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Lin Chang-Gang,Zou Ming-Song,Zhang Hai-Cheng,Qi Li-Bo,Liu Shu-Xiao 대한조선학회 2021 International Journal of Naval Architecture and Oc Vol.13 No.1
To investigate the mechanism of friction-induced vibration and noise of ship water lubricated stern bearings, a two-degree-of-freedom (2-DOF) nonlinear self-excited vibration model is established. The novelty of this work lies in the detailed analysis of influence of different parameters on the stability and nonlinear vibration characteristics of the system, which provides a theoretical basis for the various friction vibration and noise phenomenon and has a very important directive meaning for low noise design of water lubricated stern bearings. The results reveal that the change of any parameter, such as rotating speed of shaft, contact pressure, friction coefficient, system damping and stiffness, has an important influence on the stability and nonlinear response of the system. The vibration amplitudes of the system increase as (a) rotating speed of shaft, contact pressure, and the ratio of static friction coefficient to dynamic friction coefficient increase and (b) the transmission damping between motor and shaft decreases. The frequency spectrum of the system is modulated by the first mode natural frequency, which is continuous multi-harmonics of the first mode natural frequency. The response of the system presents a quasi-periodic motion.
Pharmacokinetics of Carbamazepine Polymorphs and Dihydrate in Rats, Related to Dogs and Humans
Caihong Xu,Gang Cheng,Meijuan Zou,Yi Liu,Jungang Ren,Ye Tian,Jing Yan,Yiping Wang 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.11
Species differences in the oral pharmacokinetics and absolute bioavailability (F_abs) of carbamazepine polymorphs (form I and form III) and dihydrate were studied. The pharmacokinetics of each form was investigated in rats following a single oral/intravenous administration of 10 mg/kg and an oral dose of 80 mg/kg, which were compared with the published data obtained from dogs and humans. No significant differences were found in their C_max, T_max, AUC_(0-∞) and F_abs among the forms at the low dose. However, significant differences were observed at the high dose. The F_abs of each form was markedly reduced with increasing of doses in species (e.g. F_abs in rats ranged from > 82% to 38.4% - 56.0%). At a comparable dose, the C_max, and AUC_(0-∞)of rats and humans were about 3-10 times higher than in dogs. The absorption rate of form III in rats exhibited a similar trend to that in humans, and was far higher in dogs. A multi-peak phenomenon in plasma curves was observed in rats and humans, but not in dogs. In conclusion, rats appear to be a better predictor of carbamazepine polymorphs absorbed in humans,and form III may be more suitable as a pharmaceutical crystal.
Effect of Diallyl Trisulfide on the Pharmacokinetics of Dipyridamole in Rats
Yue Wang,Gang Cheng,Meijuan Zou,Nan Zhao,Jungang Ren,Hong Zhou 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.11
This study was aimed to evaluate the effect of diallyl trisulfide (DATS), a major component derived from garlic used to inhibit platelet thromboxane formation, on the pharmacokinetics of dipyridamole. Pharmacokinetic parameters of dipyridamole were determined in rats following intragastric (80 mg/kg suspension or 40 mg/kg solution) or intravenous (3 mg/kg) administration of dipyridamole with coadministration (20 mg/kg) and long-term pretreatment of DATS (10 or 20 mg/kg/day for 15 consecutive days). In addition, everted gut sac models were used to assess transepithelial transport of dipyridamole and the effect of DATS on the intestinal absorption of dipyridamole. After coadministration and long-term pretreatment of DATS, significantly lower C_max and AUC_(0–240 h were observed for intragastric administration of dipyridamole,whereas little change was noted after intravenous dipyridamole administration. After adding DATS (10 and 50 μg/mL) in the everted gut sacs, absorption of dipyridamole was remarkably decreased in the ileum and jejunum (p < 0.01). In conclusion, DATS reduced the oral exposure of dipyridamole in rats likely by the modification of the dissolution rate and intestinal absorption of dipyridamole, indicating that combined use of DATS or DATS-containing supplements with dipyridamole may require caution as low plasma concentrations of dipyridamole may lead to a subtherapeutic effect of this agent.
Qin-Yi Wu,Yue-Yan Zhu,Cheng-Gang Zou,Ying-Qian Kang,Lian-Ming Liang 한국미생물학회 2016 The journal of microbiology Vol.54 No.11
Turgor is very important for the invasive growth of fungal pathogens. Glycerol, a highly osmotic solvent, is considered to play an important role in turgor generation. The nematophagous fungus Arthrobotrys oligospora mainly lives as a saprophyte. In the presence of nematodes, A. oligospora enters the parasitic stage by forming three-dimensional networks (traps) to capture nematodes. In A. oligospora, we found that glycerol accumulated during nematode-induced trap formation. We demonstrated that deleting gph1, which encodes glycogen phosphorylase, decreased the glycerol content, compared with that of a wild-type strain. Although the number of traps induced by nematodes was not affected in the Δgph1 mutant, the capture rate was lower. Meanwhile, deleting gph1 also affected the growth rate and conidiation capacity of the fungus. These results indicate that glycerol derived from GPH1 is essential for the full virulence of A. oligospora against nematodes.
Xin Li,Ying-Qian Kang,Yan-Lu Luo,Ke Qin Zhang,Cheng-Gang Zou,Lian-Ming Liang 한국미생물학회 2017 The journal of microbiology Vol.55 No.11
Reactive oxygen species (ROS) produced by NADPH oxidases can serve as signaling molecules to regulate a variety of physiological processes in multi-cellular organisms. In the nematophagous fungus Arthrobotrys oligospora, we found that ROS were produced during conidial germination, hyphal extension, and trap formation in the presence of nematodes. Generation of an AoNoxA knockout strain demonstrated the crucial role of NADPH oxidase in the production of ROS in A. oligospora, with trap formation impaired in the AoNoxA mutant, even in the presence of the nematode host. In addition, the expression of virulence factor serine protease P186 was up-regulated in the wild-type strain, but not in the mutant strain, in the presence of Caenorhabditis elegans. These results indicate that ROS derived from AoNoxA are essential for full virulence of A. oligospora in nematodes.
SSR and SCAR mapping of a multiple-allele male-sterile gene in Chinese cabbage (Brassica rapa L.)
Feng, Hui,Wei, Peng,Piao, Zhong-Yun,Liu, Zhi-Yong,Li, Cheng-Yu,Wang, Yu-Gang,Ji, Rui-Qin,Ji, Shu-Juan,Zou, Ting,Choi, Su-Ryun,Lim, Yong-Pyo Springer-Verlag 2009 TAG. Theoretical and applied genetics. Theoretisch Vol.119 No.2