비오존량이 각각 약 1.5와 2.3일 때 각자 25%와 32%로서 최대의 DOC 처리효율을 나타내었다. 낙동강 상수원수에 전오존을 처리할 경우 오존주입량은 초기 DOC mg당 소비된 오존이 1.5 mg 이내의 농도가 되도록 주입하고, 후오존은 유입수인 모래여과수의 초기 DOC mg당 소비된 오존이 2.3 mg이내의 농도가 되도록 조절하여 주입하면 적당할 것으로 생각되었다. This study was carried out to evaluate the pollutant removal efficiencies of the advanced drinking water treatment using ozonation process. For raw water. Nakdong River was used. By conducting continuous ozonation experiments, the following results were obtained. Efficiency of water treatment was enhanced with increase in ozone dosage. When ozone dosage of 3 mg/L was used, preozonation of raw water reduced TDOC, ADOC, A&BDOC and NRDOC as much as 0.6 mg/L, 0.2 mg/L, 0.1 mg/L and 1.0 mg/L, respectively. On the other hand, content of BDOC Increased at the level of 0.8 mg/L. Ratio of UV254 absorbance to DOC content by the preozonation with 1, 3 and 5 mg/L dosage were 0.048, 0.044 and 0.037, respectively. In case of postozonation, it were 0.018, 0.015 and 0.012, respectively. When the ratios of consumpted ozone content to 1 mg of initial DOC were 1.5 and 2.3 in preozonation and postozonation treatment, respectively, the highest DOC removal rates of 25% and 32% were obtained by the continuous ozonation.

강원도지역에서 발생한 발진열과 쯔쯔가무시병

민창홍,장우현,강재승,조수익,최문기,조민기,윤창순,김윤원 대한감염학회 1988 감염 Vol.20 No.2

In Korea, there has been an increasing concern on rickettsiosis as one of most prevailing acute febrile illness, since murine typhus and scrub typhus had not been reported for 2 decades until 1986 and thereafter a few studies were reported on these diseases. A microimmunofluorescence test was used to study antibodies to R. typhi and R. tsutsugamushi in urban and rural inhabitants students, and patiants suspected of leptospirosis or rickettsiosis from 1986 to 1987 in Kangwon-do Korea. 43% of inhabitatnts and 17% of students reacted to R. typhi. Only one inhabitant among inhabitants and students reacted to R. tsutsugamushi. Among 169 patients, 43(25%) reacted to R. typhi, 38(22%) to R. tsutsugamushi and 25(15%) to Leptospira interrogans. Sexual rate(male; female) in murine typhus was 1.7:1, that in scrub typhus was 1:2.2 and that in leptospirosis was 1.5;1. The age ditribution of patients with murine typhus was generally even over 20 years old. But 71% of patients with scrub typhus were over 40 years old. Scrub typhus was most prevailing in female over 40 years old. Murine typhus was relatively more prevailing in Choonchun city than rural area as compared with scrub typhus and leptospirosis. Most of scrub typhus occurred in rural area. Most of each disease occurred between September and November (murine typhus; 93%, scrub typhus; 95%, leptospirosis; 84%) with a peak in October. Scrub typhus considerably occurred not only October(58%) but also November(28%). All patients with scrub typhus were immediately diagnosed by antibody when they visited hospital. 53% of patients with murine typhus were diagnosed when they visited hospital within 7 days after onset of illness, and others were done by second sera obtained 8 days after. The patients in whom IgM was seronegative but antibodies of other class were seropsitive by 20 days after onset of illness, were 14% in murine typhus and 26% in scrub typhus. At least those patients were considered to be infected second. Murine typhus and scrub typhus were suggested to be endemic diseases in Kangwon-do as antibodies of inhabitants and characteristics of patients' sera were considered. By serologic finding of patients with scrub typhus in Kangwon-do, Gilliam was 59'% of etiologic strain of scrub typhus, Karp was 41q% and Kato was none. Most scrub typhus occurred in person to be related to agriculture, but murine typhus was not related to job and occurred more in small city than rural area. Rash was scarcely detected in murine typhus and scrub typhus, and eschar was in 50% of scrub typhus only. Serum transaminase elevated in many patients with scrub typhus and murine typhus. Leukocytosis and abnormal finding in chest X-ray were showed in some patients with scrub typhus but were scarcely in murine typhus.