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RISS 인기검색어
- 검색키워드
- 저자 : Masato Yoneda (검색결과 4 건)
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Noninvasive diagnosis of NAFLD
( Masato Yoneda ),( Kento Imajo ),( Satoru Saito ),( Atsushi Nakajima ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) is an important cause of chronic liver injury in many countries around the world. The degree of liver fibrosis must be estimated to determine the prognosis, surveillance, and optimal treatment for NAFLD/NASH, similar to the situation for other liver diseases. Liver biopsy remains the gold standard for evaluating the degree of hepatic fibrosis. However, liver biopsy is an invasive and expensive method and is associated with a relatively high risk of complications. Furthermore it is impossible to enforce liver biopsy in all NAFLD patients, because the number of NAFLD patients has reached 80-100 million in the U.S. and about 5-10 million NAFLD patients are estimated to exist even in Korea. Thus, a rapid and noninvasive method of detecting fibrosis in patients with NAFLD is of major clinical interest. Several noninvasive investigations, such as serum biomarkers, scoring systems, imaging method have been developed to establish the diagnosis of NASH. First, we validated scoring systems (FIB4 index, AST/ALT ratio, AST to platelet ratio, Age-platelet index, NAFLD fibrosis score, BARD score) in biopsy-proven Asian population (n=576). Next, we investigated the clinical usefulness of ultrasound-based elastography such as transientelastography (Fibroscan) and Acoustic Radiation Force Impulse (ARFI) Elastography for detecting the advanced fibrosis in NAFLD patients. The major advantages of transient elastography and ARFI elastography, as compared with liver biopsy, are that these techniques are painless, rapid, and have no associated complications, and are, therefore, very easily accepted by the patients. It is not uncommon for patients to present with the complications of previously unrecognized cirrhosis despite being under long-standing medical care, because these patients often do not manifest the classic physical changes associated with cirrhosis. By using these noninvasive scoring systems and/or imaging methods, efficient recruitment of NASH patients with advanced stage may be facilitated.
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Noninvasive diagnosis of NAFLD
( Masato Yoneda ),( Kento Imajo ),( Satoru Saito ),( Atsushi Nakajima ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) is an important cause of chronic liver injury in many countries around the world. The degree of liver fibrosis must be estimated to determine the prognosis, surveillance, and optimal treatment for NAFLD/NASH, similar to the situation for other liver diseases. Liver biopsy remains the gold standard for evaluating the degree of hepatic fibrosis. However, liver biopsy is an invasive and expensive method and is associated with a relatively high risk of complications. Furthermore it is impossible to enforce liver biopsy in all NAFLD patients, because the number of NAFLD patients has reached 80-100 million in the U.S. and about 5-10 million NAFLD patients are estimated to exist even in Korea. Thus, a rapid and noninvasive method of detecting fibrosis in patients with NAFLD is of major clinical interest. Several noninvasive investigations, such as serum biomarkers, scoring systems, imaging method have been developed to establish the diagnosis of NASH. First, we validated scoring systems (FIB4 index, AST/ALT ratio, AST to platelet ratio, Age-platelet index, NAFLD fibrosis score, BARD score) in biopsy-proven Asian population (n=576). Next, we investigated the clinical usefulness of ultrasound-based elastography such as transientelastography (Fibroscan) and Acoustic Radiation Force Impulse (ARFI) Elastography for detecting the advanced fibrosis in NAFLD patients. The major advantages of transient elastography and ARFI elastography, as compared with liver biopsy, are that these techniques are painless, rapid, and have no associated complications, and are, therefore, very easily accepted by the patients. It is not uncommon for patients to present with the complications of previously unrecognized cirrhosis despite being under long-standing medical care, because these patients often do not manifest the classic physical changes associated with cirrhosis. By using these noninvasive scoring systems and/or imaging methods, efficient recruitment of NASH patients with advanced stage may be facilitated.
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Nonalcoholic Fatty Liver Disease as a Systemic Disease and the Need for Multidisciplinary Care
Yoneda Masato,Kobayashi Takashi,Iwaki Michihiro,Nogami Asako,Saito Satoru,Nakajima Atsushi 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.6
Nonalcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease, and there has been a rapid increase in cases worldwide. NAFLD is rapidly becoming the leading cause of hepatocellular carcinoma and is also associated with an increased risk of cardiovascular disease or exacerbation of other organ diseases, thus posing a significant health problem from both a medical and a socioeconomic perspective. NAFLD is a systemic disease and requires the involvement of numerous medical professionals. Multidisciplinary collaboration, in which different professionals within different specialties come together and work together toward a common goal, supports better patient care by integrating perspectives of multiple experts and facilitating the exchange of opinions. Due to the large number of potential patients, gastroenterologists and hepatologists cannot manage the patients alone, and collaboration between specialists in various fields, including family doctors, dentists, nutritionists, and pharmacists is required for treatment of NAFLD. This review will discuss NAFLD from the perspective of various specialties and introduce multidisciplinary collaboration.
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Asako Nogami,Masato Yoneda,Michihiro Iwaki,Takashi Kobayashi,Yasushi Honda,Yuji Ogawa,Kento Imajo,Satoru Saito,Atsushi Nakajima 대한간학회 2023 Clinical and Molecular Hepatology(대한간학회지) Vol.29 No.-
Non-alcoholic fatty liver disease is currently the most common chronic liver disease, affecting up to 25% of the global population. Simple fatty liver, in which fat is deposited in the liver without fibrosis, has been regarded as a benign disease in the past, but it is now known to be prognostic. In the future, more emphasis should be placed on the quantification of liver fat. Traditionally, fatty liver has been assessed by histological evaluation, which requires an invasive examination; however, technological innovations have made it possible to evaluate fatty liver by non-invasive imaging methods, such as ultrasonography, computed tomography, and magnetic resonance imaging. In addition, quantitative as well as qualitative measurements for the detection of fatty liver have become available. In this review, we summarize the currently used qualitative evaluations of fatty liver and discuss quantitative evaluations that are expected to further develop in the future.
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