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Liu Rui,Gu Qian-Qun,Zhu Wei-Ming,Cui Cheng-Bin,Fan Guo-Tao The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.9
Two known modified dipeptides, trichodermamide A (1) and aspergillazine A (2), were isolated from an ethyl acetate extract of the metabolite of a marine-derived fungus Spicaria elegans, and were found to have a weak cytotoxic effect on three cancer cell lines P388, A-549, and HL-60 agreed. To our knowledge, this is the first report on the isolation of compounds 1 and 2 from the fungus Spicaria elegans and their cytotoxic effect.
Rui Liu,Qian-Qun Gu,Wei-Ming Zhu,Cheng-Bin Cui,Guo-Tao Fan 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.9
Two known modified dipeptides, trichodermamide A (1) and aspergillazine A (2), were isolated from an ethyl acetate extract of the metabolite of a marine-derived fungus Spicaria elegans, and were found to have a weak cytotoxic effect on three cancer cell lines P388, A-549, and HL-60 agreed. To our knowledge, this is the first report on the isolation of compounds 1 and 2 from the fungus Spicaria elegans and their cytotoxic effect.
Xueqian He,Zhenzhen Zhang,Qian Che,Tianjiao Zhu,Qian-Qun Gu,Dehai Li 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.1
Seven polyketides, including four new onesnamed as varilactones A–B (1–2) and wortmannilactonesM–N (3–4), as well as three biogenetically related knownwortmannilactones E, F and H (5–7), were isolated fromthe fungus Penicillium variabile HXQ-H-1, cultivated inpotato-based medium with the histone deacetylase inhibitorsuberoylanilide hydroxamic acid (SAHA). Their structures(1–7) were established by analysis of NMR and MS data,and the absolute configuration of oxabicyclo[2.2.1]heptaneunit was deduced from 1H-NMR analyses on MPA estersafter chemical reduction reaction. Among them, varilactonesA and B (1 and 2), features a novel skeleton with atriene unit linking an oxabicyclo[2.2.1]heptane and anoxabicyclo[3.3.0]octane rings.
Aiqun Lin,Guangwei Wu,Qian Qun Gu,Tian-Jiao Zhu,De-Hai Li 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.7
Chemical investigation of an Antarctic deepseaderived fungus Penicillium sp. PR19 N-1 yielded fivenew eremophilane-type sesquiterpenes 1–5 and a new rarelactam-type eremophilane 6, together with three knowncompounds 7–9. The structures of these diverse sesquiterpeneswere determined by extensive NMR and massspectroscopic analyses. Compounds 1, 2, 4–6, 8 and 9 wereevaluated for their cytotoxities against HL-60 and A-549human cancer cell lines, and 5 was the most active one withIC50 value of 5.2 lM against the A-549 cells.
Rui Liu,Cheng-Bin Cui,Lin Duan,Qian-Qun Gu,Wei-Ming Zhu 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.12
Bioassay-guided fractionation of CHCl3 extract from the fermentation broth of a sponge Mycale plumose-derived actinomycete Saccharopolyspora sp. nov., led to the isolation of two known prodigiosin analogs - metacycloprodigiosin (1) and undecylprodigiosin (2). These compounds exhibited significant cytotoxic activities against five cancer cell lines: P388, HL60, A-549, BEL- 7402, and SPCA4. This is the first report on the significant cytotoxicity of metacycloprodigiosin (1) against human cancer cell lines.
Penipyrols A–B and peniamidones A–D from the mangrove derived Penicillium solitum GWQ-143
Wenqiang Guo,Xianglan Kong,Tianjiao Zhu,Qian Qun Gu,Dehai Li 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.8
Chemical investigation the extract of Penicillium solitum GWQ-143 led to yield four new compounds penipyrols A–B (1–2) and peniamidones A–B (3–4), together with peniamidones C–D (5–6), which had been previously described as synthetic intermediates, not obtained from natural resource. The structures of those new compounds were established through extensive spectroscopic analysis. Compounds 1–6 exhibited great radical scavenging activities against DPPH with IC50 values ranged from 4.7 to 15.0 lM.
Liu, Rui,Cui, Cheng-Bin,Duan, Lin,Gu, Qian-Qun,Zhu, Wei-Ming The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.12
Bioassay-guided fractionation of $CHCl_{3}$ extract from the fermentation broth of a sponge Mycale plumose-derived actinomycete Saccharopolyspora sp. nov., led to the isolation of two known prodigiosin analogs - metacycloprodigiosin (1) and undecylprodigiosin (2). These compounds exhibited significant cytotoxic activities against five cancer cell lines: P388, HL60, A-549, BEL7402, and SPCA4. This is the first report on the significant cytotoxicity of metacycloprodigiosin (1) against human cancer cell lines.
Xianglan Kong,Xinhua Ma,Yunying Xie,Shengxin Cai,Tianjiao Zhu,Qian Qun Gu,De-Hai Li 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.6
In our screening for antitubercular agents, fivenaphtho-c-pyrones including two new naphtho-c-pyronesglycosides, indigotides G and H (1 and 2), and two diphenylethers were isolated from the extract of a sponge-derivedfungus Metarhizium anisopliae mxh-99. Their structureswere established on the basis of chemical and spectroscopicevidence. The antitubercular activities of all the compoundswere evaluated against Mycobacterium phlei. The knownisochaetochromin B2 (6) and ustilaginoidin D (7) exhibitedthe highest activity with MICs 50.0 lg/mL.
Saroclazines A–C, thio-diketopiperazines from mangrove-derived fungi Sarocladium kiliense HDN11-84
Feng Li,Wenqiang Guo,Li Wu,Tian-jiao Zhu,Qian Qun Gu,De-Hai Li,Qian Che 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.1
Three new diketopiperazine derivatives (DKPs), saroclazines A–C (1–3) along with three known DKPs (4– 6) were isolated from mangrove-derived fungi Sarocladium kiliense HDN11-84. Saroclazines A–B (1 and 2) possessed a free amide structure, which was first found in sulfurcontaining aromatic DKPs. Their structures were elucidated by NMR, HRESIMS and X-ray. The cytotoxic activity of new compounds (1–3) was tested against HeLa cell lines, among which compound 2 showed an IC50 value of 4.2 lM.
Huquan Gao,Tian-Jiao Zhu,De-Hai Li,Qian Qun Gu,Weizhong Liu 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.8
One new prenylated indole diketopiperazinealkaloid, named dihydroneochinulin B (1), one known spiropolyketide-diketopiperazine hybrid cryptoechinuline D (2)and three related known metabolites didehydroechinulin B(3), neoechinulin B (4) and auroglaucin (5) were isolatedfrom the mangrove rhizosphere soil derived fungus, Aspergilluseffuses H1-1. The structures were assigned by detailedspectroscopic analysis. The enantiomers of cryptoechinulineD (2) were separated to be (?)-cryptoechinuline D (2a) and(-)-cryptoechinuline D (2b) by chiral HPLC, and theirabsolute configurations were determined by ECD analysis. The cytotoxic effects of the compounds were preliminarilyevaluated on P388, HL-60, BEL-7402 and A-549 cell linesby SRB or MTT methods, and compounds 2, 2a and 3showed significant activities.