Dual graph-regularized Constrained Nonnegative Matrix Factorization for Image Clustering

( Jing Sun ),( Xibiao Cai ),( Fuming Sun ),( Richang Hong ) 한국인터넷정보학회 2017 KSII Transactions on Internet and Information Syst Vol.11 No.5

Nonnegative matrix factorization (NMF) has received considerable attention due to its effectiveness of reducing high dimensional data and importance of producing a parts-based image representation. Most of existing NMF variants attempt to address the assertion that the observed data distribute on a nonlinear low-dimensional manifold. However, recent research results showed that not only the observed data but also the features lie on the low-dimensional manifolds. In addition, a few hard priori label information is available and thus helps to uncover the intrinsic geometrical and discriminative structures of the data space. Motivated by the two aspects above mentioned, we propose a novel algorithm to enhance the effectiveness of image representation, called Dual graph-regularized Constrained Nonnegative Matrix Factorization (DCNMF). The underlying philosophy of the proposed method is that it not only considers the geometric structures of the data manifold and the feature manifold simultaneously, but also mines valuable information from a few known labeled examples. These schemes will improve the performance of image representation and thus enhance the effectiveness of image classification. Extensive experiments on common benchmarks demonstrated that DCNMF has its superiority in image classification compared with state-of-the-art methods.

Influence of zircon on cristobalite crystallization of silicabased ceramic cores

Jing-jing Liang,Quan-hong Lin,Xuan Zhang,Tao Jin,Xiao-feng Sun,최백규,김인수,도정현,조창용 한양대학교 세라믹연구소 2016 Journal of Ceramic Processing Research Vol.17 No.8

Zircon is usually used as a main additive to silica-based ceramic core materials in precise investment casting in order toimprove their high temperature properties. But there is still a disagreement in its effect on crystallization behavior of fusedsilica. In this study, cristobalite crystallization of fused silica in three silica-based core materials containing 10, 30 and 50 wt%zircon respectively were investigated through X-ray diffraction (XRD) and scanning electron microscopy equipped with energydispersive spectrometer (SEM/EDS). Results showed that zircon addition had neglected effect on cristobalite crystallizationduring sintering at 1180 oC, 1200 oC, and 1220 oC, but could decrease crystallization during simulated casting process at1500 oC. It was suggested that diffusion of zirconium atoms played a crucial role in this suppressing behavior of zircon on thecristobalite crystallization. During cooling from 1500 oC, cristobalite transformation from β to α caused microcracks in thesesamples that containing 10% or 30% zircon. But when zircon content increased to 50%, crack was prevented. Less phasetransformation of fused silica → cristobalite and enhanced strength by zircon was supposed to be the reason that wasresponsible for prevented cracks.

여정실 추출물을 첨가한 양갱의 품질특성 및 항산화활성 평가

Jing Jing Li,Hong-Sun Yook 한국생활과학회 2021 한국생활과학회 학술대회 Vol.2021 No.11

발효 고춧잎의 항산화 활성 평가

Jing Jing Li,Min-Sun Jeon,Hong-Sun Yook 한국생활과학회 2021 한국생활과학회 학술대회 Vol.2021 No.5

발효 여정실의 건강기능성 식품 및 화장품 소재로써 사용 가능성 평가

이정정(Jing-Jing Li),김경희(Kyoung-Hee Kim),육홍선(Hong-Sun Yook) 한국식품영양과학회 2023 한국식품영양과학회지 Vol.52 No.7

본 연구에서는 여정실을 여러 유용 미생물 B. subtilis KCTC 14549(BS), S. cerevisiae KCTC 48234(SC), L. brevis KCTC 18270(LB), L. casei KCTC 12413(LC), L. plantarum KCTC 18510(LP)으로 발효한 후 항균, 항산화 및 효소 저해 활성을 측정하여 발효 여정실의 건강 기능성 및 화장품 등과 같은 산업원료 소재로서 활용성을 탐색하였다. 여정실 발효액의 pH, OD600nm, 생균수 측정 결과는 각각 3.45~4.43, 0.73~1.21, 5.20~8.75 log CFU/mL의 범위를 나타내서 발효가 잘 진행되었음을 확인하였다. 여정실 발효물의 항산화 활성(총 페놀 함량, DPPH 라디칼 소거능 및 FRAP)을 측정한 결과, 모두 SC를 이용한 발효 여정실의 항산화 활성이 유의적으로 가장 높게 나타내었다. 항균 활성을 측정한 결과, LP 발효균이 P. aeruginosa에 아주 뛰어난 항균 활성을 나타내었다. 여정실 tyrosinase 저해 활성을 측정한 결과, 모두 발효군이 비발효군보다 높게 나타났으며 특히 LB, LP, SC 발효군이 비교적 높았다. 여정실 발효물의 elastase 및 collagenase 저해 활성은 SC 발효군이 가장 높게 나타내었다. 본 연구 결과, 여정실 발효를 통해 항산화, 항균 및 효소 저해 활성을 증진할 수 있으며, 특히 SC를 이용한 발효 여정실의 항산화 및 효소 저해 활성 강화, LP를 이용한 발효 여정실의 항균 활성 증대를 확인하여 발효 여정실이 건강기능성 식품 및 화장품 원료 소재 등으로 활용할 수 있음을 제시하고 있다. In this study, Fructus Ligustri Lucidi was fermented with B. subtilis, S. cerevisiae (SC), L. brevis (LB), L. casei (LC), and L. plantarum (LP). To evaluate the role of the resultant fermentation products as raw materials in functional health foods and cosmetics, the antioxidant, antibacterial, and enzyme inhibitory activities were measured. The pH, 600 nm absorbance, and live cell count of the fermentation products in the fermentation room were in the range of 3.45∼4.43, 0.73∼1.21, and 5.20∼8.75 log CFU/mL, respectively, confirming that the fermentation had proceeded well. The antioxidant activity based on the total phenol content, 2,2-diphenyl-1-picrylhydrazyl radical scavenging ability and ferric reducing antioxidant power assay, was highest in the fermentation product associated with SC (P<0.05). The fermentation product associated with LP showed excellent antibacterial activity against P. aeruginosa. All the fermented products showed higher tyrosinase inhibitory activity than the non-fermented product, and this was especially true of the LB, LP, and SC fermented products. The elastase and collagenase inhibitory activities were observed to be the highest in the SC fermentation product. The results of this study confirm that antioxidant and enzyme inhibitory activities can be enhanced through Fructus Ligustri Lucidi fermentation with S. cerevisiae. Also, L. plantarum fermentation produced a product with highest antibacterial activity. This suggests the possibility of using the fermented products of Fructus Ligustri Lucidi as raw material for the manufacture of functional health foods and cosmetics.

여정실 추출물을 첨가한 양갱의 품질 특성 및 항산화 활성 평가

이정정(Jing-Jing Li),김경희(Kyoung-Hee Kim),육홍선(Hong-Sun Yook) 한국식품영양과학회 2022 한국식품영양과학회지 Vol.51 No.6

본 연구에서는 우수한 생리활성을 가진 여정실 추출물을 앙금 대비 0~8%(2% 간격)를 첨가하여 제조한 양갱의 품질 특성 및 항산화 활성을 분석하고 여정실의 건강식품 소재로서의 이용 가치를 확인하고자 하였다. 양갱의 pH와 당도는 모두 여정실 추출물 첨가량이 증가할수록 유의적으로 낮아졌다(P<0.05). 수분 함량은 여정실 추출물 첨가량이 증가할수록 유의적으로 증가하였다(P<0.05). 양갱의 명도 L값은 대조군이 가장 낮았으며 여정실 추출물을 첨가할수록 낮아지는 경향을 보였다. 반면에 적색도 a값과 황색도 b값은 모두 첨가군이 대조군보다 높게 나타났으며 여정실 추출물 첨가량이 증가할수록 높아지는 경향을 보였다. 기계적 조직감 측정 결과 경도는 대조군이 가장 높았고, 여정실 추출물 첨가량이 많을수록 감소하여 8% 첨가군이 가장 낮은 값을 보였다. 부착성, 탄력성은 대조군과 여정실 추출물 첨가군 사이에 유의적인 차이가 없었다. 여정실 양갱의 항산화 활성을 측정한 결과, 총 폴리페놀 및 플라보노이드 함량은 여정실 추출물 첨가량이 증가함에 따라 증가하였다(P<0.05). 또한, DPPH 및 ABTS 라디칼 소거능, 환원력(FRAP)의 활성은 모두 여정실 추출물 첨가량이 증가함에 따라 유의적으로 증가하여 8% 첨가군에서 가장 높게 나타났다(P<0.05). 이상의 연구 결과를 바탕으로 여정실 추출물 8%를 첨가하여 제조된 양갱은 건강 양갱으로서 충분히 가치가 있으며 우수한 항산화 활성을 가진 여정실은 건강기능성 식품 소재로써 활용 가능성이 있을 것으로 판단된다. This study investigated methods to increase the availability and value of Fructus Ligustri Lucidi to be used as a healthy functional food material. The quality characteristics and antioxidant activity of Yanggaeng with different percentages (0%, 2%, 4%, 6%, 8% w/v) of Fructus Ligustri Lucidi extract were analyzed. The pH and sweetness of Yanggaeng decreased with the addition of Fructus Ligustri Lucidi extract (P<0.05). The moisture content of Yanggaeng increased with an increase in the proportion of Fructus Ligustri Lucidi extract (P<0.05). An analysis of color values showed that the lightness (L) of Yanggaeng decreased with increasing amounts of Fructus Ligustri Lucidi extract, but the redness (a) and yellowness (b) increased (P<0.05). The texture profile analysis showed that the hardness increased with the increasing content of Fructus Ligustri Lucidi extract (P<0.05), but the adhesiveness and springiness showed no significant differences between the control and experimental groups (P<0.05). Upon testing the antioxidant activity of Fructus Ligustri Lucidi with Yanggaeng, the total content of polyphenols and flavonoids increased as the amount of Fructus Ligustri Lucidi extract increased. In addition, the DPPH, ABTS free radical scavenging activities, and ferric reducing antioxidant power were the lowest in the control group and significantly increased as the Fructus Ligustri Lucidi extract content increased (P<0.05). Based on these results, Yanggaeng with an 8% content of Fructus Ligustri Lucidi extract shows promise as a health food. Fructus Ligustri Lucidi thus has the potential to be used as a healthy functional food material that also exhibits antioxidant activity.

[P1-06] Characterization of the Cucumber Mosaic Virus Coat Protein Expressed in a Genetically Modified Pepper and a E. coli System for Biosafety Assesment

Sun-Nye Bang,Yu-Sun Jung,Geun-Bae Kim,Kyu-Hwan Chung,Gung-Pyo Lee,Chan Lee,Dae-Yeul Son,Kwen-Woo Park,Jing-Sung Hong,Ki-Hyun Ryu 한국식품영양과학회 2009 한국식품영양과학회 학술대회발표집 Vol.2009 No.11

Multi-stage Nonlinear Model Predictive Control with Online Scenario Update for Semi-batch Polymerization Processes

Jing-Gao Sun,Xian-Feng Chen,Guang-Hao Su,Meng Wang,Hong-Guang Pan 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.10

In this paper, the problem of multi-stage nonlinear model predictive control with scenario update is investigated for semi-batch polymerization processes. The objective is to propose novel online scenario update schemes such that the more reasonable scenario tree can be generated. Firstly, based on the Orthogonal Configuration of Finite Elements (OCFE) method of direct radau configuration, the dynamic optimization problems are converted to Nonlinear Programing (NLP) problems such that the speed and accuracy of real-time optimization problem solving are effectively improved. Then, the scenario deviation is calculated based on model prediction information of each scenario and process measurement information. After that, calculate the bayesian probability weight of corresponding scenario is obtained. The online scenario reduction scheme uses the weight information update scenarios gradually reduce the scope of scenario tree representation. The online scenario weight update scheme uses the weight information as the basis for weight assignment of each scenario in the optimization problem. They use different methods to make the scenario tree modeling approach the real realization of uncertainty, and reduce the conservativeness compared with the traditional MSNMPC fixed scenario tree method. Through multiple batches numerical simulations of a semi-batch polymerization process, the advantages and effectiveness of the two proposed schemes are verified.

Continuous Transarterial Infusion Chemotherapy with Gemcitabine and 5-Fluorouracil for Advanced Pancreatic Carcinoma

Hong, Guo-Bin,Zhou, Jing-Xing,Sun, Hua-Bin,Li, Chun-Yang,Song, Li-Qing Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6

Purpose: Pancreatic carcinoma is one of the most malignant tumors of the alimentary system, with relatively high incidence rates. The purpose of this study was to assess the efficacy and safety of two regimens for advanced pancreatic carcinoma: continuous transarterial infusion versus systemic venous chemotherapy with gemcitabine and 5-fluorouracil. Methods: Of the 48 patients with advanced pancreatic carcinoma receiving chemotherapy with gemcitabine and 5-fluorouracil, 24 received the selective transarterial infusion, and 24 the systemic chemotherapy. For the continuous transarterial infusion group (experimental group), all patients received gemcitabine 1000 mg/$m^2$, given by 30-minute transarterial infusion, on day 1 of a 4-week cycle for 2 cycles, and a dose of 600 mg/$m^2$ 5-fluorouracil was infused on days 1~5 of a 4-week cycle for 2 cycles. For the systemic venous group (control group), gemcitabine and 5-fluorouracil were infused through a peripheral vein, a dose of 1000 mg/$m^2$ gemcitabine being administrated over 30 min on days 1 and 8 of a 4-week cycle for 2 cycles, and a dose of 600 mg/$m^2$ 5-fluorouracil was infused on days 1~5 of a 4-week cycle for 2 cycles. The effectiveness and safety were evaluated after 2 cyclesaccording to WHO criteria. Results:The objective effective rate in transarterial group was 33.3% versus 25% in the systemic group, the difference not being significant (P=0.626). Clinical benefit rates(CBR) in the transarterial and systemic groups were 83.3% and 58.3%, respectively (P=0.014). The means and medians for survival time in transarterial group were higher than those of the systemic group (P < 0.005). at the same time, the adverse effects did not significantly differ between the two groups (P > 0.05). Conclusion: Continuous transarterial infusion chemotherapy with gemcitabine and 5-fluorouracil could improve clinical benefit rate and survival time of patients with advanced pancreatic carcinoma, compared with systemic venous chemotherapy. Since adverse effects were limited in the transarterial group, the regimen of continuous transarterial infusion chemotherapy can be used more extensively in clinical practice. A CT and MRI conventional sequence can be used for efficacy evaluation after chemotherapy in pancreatic carcinoma.

Electromagnetic Field Exposure and Male Breast Cancer Risk: A Meta-analysis of 18 Studies

Sun, Jing-Wen,Li, Xiao-Rong,Gao, Hong-Yu,Yin, Jie-Yun,Qin, Qin,Nie, Shao-Fa,Wei, Sheng Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1

Background: The possibility that electromagnetic fields (EMF) exposure may increase male breast cancer risk has been discussed for a long time. However, arguments have been presented that studies limited by poor quality could have led to statistically significant results by chance or bias. Moreover, data fo the last 10 years have not been systematically summarized. Methods and Results: To confirm any possible association, a meta-analysis was performed by a systematic search strategy. Totals of 7 case-control and 11 cohort studies was identified and pooled ORs with 95% CIs were used as the principal outcome measures. Data from these studies were extracted with a standard meta-analysis procedure and grouped in relation to study design, cut-off point, exposure assessment method, adjustment and exposure model. A statistical significant increased risk of male breast cancer with EMF exposure was defined (pooled ORs = 1.32, 95% CI = 1.14-1.52, P < 0.001), and subgroup analyses also showed similar results. Conclusions: This meta-analysis suggests that EMF exposure may be associated with the increase risk of male breast cancer despite the arguments raised.