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        가토에서 관절원판을 전방변위시킨 후 두개하악관절의 조직병리학적 변화

        김문수,여환호,김수관,강태호,박정열,장현석 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.5

        To investigate the histopathologic changes of the rabbit craniomandibular joint (CMJ), anterior disc displacement (ADD) was surgically induced. Of 15 rabbits, 9 were classified as experimental group, 3 as control of group, and 3 as sham-operation group, respectively The experimental group (9 rabbit) was subdivided into 6 weeks, 12 weeks, and 20 weeks group, respectively 3 rabbits. In experimental group, the disc was displaced anteriorly at the right side(operation side) and left CMJ was not operated(non-operation side). Both CMJs were harvested at 6, 12, and 20 weeks following surgery in experimental group. The CMJ was harvested at 6 weeks following surgery in sham-operation group. The specimens were examined under light microscope after hematoxylineosin and verhoeff staining. The obtained results were as follows: 1.In midsagittal view of control and sham-operation group, there were no degenerative and hyperplastic changes in the CMJ including articular disc, mandibular condyle, and temporal fossa. 2.Disc was shortened anterior-posteriorly and deformed of biconcave shape in all experimental group. In 20 week experimental group, intermediate zone of disc width was almost same as the width of posterior band of disc. 3.Soft tissue hyperplasia at the posterior attachment area of the disc and condylar hyperplasia were seen in the all experimental groups, but the degree of the hyperplasia was greater at 12, 20 weeks than at 6 weeks. 4.The number of elastic fiber in the disc proper was decreased and the direction and morphology was chanced in all experimental groups compared with those of control of groups. 5.Fatty degeneration was shown in non-operation side of 20 weeks experimental group. These results suggest that induced ADD in craniomandibular joint of rabbits could lead to a reparative and degenerative changes of the affected joint similar to those described for osteoarthrosis and osteoarthritis in human.

      • 생약추출물에 의한 화상치료효과

        문선인, 홍장수 충북대학교 의과대학 충북대학교 의학연구소 2012 忠北醫大學術誌 Vol.22 No.1

        연구목적: 본 연구는 당귀, 작약, 시호 등 다양한 약초 성분을 혼합하여 제조한 생약추출물이 화상치 료제로서의 가능성이 있는지 확인하기 위한 전임상 예비실험으로 2도 화상을 입힌 랫드의 피부에 수차 례 살포하고 시간경과에 따른 피부조직의 치유 정도를 자연치유군과 비교해 평가하고자 하였다. 대상 및 방법: 4주령의 랫드를 5마리씩 양군에 배정하여 2도 화상을 유도한 후 한군은 자연치과정을, 나머지 한 군은 생약추출물을 살포한 후 3일간 치유과정을 육안으로 관찰하고 면역조직염색을 통한 조 직변화를 비교 평가하였다. 결과: 화상 3일 후의 창상부위는 육안 상으로 관찰했을 때 생약처리군의 경우가 자연치유군에 비해 상 대적으로 매우 빠르게 호전되는 것으로 나타났으며 병리조직학적 비교에서도 생약처리군의 경우가 다 소 경미한 것으로 나타났으나 화상 중앙부위에 대한 조직학적 차이는 관찰되지 않았다. 결론: 본 연구에서 비록 조직학적 측면에서의 효과를 검증하지는 못하였으나 생약추출물의 화상치유 효과에 대한 충분한 가능성을 확인할 수 있었다. 보다 구체적이고 장기적인 연구를 통하여 생약추출물 의 화상치유 효과를 검증할 필요성이 있다.

      • 6시그마 방법론을 활용한 부춤 수명 개선 사례 연구

        이장희,이문수 한국기술교육대학교 2006 論文集 Vol.13 No.1

        This paper presented a case study of a six sigma application for improving part lifetime. We implemented Guage R&R study, Process Capability Analysis, 4-Step Diagram and Lifetime Estimation based on Accelerated Life Test data according to the DMAIC procedure of six sigma in order to find significant fail modes and their main causes and set up corrective action plans for improving lifetime of part such as motor. Through the use of six sigma methodology, we could systematically improve the lifetime of motor and establish an effective motor's lifetime control system.

      • 단독주택의 용도별 에너지 소비에 관한 연구

        김병수,장문석,박효순,송인춘 충남대학교 산업기술연구소 2000 산업기술연구논문집 Vol.15 No.1

        The purpose of this study is to analyze the situation of energy consumption and its characteristics in detached houses. The survey is carried out in detached houses to investigate the energy consumption and energy use trend in according to three different climate zones. Building energy simulation by DOE-2 computer program was undertaken for detailed analysis of the energy use characteristic in detached houses. Also, The room temperature and the energy use of the year were also calculated. Finally, The energy consumption characteristics of heating, cooling, cooking and electric equipments in detached houses depends on life style of resident such as room temperature, occupancy type and equipment operating schedule and etc. And also, the results of this study will be to provide basic data concerned with total energy consumption in detached houses.

      • KCI등재후보

        건물화재시 창문재료에 따른 내화특성 연구

        허만성,장문석,조수 한국화재소방학회 2003 한국화재소방학회논문지 Vol.17 No.1

        실제 건물화재에서 창문재료의 내화특성을 평가하기 위하여 건물화재실험이 수행되었다. 4m×3.8m×2.4m 방에서 PVC 창문, 알루미늄 창문, AL+Wood 창문을 각각 설치하고 화원은 소파와 매트리스를 사용하였다. 창문은 아파트 베란다에 많이 사용하는 유리두께 6 mm 사이에 공기층 12 mm인 것을 사용하였다. 건물내부와 창문 주변의 온도분포를 살펴보기 위하여 32개 지점의 온도를 측정하였다. 실험 결과 건물내의 온도분포, 창틀의 변화, 유리창의 파손 정도 등을 조사하여 분석하였다. The full-scale compartment fire tests were carried out to evaluate the characteristics of fire resistance of window material under actual fire conditions. The room size used for full-scale room fire tests was 4 by 3.8 m with 2.4 m high ceiling. The windows with PVC, Aluminum and AL+Wood frame materials were established, sofa and mattress were used as fire sources. The window contained pair glasses with the air between 6 mm glasses. Temperatures at total 32 points in the room were measured to find the temperature distribution in the room fire. It is examined that thermal effects on window frame materials such as charring, distortion, melting, structural collapse, and other effects.

      • Coacervation-상분리법으로 만든 Ethyl Cellulose 마이크로캅셀의 Glibenclamide 방출특성 및 수용성 첨가제의 영향

        김병조,장정수,이문주,김상헌,최영욱 중앙대학교 약학연구소 1996 약학 논총 Vol.10 No.-

        Glibenclamide (GBC) is a well-known antidiabetic agent, which stimulates the secretion of endogenous insulin by pancreatic βcells. However, administration of GBC at a high dose can occasionally induced the fatal hypoglycemia, especially in the patients with impaired liver function. Therefore, in order to develop an oral sustained-release preparation which reduces the side effect, microcapsulation of GBC has been carried out in this experiment. Microcapsules of GBC were prepared by coacervation-phase separation method with ethylcellulose as a wall-forming material in cyclohexane, using polyisobutylene as a coacervation-inducing agent. Different amounts of hydrophilic additives. L-arginine(ARG) and polyethylene glycol 4000 (PEG), were added to the microcapsule wall, in order to alter the porosity of the wall and hence to enhance the release of the core material. The microcapsules prepared were examined for physical properties by scanning electron microscopy (SEM) and particle size analysis. The release of the poorly water-soluble GBC was found to be very slow from the microcapsules and strongly dependent on the core to wall ratio of the microcapsules, but it was accelerated considerably with increasing amount of PEG or ARG. In general, on the basis of dissolution kinetics, GBC releases from microcapsules were followed apparent first-order kinetics, while the dissolution data of GBC powder conformed to Hixon-Crowell's cube root law. Therefore, in conclusion, it might be possible to design the sustained-release formulation by the combination of both GBC powder and microcapsules of different core wall ratio with or without hydrophilic additives.

      • 굴껍질에 의한 산성폐수 중화능에 관한 연구

        박진식,장성호,문추연,성낙창,김수생 동아대학교 환경문제연구소 1995 硏究報告 Vol.18 No.2

        This Study has been carried out to evaluate the neutralization ability of waste oyster shelles. The results of this study are summerized as following ; 1. For reactiontime, neutralization effective were investigate smally but pH variations were investigate largely for 10 minutes reactiontime. 2. pH variations with dosage of oyster shelles were small except pH 2 3. Therefore, waste oyster shelles is able to neutralize for acid wastewater.

      • SCIESCOPUSKCI등재

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