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경막 내 colistimethate 투여로 치료한 다제 내성 cinetobacter baumannii 뇌실염
홍유아,유진홍,김진진,모은영,안건희,정희경,김진석,이현정,정미향,윤승배 대한감염학회 2009 감염과 화학요법 Vol.41 No.4
Acinetobacter species is a non-fermentative aerobic gram-negative coccobacillus that is an important pathogen found in nosocomial infections. Recently, multi-drug resistant Acinetobacter baumannii (MDR-AB) infections have been increasing and pose a serious problem. Most such infections present as bacteremia, pneumonia, or a wound infection; however, CNS infections are very rare. We herein present a case of ventriculitis caused by MDR-AB in a 37-year old man after a neurosurgical intervention. The patient was successfully treated with intrathecal colistimethate.
Bacillus sp. KCM-101에 의한 내열성 α-amylase의 생산 및 효소학적 성질
강상모,최유정,황윤영,이동희,권태종 건국대학교 산업기술연구원 2000 건국기술연구논문지 Vol.25 No.-
A strain isolated from soil was able to produce thermostable α-amylase. The strain (KC-101) was identification as Bacillus sp. Bacillus sp. KC-101 was treated NTG(N-methyl-nitro-nitrosoguanidine). The mutant KCM-101 increased α-amylase activity and decreased pretease activity. The condition for production, purification, and properties of α-amylase were investigated. α-Amylase production was maximized when was grown on soluble starch 2.0%, yeast extract 0.5%, K2HPO4 0.1% and MnCl2 0.02% for 24hrs at 37℃, and initial pH 7.0. The enzyme production was also increased by the addition of 0.01% Triton X-100. The enzyme was purified by ultrafiltration(MW 10,000), 80% ammonium sulfate precipitation, and Sephadex G-75 gel chromatography and it's yield 15.0%, The characteristics of purified α-amylase were as follow : MW 55,000, optimal pH and temperature were 7.0 and 95℃, respectively. The enzyme was activated by Ca++ and Mn++ ion but inhibited Co++, Cu++, Hg++, and Pb++ ion. The enzyme was stable at 95℃ and it's thermostability was greatly increased by the addition of Ca++. In kinetic studies, the Km value of α-amylase for soluble starch was 0.93mg/mL.
Ferric Reductase Activity of the ArsH Protein from Acidithiobacillus ferrooxidans
( Mo Hong Yu ),( Qian Chen ),( Juan Du ),( Lin Tang ),( Fang Qin ),( Bo Miao ),( Xue Ling Wu ),( Jia Zeng ) 한국미생물 · 생명공학회 2011 Journal of microbiology and biotechnology Vol.21 No.5
The arsH gene is one of the arsenic resistance system in bacteria and eukaryotes. The ArsH protein was annotated as a NADPH-dependent flavin mononucleotide (FMN) reductase with unknown biological function. Here we report for the first time that the ArsH protein showed high ferric reductase activity. Glu104 was an essential residue for maintaining the stability of the FMN cofactor. The ArsH protein may perform an important role for cytosolic ferric iron assimilation in vivo.
Yu, Chan-Mo,Youn, Jin-soup,Jung, Hee-Keum Korean Chemical Society 2006 Bulletin of the Korean Chemical Society Vol.27 No.4
The preparation of enatiomerically enriched homoallylic alcohols through asymmetric addition of chiral allylic transfer reagents and allylating reagents with chiral catalysts to the carbonyl functionalities represents an important chemical transformation. Excellent progress has been made over past decade in the development and application of catalytic asymmetric allylic transfer reactions. In this account, our efforts for the various intermolecular allylic transfer reactions such as allylation, propargylation, allenylation, and dienylation utilizing accelerating strategy and sequential allylic transfer reactions to achieve multiple stereoselection mainly using transition metal catalysts are described.
Yu, Mo,Evans II, Neal J.,Dodson-Robinson, Sarah E.,Willacy, Karen,Turner, Neal J. American Astronomical Society 2017 The Astrophysical journal Vol.850 No.2
<P>Turbulence is the leading candidate for angular momentum transport in protoplanetary disks and therefore influences disk lifetimes and planet formation timescales. However, the turbulent properties of protoplanetary disks are poorly constrained observationally. Recent studies have found turbulent speeds smaller than what fullydeveloped MRI would produce (Flaherty et al.). However, existing studies assumed a constant CO/H-2 ratio of 10(-4) in locations where CO is not frozen-out or photo-dissociated. Our previous studies of evolving disk chemistry indicate that CO is depleted by incorporation into complex organic molecules well inside the freeze-out radius of CO. We consider the effects of this chemical depletion on measurements of turbulence. Simon et al. suggested that the ratio of the peak line flux to the flux at line center of the CO J = 3-2 transition is a reasonable diagnostic of turbulence, so we focus on that metric, while adding some analysis of the more complex effects on spatial distribution. We simulate the emission lines of CO based on chemical evolution models presented in Yu et al., and find that the peak-to-trough ratio changes as a function of time as CO is destroyed. Specifically, a CO-depleted disk with high turbulent velocity mimics the peak-to-trough ratios of a non-CO-depleted disk with lower turbulent velocity. We suggest that disk observers and modelers take into account the possibility of CO depletion when using line profiles or peak-to-trough ratios to constrain the degree of turbulence in disks. Assuming that CO/H-2 = 10(-4) at all disk radii can lead to underestimates of turbulent speeds in the disk by at least 0.2 km s(-1).</P>
Yu, Chan-Mo,Youn, Jinsuop,Jung, Juyoung WILEY-VCH Verlag 2006 Angewandte Chemie Vol.45 No.10
<B>Graphic Abstract</B> <P>More adventures of tin–tin: The stereospecific synthesis of 2-stannylvinyl-1,3-diols was achieved through a one-pot allylic transfer/distannation/allylic transfer reaction sequence (see scheme). The method was applied to the concise asymmetric syntheses of (−)-avenaciolide and (−)-isoavenaciolide. <img src='wiley_img/14337851-2006-45-10-ANIE200503863-content.gif' alt='wiley_img/14337851-2006-45-10-ANIE200503863-content'> </P>
Disk Masses around Solar-mass Stars are Underestimated by CO Observations
Yu, Mo,Evans II, Neal J.,Dodson-Robinson, Sarah E.,Willacy, Karen,Turner, Neal J. American Astronomical Society 2017 The Astrophysical journal Vol.841 No.1
<P>Gas in protostellar disks provides. the raw material for giant planet formation and controls the dynamics of the planetesimal-building dust grains. Accurate gas mass measurements help map the observed properties of planet-forming disks onto the formation environments of known exoplanets. Rare isotopologues of carbon monoxide (CO) have been used as gas mass tracers for disks in the Lupus star-forming region, with an assumed interstellar CO/H-2 abundance ratio. Unfortunately, observations of T-Tauri disks show that CO abundance is not interstellar, a finding reproduced by models that show CO abundance decreasing both with distance from the star and as a function of time. Here, we present radiative transfer simulations that assess the accuracy of CO-based disk mass measurements. We find that the combination of CO chemical depletion in the outer disk and optically thick emission from the inner disk leads observers to underestimate gas mass by more than an order of magnitude if they use the standard assumptions of interstellar CO/H-2 ratio and optically thin emission. Furthermore, CO abundance changes on million-year timescales, introducing an age/mass degeneracy into observations. To reach a. factor of a few accuracy for CO-based disk mass measurements, we suggest that observers and modelers adopt the following strategies: (1) select. low-J transitions; (2) observe multiple CO isotopologues and use either intensity ratios or normalized line profiles to diagnose CO chemical depletion; and (3) use spatially resolved observations to measure the CO-abundance distribution.</P>
AI, IOT 기술을 활용한 자기계발 스마트 워치 & 어플 ‘MO:TIVE’
김소연 ( So-yeon Kim ),모하연 ( Ha-yeon Mo ),이유영 ( Yu-young Lee ),이예성 ( Ye-sung Lee ),최가현 ( Ga-hyun Choi ) 한국정보처리학회 2023 한국정보처리학회 학술대회논문집 Vol.30 No.2
‘MO:TIVE’는 AI 및 IoT를 활용하여 자기계발을 촉진하는 모바일 서비스로, 사용자 정보 학습과 정밀한 추천을 제공하며 생성형 AI를 활용한 개인화 조언을 제공한다. 이를 통해 사용자는 스마트 워치를 통해 자투리 시간을 효과적으로 활용하여 자기계발과 삶의 질을 향상을 기대할 수 있으며 지속적인 개선과 학습을 통해 더 나은 사용자 경험을 제공한다.
Yu-lou Tian,Fang Liu,Hong-jing Sun,Pin Lv,Yu-ming Cao,Mo Yu,Yang Yue 대한치과교정학회 2015 대한치과교정학회지 Vol.45 No.5
Objective: To assess the labial and lingual alveolar bone thickness in adults with maxillary central incisors of different inclination by cone-beam computed tomography (CBCT). Methods: Ninety maxillary central incisors from 45 patients were divided into three groups based on the maxillary central incisors to palatal plane angle; lingual-inclined, normal, and labial-inclined. Reformatted CBCT images were used to measure the labial and lingual alveolar bone thickness (ABT) at intervals corresponding to every 1/10 of the root length. The sum of labial ABT and lingual ABT at the level of the root apex was used to calculate the total ABT (TABT). The number of teeth exhibiting alveolar fenestration and dehiscence in each group was also tallied. One-way analysis of variance and Tukey’s honestly significant difference test were applied for statistical analysis. Results: The labial ABT and TABT values at the root apex in the lingual-inclined group were significantly lower than in the other groups (p < 0.05). Lingual and labial ABT values were very low at the cervical level in the lingual-inclined and normal groups. There was a higher prevalence of alveolar fenestration in the lingual-inclined group. Conclusions: Lingual-inclined maxillary central incisors have less bone support at the level of the root apex and a greater frequency of alveolar bone defects than normal maxillary central incisors. The bone plate at the marginal level is also very thin.