백서의 척수에서 GABAB 수용체의 심혈관 조절 작용

이석호,이상구,류광현,이규택,김재준,김창섭,강인구,최규완,백승운,이종균,이준혁,고광철,이풍렬,이종철,성인경,심상군,최문석 대한내과학회 1999 대한내과학회지 Vol.56 No.1

Objectives : The purpose of present study is to investigate the influence of a spinal gamma-aminobutyric acid B (GABAB) receptor on a central regulation of blood pressure(BP) and heart rate(HR), and to define its mechanism in the spinal cord. Methods : In urethane-anesthetized, d-tubocurarine- paralyzed and artificially ventilated male Sprague-Dawley rats, intrathecal administration of drugs were carried out using injecton cannula(33-gauge stainless steel) through the guide cannula(PE 10) which was inserted intrathecally at lower thoracic level through the puncture of a atlantooccipital membrane. Results : Intrathecal injection of an GABAB receptor agonist baclofen(30, 60, 100 nmol) decreased both blood pressure and heart rate dose-dependently. Pretreatment with 8-bromo-cAMP(50 nmol), a cAMP analog or glipizide(50 nmol), a ATP-sensitive K+ channel blocker attenuated the depressor and bradycardic effects of baclofen (100 nmol) but not with 8-bromo-cGMP(50 nmol) a cGMP analog. Conclusions : The GABAB receptor in the spinal cord plays an inhibitory role in central cardiovascular regulation and that this depressor and bradycardic actions are mediated by the decrease of cAMP via the inhibition of adenylate cyclase and the opening of K+ channel.

조직학적으로 진단된 담낭용종의 임상적 특징

이석호,최윤호,손희정,류광현,이규택,김재준,김용일,최규완,최성호,백승운,이종균,고광철,이풍렬,이종철,노재형,이준혁,심상군 대한소화기학회 1999 대한소화기학회지 Vol.34 No.1

Background/Aims: We aimed to clarify clinical factors which suggest the possibility of neoplastic polyps of gallbladder. Methods: Ninety-five resected gallbladders with polyps were included. Size and number of the polyps were obtained by preoperative ultrasonography. Histollogically, the polyps were classified into non-neoplastic (cholesterol and inflammatory or hyperplastic polyp) and neoplastic lesions (adenoma and adenocarcinoma). Clinical features, maximum diameter and number of the polyps were compared between the two groups. Results: Of 95 patients, non-neoplastic polyps were observed in 65.3% and neoplastic polyps were observed in 34.7%. We found cholesterol polyp in 47.4%, inflammatory or hyperplastic polyp in 17.9%, adenoma in 25.2% and adenocarcinoma in 9.5%. Two groups showed no difference in age, sex, body mass index, cholesterol, triglyceride, glucose, ALT, HBsAg carriage and the number of polyps. Among the patients with non-neoplastic polyps, 70.2% was under 60 years, while 72.7% of the patients with neoplastic polyps was over 60 years (p$lt;0.05). The size of polyps was under 10 mm in 88.9% of non-neoplastic polyps, and between 10 and 15 mm in 40% of neoplastic leisions. Moreover, 68.4% of neoplastic polyps exceeds 15 mm in diameter (p$lt;0.05). Conclusions: The size of polyp (≥10 mm) and patient's age (≥60 years) could be indicators for neoplastic polyps.

말초형 간내담관암의 수술 후 예후에 관한 고찰

이종철,이상수,이종균,이규택,최성호,김재준,최규완,백승운,고광철,이풍렬,심상군,류광현,이준혁,박철근,손태성,여규동 대한소화기학회 2000 대한소화기학회지 Vol.36 No.5

Background/Aims: Prognostic factors related to the postoperative survival of patients with peripheral cholangiocarcinoma (PCC) are not well documented. The purpose of this study was to evaluate the clinical and pathologic factors that might influence the postoperative survival of patients with PCC. Methods: Twenty-nine patients with PCC underwent laparotomy between September 1994 and September 1999. Fourteen clinicopathologic factors influencing postoperative survival were analyzed in nineteen patients who underwent hepatic resection (resection group). Ten patients had unresectable advanced tumor (unresectable group). Results: In the resection group, the overall 1-, 2-, and 3-year survival rate was 51.4%, 45.0%, and 28.1%, respectively (median survival of 17.6 months). The median survival in the unresectable group was 4.1 months and no patient lived longer than 1 year. In univariate survival analysis, tumor size and perineural invasion were correlated significantly with overall survival. The survival of patients who underwent resection with positive margin was significantly longer than that of the unresectable group. Conclusions: An aggressive surgical approach provides the best chance for long-term survival of patients with PCC. Tumor size and perineural invasion may be considered as prognostic factors for postoperative survival, but a large, long-term study is needed.

GOTHIC-3D APPLICABILITY TO HYDROGEN COMBUSTION ANALYSIS

LEE JUNG-JAE,LEE JIN-YONG,PARK GOON-CHERL,LEE BYUNG-CHUL,YOO HOJONG,KIM HYEONG-TAEK,OH SEUNG-JONG Korean Nuclear Society 2005 Nuclear Engineering and Technology Vol.37 No.3

Severe accidents in nuclear power plants can cause hydrogen-generating chemical reactions, which create the danger of hydrogen combustion and thus threaten containment integrity. For containment analyses, a three-dimensional mechanistic code, GOTHIC-3D has been applied near source compartments to predict whether or not highly reactive gas mixtures can form during an accident with the hydrogen mitigation system working. To assess the code applicability to hydrogen combustion analysis, this paper presents the numerical calculation results of GOTHIC-3D for various hydrogen combustion experiments, including FLAME, LSVCTF, and SNU-2D. In this study, a technical base for the modeling oflarge- and small-scale facilities was introduced through sensitivity studies on cell size and bum modeling parameters. Use of a turbulent bum option of the eddy dissipation concept enabled scale-free applications. Lowering the bum parameter values for the flame thickness and the bum temperature limit resulted in a larger flame velocity. When applied to hydrogen combustion analysis, this study revealed that the GOTHIC-3D code is generally able to predict the combustion phenomena with its default bum modeling parameters for large-scale facilities. However, the code needs further modifications of its bum modeling parameters to be applied to either small-scale facilities or extremely fast transients.

GOTHIC-3D Applicability to Hydrogen Combustion Analysis

Jung-Jae Lee,Jin-Yong Lee,Goon-Cherl Park,Byung-Chul Lee,Hojong Yoo,Hyeong-Taek Kim,Seung-Jong Oh 한국원자력학회 2005 Nuclear Engineering and Technology Vol.37 No.3

저등급 악성도 위 MALT 림프종의 임상적 고찰

이준혁(Joon Hyoek Lee),백승운(Seung Woon Paik),심상군(Sang Goon Shim),류광현(Kwang Hyun Ryu),이풍렬(Poong Lyul Rhee),김재준(Jae Jun Kim),이종철(Jong Chul Rhee),최규완(Kyoo Wan Choi),이석호(Suk Ho Lee),이규택(Kyu Taek Lee),이종균(Jong 대한내과학회 1999 대한내과학회지 Vol.57 No.1

N/A Low-grade gastric MALT lymphoma arises from long-standing Helicobacter pylori(Hp) infection. High remission rates for these lymphoma have been observed after H. pylori eradication. There was debates on the optimal treatment of low-grade gastric MALT lymphoma. The purpose of this study is to investigate clinical and endoscopic characteristics of primary low-grade gastric MALT lymphoma and to assess short-term clinical outcome of various modalities of treatment. Methods : 30 patients(14 male, 16 female, mean age 44.9 years, range 26-76, mean follow-up 22.9 months) with primary low-grade gastric MALT lymphoma, diagnosed at the Samsung Medical Center from March 1995 to September 1998, were evaluated in a retrospective study. We evaluated patient's presenting symptoms, endoscopic finding, Hp status, staging by Musshoff system, and recurrence rate according to treatment mordalities. Results : The most common symptom is epigastric discomfort or pain(36.7%). Endoscopic appearances of gastric MALT lymphoma shows the wide variation from mucosal thickening to overt malignancy. The most common site of gastric MALT lymphoma is the gastric antrum and lower body(9 and 6 patients). Histologically, 70% were found to be Hp infected. Of 21 Hp(+) patients, 11 patients were clinical stage IE and received Hp eradication by PPI-based triple regimens. 81.8%(9/11) showed complete remission. Among 11 patients, 6 patients studied by PCR. After Hp eradication, 5 in 6 patients showed persistent IgH rearangement by PCR. The mean follow-up time is 22.8 months(range 3 to 36 months), One patient, who showed complete histologic regression during second endoscopy, relapsed MALT lymphoma after 6 months. The other one patient showed no change of lymphoma and underwent surgery. 12 patients underwent surgical treatment and showed no evidence of relapse. The mean follow-up time is 35.9 months. 2 patients received chemotherapy with CHOP regimen and showed complete remission. The mean follow-up time is 6.7 months. 2 patients received radiotherapy and showed no evidence of relapse. The mean follow-up time is 15 months. Conclusion ' Our study shows that complete remission rate after Hp eradication is as high as some studies recently reported. This suggest that Hp eradication may be considered as first-line therapy of low-grade gastric MALT lymphoma of stage IE.

내시경적 역행성 담췌관조영술 시 예방적 항생제 투여의 유용성

이규택,김재준,최규완,백승운,이종균,고광철,이풍렬,이종철,성인경,심상군,김창섭,최문석,이준혁,류광현 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.6

Background/Aims: Prophylactic antibiotics are used in an attempt to avoid the septic complications of endoscopic retrograde cholangiopancreatography (ERCP). But, there is individual tendency to choose prophylactic antibiotics due to a lack of definite guidelines for prophylactic antibiotics. Therefore, the effectiveness of ciprofloxacin to prevent post ERCP infectious complications was evaluated. Methods: One hundred patients underwent 75 diagnostic ERCPs and 25, therapeutic ERCPs. They were classified randomly into a group of 51 prophylaxis (ciprofloxacin 200 mg i.v. 30 min before the procedure) and 49 controls. Pre- and post-ERCP blood cultures were prospectively performed and surveyed for infectious complications. Results: Sepsis was detected in 4 patients in each group (p>0.05). Two cases were related to diagnostic ERCP and the remaining six cases, therapeutic ERCP (p<0.01). Bacteremia was found in 6 cases, but only two cases (Escherichia coli, Citrobacter freundii) were clinically significant. Conclusis: The frequency of sepsis following ERCP was not significantly reduced by antibiotic prophylaxis (7.8% vs. 8.2%).

시사프라이드의 대장내시경 전처치 용액의 감량 효과

이성호,김현수,박찬원,이현택,이홍석,조대현,박정호,심상군,김현서,권정훈,장재권,성인경 대한소화기내시경학회 2000 Clinical Endoscopy Vol.21 No.5

Background/Aims: Polyethylene glycol (PEG) electrolyte lavage solution is now commonly used for peroral colonic preparation. However, the need to ingest a large volume reduces patient acceptance and may limit compliance, thereby resulting in improper preparation. This study was designed to assess whether adding of magnesium oxide or cisapride to PEG solution decreased the volume of PEG solution required without compromising the quality of the preparation. Methods: One hundred thirty seven patients undergoing outpatient colonoscopy were randomly chosen to receive one of three preparations (Group A: 4 L PEG; Group B: 2 L PEG plus cisapride 20 mg; Group C: 2 L PEG plus magnesium oxide 2 g). Endoscopist was blinded as to the method of preparation and scored the degree of colonic preparation (1 to 4). Results: Mean scores of preparation in group A, B, and C were 2.85, 2.69, and 2.20, respectively (p=0.001). There were significant differences of the degree of preparation between group A and group C, between group B and group C, but not between group A and group B. Conclusions: Two liters of PEG plus cisapride induced equally effective colonic preparation compared to four liter PEG solution. This results show that the addition of cisapride to PEG solution can reduce volume of PEG solution during colonoscopy preparation.

적용된 분석방법 차이에 따른 토양 중 풍화 경유 함량 비교

이군택,Lee Goon-Taek 한국지하수토양환경학회 2004 지하수토양환경 Vol.9 No.3

본 실험에 사용된 토양은 유류 유출사고가 발생한 후 7년 동안 방치 되어왔던 지역에서 채취되었으며 정성분석을 수행한 결과 풍화된 형태의 경유로 오염된 사실이 확인되었다. 토양 중 경유의 정량은 1999년 7월에 개정된 토양오염 공정시험방법 (시험법 1)과 US EPA method 8015b (시험법 2)에 준하여 이루어졌으며, 또한 2002년 7월에 개정되어 현재 시행되고 있는 토양오염공정시험방법 (시험법 3)과의 비교를 위하여 일부 추가 시료에 대한 정량분석이 수행되었다. 시험법 1을 적용하였을 때 분석에 사용된 총 46개의 시료 중 4개의 시료에서만 유류성분이 검출되었으며 시험법 2를 적용하였을 때는 모든 시료에서 유류성분이 검출되었으며 43개 시료의 농도가 토양오염우려기준인 2000mg/kg을 초과하였다. 시험법 2와 3에 의하여 수행된 결과를 이용하여 1차 회귀직선식을 도출해보면, 기울기 값이 0.9845로 높은 정의 상관관계($r^2$=0.99)를 보여주었다. 이들 결과로 볼 때 시험법 2와 3은 시험법 1과 비교하여 토양 중 풍화가 진행된 경유를 정량 할 경우 보다 적절한 방법으로 판단되었으며 시험법 2와 시험법 3은 거의 같은 수준의 정확성과 재현성을 보여주었다. Soil samples used in this study were taken from the site at which diesel spill accident had occurred in 1995. It was confirmed that all of soil samples were contaminated with diesel which was going on weathering. The concentrations of diesel in soils were determined by Korea standard method revised in July 1999 (Method 1) and US EPA method 8015b (Method 2). Some additional soil samples were analyzed with Korea standard method revised in July 2002 (Method 3) to compare the accuracy and reproducibility with Method 2. The only four of forty-six samples were determined when the analysis carried out according to Method 1 while forty-three of forty-six samples had the value above criterion (2000mg kg$^{-1}$ ) according to Method 2. There were no significant differences between the results of the analysis by Method 2 and Method 3. Based on these results, Method 2 and 3 were more appropriate than Method 1 for the determination of weathered diesel in soil. Method 2 had almost equivalent accuracy and reproducibility to Method 3.

Analysis of Physicochemical Properties and Oil Compounds of the Soil Near Donghae Railroad site

Jae-Hwang Lee,Youn-seok Choi,Goon-Taek Lee,Kye-Hoon Kim 한국토양비료학회 2005 한국토양비료학회 학술발표회 초록집 Vol.2005 No.9