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Lai Nar Tung,Senchuan Song,Kin Tak Chan,Mei Yuk Choi,Ho Yu Lam,Chung Man Chan,Zhiyong Chen,Hector K. Wang,Hoi Ting Leung,Simon Law,Yanmin Huang,Huacan Song,Nikki P. Lee 대한암학회 2018 Cancer Research and Treatment Vol.50 No.4
Purpose Tumor xenograft model is an indispensable animal cancer model. In esophageal squamous cell carcinoma (ESCC) research, orthotopic tumor xenograft model establishes tumor xenograft in the animal esophagus, which allows the study of tumorigenesis in its native microenvironment. Materials and Methods In this study, we described two simple and reproducible methods to develop tumor xenograft at the cervical or the abdominal esophagus in nude mice by direct injection of ESCC cells in the esophageal wall. Results In comparing these two methods, the cervical one presented with more clinically relevant features, i.e., esophageal stricture, body weight loss and poor survival. In addition, the derived tumor xenografts accompanied a rapid growth rate and a high tendency to invade into the surrounding structures. This model was subsequently used to study the anti-tumor effect of curcumin, which is known for its potential therapeutic effects in various diseases including cancers, and its analogue SSC-5. SSC-5 was selected among the eight newly synthesized curcumin analogues based on its superior anti-tumor effect demonstrated in an MTT cell proliferation assay and its effects on apoptosis induction and cell cycle arrest in cultured ESCC cells. Treatment of orthotopic tumor-bearing mice with SSC-5 resulted in an inhibition in tumor growth and invasion. Conclusion Taken together, we have established a clinically relevant orthotopic tumor xenograft model that can serve as a preclinical tool for screening new anti-tumor compounds, e.g., SSC-5, in ESCC.
Lai Yun-Ju,Sung Yi-Ting,Lai Yi-An,Chen Li-Nian,Chen Tung-Sheng,Chien Chiang-Ting 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.6
BACKGROUND: Liver inflammation is the main cause of severe liver diseases, including liver fibrosis, steatohepatitis, cirrhosis and hepatocellular carcinoma. Cell therapy topics are receiving increasingly more attention. The therapeutic applications of mesenchymal stem cells (MSC) have become one of the most discussed issues. While other stem cells have therapeutic effects, they have only one or two clinical applications. MSCs are responsible for repairing a variety of tissue injuries. Moreover, MSCs could be derived from several sources, including adipose tissue. MSCs are usually more abundant and easier to obtain compared to other stem cells. METHODS: To prove the concept that MSCs have homing ability to the injured tissue and assist in tissue repair, we examined the effects of intravenous injected adipose-derived mesenchymal stem cells (ADSCs) in a N-nitrosodiethylamine (DEN)-induced liver injury rat model. RESULTS: The significant repairing ability of ADSCs was observed. The levels of fibrosis, apoptosis, and tumorigenesis in the DEN-injured liver tissues all decreased after ADSC treatment. Furthermore, to enhance the therapeutic effects of ADSCs, we pretreated them with L-theanine, which promotes the hepatocyte growth factor secretion of ADSC, and therefore improved the healing effects on injured liver tissue. CONCLUSION: ADSCs, especially L-theanine-pretreated ADSCs, have anti-inflammation, anti-apoptosis, and anti-tumorigenesis effects on the N-nitrosodiethylamine-induced liver injury rat model.
Wu Wen-Pei,Lai Hung-Wen,Liao Chiung-Ying,Lin Joseph,Huang Hsin-I,Chen Shou-Tung,Chou Chen-Te,Chen Dar-Ren 대한영상의학회 2023 Korean Journal of Radiology Vol.24 No.7
Objective: Prospective studies on postoperative residual breast tissue (RBT) after robotic-assisted nipple-sparing mastectomy (R-NSM) for breast cancer are limited. RBT presents an unknown risk of local recurrence or the development of new cancer after curative or risk-reducing mastectomies. This study investigated the technical feasibility of using magnetic resonance imaging (MRI) to evaluate RBT after R-NSM in women with breast cancer. Materials and Methods: In this prospective pilot study, 105 patients, who underwent R-NSM for breast cancer at Changhua Christian Hospital between March 2017 and May 2022, were subjected to postoperative breast MRI to evaluate the presence and location of RBT. The postoperative MRI scans of 43 patients (age, 47.8 ± 8.5 years), with existing preoperative MRI scans, were evaluated for the presence and location of RBT. In total, 54 R-NSM procedures were performed. In parallel, we reviewed the literature on RBT after nipple-sparing mastectomy, considering its prevalence. Results: RBT was detected in 7 (13.0%) of the 54 mastectomies (6 of the 48 therapeutic mastectomies and 1 of the 6 prophylactic mastectomies). The most common location for RBT was behind the nipple-areolar complex (5 of 7 [71.4%]). Another RBT was found in the upper inner quadrant (2 of 7 [28.6%]). Among the six patients who underwent RBT after therapeutic mastectomies, one patient developed a local recurrence of the skin flap. The other five patients with RBT after therapeutic mastectomies remained disease-free. Conclusion: R-NSM, a surgical innovation, does not seem to increase the prevalence of RBT, and breast MRI showed feasibility as a noninvasive imaging tool for evaluating the presence and location of RBT.
( Khac Phong Do ),( Ba Tung Nguyen ),( Xuan Thanh Nguyen ),( Quang Hung Bui ),( Nguyen Le Tran ),( Thi Nhat Thanh Nguyen ),( Van Quynh Vuong ),( Huy Lai Nguyen ),( Thanh Ha Le ) 한국정보처리학회 2015 Journal of information processing systems Vol.11 No.4
This paper presents the applications of spatial interpolation and assimilation methods for satellite and ground meteorological data, including temperature, relative humidity, and precipitation in regions of Vietnam. In this work, Universal Kriging is used for spatially interpolating ground data and its interpolated results are assimilated with corresponding satellite data to anticipate better gridded data. The input meteorological data was collected from 98 ground weather stations located all over Vietnam; whereas, the satellite data consists of the MODIS Atmospheric Profiles product (MOD07), the ASTER Global Digital Elevation Map (ASTER DEM), and the Tropical Rainfall Measuring Mission (TRMM) in six years. The outputs are gridded fields of temperature, relative humidity, and precipitation. The empirical results were evaluated by using the Root mean square error (RMSE) and the mean percent error (MPE), which illustrate that Universal Kriging interpolation obtains higher accuracy than other forms of Kriging; whereas, the assimilation for precipitation gradually reduces RMSE and significantly MPE. It also reveals that the accuracy of temperature and humidity when employing assimilation that is not significantly improved because of low MODIS retrieval due to cloud contamination.
Do, Khac Phong,Nguyen, Ba Tung,Nguyen, Xuan Thanh,Bui, Quang Hung,Tran, Nguyen Le,Nguyen, Thi Nhat Thanh,Vuong, Van Quynh,Nguyen, Huy Lai,Le, Thanh Ha Korea Information Processing Society 2015 Journal of information processing systems Vol.11 No.4
This paper presents the applications of spatial interpolation and assimilation methods for satellite and ground meteorological data, including temperature, relative humidity, and precipitation in regions of Vietnam. In this work, Universal Kriging is used for spatially interpolating ground data and its interpolated results are assimilated with corresponding satellite data to anticipate better gridded data. The input meteorological data was collected from 98 ground weather stations located all over Vietnam; whereas, the satellite data consists of the MODIS Atmospheric Profiles product (MOD07), the ASTER Global Digital Elevation Map (ASTER DEM), and the Tropical Rainfall Measuring Mission (TRMM) in six years. The outputs are gridded fields of temperature, relative humidity, and precipitation. The empirical results were evaluated by using the Root mean square error (RMSE) and the mean percent error (MPE), which illustrate that Universal Kriging interpolation obtains higher accuracy than other forms of Kriging; whereas, the assimilation for precipitation gradually reduces RMSE and significantly MPE. It also reveals that the accuracy of temperature and humidity when employing assimilation that is not significantly improved because of low MODIS retrieval due to cloud contamination.
Metallic Stent Placement in Hemodialysis Graft Patients after Insufficient Balloon Dilation
Huei-Lung Liang,Huay-Ben Pan,Yih-Huie Lin,Chiung-Yu Chen,Hsiao-Min Chung,Tung-Ho Wu,Kang-Ju Chou,Pin-Hong Lai,Chien-Fang Yang 대한영상의학회 2006 Korean Journal of Radiology Vol.7 No.2
Objective: We wanted to report our experience of metallic stent placement after insufficient balloon dilation in graft hemodialysis patients. Materials and Methods: Twenty-three patients (13 loop grafts in the forearm and 10 straight grafts in the upper arm) underwent metallic stent placement due to insufficient flow after urokinase thrombolysis and balloon dilation. The indications for metallic stent deployment included 1) recoil and/or kinked venous stenosis in 21 patients (venous anastomosis: 17 patients, peripheral outflow vein: four patients); and 2) major vascular rupture in two patients. Metallic stents 8 10mm in diameter and 40 80 mm in length were used. Of them, eight stents were deployed across the elbow crease. Access patency was determined by clinical follow-up and the overall rates were calculated by Kaplan-Meier survival analysis. Results: No procedure-related complications (stent fracture or central migration) were encountered except for a delayed Wallstent shortening/migration at the venous anastomosis, which resulted in early access failure. The overall primary and secondary patency rates ( standard error) of all the vascular accesses in our 23 patients at 3, 6, 12 and 24 months were 69% 9 and 88% 6, 41% 10 and 88% 6, 30% 10 and 77% 10, and 12% 8 and 61% 13, respectively. For the forearm and upper-arm grafts, the primary and secondary patency rates were 51% 16 and 86% 13 vs 45% 15 and 73% 13 at 6 months, and 25% 15 and 71% 17 vs 23% 17 and 73% 13 at 12 months (p = .346 and .224), respectively. Conclusion: Metallic stent placement is a safe and effective means for treating peripheral venous lesions in dialysis graft patients after insufficient balloon dilation. No statistically difference in the patency rates between the forearm and upper-arm patient groups was seen.