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Experimental study on fire performance of axially-restrained NSC and HSC columns
Bo Wu,Yi-Hai Li 국제구조공학회 2009 Structural Engineering and Mechanics, An Int'l Jou Vol.32 No.5
This paper describes fire performance of eight axially restrained reinforced concrete (RC) columns under a combination of two different load ratios and two different axial restraint ratios. The eight RC columns were all concentrically loaded and subjected to ISO834 standard fire on all sides. Axial restraints were imposed at the top of the columns to simulate the restraining effect of the rest of the whole frame. The axial restraint was effective when the column was expanding as well as contracting. As the results of the experiments have shown, the stiffness of the axial restraint and load level play an important role in the fire behaviors of both HSC and NSC columns. It is found that (a) the maximum deformations during expanding phase were influenced mostly by load ratio and hardly by axial restraint ratio, (b) For a given load ratio, axial restraint ratio had a great impact on the development of axial deformation during contraction phase beyond the initial equilibrium state, (c) increasing the axial restraint increased the value of restraint force generated in both the NSC and HSC columns, and (d) the development of column axial force during the contracting and cooling phase followed nearly parallel trend for columns under the same load ratio.
The Oxidation of Catechins into Dimers,Trimer and Polymers through Enzymatic Catalysis
Hai-bo Pan,Eunhye Kim,Qin Meng,Yuan-yuan Wu,You-yingTu 한국차학회 2015 한국차학회지 Vol.- No.S
Tea is one of the most popular beverages worldwide. The major components of green tea include (−)-epicatechin (EC), (−)-epicatechin -3-O-gallate (ECG), (−)-epigallocatechin (EGC) and (−)-epigallocatechin- 3-gallate (EGCG). The typical pigments in black tea are theaflavins (TFs) and thearubigins (TRs), which are formed by oxidation of catechins during fermentation processing. Polyphenoloxidase (PPO) and peroxidase (POD) are two key enzymes in pigment formation during the process of black tea. Many studies have been conducted to reveal how PPO and POD catalyze the formation of dimers, trimer and polymers from tea catechins. However, there were few reports to summarize catalytic reaction of PPO and POD until now. The present review summarized the studies regarding the transformation of catechins to different kinds of dimers, trimers and polymers in various conditions.
Experimental study on fire performance of axially-restrained NSC and HSC columns
Wu, Bo,Li, Yi-Hai Techno-Press 2009 Structural Engineering and Mechanics, An Int'l Jou Vol.32 No.5
This paper describes fire performance of eight axially restrained reinforced concrete (RC) columns under a combination of two different load ratios and two different axial restraint ratios. The eight RC columns were all concentrically loaded and subjected to ISO834 standard fire on all sides. Axial restraints were imposed at the top of the columns to simulate the restraining effect of the rest of the whole frame. The axial restraint was effective when the column was expanding as well as contracting. As the results of the experiments have shown, the stiffness of the axial restraint and load level play an important role in the fire behaviors of both HSC and NSC columns. It is found that (a) the maximum deformations during expanding phase were influenced mostly by load ratio and hardly by axial restraint ratio, (b) For a given load ratio, axial restraint ratio had a great impact on the development of axial deformation during contraction phase beyond the initial equilibrium state, (c) increasing the axial restraint increased the value of restraint force generated in both the NSC and HSC columns, and (d) the development of column axial force during the contracting and cooling phase followed nearly parallel trend for columns under the same load ratio.
Hui Wu,Ting Xu,Xiao Wang,Yong-Bo Yu,Zhong-Yuan Fan,Dan-Xia Li,Lei Luo,Xue-Cheng Yang,Wei Jiao,Hai-Tao Niu 대한남성과학회 2020 The World Journal of Men's Health Vol.38 No.2
Purpose: To compare the diagnostic efficiency of 68Gallium labelled prostate-specific membrane antigen positron emission tomography (68Ga-PSMA PET) and magnetic resonance imaging (MRI) for staging the lymph node metastases (LNMs) in the prostate cancer. Materials and Methods: A broad search of scientific databases including PubMed, EMBASE, Web of Science, Cochrane Database, and Chinese Biomedicine Literature Database (updated prior to November 1st, 2018) was conducted systematically by two reviewers. In this paper, we evaluated the methodological quality of each included article independently and performed a systematic review and meta-analysis to reveal the summary of the diagnostic performance of 68Ga-PSMA PET and MRI in properly identifying LNMs of intermediate- and/or high-risk prostate cancer.Results: Thirteen eligible articles comprising 1,597 patients were included. For LNMs detection, the pooled sensitivity and specificity of 68Ga-PSMA PET were 0.65 (95% confidence interval [CI]: 0.49–0.79) and 0.94 (95% CI: 0.88–0.97), respectively, while the corresponding values of MRI were 0.41 (95% CI: 0.26–0.57) and 0.92 (95% CI: 0.86–0.95). The area under the symmetric receiver-operating characteristic (SROC) curve for 68Ga-PSMA PET and MRI were 0.92 and 0.83, respectively. Conclusions: In intermediate- or high-risk pre-treatment prostate cancer, 68Ga-PSMA PET had a higher sensitivity and a slightly different specificity in probing the LNMs when comparing with MRI. Moreover, the area under the SROC curve indicated that 68Ga-PSMA PET was a more effective weapon for predicting the LNMs prior to radical surgery.
Comprehensive Study on Associations Between Nine SNPs and Glioma Risk
Liu, Hai-Bo,Peng, Yu-Ping,Dou, Chang-Wu,Su, Xiu-Lan,Gao, Nai-Kang,Tian, Fu-Ming,Bai, Jie Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10
Aim: Glioma cancer is the most common type of adult brain tumor. Recent genome-wide association studies (GWAS) have identified various new susceptibility regions and here we conducted an extensive analysis of associations between 12 single nucleotide polymorphisms (SNPs) and glioma risk. Methods: A total of 197 glioma cases and 197 health controls were selected, and 9 SNPs in 8 genes were analyzed using the Sequenom MassARRAY platform and Sequenom Assay Design 3.1 software. Results: We found the MAF among selected controls were consistent with the MAF from the NCBI SNP database. Among 9 SNPs in 8 genes, we identified four significant SNP genotypes associated with the risk of glioma, C/C genotype at rs730437 and T/T genotype at rs1468727 in ERGF were protective against glioma, whereas the T/T genotype at rs1799782 in XRCC1 and C/C genotype at rs861539 in XRCC3 conferred elevated risk. Conclusion: Our comprehensive analysis of nine SNPs in eight genes suggests that the rs730437 and rs1468727 in ERGF, rs1799782 in XRCC1 gene, and rs861539 in XRCC3 gene are associated with glioma risk. These findings indicate that genetic variants of various genes play a complex role in the development of glioma.
An Iterative Calculation Method for Internal Forces and Deformation of Curved Tunnel Lining
Lu-yuan Wu,Meng Li,Hai-bo Bai,Yong-feng Yun,Hui Li,Yi Feng 대한토목학회 2024 KSCE Journal of Civil Engineering Vol.28 No.4
The accurate prediction of lining forces and deformations is crucial for the design of arched tunnel lining. However, in traditional tunnel structural mechanics methods, the distribution shape of the surrounding rock elastic resistance (SRER), as well as the zero point and maximal point locations of SRER, are not clearly defined. In this paper, an iterative calculation method is proposed based on the gradual convergence of the unitized values of SRER and total displacement (TD) of the lining, and the one-to-one functional relationship between the two in the stability process of the surrounding rock and lining. In this method involves using the initial displacement caused by the pressure of the surrounding rock pressure is used to initiate the iterative process, and iterative calculation is carried out until the errors between the unitized value of SRER and the unitized value of TD of the lining structure meet the error requirements. This enables precise determination of the SRER and TD. In order to verify the effectiveness of the proposed method, a case study is conducted on the tunnel of Lianghe Expressway tunnel in Yunnan province, China . The results showed that when the semi-lining structure is divided into unit blocks and the average error of consistency is required to be less than 1e-3, it takes about 20 iterations are needed to meet the error requirement. Furthermore, the accuracy of the calculated results is verified through site-measuring experiments. This method provides an effective tool for failure analysis of arched tunnel lining structures.
Hu, Liu,Wu, Qin-Qin,Wang, Wen-Bo,Jiang, Huan-Gang,Yang, Lei,Liu, Yu,Yu, Hai-Jun,Xie, Cong-Hua,Zhou, Yun-Feng,Zhou, Fu-Xiang Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2
Ku70/80 heterodimer is a central element in the nonhomologous end joining (NHEJ) DNA repair pathway, Ku80 playing a key role in regulating the multiple functions of Ku proteins. It has been found that the Ku80 protein located at telomeres is a major contributor to radiosensitivity in some telomerase positive human cancer cells. However, in ALT human osteosarcoma cells, the precise function in radiosensitivity and telomere maintenance is still unknown. The aim of this study was to investigate the effects of Ku80 depletion in the U2OS ALT cell line cell line. Suppression of Ku80 expression was performed using a vector-based shRNA and stable Ku80 knockdown in cells was verified by Western blotting. U2OS cells treated with shRNA-Ku80 showed lower radiobiological parameters (D0, Dq and SF2) in clonogenic assays. Furthermore, shRNA-Ku80 vector transfected cells displayed shortening of the telomere length and showed less expression of TRF2 protein. These results demonstrated that down-regulation of Ku80 can sensitize ALT cells U2OS to radiation, and this radiosensitization is related to telomere length shortening.
In Vitro and in Vivo Antitumor Evaluation of Berbamine for Lung Cancer Treatment
Hou, Zhi-Bo,Lu, Kai-Jin,Wu, Xiao-Li,Chen, Cong,Huang, Xin-En,Yin, Hai-Tao Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.4
Purpose: Lung cancer, one of the most frequently diagnosed cancers in the world, is characterized by relatively high morbidity and mortality. Berbamine (BER) has been initially reported to exert anti-proliferative effects against a series of cancers. Methods: In this study the in vitro cytotoxicity of BER was measured by MTT assay. In vivo anti-cancer efficacy of BER was assessed in A549 xenografts. Results: Cytotoxicity tests showed dose-dependent cell growth inhibition effects of BER against A549 cells. Moreover, BER significantly reduced the growth of lung cancer in a dose-dependent manner in nude mice with prolonged survival time. Conclusion: Therefore, BER might be in herbal medicine for cancer therapy and further efforts are needed to explore therapeutic strategies.