http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
A NOVEL FUNCTIONAL MATERIAL OF Ag-S$i_3N_4$ NANOSTRUCTURED COMPOSITE
Zhu, Zhu, Yi-Hun,Zhu, Zhu, Hong-Jie,Han, Han, Jin-Yi,Hu, Li-Ming 한국재료학회 1995 Fabrication and Characterization of Advanced Mater Vol.1 No.1
$Ag-Si_3N_4$ nanostrutured composite has been investigated. The results show that it exhibits some novel properties such as strong piezpelectricity and high dielectricity. It can be constituted a battery using graphite and aluminum as the positive and the negative electrodes, respectively. The origins of these properties have been discussed.
20, 30대 중국 소비자의 생명보험 가입 의도 -국가에 대한 인식 및 집단주의 성향에 따른 유형별 특성과 코로나19 불안의 조절 효과-
Ming-Yi Zhu,천혜정 한중사회과학학회 2023 한중사회과학연구 Vol.21 No.2
The purpose of this study is to categorize Chinese consumers in their 20s and 30s according to their perception of the state and their collectivism tendency, and to empirically analyze how perception of the state, collectivism tendency, attitudes toward insurance, and preparation for old age affect insurance purchasing intention. In addition, it also analyzes the moderating effect of anxiety caused by covid-19. To this end, an online survey was conducted on Chinese consumers in their 20s and 30s living in Shanghai, China, and a total of 500 questionnaires were used for analysis. The main findings are as follows. First, according to the perception of the state and the tendency of collectivism, Chinese consumers in their 20s and 30s were categorized into three groups. Specifically, the three groups are “individualist critics” who are negative and critical of the state and have the lowest collectivism tendency, “moderate neutrals” who have a moderate attitude toward the state and collectivitism, and “collectivist optimists” who are positive and optimistic about the state and have the highest collectivism tendency. Second, there were no significant demographic differences among the three groups, but significant differences were found in the attitude toward insurance, the degree of preparation for old age, and the level of anxiety about covid-19. Third, attitude toward insurance, perception of the state, and collectivism tendency were found to affect the insurance purchasing intention among 3 groups, respectively, and covid-19 anxiety has a moderating effect to attitude toward insurance, perception of the state, and collectivism tendency for each group. Based on these results, the relationship between covid-19 anxiety and insurance purchasing intention was discussed in various ways along with diversity within the Chinese consumers in their 20s and 30s. 본 연구의 목적은 국가에 대한 인식 및 집단주의 성향에 따라 20, 30대 중국 소비자를 유형화하고 집단별 보험 가입 의도에 영향을 미치는 요인을 실증적으로 살펴보고, 이 과정에서 코로나19로 인한 불안이 어떠한 조절 효과를 가지는지 분석하는 것이다. 이를 위해 중국 상하이시에 거주하는 20, 30대 중국 소비자를 대상으로 온라인 설문조사를 실시했으며 총 500부의 자료를 분석에 활용했다. 주요 연구 결과는 다음과 같다. 첫째, 국가에 대한 인식 및 집단주의 성향에 따라 20, 30대 중국 소비자를 유형화한결과 3개의 집단으로 분류되었다. 구체적으로 이 세 집단은 국가에 대해 부정적이고비판적인 태도를 가지면서 집단주의 성향도 가장 낮은 “개인주의적 비판론자”, 국가에대해 중도적인 온건한 태도를 가지면서 집단주의 성향도 중간 정도 수준을 보이는 “온건한 중립자”, 그리고 국가에 대해 긍정적이고 낙관적인 태도를 가지면서 집단주의 성향도 가장 높은 “집단주의적 낙관론자”이다. 둘째, 세 집단간 유의미한 인구통계학적차이는 나타나지 않았지만, 보험에 대한 태도, 노후 준비 정도, 그리고 코로나19 불안수준에서는 유의미한 차이가 나타났다. 셋째, 집단별 보험 가입 의도에 영향을 미치는요인과 이 과정에서 코로나19 불안의 조절 효과를 분석한 결과, 개인주의적 회의론자집단은 보험에 대한 태도, 온건한 중립자 집단은 국가에 대한 인식, 그리고 집단주의적 낙관론자는 집단주의 성향이 유의미한 요인으로 확인되었으며 각각의 독립변수와코로나19 불안과의 상호작용 또한 유의미한 것으로 나타났다. 이러한 결과를 바탕으로20, 30대 중국 소비자 집단 내부의 다양성과 함께 코로나19 불안과 보험 가입 의도와의 관계를 다각적으로 논의하였다.
( Ming Yi Zhao ),( Ming Hua Yang ),( Liang Chun Yang ),( Yan Yu ),( Min Xie ),( Shan Zhu ),( Rui Kang ),( Dao Lin Tang ),( Zhi Gang Jiang ),( Wu Zhou Yuan ),( Xiu Shan Wu ),( Li Zhi Cao ) 생화학분자생물학회(구 한국생화학분자생물학회) 2011 BMB Reports Vol.44 No.9
HMGB1 is associated with human cancers and is an activator of autophagy which mediates chemotherapy resistance. We here show that the mRNA levels of HMGB1 are high in leukemia cells and it is involved in the progression of childhood chronic myeloid leukemia (CML). HMGB1 decreases the sensitivity of human myeloid leukemia cells K562 to anti-cancer drug induced death through up-regulating the autophagy pathway, which is confirmed by the observation with an increase in fusion of autophagosomes and autophagolysosomes. When overexpressing HMGB1, both mRNA levels of Beclin-1, VSP34 and UVRAG which are key genes involved in mammalian autophagy and protein levels of p-Bcl-2 and LC3-II are increased. Luciferase assays document that over-expression of HMGB1 increases the transcriptional activity of JNK and ERK, which may be silenced by siRNA. The results suggest that HMGB1 regulates JNK and ERK required for autophagy, which provides a potential drug target for therapeutic interventions in childhood CML. [BMB reports 2011; 44(9): 601-606]
Zhu, Jian,Chu, Bing-Feng,Yang, Yi-Peng,Zhang, Sheng-Lai,Zhuang, Ming,Lu, Wen-Jie,Liu, Ying-Bin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5
Objective: This study aimed to investigate the expression of B7-H4 in human thyroid cancer and determine any association with patient clinicopathological parameters and survival. Methods: B7-H4 expression in 64 clinical thyroid cancer specimens was assessed with immunohistochemistry. Moreover, B7-H4 mRNA expression in 10 fresh resected specimens were evaluated by the reverse transcription-polymerase chain reaction (RT-PCR). Immunohistochemical staining of CD3 was performed to assess the number of tumor infiltrating T lymphocytes (TILs) in thyroid cancers. Results: Positive B7-H4 immunohistochemical staining was observed in 61 out of 64 (95.3%) specimens of thyroid cancer tissues. Significantly more B7-H4 mRNA copies were found in thyroid cancer tissue than that adjacent normal tissue. Moreover, B7-H4 expression in human thyroid cancer tissues was significantly correlated with patient TNM stages and extrathyroidal extension (P<0.05), being inversely correlated with the number of TILs (P<0.05). The overall survival rate of the patients with higher B7-H4 expression was significantly worse than that of the patients with lower B7-H4 expression. Conclusions: This present study suggests that high B7-H4 expression is associated with cancer progression, reduced tumor immunosurveillance and worse patient outcomes in human thyroid cancer.
( Yi Yong Luo ),( Jin Kui Yang ),( Ming Liang Zhu ),( Jin Ping Yan ),( Minghe Mo ),( Ke Qin Zhang ) 한국미생물 · 생명공학회 2008 Journal of microbiology and biotechnology Vol.18 No.1
Four series (S, M, R, and W) of Alternaria longipes isolates were obtained based on consecutive selection with Dimethachlon (Dim) and ultraviolet irradiation. These isolates were then characterized according to their tolerance to Dim, sensitivity to osmotic stress, and phenotypic properties. All the selected Dim-resistant isolates showed a higher osmosensitivity than the parental strains, and the last generation was more resistant than the first generation in the M, R, and W series. In addition, the changes in the Dim resistance and osmotic sensitivity were not found to be directly correlated, and no distinct morphologic characteristics were found among the resistant and sensitive isolates, with the exception of the resistant isolate K-11. Thus, to investigate the molecular basis of the fungicide resistance, a group III two-component histidine kinase (HK) gene, AIHK1, was cloned from nineteen A. longipes isolates. AIHK1p was found to be comprised of a six 92-amino-acid repeat domain (AARD), HK domain, and response regulator domain, similar to the Os-1p from Neurospora crassa. A comparison of the nucleotide sequences of the AIHK1 gene from the Dim-sensitive and -resistant isolates revealed that all the resistant isolates contained a single-point mutation in the AARD of AIHK1p, with the exception of isolate K-11, where the AIHK1p contained a deletion of 107 amino acids. Moreover, the AIHK1p mutations in the isolates of each respective series involved the same amino acid substitution at the same site, although the resistance levels differed significantly in each series. Therefore, these findings suggested that a mutation in the AARD of AIHK1p was not the sole factor responsible for A. longipes resistance to dicarboximide fungicides.
Perioperative stress prolong post-surgical pain via miR-339-5p targeting oprm1 in the amygdala
Zhu, Yi,Sun, Mei,Liu, Peng,Shao, Weidong,Xiong, Ming,Xu, Bo The Korean Pain Society 2022 The Korean Journal of Pain Vol.35 No.4
Background: The decreased expression of mu-opioid receptors (MOR) in the amygdala may be a key molecular in chronic post-surgical pain (CPSP). It is known that miR-339-5p expression in the amygdala of a stressed rat model was increased. Analyzed by RNAhybrid, miR-339-5p could target opioid receptor mu 1 (oprm1) which codes MOR directly. So, the authors hypothesized that miR-339-5p could regulate the expression of MOR via targeting oprm1 and cause the effects to CPSP. Methods: To simulate perioperative short-term stress, a perioperative stress prolongs incision-induced pain hypersensitivity without changing basal pain perception rat model was built. A pmiR-RB-REPORT<sup>TM</sup> dual luciferase assay was taken to verify whether miR-339-5p could act on oprm1 as a target. The serum glucocorticoid level of rats was test. Differential expressions of MOR, GFAP, and pERK1/2 in each group of the rats' amygdala were tested, and the expressions of miR-339-5p in each group of rats' amygdalas were also measured. Results: Perioperative stress prolonged the recovery time of incision pain. The expression of MOR was down-regulated in the amygdala of rats in stress + incision (S + IN) group significantly compared with other groups (P < 0.050). miR-339-5p was up-regulated in the amygdala of rats in group S + IN significantly compared with other groups (P < 0.050). miR-339-5p acts on oprm1 3'UTR and take MOR mRNA as a target. Conclusions: Perioperative stress could increase the expression of miR-339-5p, and miR-339-5p could cause the expression of MOR to decrease via targeting oprm1. This regulatory pathway maybe an important molecular mechanism of CPSP.
Qin-Yi Wu,Yue-Yan Zhu,Cheng-Gang Zou,Ying-Qian Kang,Lian-Ming Liang 한국미생물학회 2016 The journal of microbiology Vol.54 No.11
Turgor is very important for the invasive growth of fungal pathogens. Glycerol, a highly osmotic solvent, is considered to play an important role in turgor generation. The nematophagous fungus Arthrobotrys oligospora mainly lives as a saprophyte. In the presence of nematodes, A. oligospora enters the parasitic stage by forming three-dimensional networks (traps) to capture nematodes. In A. oligospora, we found that glycerol accumulated during nematode-induced trap formation. We demonstrated that deleting gph1, which encodes glycogen phosphorylase, decreased the glycerol content, compared with that of a wild-type strain. Although the number of traps induced by nematodes was not affected in the Δgph1 mutant, the capture rate was lower. Meanwhile, deleting gph1 also affected the growth rate and conidiation capacity of the fungus. These results indicate that glycerol derived from GPH1 is essential for the full virulence of A. oligospora against nematodes.