지문과 정신분열증

우숙희,정국동,최송표,조근자,양은진,김수일,박경란,이영호,김원식 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Fingerprint patterns of 333 schizophreniacs who met with the diagnostic criterias of International Pilot Study of Schizophrenia except items associated with chronicity in exclusion criteria were studied, and the following results were obtained. 1. The frequency distribution of the fingerprint patterns in the 333 schizophreniacs was ulnar loop, whorl, twinned loop, arch, radial loop in order in both control and schizophrenia groups. 2. Finger ridge counts of both sexes were decreased significantly in schizophrenia group. 3. Dissociation of fingerprint pattern in the schizophrenia group was 51.1%, which was far greater than 6.25% of control group. Number of dissociation was greatest in the thumb, followed by index, middle, ring, and little finger in order. According to the above results, it is considered that both the number of finger ridges and degree of dissociation of fingerprint patterns were closely related with schizophrenia. Analysis of fingerprints and palmprints with the aid of chromosomal analysis would contribute the early diagnosis and prevention of schizophrenia.

Purification and Cloning of an Extracellular Serine Protease from the Nematode-Trapping Fungus Monacrosporium cystosporium

( Jin Kui Yang ),( Feng Ping Ye ),( Qi Li Mi ),( Song Qing Tang ),( Juan Li ),( Ke Qin Zhang ) 한국미생물 · 생명공학회 2008 Journal of microbiology and biotechnology Vol.18 No.5

Glia Dose not Participate in Antinociceptive Effects of Gabapentin in Rats with Trigeminal Neuropathic Pain

Kui Y. Yang,Hak K. Kim,Myoung U. Jin,Jin S. Ju,Dong K. Ahn KOREAN ACADAMY OF ORAL BIOLOGY 2012 International Journal of Oral Biology Vol.37 No.3

Previous clinical studies have demonstrated that gabapentin, a drug that binds to the voltage-gated calcium channel α2δ1 subunit proteins, is effective in the management of neuropathic pain, but there is limited evidence that addresses the participation of glial cells in the antiallodynic effects of this drug. The present study investigated the participation of glial cells in the anti-nociceptive effects of gabapentin in rats with trigeminal neuropathic pain produced by mal-positioned dental implants. Under anesthesia, the left mandibular second molar was extracted and replaced by a miniature dental implant to induce injury to the inferior alveolar nerve. Mal-positioned dental implants significantly decreased the air-puff thresholds both ipsilateral and contralateral to the injury site. Gabapentin was administered intracisternally beginning on postoperative day (POD) 1 or on POD 7 for three days. Early or late treatment with 0.3, 3, or 30 μg of gabapentin produced significant anti-allodynic effect in the rats with mal-positioned dental implants. On POD 9, in the mal-positioned dental implants group, OX-42, a microglia marker, and GFAP, an astrocyte marker, were found to be up-regulated in the medullary dorsal horn, compared with the naive group. However, the intracisternal administration of gabapentin (30 μg) failed to reduce the number of activated microglia or astrocytes in the medullary dorsal horn. These findings suggest that gabapentin produces significant antinociceptive effects, which are not mediated by the inhibition of glial cell function in the medullary dorsal horn, in a rat model of trigeminal neuropathic pain.

High dose of QX-314 produces anti-nociceptive effect without capsaicin in rats with inflammatory TMJ pain

Kui-Ye Yang,Min-Su Kim,Eun-Kyung Kim,Mi-Sun Kong,Jong-Soo Ahn,Jong-Hun Lee,Jin-Sook Ju,Dong-Kuk Ahn KOREAN ACADAMY OF ORAL BIOLOGY 2013 International Journal of Oral Biology Vol.38 No.4

The present study investigated the effects of QX-314 on inflammatory pain of the temporomandibular joint (TMJ). Experiments were carried out on male Sprague-Dawley rats weighing 220-280 g. Under anesthesia, the TMJ of each animal was injected with 50 μL of formalin (5%). The number of noxious behavioral responses, including rubbing or scratching of the facial region including the TMJ area, was recorded over 9 sequential 5 min intervals for each animal. Although 2.5% QX-314 did not affect formalin-induced nociceptive behavior, administration of 5% QX-314 with formalin significantly decreased the number of scratches produced by the formalin injection. Co-administration of capsaicin, a TRPV1 agonist, with 2.5% QX-314 produced significant anti-nociceptive effects whereas 2.5% QX-314 alone did not. However, the co-administration of capsaicin did not enhance the anti-nociceptive effects in the 5% QX-314-treated rats. Moreover, the co-administration of capsazepine, a TRPV1 antagonist, did not attenuate anti-nociceptive effects in the 5% QX-314-treated rats. These findings suggest that TRPV1 is effective in the transport of low but not high doses of QX-314. Moreover, a high dose of QX-314, which is not mediated by peripheral TRPV1 activity, may be viable therapeutic strategy for inflammatory pain in the TMJ.

Participation of Central P2X7 Receptors in CFA-induced Inflammatory Pain in the Orofacial Area of Rats

Kui-Ye Yang,Myung-Dong Kim,Jin-Sook Ju,Min-Ji Kim,Dong-Kuk Ahn KOREAN ACADAMY OF ORAL BIOLOGY 2014 International Journal of Oral Biology Vol.39 No.1

We investigated the role of central P2X receptors in inflammatory pain transmission in the orofacial area in rats. Experiments were carried out using male Sprague-Dawley rats weighing 230-280g. Complete Freund's adjuvant (CFA, 40 μL) was applied subcutaneously to the vibrissa pad to produce inflammatory pain. The intracisternal administration of iso-PPADS tetrasodium salt, a non-selective P2X receptor antagonist, A317491 sodium salt hydrate, a P2X2/3 receptor antagonist, 5-BDBD, a P2X4 receptor antagonist, or A438079 hydrochloride, a P2X7 receptor antagonist, was performed 5 days after CFA injection. Subcutaneous injections of CFA produced increases in thermal hypersensitivity. Intracisternal injections of iso-PPADS (25 μg) or A438079 (25 or 50 μg) produced significant anti-hyperalgesic effects against thermal stimuli compared to the vehicle group. A317491 or 5-BDBD did not affect the head withdrawal latency times in rats showing an inflammatory response. Subcutaneous injections of CFA resulted in the up-regulation of OX-42, a microglia marker, and GFAP, an astrocyte marker, in the medullary dorsal horn. The intracisternal administration of A438079 reduced the numbers of activated microglia and astrocytes in the medullary dorsal horn. These results suggest that a blockade of the central P2X7 receptor produces antinociceptive effects, mediated by inhibition of glial cell function in the medullary dorsal horn. These data also indicate that central P2X7 receptors are potential targets for future therapeutic approaches to inflammatory pain in the orofacial area.

Antinociceptive Effects of Transcytosed Botulinum Neurotoxin Type A on Trigeminal Nociception in Rats

Hye-Jin Kim,Geun-Woo Lee,Min-Ji Kim,Kui-Ye Yang,Seong-Taek Kim,Yong-Cheol Bae,Dong-Kuk Ahn 대한생리학회-대한약리학회 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.4

We examined the effects of peripherally or centrally administered botulinum neurotoxin type A (BoNT-A) on orofacial inflammatory pain to evaluate the antinociceptive effect of BoNT-A and its underlying mechanisms. The experiments were carried out on male Sprague-Dawley rats. Subcutaneous (3 U/kg) or intracisternal (0.3 or 1 U/kg) administration of BoNT-A significantly inhibited the formalin-induced nociceptive response in the second phase. Both subcutaneous (1 or 3 U/kg) and intracisternal (0.3 or 1 U/kg) injection of BoNT-A increased the latency of head withdrawal response in the complete Freund’s adjuvant (CFA)-treated rats. Intracisternal administration of N-methyl-D-aspartate (NMDA) evoked nociceptive behavior via the activation of trigeminal neurons, which was attenuated by the subcutaneous or intracisternal injection of BoNT-A. Intracisternal injection of NMDA up-regulated c-Fos expression in the trigeminal neurons of the medullary dorsal horn. Subcutaneous (3 U/kg) or intracisternal (1 U/kg) administration of BoNT-A significantly reduced the number of c-Fos immunoreactive neurons in the NMDA-treated rats. These results suggest that the central antinociceptive effects the peripherally or centrally administered BoNT-A are mediated by transcytosed BoNT-A or direct inhibition of trigeminal neurons. Our data suggest that central targets of BoNT-A might provide a new therapeutic tool for the treatment of orofacial chronic pain conditions.

영일만 수질의 시공간적 변동

강양순(Yang Soon Kang),김귀영(Kui Young Kim),심정민(Jeong Min Shim),성기탁(Ki Tack Sung),박진일(Jin Il Park),공재열(Jai Yul Kong) 한국수산과학회 2002 한국수산과학회지 Vol.35 No.4

영일만 수질의 시공간적인 변동상황을 파악하기 위하여 영일만의 13개 조사정점의 1990년부터 1998년까지 9개년간 각 계절별 수질조사결과를 바탕으로 수질의 시·공간적 변동상황을 조사하였다. 염분은 강수량이 많은 8월에 가장 낮은 값을 보였고, 정점별로는 하천수가 유출되는 만내측인 St-2에서부터 만외측으로 갈수록 점차 염분의 양이 높아졌다. 용존무기질소 평균농도 중에서 질산질소가 65.04%로 가장 높은 비율을 차지했으며, 또한 염분이 낮고 강수량이 많은 8월에 가장 높은 값을 보였으며, 만내측에서 외측으로 갈수록 그 양이 감소되었다. 염분과 영양염간의 상관을 종합해서 보면 모든 정점에서 질산질소와 유의적 음의 상관관계를 보이는 것으로 보아 형산강, 냉천 등의 하천수의 유입이 질산질소 증가에 영향을 미치는 것으로 나타났다. 따라서 영일만의 주오염원은 하천수 유입에 의한 질산질소인 것으로 생각된다. 주성분분석결과를 통해 영일만의 시·공간적인 변화를 일으키는 주된 요인은 하천수 유입에 따른 질산질소의 증가로 영일만의 계속되는 적조를 막고, 만내의 수질개선을 위해서는 하천으로부터 질산질소의 유입량을 조절하는 것이 중요함을 알 수 있었다. In order to understand the spatiotemporal variation of water quality, an investigation on variation characteristics of water quality was conducted at 13 stations in Yongil bay from 1990 to 1998. The salinity in summer was relatively lower than that in other seasons and it have increased from inner bay to outside of the bay gradually. However, nitrate concentration in summer was relatively higher than that in other seasons, and it was the highest, up to 65.40%, among dissolved inorganic nitrogens. Nitrate concentration indicates the possibility of affecting by freshwater discharges to Yongil bay. Correlation analysis showed that salinity had a significantly good correlation with nitrate. This result suggested that inflow of river had an influence on increase of nitrate. The result of Principal Component Analysis (PCA) indicated that nitrate was major factor to influence the water quality in Yongil Bay.

CFD를 이용한 프란시스 수차 Vortex Rope 거동분석

이규명(Kui Ming Li),권욱(Wook Kwon),한우범(Woo Beom Han),박준관(Jungwan Park),양진우(Jin Woo Yang),황태규(TaeGyu Hwang) 한국유체기계학회 2018 한국유체기계학회 학술대회 논문집 Vol.2018 No.11

Antinociceptive Effects of Transcytosed Botulinum Neurotoxin Type A on Trigeminal Nociception in Rats

Kim, Hye-Jin,Lee, Geun-Woo,Kim, Min-Ji,Yang, Kui-Ye,Kim, Seong-Taek,Bae, Yong-Cheol,Ahn, Dong-Kuk The Korean Society of Pharmacology 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.4

We examined the effects of peripherally or centrally administered botulinum neurotoxin type A (BoNT-A) on orofacial inflammatory pain to evaluate the antinociceptive effect of BoNT-A and its underlying mechanisms. The experiments were carried out on male Sprague-Dawley rats. Subcutaneous (3 U/kg) or intracisternal (0.3 or 1 U/kg) administration of BoNT-A significantly inhibited the formalin-induced nociceptive response in the second phase. Both subcutaneous (1 or 3 U/kg) and intracisternal (0.3 or 1 U/kg) injection of BoNT-A increased the latency of head withdrawal response in the complete Freund's adjuvant (CFA)-treated rats. Intracisternal administration of N-methyl-D-aspartate (NMDA) evoked nociceptive behavior via the activation of trigeminal neurons, which was attenuated by the subcutaneous or intracisternal injection of BoNT-A. Intracisternal injection of NMDA up-regulated c-Fos expression in the trigeminal neurons of the medullary dorsal horn. Subcutaneous (3 U/kg) or intracisternal (1 U/kg) administration of BoNT-A significantly reduced the number of c-Fos immunoreactive neurons in the NMDA-treated rats. These results suggest that the central antinociceptive effects the peripherally or centrally administered BoNT-A are mediated by transcytosed BoNT-A or direct inhibition of trigeminal neurons. Our data suggest that central targets of BoNT-A might provide a new therapeutic tool for the treatment of orofacial chronic pain conditions.

Retrospective clinical study of ultrawide implants more than 6 mm in diameter

Ku, Jeong-Kui,Yi, Yang-Jin,Yun, Pil-Young,Kim, Young-Kyun Korean Association of Maxillofacial Plastic and Re 2016 Maxillofacial Plastic Reconstructive Surgery Vol.38 No.-

Background: The prognosis of wide implants tends to be controversial. While wider implants were initially expected to result in a larger osseointegration area and have higher levels of primary stability, they were reported to have a relatively high rate of failure. The clinical outcome of ultrawide implants of more than 6 mm in diameter was evaluated through a retrospective study. Methods: The investigation was conducted on patients who had received ultrawide implant (${\geq}6mm$ diameter) placements in Seoul National University Bundang Hospital from January 2008 to December 2013. Complications were investigated during the maintenance period, and marginal bone loss was measured using periapical radiography. Primary stability immediately after the implant placement and second stability after second surgery or during impression were measured using $Osstell^{(R)}$ Mentor (Osstell, Sweden) as an implant stability quotient (ISQ). Results: Fifty-eight implants were placed in 53 patients (30 male, 23 female), and they were observed for an average of $50.06{\pm}23.49$ months. The average ISQ value increased from $71.22{\pm}10.26$ to $77.48{\pm}8.98$ (P < 0.005). The primary and secondary stability shows significantly higher at the mandible than at the maxilla (P < 0.001). However, mean survival rate shows 98.28 %. Average marginal bone loss of 0.018 and 0.045 mm were measured at 12 and 24 months after the loading and 0.14 mm at final follow-up date (mean 46.25 months), respectively. Also in this study, the bone loss amount was noticeably small compared to regular implants reported in previous studies. Conclusions: The excellent clinical outcome of ultrawide implants was confirmed. It was determined that an ultrawide implant can be used as an alternative when the bone quality in the posterior teeth is relatively low or when a previous implant has failed.