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생약으로부터 산화적 결합 효소인 갑상선 peroxidase의 저해제 검색
이현정,장미영,김미리,배기환,석대은 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-
Thyroid peroxidase is a biochemical target protein for the antithyroid drugs. Ethanol extracts from one hundred and thirty seven natural products were screened for the inhibition of thyroid peroxidase activity. Thyroid peroxidase was purified from porcine thyroids, and the inhibition of peroxidase activity was evaluated using guaiacol oxidation (C-C coupling) assay. Twenty one natural products expressed a remarkable inhibition (>50%) of peroxidase activity at 330㎍ solid weight/ml. The 50% inhibitory concentration (IC50) of 70% ethanol extract from six potent natural products ranged from 3.1 to 31.2㎍ solid weight/ml, in contrast to the range (0.33∼0.54㎍/ml) of IC50, values for catechin and epigallocatechin gallate as positive controls. Noteworthy, the extract of Camellia taliensis showed an irreversible inhibition of the enzyme. It is suggested that extract from some natural products such as Camellia taliensis, Rheum undulatum or Euphorbia pekinsis, exhibiting a potent inhibition of peroxidase activity, may be developed as sources of potent antithyroid agents.
Mi-Ree Lee,Jin-Won Hong,Young-Soo No,Sung-Guk Jeong,Ji-Young Cho,Soo-Nyun Choi,Sun-Young Choi,Yoo-Ri Kim,Jae-Chan Song,Kil-Soo Kim 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.1
The antidiabetic effect of Calcium Ion Water<SUP>®</SUP> (CIW<SUP>®</SUP>) was investigated in neonatal streptozotocin (90 ㎎/㎏, i.p.)-induced noninsulin-dependent diabetes mellitus (NIDDM) in Sprague Dawley rats. The rats were divided into three groups: normal control, NIDDM control, and NIDDM + CIW<SUP>®</SUP>. CIW<SUP>®</SUP> treatment for 8 weeks resulted in a significant decrease in the concentration of blood glucose and an increase in the level of serum insulin in NIDDM rats. The blood glucose and serum insulin levels were significantly lower and higher, respectively, than those of the NIDDM control group after 4 weeks of CIW<SUP>®</SUP> treatment. The changes of body weight in all experimental groups were not different among normal control, NIDDM control, and NIDDM + CIW<SUP>®</SUP>. In conclusion, these results indicate that CIW<SUP>®</SUP> can be used as an antidiabetic functional drink because it increases insulin level in blood and concomitantly decreases blood glucose level.
이미리 ( Mi Ree Lee ),이영민 ( Young Min Lee ) 한국지방행정연구원 2014 地方行政硏究 Vol.28 No.3
본 연구의 목적은 서울특별시 퇴직예정 소방공무원의 퇴직관리 실태를 조사하고, 이를 바탕으로 효과적인 퇴직지원방안을 탐색하는데 있다. 50대 이상의 서울시 소방공무원 214 명을 대상으로 설문조사를 실시하였다. 연구결과는, 첫째, 퇴직준비 수준은 낮은 것으로 인식하고 있었다. 둘째, 퇴직관리 요구를 조사한 결과 대부분이 퇴직관리 프로그램이 필요하다고 응답했으며, 아울러 퇴직관리 프로그램 운용 시 참여하겠다고 응답하였다. 퇴직관리 프로그램의 내용으로는 건강관리, 여가활동, 재정관리, 재취업, 자기계발, 사회공헌, 생애설계, 창업분야 순으로 선호하는 것으로 나타났다. 셋째, 퇴직관리 프로그램 운용 주체로는 민간기관을 가장 많이 선호하였으나, 이러한 프로그램 운용을 위한 가장 적합한 방법으로는 퇴직 소방공무원 전담 지원센터를 설치·운영해야 한다는 의견이 가장 많았다. 소방공무원의 적극적인 퇴직관리 운영을 위하여 퇴직 계획부터 교육, 상담 및 퇴직 후 정보제공 등 통일된 하나의 서비스를 제공할 수 있는 시스템 구축이 필요하다는 점을 제언하였다. The purpose of this study was to examine the current states in terms of the retirement perception and policy implications for those fire-fighting officers who are scheduled to retire. The survey was conducted for the 214 Seoul fire-fighting officers aged 50 years old or above. The results of study was as follow. First, the retirement perception was shown to be generally positive; however, the preparation level for retirement was found to be low. Second, there was a high degree of interest for retirement management. Third, the most preferred institution as an operating entity for retirement management programs was found to be a private institution. In addition, the opinion of building and operating a support center dedicated for retired fire-fighting officers accounted for the highest proportion as the most appropriate method to operate the aforementioned programs. As a result, it would be imperative to seek for a measure to implement a system such as the retirement management support center, which can provide an integrated service that includes retirement planning, education, consultation, provision of information after retirement for the purpose of an active operation of retirement management of fire-fighting officers.
중소병원 간호사 감정노동과 환자안전관리활동이 직무만족에 미치는 영향 : 회복탄력성의 매개효과
이은미(Lee Eun Mi),김미연(Kim Mi Yeon),남혜리(Nam Hye Ree) 학습자중심교과교육학회 2021 학습자중심교과교육연구 Vol.21 No.20
목적 본 연구에서는 지역 중소병원 간호사의 감정노동, 환자안전관리활동이 직무만족도에 미치는 영향을 확인하고, 이들 관계에서 회복탄력성의 매개효과를 파악하기 위함이다. 방법 2개 종합병원에서 근무하는 간호사 170명을 대상으로 구조화된 자가 설문지를 이용하였다. 수집된 자료는 SPSS/WIN 21.0 통계프로그램 t-test, ANOVA, Pearson s correlation coefficients, Mediating effects regression 이용하여 분석하였다. 결과 대상자의 감정노동과 환자안전관리활동(r=.327, p<.001), 직무만족(r=.411 p<.001), 회복탄력성(r=.565, p<.001)은 모두 통계적으로 유의한 정(+)의 상관관계를 나타내었다. 회복탄력성과 직무만족(r=.466, p<.001), 환자안전관리활동 간에도 통계적으로 유의한 정(+)의 상관관계를 보였다(r=.367, p<.001). 감정노동과 직무만족도사이에서 매개효과를 분석한 결과(β=.22, p=0.12)과 회복탄력성(β=.34, p<.001) 모두 직무만족에 유의한 영향을 미치는 것으로 확인되었다. Sobel test 결과 유의하게 나타났다(Z=3.71, p<.001). 결론 이를 통해 간호사의 감정노동을 감소시키고 직무만족에 영향을 미치는 회복탄력성을 향상시키기 위해 다양한 프로그램 적용의 필요성을 시사하고 있다. Objectives The purpose of this study was to investigate the mediating effects of resilience between Nurse s for influence of job satisfaction, emotional labor and patient safety management activities nurses in small-medium sized hospitals Methods The sample consisted of 170 nurses from two general hospitals was done using structured self-administered questionnaires. Data were analyzed through the SPSS/WIN 21.0 program using descriptive statistics, t-test, ANOVA, Pearson’s correlation coefficients, and Mediating effect regression. Results There was also a positive correlation between resilience, job satisfaction (r=.466, p<.001), and patient safety management activities(r=.367, p<.001). Also, there was a positive correlation between emotional labor, patient safety management activities (r=.327, p<.001), job satisfaction (r=.411 p<.001), and resilience (r=.565, p<.001). Mediating effects of resilience(β=.34, p<.001) between nurse s emotional labor and job satisfaction for nurses in small-medium sized hospitals. As a result of the Sobel test, it was significantly confirmed (Z=3.71, p<.001) Conclusions This suggests the necessity of applying various programs to improve the resilience of nurses.
태아 선천성 갑상샘기능저하증에서 자궁 내로 티록신(thyroxine) 주입한
이미영 ( Mi Young Lee ),원혜성 ( Hye Sung Won ),김유진 ( Eu Gene Kim ),엄정민 ( Jeong Min Eom ),문제원 ( Jei Won Moon ),유래미 ( Ree Mi You ),이필량 ( Pil Ryang Lee ),김암 ( Ahm Kim ) 대한주산의학회 2009 Perinatology Vol.20 No.2
A 28-year-old primi gravida visited our department at 20 weeks gestation. The ultrasound screening revealed twin gestation, and follow up screening revealed a bilobed large fetal neck mass in the 1st twin. We measured thyroid volume with ultrasound which was 5.072 cm3. Other fetal organs appeared normal. Cordocentesis was performed for fetal thyroid function and congenital hypothyroidism was confirmed. In addition, maternal thyroid hormones were checked. The other fetus was normal. Thyroid stimulating hormone (TSH) in the maternal serum was increased, but thyroxine (T3) was (within normal range). Two weeks later, we checked TSH and free T4 in amniotic fluid and administered intra-amniotic thyroxine (200 μg). We repeated the procedures 2 more times in two consecutive weeks. After 3 intra-amniotic thyroxine injection, follow-up cordocentesis revealed euthyroid status of the fetus. Although the thyroid gland had decreased in size and volume, it was still goitrous. At 36 weeks of gestation, the patient was admitted for preterm premature rupture of the membranes and the twin was delivered vaginally. The 1st twin was proved as an euthyroid status and antithyroid antibody was not detected. During the 3 years follow up, the baby had no considerable developmental problem. The intrauterine recognition and treatment of congenital goitrous hypothyroidism may not only reduce the obstetric complications associated with large goiters, but possibly improve the prognosis for normal growth and mental development of affected fetuses.