급성 췌장염에서 내시경적 역행성 담췌관 조영술의 임상적 의의

강진경,박인서,송건훈,정재복,송시영,한기준 대한소화기내시경학회 1996 Clinical Endoscopy Vol.16 No.3

The safety of endoscopic retrograde cholangiopancreatography(ERCP) in patients with acute pancreatitis(AP) was confirmed in the past decade. Especially in ease of acute gallstone panereatitis, early ERCP/EST(endoscopic sphincterotomy) may reduce the incidence of complications by removing gallstone which causes acute attack of pancreatitis. To assess clinical usefulness of ERCP/EST in the setting of AP, we reviewed clinical records of 58 patients with AP who had undergone ERCP /EST during the same period of admission. 1) There were thirty-four men and twenty-four women with a mean age of 51.4 (range 14-82). According to the Atlanta classification, forty-two patients were determined to have 'mild' pancreatitis, while the remaining sixteen were determined to have `severe' pancreatitis. 2) The most common indication which urged to perform ERCP was common bile duct(CBD) stones suspected by other imaging reodalities(23 cases). The next common was dilatation of CBD detected on ultrasonography in nine cases. 3) Seven patients received ERCP within 24 hours and seventeen underwent ERCP between the period of 24-72 hours after admission. Therefore 24 patients(41.4%) underuvent ERCP within 72 hours after admission. 4) The rate of visualization of either bile duct(BD) or pancreatic duct(PD) was 93.1 %. There was no significant complication attributable to the procedure itself. 5) In 8 patients(21.1%), pancreatogram revealed chronic pancreatitis. This finding was more commonly encountered in patients who were determined to have 'severe' pancreatitis. Eighteen patients(39.1%) had stones of common bile duct and this was the most common cholangiographic finding. But the incidence of CBD stone was not different between `mild' and 'severe' pancretitis groups. 6) Among various predictors of gallstone panreatitis such as elevated total blirubin, alcalin pbosphatase, gamma-glutamyl transpeptidase and suspected stones on sonography the stones found orb sonography was proceed to be the most sgnificant factor in prediction of gallstaMe pancreatitis(p=0.032). 7) EST was successfully performed in 13 patents without significant procedurerelated complication. 8) In patients who were treated for acute gallstone pancreatitis, there was no significant difference in various clinical paramlters including severity, in-hospital stay, incidence of complication and laboratory indings between the surgery group and the EST group. 9) ERCP was useful in 35 patients(60.3%) by providing diagnostic information or therapeutic modalities. The confirmation and endoscopic removal of CBD stones represented the most part of advantages. In conclusion, we have found ERCP/EST to be a safe and useful modality in both diagnostic and therapeutic aspects for patients with AP. Especially in patients with gallstone pancreatitis, ERCPIEST lave evolved into an important role by early identification and safe removal of gallstone.

일부 흡연 대학생의 지각된 스트레스와 흡연실태에 대한 상관관계 연구

강초록,권시내,권혜림,박수경,송인혜,오해인,이미지,한승아,황선아,김수지 이화여자대학교 간호과학대학 2003 이화간호학회지 Vol.- No.37

In spite of the seriousness of smoking harm has been developed these days. the increase of national smoking rate and that the people in the twenties are especially leading the rise of national smoking rate is an important issue of national health. Smoking of the university students can occur health problem and cause loss of manpower and expenses in their social activity period. So then the actual state for prevention of smoking and development of a program to prohibit smoking has to be seized urgently and starting with the study of the realities of university students, the effort to find a related fluent of smoking has to be studied. Related to this, the purpose of this study is to seize the general characteristics of smoking university students and to find out the relationship between perceived stress and smoking status among smoking university students. In addition, by collating the relationship between perceived stress and smoking status among smoking university students we have the purpose to furnish the basal data of stress care, the best way to cope with stress through group training and the plan for nursing implementation to decrease the smoking rate. For this study, a survey was conducted for 204 smoking university students of 13 universities in Seoul from 9th of May to 16th of May, 2003. The collected data was analyzed by t-test, Pearson Correlation and ANOVA in the statistical packages SPSS/PC. Major findings of this study are as follows; 1. Of the 204 respondents 85.4% of them were male and 14.6% of them were female. The average age of the sample was 23.19 years old and 41.8% of them were in senior, 21.4% in junior, 16.9% in sophomore, 19.9% in freshman grade. The major motivation to start smoking was 'because of curiosity'(33.8%) and the first smoking experience was at 'senior high school' (41.9%) and at 'college' (41.9%). 2 The highest scored stress factor of smoking university students were stresses about school work. 3. 72.7% had experience to quit smoking at least one or more times. Most of the reason to keep on smoking was 'short will to quit'(51.0%) and the smoking place was usually at 'school' (41.4%). Most respondents for the number ofsmoking friends were '5 people and above' (73.2%). 4. There was a negative relationship between the general characteristics and the entire perceived stress, however, there was a positive relationship between the general characteristics and the perceived stress in 4 categories which is 'sex distinction', 'major of study', 'residence form' and' inmate'. 5. There was a negative relationship between the general characteristics and the entire smoking status, however, there was a positive relationship between the general characteristics and the smoking status in 2 categories which is 'presence of hobby' and 'number of smoking friends'. 6. There was a negative relationship between the perceived stress and the smoking status. Through this study we have seized the relationship between the general characteristics, perceived stress and the smoking status of smoking university students. There was a positive relationship between some of the general characteristics with the perceived stress and the smoking status of smoking university students. Also there was a negative relationship between the perceived stress and the smoking status.

진로 교육 자료의 중학교 가정과 수업에의 적용 연구

강인애,윤인경 한국 가정과 교육 학회 1993 한국가정과교육학회지 Vol.5 No.-

This study, in order to seek for a more effective teaching method, I am to propose a measure that the carrer education materials for female middle school students, a program produced already, could be applicable on the class and to understand the efficiency by examining practically it to the student. The research method was to make up a questionnaire, and gaze two kinds of educational effect. The procedure was that, after surveying the general features in order to help them know their consciousness on the carrer education, Researcher practiced common theorectical teaching on comparative class and moduling teaching on comparative class through making a guiding data. Then Researcher analysed the changing of consciousness on carrer, knowledge on kinds and numbers of jobs, and the results and rate of interest in the teaching with persentage and t-test. The results are as followed; First, on the consciousness on carrer, both group showed little change on their wishful job between before and after teaching. On the purpose to get a job, consciousness on work and job, and fixed idea of job gender, there were some changes, but groups had few defferences in the changing rate. Second, on the consciousness on work and job, experimental group recognized the variety of hob more than comparative group and wrote more hind of job. Third, on the evaluating result, the record of experimental group was higher. Fourth, on the rate of interesting in learning, the rate of experimental group was higher. As observed, the class applied by the module of female carrer education is effective, since experimental group showed more consciousness on work and job, evaluation of record after teaching, and the rat of interesting in learning, though there was no difference in the consciousness of the carrer.

中等學校 家政科 實驗學習 敎員ㆍ設備基準의 適正性에 關한 硏究

강혜숙,윤인경 한국 가정과 교육 학회 1993 한국가정과교육학회지 Vol.5 No.-

Because of the specificity of subjects belong to middle school curriculum of Home Economics Education of function training is very important. But it pointed out that the existing standards are out-dated, and because of it, it incongruent to our realities. Therefore, whenever the curriculum of education and the national textbook are reorgrnized periodically, the reform of standards of educational materials & facilities must be followed by it. But in my opinion, in korean middle school, especially in Home Economics Education, educational facilities are not reformed at a proper time. Therefore, to enhance the qualities of experimentation/practice of Home Economics Education, in the first place, the preparation for the given conditions of standards of educational materials & facilities are needed. But the educational facilities of Home Economics Education have many problems not only in the qualitative aspect but also in the quantitative aspect. And in addtion to it, lots of educational facilities which cannot match contents of national textbook of Home Economics Education are exist. Therefore, this thesis aims at examining comprehensively the problem of experimentation/practice of experimental materials & facilties of Home Economics Education, connect with contents of Home Economics Education, holding several problems of experimentation/practice of Home Economics Education in middle school, grouping ; the principles and ways concerning the innovation of experimental materials & facilties of Home Economics Education by which many teachers and students make sure of more efficient teaching/studying, and obtaining basic data which guarantee the ability of innovation concerning problems of the education of experimentation/practice of Home Economics Education. Methods are : 1) grasp our educational realities with my original(question). 2) integrate/analyse results of 1) 3) check the frequency, percentage with methods of X?-test, T-test, and 'One-way Analysis of Variances'. 4) suggest my own alternative proposal. Conclusions are : 1) To the problems concerning the plan, method, frequency, choice of contents, budget, and experimental materials & facilties of experimentation/practice, any meaningful difference are not revealed likewise, but, these problems can affect to teachers' guidance of practical examination, therefore it needs to give a indirect financial, and administration aids to teachers/schools from the government. 2) Contents of experimentation/practice are subjected to contents of textbook. In this reason, educational facilities are suitable to contents of textbook for the efficacy of experimentation/practice. Therefore, whenever contents of national textbooks are revised, the proper experimental materials & facilties must be established. And then, according to these standards, educational facilities must be prepared equally. 3) The capacity of educational facilities are conciderably different according to the type, region, and established pattern of school. Therefore, in order to eliminate these differences, it needs to prepare practice classrooms, and to import the new educational facilities. For these preperations, and for the efficient education of practical skill, financial aids from government are necessary. 4) In comparison with contents of textbook the educational facilities which are not enlisted in experimental materials & facilties but very important and very necessary for the classwork of Home Eocnomics Education must be included in new experimental materials & facilities. 5) The problems of existing experimental materials & facilties of Home Economics Education are identified as following ; i) disagreement between names of educational facilities and contents of the textbook of Home Economics Education. ii) the standard of need in relation to the number of class, isn't fit to our educational reality likewise. iii) the difficulty of elastic application. Therefore, to be sure of the development of Home Economics Education, various efficient methods of education must be groped, and endeavour for correction of imperfection must be maintained continuously.

Low serum bilirubin level predicts the develop-ment of chronic kidney disease in patients with type 2 diabetes mellitus

( Kang Hee Ahn ),( Sang Soo Kim ),( Won Jin Kim ),( Jong Ho Kim ),( Yun Jeong Nam ),( Su Bin Park ),( Yun Kyung Jeon ),( Bo Hyun Kim ),( In Joo Kim ),( Yong Ki Kim ) 대한내과학회 2017 The Korean Journal of Internal Medicine Vol.32 No.5

Background/Aims: We evaluated whether serum bilirubin levels can predict the development of chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T₂DM). Methods: This was a retrospective observational longitudinal study of patients presenting at the Pusan National University Hospital. A total of₃₄₉ patients with T₂DM and preserved kidney function (estimated glomerular filtration rate ≥ 60 mL/min/1.73 m²) were enrolled. The main outcome was the development of CKD stage 3 or greater. The patients were divided into four groups according to the quartiles of the total serum bilirubin levels at baseline. Results: The group with the lowest range of total serum bilirubin level (Q₁) showed the highest cumulative incidence of CKD stage 3 or greater than that of the other lower quartiles (Q₁ vs. Q₄; hazard ratio [HR], 6.75; 95% confidence in-terval [CI], 1.54 to 29.47; p = 0.011). In multivariate analysis, the risk of developing CKD stage 3 or greater was higher in the second lowest quartile of the serum bili-rubin level than that in the highest quartile of the serum bilirubin level (Q₂ vs. Q₄; HR, 9.36; 95% CI, 1.33 to 65.73; p = 0.024). In the normoalbuminuria subgroup (n = 236), multivariate analysis showed that the risk of developing CKD stage 3 or greater was higher in the lowest quartile of the serum bilirubin level than that in the highest quartile of the serum bilirubin level (Q1 vs. Q4; HR, 7.36; 95% CI, 1.24 to 35.82; p = 0.019). Conclusions: Serum bilirubin might be an early clinical marker for predicting the progression of CKD in patients with T₂DM and preserved renal function.

P067 A retrospective analysis of low dose acitretin and cyclosporine combination therapy in psoriasis patients

( In-hye Kang ),( Hye-jin Ahn ),( Eun-jae Shin ),( Min Jae Gwak ),( Min Kyung Shin ),( Nack-in Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Psoriasis is a chronic in.ammatory disorder. Approximately 25% of patients present with a moderate-to-severe form of psoriasis and may require lifelong systemic therapy. Up until recently, there have been few reports showing the effectiveness and safety of adding cyclosporine to acitretin for treatment. Objectives: The aim of our study was to gain more knowledge about systemic combination therapies with retinoids and cyclosporine. Methods: Retrospective review of the databases of dermatological departments at Kyung Hee Medical Center was performed. 11 patients treated with oral acitretin and cyclosporine combination therapy, 12 and 14 patients treated with acitretin and cyclosporine monotherapy, respectively were included in the study. The data including age, gender, comorbidity, treatment regimen, period, presence of adverse events, and the PASI score were collected. Results: There were no significant differences in the degree of reduction of PASI scores after 12 weeks among the three groups. The number of patients with adverse events was 19 in the acitretin monotherapy group, 10 in the cyclosporine monotherapy group, and 9 in the combination treatment group. Conclusion: Although low dose combination therapy of acitretin and cyclosporine has similar effects compared to the monotherapy, side effects was lower in combination therapy because of drug sparing effects. We suggest combination therapy employing systemic agents are becoming more widely used for the treatment of psoriasis.

휴경 연차에 따른 휴경지 군락내 식생 특성

강병화,심상인,마경호 한국환경농학회 2003 한국환경농학회지 Vol.22 No.1

휴경지의 식생 특성을 묵밭과 묵논과 같이 토양의 수분 상태가 다른 조건과 휴경 연차에 따라 조사하었다. 같은 묵논이라도 습한 상태로 휴경한 경우와 건조한 상태로 휴경한 경우 식생의 차이가 컸으며, 건조한 상태에서 다년생으로의 천이가 빠르게 일어났다. 천이 단계는 휴경 기간보다 휴경지의 토양 조건에 더욱 큰 영향을 받았다. 묵밭의 경우 휴경 2년차에 우점하였던 돌콩, 칡, 쑥, 새팥, 노랑물봉선 등은 휴경이 6년간 진전된 경우 칡, 억새, 돌콩, 쪽 등의 순으로 우점도가 변하였다. 논을 건답상태로 휴경한 경우 3년차에는 들깨풀, 돼지풀, 강아지풀 등이 주요 우점 초종이었으나 7년차에는 억새, 미국쑥부쟁이, 쇠치기풀 등이 우점하여 다년생으로 천이 되었다. 논을 습답 조건으로 휴경한 경우 수생 잡초가 우점하였다. 7년차에는 갈대, 돌콩, 부들, 고마리가 우점하였으나, 11년차에는 갈대, 줄, 고마리, 부들이 우점하는 초종이었다. 휴경지의 식물종 다양성은 건조한 토양 조건보다 다소 습한 조건의 토양에서 높게 나타났다. The present study was conducted to analyze the vegetational difference in fallowed fields at the different semi stages. Plant species were surveyed on the fields haviit different cropping history, soil moisture conditions, and the duration of set-aside. Effects of soil moisture condition and fallowing duration on the vegetational profiles of fallowed fields in the course of different send stages. In the fields fallowed for more than three years, a conspicuous feature of vegetations was the dominance of perennial species, which was less dominant in the fields fallowed for less than 3 years. The floristic composition of fallowed fields was dependent on the soil moisture condition. However, the influence of fallow history on vegetational composition was less than that of the soil moisture conditions. The dominant species occurred in fallowed upland (dry) fields were changed from Glycine NO, Persicaria thunhetgiana, and Artemisia princeps at 2-year-fallowed to Persicaria thunbergiana, Miscanthhus sinumsis, and Glycine sofa at 6-year-fallowed. In wet followed paddy fields, annual Mo sla pwnctulata, Ambrosia artenuisiifalia, and Setaria vifzdis, the dominant species at 3-year-fallowed, were substituted by perennial A iscanthus simnsis, Aster pilosus, and Hemarthria sibirica at 7-year-followed. When the succession continued for 11 years in wet fields, the vegetation was characterized by the domination of perennials such as Phragn tes com uanis, Tazania Walla, and Typha orientalis. It was suggested that the soil moisture condition was a strong determinant of the dominant species on early send conditions. In the fallowed paddy fields, the species diversity was relatively higher in the fields set-asided as wet condition compared to the fields followed as dry condition.

Concurrent Chemoradiation Therapy in Stage III Non-small Cell Lung Cancer

김인아(In Ah Kim),최일봉(Ihl Bhong Choi),강기문(Ki Mun Kang),장지영(Jie Young Jang),문한림(Han Lim Mun),송정섭(Jung Sub Song),이선희(Sun Hee Lee),곽문섭(Mun Sub Kuak),신경섭(Kyung Sub Shinn) 대한방사선종양학회 1997 Radiation Oncology Journal Vol.15 No.1

목 적 : 국소진행된 III기 비소세포성 폐암에서 방사선감작제로서의 저용량 Cisplatin과 방사선 동시병합요법의 효과를 알아보고자하여, 관해율, 전체생존율, 무병생존율 및 치료에 따른 부작용을 방사선 단독치료군과 후향적으로 비교분석하였다. 대상 및 방법 : 1992년 4월부터 1994년 3월까지 32명의 III기 비소세포성 폐암환자(IIIa 12명, IIIb 20명)가 항암제 및 방사선동시병합요법을 받았다. 방사선치료는 3000cGy/ 10회를 2주간에 걸쳐 시행한 뒤 3주후에 2500cGy/ 10회를 추가하였으며, 방사선감작제로 cis platin 6mg/m2를 매일 방사선치료 전에 정맥주사하였다. 추적관찰기간은 13개월에서 48개월로 중간값은 24개월이었다. 방사선단독치료군 32명(IIIa 13명, IIIb 19명)은 매일 170- 200cGy씩 총 5580- 7000cGy (중간값 5960cGy) 치료받았으며, 추적관찰기간은 36개월에서 105개월로 중간값은 62개월이었다. 결 과 : cis platin- 방사선동시요법군이 방사선 단독치료군에 비해 유의하게 높은완전반응률(18.8% vs . 5.6%)및 낮은 조사야내 재발율(25% vs . 47%)을 나타내었다. 2년 전체생존율은 Cisplatin- 방사선동시요법군이 17%, 방사선단독치료군이 9.4%로 유의한 차이는 보이지 않았다.국소재발 없는 2년 무병생존율(16.5% vs. 5.3%) 및 원격전이 없는 2년 무병생존율(17% vs. 4.6%)도 두군간에 유의한 차이를 보이지 않았다. 그러나 Karnofsky performance scale 80 이상인 환자군만을 대상으로 분석한 결과, cisplatin- 방사선동시요법군이 방사선단독치료군에 비해 유의하게 높은 2년 전체생존율을 보였다(62.5% vs. 15.6%). 전체생존율에 영향을 미치는 예후인자로 cisplatin- 방사선동시요법군에 있어서는 performance status 및 조직학적 진단유형(상피세포암 vs. 비상피세포암)으로 나타났고, 방사선단독치료군에 있어서는 performance status 및 병기(IIIa vs. IIIb)로 나타났다. 치료에 따른 급성부작용으로 RTOG/ECOG grade 2 이상의 오심, 구토는 cisplatin- 방사선동시요법군이 방사선단독치료군 (22% vs. 6%)에 비해 유의하게 높은 빈도를 나타내었다. Gra de 2 이상의 혈액학적 독성은 Cis platin- 방사선동시요법군에서 방사선단독치료군에 비해 높은 빈도를 나타내었다(25% vs. 15.6%). 방사선단독치료군에 비해 cis platin- 방사선동시요법군에서, RTOG/ECOG Grade 2 이상의 폐독성의 빈도(31% vs. 19%)나 WHO Grade 3 이상의 폐섬유화의 빈도(38% vs. 25%)의 유의한 증가는 관찰되지 않았다. 방사선치료부위의 면적이 200cm2 이상이었던 경우, 두군 모두에서 폐독성 빈도의 유의한 증가를 보였다. 결 론 : cisplatin- 방사선동시병합요법이 방사선단독치료군에 비해 높은 국소제어율을 나타내었으나, 전체생존율이나 무병생존율의 유의한 증가는 보이지 않았다. KPS 80이상인 환자군에 있어서는 cisplatin- 방사선동시요법군이 방사선단독군에 비해 높은 전체생존율을 보였다. cisplatin- 방사선동시병합요법군에서 급성부작용이 증가되는 경향을 보였으나, 방사선에 의한 폐독성의 유의한 증가는 관찰되지 않았다. cisplatin- 방사선동시병합요법군이 방사선단독치료군에 비해 1년 이내에 조기사망율이 높은 반면, 2년이상 장기생존율이 높은 경향을 보여, 이러한 환자군에 대한 장기적인 추적조사를 통해 생존율에 대한 본 치료의 영향을 좀더 명확하게 평가할 수 있을것으로 기대되며, 향후 치료효과를 증가시키기위해 large fraction size의 split course RT 대신 continuous course의 conventional RT 혹은 hyperfractionated RT와 Cisplatin의 동시병합요법 등이 고려되어야할 것으로 사료된다. Purpose : This study was tried to evaluate the potential be nefits of concurrent chemoradiation therapy (low dose daily cisplatin combined with split course radiation therapy) compared with conventional radiation thera py alone in stage III non- small cell lung cancer. The end points of analyses were responserate , overalls urvival, survival without locoregional failure , survival without distant metastasis , prognostic factors affecting survival and treatment related toxicities. Materials and Methods : Between April 1992 and March 1994, 32 patients who had stage III non-small cell lung cancer were treated with concurrent chemoradiation therapy. Radiation therapy for 2 weeks (300cGy given 10 times up to 3000cGy) followed by a 3 weeks rest period and then radiation therapy for 2 more weeks (250cGy given 10 times up to 2500cGy) was combined with 6mg/M2 of cisplatin. Follow-up period ranged from 13 months to 48 months with median of 24 months . Historical control group consisted of 32 patients who had stage III non-small cell lung cancer were received conventionally fractionated (daily 170- 200cGy) radiation therapy a lone. Total radiation dose ranged from 5580cGy to 7000cGy with median of 5940cGy. Follow-up period ranged from 36 months to 105 months with median of 62 months . Results : Complete reponse rate was higher in chemoradiation therapy (CRT) group than radiation therapy (RT) group (18.8% vs. 6.3%). CRT group showed lower in-field failure rate compared with RT group(25% vs. 47%). The overall survival rate had no significant differences in between CRT group and RT group(17.5% vs. 9.4% at 2 years). The survival without locoregional failure (16.5% vs. 5.3% at 2 years) and survival without distant metastas is (17% vs. 4.6% at 2 years) also had no significant differences . In subgroup analyses for patients with good performance status (Karnofsky performance scale 80), CRT group showed significantly higher overall survival rate compared with RT group (62.5% vs. 15.6% at 2 years). The prognostic factors affecting survival rate were performance status and pathologic subtype (squamous cell cancer vs. nonsquamous cell cancer) in CRT group. In RT alone group, performance status and stage (IIIa vs IIIb) were identified as a prognostic factors . RTOG/EORTC grade 2-3 nausea and vomiting(22% vs. 6%) and bone marrow toxicities (25% vs. 15.6%) were significantly higher in CRT group compared with RT alone group. The incidence of RTOG/EORTC grade 3-4 pulmona ry toxicity had no significant differences in between CRT group and RT group (16% vs. 6%). The incidence of WHO grade 3-4 pulmonary fibrosis also had no significant differences in both group(38% vs . 25%). In analyses for relationship of field size and pulmonary toxicity, the patients who treated with field size beyond 200cm2 had s ignificantly higher rates of pulmonary toxicities. Conclusion : The CRT group showed significantly higher local control rate than RT group. There were no significant differences of survival rate in between two groups. The subgroup of patients who had good performa nce status showed higher overall survival rate in CRT group than RT group. In spite of higher incidence of acute toxicities with concurrent chemoradiation therapy, the survival gain in subgroup of patients with good pe rformance status were encouraging. CRT group showed higher rate of early death within 1 year, higher 2 year survival rate compared with RT group. The refore, to evaluate the accurate effect on survival of concurrent chemoradiation therapy, systematic follow-up for long term survivors are needed.

신생아 중증 세균성 감염에 대한 Augmentin(clavulanate potentiated amoxycillin)의 치료효과 및 안전성 연구

성인경,강진한,고대균,이경수 대한감염학회 1995 감염 Vol.27 No.1

Combination therapy of β-lactam antibiotics has been used widely to treat severe infections in neonates. The widespread use of β-lactam antibiotics has resulted in emergence of a broad variety of plasmid or chromosome mediated β-lactamases. Also, there is a great propensity for these enzymes to spread among various species of bacteria. Thus, the use of β-lactamase inhibitor antibiotics may be of great interest and has potential therapeutic value in severe neonatal infections. We tried to find out the efficacy and safety of clavulanate potentiated amoxycillin (Augmentin) in treatment of severe neonatal infections. Total thirty-five neonates with sepsis(26) or severe organ infections(9) were involved. Each 30mg/kg dose of Augmentin was injected at 12hr-or 8hr-or 6hr-intervals according to the age and weight of neonates. Clinically 77.1% of the cases were cured, and microbiologically 80.0% were eliminated. 88.9% of eighteen gram positive organisms(S. aureus, S. epidermidis, a -hemolytic strep., S. pneumoniae , E. faecalis) isolated from study group were susceptible to Augmentin. 47.0% of gram-negative organisms (K. pneumoniae, E.coli, P. mirabilis, S. marcescens, C. freundii) were suceptible. Thus, it was confirmed that Augmentin was very effective in ampicillin-or ceftriaxone-resistant gram positive cocci infections, but less effective in isolated K. pneumoniae and S.marcescens cases. The serum levels of amoxycillin in the neonates were maintined about 6㎍/ml until 1hr. at each injection. We observed that alkaline phosphatase level was elevated above 1,000IU/ℓ in three neonates and that skin rash developed after injection in one neonate. But, these side effects were mild and transient. These results suggest that Augmentin may be tolerable and effective in treating severe gram positive cocci infections in neonates.

鷄糞의 飼料利用性에 關한 硏究 : 乾燥鷄糞의 採卵鷄育成에 있어서의 經濟性 Economic returns of Dried poultry waste in brooding of Laying hens

扈敬鎭,印致雄,한기영,許康七 안성산업대학교 1978 論文集 Vol.10 No.-

1. In order to decide a feasibility for partial substitution of dried poultry waste for complete formula feed and to decide an eligible levels for the substitution, growing trials were carried out under four treatments with three veplications in randomized block design, and the treatments were based upon the substitution rates such as 5%, 10%, 15% and check for two groups of chicks for Layer, namely, 7 to 12 weeks aged one and 13 to 20 weeks aged one. 2. While no significant differences were found in the increased body weight, feed consumption and egglaying rate among the treatments, partial substitution of the D. P. W, for complete formula feed seemed to be feasible, like as that of grain or grain bran, since no any interruptions were occurred in the way of the substitution. 3. The reason that the feeding efficiency of substitution of D. P. W. for complete formula feed to those of 13 to 20 weeks aged chicks, was shown far better than that of those of 7 to 12 weeks aged chicks, seemed to be attributable to the less nutrient deficlency derived from those substitutions. Therefore, such results might be reflected to those advantages for 13 to 20 weeks aged chicks over those of the other chicks. 4. While no significant differences were found in egg laying rate and egg weight among the treatments, 15% substitution plot showed a little over that of check plot, and this result might indicate that the egg laying may not be influenced by the substitution of feeding. 5. Refering to economic returns of substitution utilization of D. P. W for complete formula feed, while the advantages were shown top grade at 5% and in order of 10%, 15% of the substitution on 7 to 12 weeks aged chicks, advantages were also shown in order of 5%, 10%, 15% of the substitution on 13 to 20 weeks aged chicks. These results seemed to be feasible even in beyond of 15% of the substitution. 6. Since it was not able to find out the eligible levels of the substitution D. P. W. for complete formula feed for 13 to 20 weeks aged chicks in this study, the following studies shall be desirable in the future. (1) eligible substitution levels of D. P. W. for complete formula feed in those of 13 to 20 weeks aged chicks. (2) economic returns for Laying Hens through substitution D. P. W. for complete foumula feed in growing.