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Crohn`s disease and smoldering multiple myeloma: a case report and literature review
( So Young Park ),( Jae Min Kim ),( Hyun Joon Kang ),( Minje Kim ),( Jae Joon Han ),( Chi Hoon Maeng ),( Sun Kyung Baek ),( Hwi-joong Yoon ),( Si-young Kim ),( Hyo Jong Kim ) 대한장연구학회 2017 Intestinal Research Vol.15 No.2
Crohn`s disease (CD) is a chronic inflammatory bowel disease (IBD) that presents with abdominal pain, weight loss, and diarrhea. Although the etiology has not been fully elucidated, both environmental and genetic causes are known to be involved. In chronic inflammatory conditions such as IBD, B lymphocytes are chronically stimulated, and they induce monoclonal expansion of plasma cells, sometimes resulting in monoclonal gammopathy of undetermined significance. Immunomodulators that are commonly used to control inflammation, such as tumor necrosis factor-α (TNF-α) blockers could increase the possibility of hematologic malignancy. The pathogenesis of multiple myeloma in association with TNF-α inhibitor therapy is attributed to decreased apoptosis of plasma cell populations. Here, we describe a case of a 36-year-old male patient who was diagnosed with immunoglobulin A subtype smoldering multiple myeloma during the treatment for CD with infliximab and adalimumab. We report this case along with a review of the literature on cases of multiple myeloma that occurred in conjunction with CD. (Intest Res 2017;15:249-254)
위장관 : 급성 TNBS-유발 대장염에서 동종 골수이식에 의한 치료 효과
맹이소 ( Lee So Maeng ),장은덕 ( Eun Duck Chang ),채현석 ( Hiun Suk Chae ),김진수 ( Jin Soo Kim ),민정요 ( Jeong Yo Min ),손혜숙 ( Hye Sook Sohn ),노상영 ( Sang Young Rho ),김형근 ( Hyung Keun Kim ),조영석 ( Young Suk Cho ),최규용 대한소화기학회 2009 대한소화기학회지 Vol.54 No.1
목적: 골수에서 유래한 세포들은 여러 병적인 환경에서 조직을 유지하는 데 기여한다. 저자들은 흰쥐의 실험 대장염에서 골수 이식 시 대장염의 치료에 대해 골수유래세포들의 역할을 알아보기 위해 연구를 시행하였다. 대상 및 방법: 실험에 사용한 흰쥐는 3개의 군으로 나누어 대조군 (50% ethanol), 2,4,6-trinitrobenzene sulfinic aicd (TNBS군) 장염군, TNBS+골수이식군(BMT군)으로 하였다. 장염을 유발하기 위해 50% 알코올에 녹인 TNBS (5.0 mg/마리)를 일주일에 한 번씩 2주 동안 항문을 통해 투여하였다. 동종 골수 이식은 TNBS 투여 3주 전에 green fluorescence protein (GFP)를 지닌 수컷 유전자 도입 쥐의 골수 세포를 야생형 생쥐의 꼬리 정맥에 투여하였다. 모든 동물은 TNBS 투여 후 일주일 후에 희생하여 대장을 추출하였다. 골수이식이 되었는지를 확인하기 위해 GFP에 대한 면역조직화학검사를 시행하였고 상피하 근육섬유모세포의 존재를 확인하기 위해 vimentin과 α-SMA에 대한 면역조직검사를 시행하였다. 결과: 장염의 정도는 TNBS군에서 가장 심하였고 골수이식에 의해 유의하게 감소하였다(p<0.05). GFP 양성 세포는 주로 선와의 니쉐 부위에서 염색되었으며 골수 이식군에서만 양성이었다. 근육섬유세포에 대한 vimentin, α-SMA에 대한 염색도 주로 선와 니쉐에서 양성이었고 대조군이나 TNBS군에 비해 골수 이식군에서 많았다. 결론: 흰쥐의 급성 대장염 치료에 골수이식은 효과적이며 골수유래세포는 선와니쉐 부위에서 근육섬유세포로 분화되어 장염의 치료에 관여한다. Background/Aims: Bone marrow-derived cells (BMDC) contribute to tissue maintenance under many kinds of pathologic conditions. We carried out a study to see how BMDC play a role in the treatment of experimental murine colitis. Methods: We divided the animals into 3 groups and treated them with 50% ethanol (control group), 2,4,6-trinitrobenzene sulfinic acid colitis (TNBS group), and TNBS+bone marrow transplant (BMT group). To induce colitis, TNBS (5.0 mg/mouse) dissolved in 50% ethanol was injected into anus weekly for two weeks. Bone marrow transplantations were performed using bone marrow of male transgenic mouse (donor) with green fluoresence protein (GFP) into female wild type mouse (recipient) three weeks before TNBS instillation. All animals were sacrificed, and colons were extracted one week after the last TNBS instillation. We measured microscopic scores of mucosal injury and investigated the GFP expression for bone marrow engraftment. The immunostaining of vimentin and α-smooth muscle actin (α-SMA) for myofibroblasts was performed. Results: The score of mucosal injury in the TNBS group was much more severe than those in control, and reduced significantly by BMT (p<0.05). GFP-positive cells were almost deposited in pericryptal niche of BMT group but not at all in both control and TNBS group. Most of myofibroblasts stained with both vimentin and SMA also infiltrated into pericryptal niche. But, the number of myofibroblasts stained with vimentin and SMA in both control and TNBS group was smaller than that in BMT group. Conclusions: BMDC deposited on pericryptal niche might have a significant role in repairing acute experimental murine colitis. (Korean J Gastroenterol 2009;54:20-27)
So Jeong Park,Ju Young Maeng,Minhee Joo,Jun-Gill Kang,Choong Kyun Rhee,Youngku Sohn 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.106 No.-
Indium tin oxide (ITO) has extensively used as an electrode in diverse application areas of electrochemistry,displays, photovoltaics, and catalysts. Herein, terpyridine-modified ITO and thioterpyridinefunctionalizedAu-modified ITO electrodes were prepared and evaluated for electrochemical redoxbehaviors and conversion rates of Ce(III)/Ce(IV) ions, and recycling recovery rates on the newly developedelectrode by cyclic voltammetry and amperometry. Scanning electron microscopy, X-ray photoelectronspectroscopy, Ultraviolet photoelectron spectroscopy, X-ray diffraction crystallography, and fluorescencespectroscopy were employed for the physiochemical properties of the demonstrated electrodes beforeand after electrochemistry. The interfacial energy level was examined by ultraviolet photoelectron spectroscopyfor ITO-Au and ITO-Au-STpy. Density functional theory calculations were performed to examinecomplexation between the functionalized ligand and Ce(III)/Ce(IV) ions by obtaining molecular orbitalenergy levels and thermodynamics. Thermal CO oxidation catalytic activity was tested for CeelectrodepositedITO electrode. In addition, electrochemical CO2 reduction performance was evaluatedfor Au-modified ITO electrode with and without thioterpyridine-functionalization.
Jin, So-Jeong,Khan, Yeasin,Maeng, Jee Hyun,Kim, Young Jin,Hwang, Junhyeok,Cheong, Minserk,Lee, Je Seung,Kim, Hoon Sik Elsevier BV 2017 Applied Catalysis B Vol.209 No.-
<P><B>Abstract</B></P> <P>The carboxylation of diamines to cyclic ureas by CO<SUB>2</SUB> in the presence of an alkali metal carbonate or alkali metal bicarbonate exhibits a typical autocatalysis behavior, in which the rates of corresponding cyclic urea formations increase with time as in a S-shaped curves. The activity of the alkali metal carbonate was greatly enhanced when ethylene urea was co-present. Computational calculation results on the carboxylation of ethylenediamine in the co-presence of KHCO<SUB>3</SUB> and ethylene urea suggest that ethylene urea of keto form could tautomerize into enol form with the aid of KHCO<SUB>3</SUB> at least to a certain extent, thereby playing a role as a proton donor. With such transformation and the consequent favorable hydrogen bonding interaction with KHCO<SUB>3</SUB>, the proton accepting and donating abilities of KHCO<SUB>3</SUB> can be enhanced and, as a result, the carboxylation is accelerated.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Synthesis of cyclic ureas by the carboxylation of diamines with CO<SUB>2</SUB>. </LI> <LI> Synergy effect of ethylene urea and a base in the carboxylation of diamines. </LI> <LI> Mechanistic and computational investigations on the active species. </LI> <LI> Effect of keto-enol tautomerization of ethylene urea on the activity of KHCO<SUB>3</SUB>. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
혈관내피세포에서 TNF-α로 유도되는 혈관염증에 대한 쏙(Upogebia major) 효소가수분해물의 억제 효과
김소연 ( So-yeon Kim ),양지은 ( Ji-eun Yang ),송재희 ( Jae-hee Song ),맹상현 ( Sang-hyun Maeng ),이지현 ( Ji-hyun Lee ),윤나영 ( Na-young Yoon ) 한국수산과학회(구 한국수산학회) 2018 한국수산과학회지 Vol.51 No.2
Arteriosclerosis is the major cause of coronary artery and cerebrovascular disease, which are leading causes of death. Pro-inflammatory cytokines induce injury to vascular endothelial cells by increasing cell adhesion molecules, leading to vascular inflammation, a major risk factor for the development of arteriosclerosis. In the current study, we investigated the inhibitory effect of enzymatic hydrolysate from Japanese mud shrimp Upogebia major on the inflammation of tumor necrosis factor-α (TNF-α)-stimulated human umbilical vein endothelial cells (HUVECs). We first evaluated the antioxidant and angiotensin I-converting enzyme (ACE) inhibitory activities of eight U. major enzymatic hydrolysates: alcalase, papain, α-chymotrypsin (α-Chy), trypsin, pepsin, neutrase, protamex and flavourzyme. Of these, α-Chy exhibited potent antioxidant and ACE inhibitory activities. The α-Chy hydrolysate was fractionated by two ultrafiltration membranes of 3 and 10 kDa. The α-Chy hydrolysate of U. major and its molecular weight cut-off fractions resulted in a significant reduction in NO production and a decrease in cell adhesion molecules [vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and endothelial-selectin (E-selectin)] and pro-inflammatory cytokines [interleukin-6 (IL-6), interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1)] in TNF-α-stimulated HUVECs. These results suggest that enzymatic hydrolysate from U. major can be used in the control and prevention of vascular inflammation and arteriosclerosis.
( Min Young Lee ),( Jung Hyun Kwon ),( Jeong Won Jang ),( Lee So Maeng ),( Eun Hui Sim ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
Introduction: The most common finding related to nonalcoholic steatohepatitis is obesity, but severe malnutrition status can also be induced by steatohepatitis. The authors describe here hepatic pathological findings in a rare case of steatohepatitis leading to hepatic decompensation caused by malnutrition after pancreaticoduodenectomy. Case: A 68-year-old female patient, who had been previously diagnosed with pancreatic cancer, and had undergone pancreaticoduodenectomy five months before this presentation, visited with abdominal distension. Routine computed tomography three months after surgery revealed severe fatty liver but no evidence of tumor recurrence. Since pancreaticoduodenectomy, her food intake had reduced and as a result, she had lost 7 Kg of body weight over 2 months. At this admission, computed tomography revealed moderate amounts of ascites without tumor recurrence. Furthermore, her albumin and lipid profile levels were markedly decreased, and she had a flapping tremor and slurred speech suggestive of hepatic encephalopathy. Liver biopsy findings were consistent with steatohepatitis and showed macrovesicular steatosis without definite fibrosis. After careful nutritional control, her symptoms disappeared and her laboratory findings improved. Conclusion: This case suggests poor nutritional status after pancreaticoduodenectomy in pancreatic cancer patients can induce severe liver steatosis and hepatic decompensation, and that there is a need to monitor and support nutritional status in these patients.