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RISS 인기검색어
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- 저자 : 민정요 ( Jeong Yo Min ) (검색결과 4 건)
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박보형 ( Bo Hyoung Park ),민정요 ( Jeong Yo Min ),여창동 ( Chang Dong Yeo ),오수성 ( Soo Seong Oh ),허기훈 ( Ki Hoon Hur ),허성은 ( Sung Eun Hur ),김진수 ( Jin Soo Kim ),김원철 ( Won Chul Kim ),김완욱 ( Wan Uk Kim ) 대한류마티스학회 2005 대한류마티스학회지 Vol.12 No.3
Adult onset Still`s disease (AOSD) is a multi-systemic inflammatory disorder characterized by several distinguished manifestations including high spiking fever, evanescent salmon-colored skin rash, arthralgia/arthritis, hepato-splenomegaly, lymphadenopathy, sore throat, serositis, and leukocytosis. The frequently noticed cardiopulmonary manifestation is pleuritis, pneumonitis, and pericarditis. Diffuse myocardial dysfunction is uncommon in AOSD, but it may be the cause of life-threatening heart failure. We have experienced a case of AOSD with acute heart failure in 20-year-old female complained of high fever and skin rash. On echocardiogram, the wall motion of left ventricle was globally decreased with a marked diminished ejection fraction (<25%). Two weeks after treatment with high dose steroid and intravenous immunoglobulin, her symptoms and cardiac function on echocardiogram was completely resolved. To our knowledge, this is the first case of AOSD with acute heart failure reported in Korea.
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최현숙 ( Hyun Sook Choi ),김은선 ( Eun Sun Kim ),민정요 ( Jeong Yo Min ),강경미 ( Kyung Mi Kang ),김지훈 ( Ji Hoon Kim ),유기동 ( Ki Dong Yoo ),김철민 ( Chul Min Kim ) 대한내과학회 2008 대한내과학회지 Vol.75 No.1
본 증례는 흡연 이외에는 심혈관 질환의 위험인자가 없는 젊은 환자에서 급성 심근경색이 발생한 경우로 자가면역질환, 다른 응고성 질환, 종양 등의 원인 없이 lupus anticoagulant 항체 양성 소견으로 원발성 항인지질 증후군에 의한 심근경색을 진단하였기에 문헌고찰과 함께 보고하는 바이다. Antiphospholipid syndrome is a multi-system disorder characterized by arterial or venous thromboses and antiphospholipid antibodies, such as lupus anticoagulant or anticardiolipin antibodies. Most common clinical manifestations are recurrent pregnancy losses and deep vein thromboses. Cardiac manifestations in antiphospholipid syndrome include valve abnormalities, occlusive arterial disease, intracardiac emboli, and ventricular dysfunction. Acute myocardial infarction is a rare manifestation of the primary antiphospholipid syndrome. We have experienced a case of myocardial infarction with antiphospholipid syndrome. A 35-year-old man with no cardiovascular risk factors, other than smoking, presented with chest pain. He was diagnosed with an acute myocardial infarction. Our evaluation for coagulapathy revealed elevated lupus anticoagulant antibody. The antiphospholipid syndrome should be considered early in the differential diagnosis as an important cause of unexplained thrombosis in young patients. (Korean J Med 75:108-111, 2008)
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혈관내피 성장인자를 차단하는 합성 펩타이드인 RRKRRR이 류마티스 염증반응에 미치는 영향
김완욱 ( Wan Uk Kim ),유승아 ( Seung Ah Yoo ),김해림 ( Hae Rim Kim ),박보형 ( Bo Hyoung Park ),민정요 ( Jeong Yo Min ),윤종현 ( Chong Hyeon Yoon ),박성환 ( Sung Hwan Park ),조철수 ( Chul Soo Cho ) 대한류마티스학회 2005 대한류마티스학회지 Vol.12 No.1
Objective: Vascular endothelial growth factor (VEGF) has been suggested to play a critical role in the pathogenesis of rheumatoid arthritis (RA). It has been demonstrated that synthetic arginine-rich hexapeptide, RRKRRR, shows significant inhibition of VEGF-induced angiogenesis, and also retarded the growth and metastasis of colon carcinoma cell by blocking the interaction between VEGF and its receptor. In this study, we investigated whether anti-VEGF RRKRRR peptide (dRK6) could regulate the activation of mononuclear cells of RA patients and suppress collagen-induced arthritis (CIA) in mice. Methods: Synovial fluid mononuclear cells (SFMC) or synoviocytes from RA patients were cultured in the presence of VEGF, and the levels of TNF-α and IL-6 were determined in the culture supernatants by ELISA. Blocking experiments were performed by adding dRK6 to thecells stimulated with VEGF. Additionally, the in vivo effect of dRK6 on the development of arthritis was tested in collagen induced arthritis (CIA) in DBA/1 mice. T cell responses to type II collagen (CII) and IgG antibodies to CII were examined in draining lymph node cells and sera of the mice, respectively. Results: dRK6 showed concentration-dependent inhibitory activity for the VEGF binding to its receptor on human vascular endothelial cells. The treatment of dRK6 completely abrogated the VEGF-induced productions of TNF-α and IL-6 by RA SFMC or synoviocytes. Moreover, a subcutaneous injection of dRK6 resulted in a dose-dependent decrease in the severity and incidence of CIA in mice. In these mice, the T cell responses to type II collagen (CII) in lymph node cells and circulating IgG antibodies to CII were also dose-dependently inhibited by the peptides. Conclusion: We observed firstly that anti-VEGF dRK6 blocked the VEGF-induced production of pro-inflammatory cytokine from RA SFMC and synoviocytes, and suppressed the ongoing paw inflammation in mice. These data suggest that dRK6 may be an effective strategy in the treatment of RA, and could be applied to modulate various chronic VEGF-dependent inflammatory diseases.
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위장관 : 급성 TNBS-유발 대장염에서 동종 골수이식에 의한 치료 효과
맹이소 ( Lee So Maeng ),장은덕 ( Eun Duck Chang ),채현석 ( Hiun Suk Chae ),김진수 ( Jin Soo Kim ),민정요 ( Jeong Yo Min ),손혜숙 ( Hye Sook Sohn ),노상영 ( Sang Young Rho ),김형근 ( Hyung Keun Kim ),조영석 ( Young Suk Cho ),최규용 대한소화기학회 2009 대한소화기학회지 Vol.54 No.1
목적: 골수에서 유래한 세포들은 여러 병적인 환경에서 조직을 유지하는 데 기여한다. 저자들은 흰쥐의 실험 대장염에서 골수 이식 시 대장염의 치료에 대해 골수유래세포들의 역할을 알아보기 위해 연구를 시행하였다. 대상 및 방법: 실험에 사용한 흰쥐는 3개의 군으로 나누어 대조군 (50% ethanol), 2,4,6-trinitrobenzene sulfinic aicd (TNBS군) 장염군, TNBS+골수이식군(BMT군)으로 하였다. 장염을 유발하기 위해 50% 알코올에 녹인 TNBS (5.0 mg/마리)를 일주일에 한 번씩 2주 동안 항문을 통해 투여하였다. 동종 골수 이식은 TNBS 투여 3주 전에 green fluorescence protein (GFP)를 지닌 수컷 유전자 도입 쥐의 골수 세포를 야생형 생쥐의 꼬리 정맥에 투여하였다. 모든 동물은 TNBS 투여 후 일주일 후에 희생하여 대장을 추출하였다. 골수이식이 되었는지를 확인하기 위해 GFP에 대한 면역조직화학검사를 시행하였고 상피하 근육섬유모세포의 존재를 확인하기 위해 vimentin과 α-SMA에 대한 면역조직검사를 시행하였다. 결과: 장염의 정도는 TNBS군에서 가장 심하였고 골수이식에 의해 유의하게 감소하였다(p<0.05). GFP 양성 세포는 주로 선와의 니쉐 부위에서 염색되었으며 골수 이식군에서만 양성이었다. 근육섬유세포에 대한 vimentin, α-SMA에 대한 염색도 주로 선와 니쉐에서 양성이었고 대조군이나 TNBS군에 비해 골수 이식군에서 많았다. 결론: 흰쥐의 급성 대장염 치료에 골수이식은 효과적이며 골수유래세포는 선와니쉐 부위에서 근육섬유세포로 분화되어 장염의 치료에 관여한다. Background/Aims: Bone marrow-derived cells (BMDC) contribute to tissue maintenance under many kinds of pathologic conditions. We carried out a study to see how BMDC play a role in the treatment of experimental murine colitis. Methods: We divided the animals into 3 groups and treated them with 50% ethanol (control group), 2,4,6-trinitrobenzene sulfinic acid colitis (TNBS group), and TNBS+bone marrow transplant (BMT group). To induce colitis, TNBS (5.0 mg/mouse) dissolved in 50% ethanol was injected into anus weekly for two weeks. Bone marrow transplantations were performed using bone marrow of male transgenic mouse (donor) with green fluoresence protein (GFP) into female wild type mouse (recipient) three weeks before TNBS instillation. All animals were sacrificed, and colons were extracted one week after the last TNBS instillation. We measured microscopic scores of mucosal injury and investigated the GFP expression for bone marrow engraftment. The immunostaining of vimentin and α-smooth muscle actin (α-SMA) for myofibroblasts was performed. Results: The score of mucosal injury in the TNBS group was much more severe than those in control, and reduced significantly by BMT (p<0.05). GFP-positive cells were almost deposited in pericryptal niche of BMT group but not at all in both control and TNBS group. Most of myofibroblasts stained with both vimentin and SMA also infiltrated into pericryptal niche. But, the number of myofibroblasts stained with vimentin and SMA in both control and TNBS group was smaller than that in BMT group. Conclusions: BMDC deposited on pericryptal niche might have a significant role in repairing acute experimental murine colitis. (Korean J Gastroenterol 2009;54:20-27)
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