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Kobayashi, Koichi,Suzuki, Masato,Dung, Le Anh,Yun, Hyun-do,Rokugo, Keitetsu Elsevier 2018 Construction and Building Materials Vol.178 No.-
<P><B>Abstract</B></P> <P>SHCC mixtures with various water cement ratios and different types of fiber (PVA and PE) were tested with an aim to clarify the properties of cracked SHCC. After examining the mechanical performances of the composites, chloride penetration and rebar corrosion tests were conducted on cracked SHCC specimens.</P> <P>PE fiber, PVA fiber, and a mixture of PE and PVA were added in SHCC. Part of the cement was replaced with limestone powder in some mixtures to vary the water cement ratio of the mortar matrix. For SHCC mixtures containing PVA fiber, which has lower strength and Young's modulus, the water cement ratio had to be increased to obtain a strain hardening property. The chloride penetration test revealed that chloride could penetrate into SHCC through fine cracks and that the width of the fine cracks had no bearing on the amount of chloride accumulated in the crack fracture surfaces. On the other hand, chloride penetration through cracks into the mortar matrix was affected by the number of cracks and water cement ratio. As a result, the corrosion area on rebar in cracked SHCC was also largely dependent on the number of cracks and water cement ratio. However, the corrosion area was smaller than that of ordinary mortar. When the strain is in a small range, the corrosion prevention performances of PE-SHCC and PVA-SHCC were more or less the same.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Rebar corrosion protection performances of cracked SHCCs were investigated. </LI> <LI> Chloride penetration through cracks into SHCC was affected by the number of cracks. </LI> <LI> It was also affected by W/C of mortar matrix. </LI> <LI> The corrosion prevention performances of PE-SHCC and PVA-SHCC were comparable. </LI> <LI> Even SHCC with low ductility can enhance the durability of RC structures. </LI> </UL> </P>
Nonalcoholic Fatty Liver Disease as a Systemic Disease and the Need for Multidisciplinary Care
Yoneda Masato,Kobayashi Takashi,Iwaki Michihiro,Nogami Asako,Saito Satoru,Nakajima Atsushi 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.6
Nonalcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease, and there has been a rapid increase in cases worldwide. NAFLD is rapidly becoming the leading cause of hepatocellular carcinoma and is also associated with an increased risk of cardiovascular disease or exacerbation of other organ diseases, thus posing a significant health problem from both a medical and a socioeconomic perspective. NAFLD is a systemic disease and requires the involvement of numerous medical professionals. Multidisciplinary collaboration, in which different professionals within different specialties come together and work together toward a common goal, supports better patient care by integrating perspectives of multiple experts and facilitating the exchange of opinions. Due to the large number of potential patients, gastroenterologists and hepatologists cannot manage the patients alone, and collaboration between specialists in various fields, including family doctors, dentists, nutritionists, and pharmacists is required for treatment of NAFLD. This review will discuss NAFLD from the perspective of various specialties and introduce multidisciplinary collaboration.
Masahiko Kobayashi,Jian Xu,Kohei Kakino,Akitsu Masuda,Masato Hino,Naoki Fujimoto,Kosuke Minamihata,Noriho Kamiya,Hiroaki Mon,Hiroshi Iida,Masateru Takahashi,Takahiro Kusakabe,이재만 한국응용곤충학회 2020 Journal of Asia-Pacific Entomology Vol.23 No.1
Interleukine-4 (IL-4) is a cytokine that plays an important role in the immune system and recognized as a biological medicine. Therefore, there is a demand for the production of IL-4 with high performance. The expression of a recombinant IL-4 protein in the prokaryotic system usually results in the formation of an inclusion body. To date, the solution to obtain those active products without the refolding process remains to be established. In this study, we tried to acquire a biologically active recombinant Mus musculus IL-4 (rMmIL-4) using a silkworm-baculovirus expression vector system (silkworm-BEVS). We constructed two recombinant baculoviruses coding rMmIL-4 with the distinct location of affinity purification tags and succeeded in the expression and purification of rMmIL-4 proteins directly without the refolding process. Both purified proteins displayed comparable biological activity to the commercial proteins produced by the E. coli expression system. Besides, we performed screening of silkworm strains to seek optimal hosts for the mass-production of rMmIL-4. Intriguingly, we found that some silkworm strains showed significantly higher secretion levels of rMmIL-4 in silkworm sera. Our study provides meaningful insights into the industrial-scale production of rMmIL-4 with high productivity for pharmaceutical applications in the future.
Local interaction imaging by SiGe quantum dot probe
정연길,Masato Hirade,Ryohei Kokawa,Hirofumi Yamada,Kei Kobayashi,Noriaki Oyabu,Toyoko Arai,Akira Sasahara,Masahiko Tomitori 한국물리학회 2012 Current Applied Physics Vol.12 No.2
Local interaction imaging of cleaved InAs surface (110) using a high aspect ratio (HAR) SiGe quantum dot (QD) probe was demonstrated by frequency-modulation mode noncontact atomic force microscopy under atmospheric pressure. The local contrast image with pronounced brightness is mainly attributed to no contact potential difference between the HAR SiGe-QD probe apex and the sample surface, and low frequency-change of the HAR SiGe-QD probe.
Takumi Kobayashi,Masato Suzuki,Chika Sugimoto,RyujiKohno 한국통신학회 2015 ICT Express Vol.1 No.2
This paper provides a space temporal interference cancellation method for ultra wide-band (UWB) communication systems based on combination of tapped delay line array antenna and orthogonal matched filter. In order to reduce the interference from the other system using overlapping frequency band, space domain signal processing such as an array antenna has been proposed. However, principal array antenna cannot be applied to impulse radio (IR) UWB because IR-UWB does not have carrier signal. In this paper, we propose a novel tapped delay line array antenna combined with orthogonal matched filter detector. From the numerical evaluation, we show that the proposed system can make null direction to face to the interference signal direction. Additionally, we show that the proposed system can reduce interference signal even if the interference signal has equivalent pulse shape and equivalent incoming direction.
Masakazu Kobayashi,Junji Akaki,Kiyofumi Ninomiya,Masayuki Yoshikawa,Osamu Muraoka,Toshio Morikawa,Masato Odawara 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.1
The number of diabetes mellitus and borderline diabetes cases is increasing and poses a serious problem worldwide. Plants of the genus Salacia are known to have α-glucosidase inhibitory activity and to lower postprandial hyperglycemia. Two randomized, double-blind, placebo-controlled clinical trials were conducted to evaluate the efficacy of Salacia chinensis extract. Study 1 was a single-dose crossover study of 150, 300, or 600 mg of Salacia extract or placebo to determine the dose dependency of the effect on postprandial hyperglycemia. The duration of the washout period between each experimental day was a minimum of 6 days. Study 2 was a 12-week, multiple-dose, parallel-group study to evaluate the effects of 600 mg/day of Salacia extract on blood glucose parameters. In Study 1, Salacia induced significant dose-dependent suppression of postprandial blood glucose, insulin, and their incremental area under the curve values. The dose of 600 mg appeared to have the most significant effect. In Study 2, Salacia significantly improved several blood glucose-related parameters, such as hemoglobin A1c, and glucose tolerance after glucose challenge. These results suggest that S. chinensis extract may have beneficial effects in patients with diabetes.
Asako Nogami,Masato Yoneda,Michihiro Iwaki,Takashi Kobayashi,Yasushi Honda,Yuji Ogawa,Kento Imajo,Satoru Saito,Atsushi Nakajima 대한간학회 2023 Clinical and Molecular Hepatology(대한간학회지) Vol.29 No.-
Non-alcoholic fatty liver disease is currently the most common chronic liver disease, affecting up to 25% of the global population. Simple fatty liver, in which fat is deposited in the liver without fibrosis, has been regarded as a benign disease in the past, but it is now known to be prognostic. In the future, more emphasis should be placed on the quantification of liver fat. Traditionally, fatty liver has been assessed by histological evaluation, which requires an invasive examination; however, technological innovations have made it possible to evaluate fatty liver by non-invasive imaging methods, such as ultrasonography, computed tomography, and magnetic resonance imaging. In addition, quantitative as well as qualitative measurements for the detection of fatty liver have become available. In this review, we summarize the currently used qualitative evaluations of fatty liver and discuss quantitative evaluations that are expected to further develop in the future.
Hirozumi Sano,Ryoji Kobayashi,Satoru Matsushima,Daiki Hori,Masato Yanagi,Koya Kodama,Daisuke Suzuki,Kunihiko Kobayashi 대한소아혈액종양학회 2021 Clinical Pediatric Hematology-Oncology Vol.28 No.2
Background: Febrile neutropenia (FN) remains an important complication in pedia-tric cancer patients. The present study compared the efficacy of meropenem (MEPM) and piperacillin/tazobactam (PIPC/TAZ) with or without intravenous immunoglobulin (IVIG) as second-line therapy for FN in pediatric patients.Methods: As first-line treatment for FN, 394 episodes in 99 patients were randomly assigned to receive PIPC/TAZ (360 mg/kg/day, maximum 18 g/day) or MEPM (120 mg/ kg/day, maximum 3 g/day). Eighty-four episodes in 42 patients were judged as fail-ures, and, thus, were enrolled for second-line treatment. In second-line treatment, antibiotics were switched to MEPM or PIPC/TAZ, and episodes were further random-ized for treatment with or without concomitant IVIG at 100 mg/kg/day (maximum 5 g/day) for 3 consecutive days.Results: The total success rate of second-line treatment was 50.0% (52.0% in PIPC/ TAZ and 47.2% in MEPM with or without IVIG, P=0.826). The success rates of patients treated with (IVIG+ group) and without IVIG (IVIG− group) were 53.8 and 46.7%, respectively (P=0.662). In the IVIG+ group, the success rate of patients younger than 8 years old was 78.6%, which was significantly higher than that of those aged 8 years and older (40.0%, P=0.043).Conclusion: PIPC/TAZ and MEPM were equally effective as second-line treatment. Concomitant IVIG was also effective, particularly in patients younger than 8 years.
Hirozumi Sano,Ryoji Kobayashi,Satoru Matsushima,Daiki Hori,Masato Yanagi,Daisuke Suzuki,Go Ohba,Hiroshi Yamamoto,Kunihiko Kobayashi 대한소아혈액종양학회 2023 Clinical Pediatric Hematology-Oncology Vol.30 No.1
Nephroblastomatosis (NBM) is a precursor of Wilms tumor. We herein report a case in which Wilms tumor was initially suspected and the affected kidney was removed. The tumor was subsequently diagnosed as intralobar NBM and a favorable outcome was achieved with postoperative chemotherapy. A 2-year-old boy who presented with gross hematuria was found to have an enlarged left kidney with hydronephrosis. Needle biopsy of the left kidney suggested Wilms tumor and left nephrectomy was performed. The tumor was histopathologically diagnosed as intralobar NBM. Although NBM is regarded as a precancerous lesion, a definite treatment plan has not yet been established. In the present case, we used a similar chemotherapy regi-men to that for Wilms tumor. Eight years after the completion of chemotherapy, Wilms tumor has not developed or recurred. Appropriate management plans need to be developed by accumulating similar cases.