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Research on Whole‑Process Tensile Behavior of Headed Studs in Steel–Concrete Composite Structures
Liang?Dong Zhuang,Hong?Bing Chen,Yuan Ma,Ran Ding 한국콘크리트학회 2021 International Journal of Concrete Structures and M Vol.15 No.4
The headed studs have been widely applied in steel–concrete composite structures as shear connectors. However, the tensile performance of headed studs is also key to the structural performance in many cases such as the semi-rigid composite joints including steel beam–concrete wall joint and steel column–base joint. Therefore, this study presents experimental and analytical study on the whole-process tensile behavior of headed studs. Tests on a total of 33 pullout specimens are first conducted. The tensile capacity and load–deformation behavior of the anchorage concrete, which dominates the structural performance of headed studs, are thoroughly analyzed. In addition, test data in the literature are collected for quantitatively evaluating the influence of embedment depth, bearing area, boundary conditions, and concrete strength on the tensile behavior of the anchorage concrete. On the basis of the influence evaluation, an analytical model represented by a piecewise function is proposed to describe the whole-process load–deformation behavior of the anchorage concrete and validated through the comparison between the predicted curves and all collected experimental results. Then the proposed model is applied to simulate the rotational behavior of the typical semi-rigid joint anchored by headed studs, which takes the contribution of the anchorage concrete into consideration, and is verified by experimental results. The research findings indicate that tensile behavior of anchorage concrete is crucial to the structural performance of semi-rigid joints, even for headed studs with large embedment depth and bearing area.
Ding, Yueyun,Qian, Li,Wang, Li,Wu, Chaodong,Li, DengTao,Zhang, Xiaodong,Yin, Zongjun,Wang, Yuanlang,Zhang, Wei,Wu, Xudong,Ding, Jian,Yang, Min,Zhang, Liang,Shang, Jinnan,Wang, Chonglong,Gao, Yafei Asian Australasian Association of Animal Productio 2020 Animal Bioscience Vol.33 No.2
Objective: Considering the physiological and clinical importance of leptin receptor (LEPR) in regulating obesity and the fact that porcine LEPR expression is not known to be controlled by lncRNAs and miRNAs, we aim to characterize this gene as a potential target of SSC-miR-323 and the lncRNA TCONS_00010987. Methods: Bioinformatics analyses revealed that lncRNA TCONS_00010987 and LEPR have SSC-miR-323-binding sites and that LEPR might be a target of lncRNA TCONS_00010987 based on cis prediction. Wild-type and mutant TCONS_00010987-target sequence fragments and wild-type and mutant LEPR 3'-UTR fragments were generated and cloned into pmiRRB-REPORT<sup>TM</sup>-Control vectors to construct respective recombinant plasmids. HEK293T cells were co-transfected with the SSC-miR-323 mimics or a negative control with constructs harboring the corresponding binding sites and relative luciferase activities were determined. Tissue expression patterns of lncRNA TCONS_00010987, SSC-miR-323, and LEPR in Anqing six-end-white (AQ, the obese breed) and Large White (LW, the lean breed) pigs were detected by real-time quantitative polymerase chain reaction; backfat expression of LEPR protein was detected by western blotting. Results: Target gene fragments were successfully cloned, and the four recombinant vectors were constructed. Compared to the negative control, SSC-miR-323 mimics significantly inhibited luciferase activity from the wild-type TCONS_00010987-target sequence and wild-type LEPR-3'-UTR (p<0.01 for both) but not from the mutant TCONS_00010987-target sequence and mutant LEPR-3'-UTR (p>0.05 for both). Backfat expression levels of TCONS_00010987 and LEPR in AQ pigs were significantly higher than those in LW pigs (p<0.01), whereas levels of SSC-miR-323 in AQ pigs were significantly lower than those in LW pigs (p<0.05). LEPR protein levels in the backfat tissues of AQ pigs were markedly higher than those in LW pigs (p<0.01). Conclusion: LEPR is a potential target of SSC-miR-323, and TCONS_00010987 might act as a sponge for SSC-miR-323 to regulate LEPR expression.
Liang Ding,Tong Wang,Bo Yang,Chuan-gang Gu 대한기계학회 2013 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.27 No.2
Inlet flow distortions, which are caused by fluid mixing, cause a significant deterioration in fan performance. An experimental test rig for an industrial fan with dual inlets and a mixing chamber was constructed. The flow fields in the mixing chamber of the fan were numerically investigated. Consequently, impact parameters, including the length of the mixing chamber (100, 200, and 300 mm) and the mass flow rate ratio (1 to 10), as well as their effects on fan performance, were discussed. A generalized formula considering the Reynolds number, hydraulic diameter, and mixing length was proposed to predict the pressure drop in dual inlets. Results show that the efficiency of and pressure in the fan decreased by 6.5% and 203 Pa, respectively, under mixing inlet condition. Optimum fan performance is achieved at a flow rate ratio of 5 under the same mass flow rate. The increase in the flow rate ratio kept the fan performance almost constant. At the design stage, fan performance and pressure decrease by an average of 2% and 70 Pa in increments of 100 mm mixing length, respectively. The results presented in this paper provide a basis in the design optimization of mixing structures.
Zhi-Hai Ni,Xian-Jun Liang,Jing-Gang Mo,Yi Zhang,Jian-Hua Liang,Yu-Sha Yang,Yong Zhou,Zhao-Hua Li,Jian-Liang Zhang,Yin-Lu Ding,Peng Zhang,Jin-Qing Wang 한국유전학회 2015 Genes & Genomics Vol.37 No.11
We aim to investigate the correlations of hypoxia inducible factor-1a (HIF-1a) C1772T (rs11549465) and G1790A (rs11549467) gene polymorphisms with digestive tract cancers. A sum of 267 digestive tract cancers patients were hospitalized in Taizhou Central Hospital of Zhejiang Province as case group between December 2012 and December 2014. Additionally, 275 healthy people who had a physical examination in our hospital at the same time were selected as control group. Polymerase chain reaction-restriction fragment length polymorphism was utilized for detecting allele and genotype frequency of different locus in case and control group. Meta-analysis was performed using Comprehensive Metaanalysis 2.0 (Biostat Inc., Englewood, New Jersey, USA). Our result showed statistical significance only exists in family history of cancer between case and control group (P\0.05). Both C1772T (rs11549465) and G1790A (rs11549467) polymorphisms showed positive correlations with an increasing risk of digestive tract cancers. The frequencies of TT genotype of C1772T (rs11549465) and GA, AA genotypes of G1790A (rs11549467) polymorphisms in case group were evidently higher compared with the controls (all P\0.05). Besides, the comparison of allele and dominant models of HIF-1a C1772T (rs11549465) and G1790A (rs11549467) between two groups showed a significant difference (all P\0.05). Meta-analysis results further confirmed that the onset risk of digestive tract cancers may be improved under allele and dominant models of HIF-1a C1772T (rs11549465) and G1790A (rs11549467) (all P\0.05). Single nucleotide polymorphisms of HIF-1a C1772T (rs11549465) and G1790A (rs11549467) may play a role in development of digestive tract cancers.
Liang, Jin,Hu, Han,Park, Hyunjung,Xiao, Chunhui,Ding, Shujiang,Paik, Ungyu,Lou, Xiong Wen (David) The Royal Society of Chemistry 2015 ENERGY AND ENVIRONMENTAL SCIENCE Vol.8 No.6
<P>Bowl-like hybrid structures have been designed and fabricated by anchoring NiO nanosheets on flat carbon hollow particles. When evaluated as an anode material for lithium-ion batteries, these unique NiO/carbon hybrid particles exhibit superior lithium storage properties in terms of high capacity, long term cycling stability and excellent rate capability.</P> <P>Graphic Abstract</P><P>Bowl-like hybrid structures constructed by anchoring NiO nanosheets on flat carbon shells exhibit superior lithium storage properties. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c5ee01125f'> </P>
Liang Zhang,Zhongyang Ding,Peng Xu,Yuhong Wang,Zhenghua Gu,Zhu Qian,Guiyang Shi,Kechang Zhang 한국생물공학회 2011 Biotechnology and Bioprocess Engineering Vol.16 No.3
Tyrosinase is a key enzyme in the biosynthesis of melanin, and the use of inhibitors against tyrosinase can prevent hyperpigmentation by inhibiting enzymatic oxidation. However, the current use of tyrosine inhibitors is limited by their low activities and high toxicities. The aim of the present research was to develop novel whitening agents, or tyrosinase-targeted medicine, from a submerged culture of the fungus Ganoderma lucidum. Methyl lucidenate F was isolated from the ethanol-soluble-acidic components (ESACs) of G. lucidum, with the structure of ESACs elucidated via UV, LC-MS, and ^(13)C-NMR spectral analysis. The tyrosinase inhibitory activity was measured using catechol as a substrate. Methyl lucidenate F displayed uncompetitive inhibition of the potato tyrosinase activity,for which Lineweaver-Burk plots revealed a maximum reaction rate (V_(max)) of 0.4367/min, Michaelis constant (K_m)of 6.765 mM and uncompetitive inhibition constant (K_i) of 19.22 μM. Meanwhile, methyl lucidenate F (tetra cyclic triterpenoid) exhibited high tyrosinase inhibitory activity,with an IC_(50) of 32.23 μM. These results suggest that methyl lucidenate F may serve as a potential candidate for skin-whitening agents.
Ding, Yan,Liang, Chun,Nguyen, Huu Tung,Choi, Eun-Mi,Kim, Jeong-Ah,Kim, Young-Ho Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.4
A new compound, 4-methoxyl 5-hydroxymethyl benzoic 3-O-$\beta$-D-glucopyranoside (1), has been isolated from the leaves and stems of Acer mandshuricum, along with nine known compounds (2-10). Their structures were determined by a variety of spectroscopic analyses. The effect of compounds 1-10 on the function of osteoblastic MC3T3-E1 cells was examined by determining alkaline phosphatase (ALP) activity, collagen synthesis, and mineralization. Compound 1 significantly increased the function of osteoblastic MC3T3-E1 cells; $5.0\;{\mu}M$ of 1 increased ALP activity, collagen synthesis, and mineralization of MC3T3-E1 cells to 114.7, 119.5, and 108.2% (P < 0.05) of the basal value, respectively. In addition, compounds 2-10 also potently increased the function of osteoblastic MC3T3-E1 cells.
A Prediction Model of the Sum of Container Based on Combined BP Neural Network and SVM
Ding, Min-jie,Zhang, Shao-zhong,Zhong, Hai-dong,Wu, Yao-hui,Zhang, Liang-bin Korea Information Processing Society 2019 Journal of information processing systems Vol.15 No.2
The prediction of the sum of container is very important in the field of container transport. Many influencing factors can affect the prediction results. These factors are usually composed of many variables, whose composition is often very complex. In this paper, we use gray relational analysis to set up a proper forecast index system for the prediction of the sum of containers in foreign trade. To address the issue of the low accuracy of the traditional prediction models and the problem of the difficulty of fully considering all the factors and other issues, this paper puts forward a prediction model which is combined with a back-propagation (BP) neural networks and the support vector machine (SVM). First, it gives the prediction with the data normalized by the BP neural network and generates a preliminary forecast data. Second, it employs SVM for the residual correction calculation for the results based on the preliminary data. The results of practical examples show that the overall relative error of the combined prediction model is no more than 1.5%, which is less than the relative error of the single prediction models. It is hoped that the research can provide a useful reference for the prediction of the sum of container and related studies.