노래를 통한 초기 알츠하이머 치매환자의 자서전적 기억

한승아 한국음악치료교육학회 2016 인간행동과 음악연구 Vol.13 No.2

This study investigated the song-induced autobiographical memory of patients with early Alzheimer’s Dementia (AD) by comparing the effects of patient-selected songs (M-AD) versus music therapist-selected songs (M-MT). A total of 19 patients with early AD participated in this study. In the M-AD and M-MT conditions, each participant listened to a song and was instructed to recall memory. The time to recall memory, the specificity of the memory, mood changes, and the type of recalled memory were measured. Perceived familiarity and preference of the used songs and association of the song with the recalled memory were also analyzed. The results of the study showed that the M-AD condition elicited more specific memory and positive mood change than the M-MT condition. In addition, AD patients reported a higher level of familiarity with and preference of songs in the M-AD condition, compared to the M-MT condition. These results indicate that patient-selected songs, which have a personal meaning to an individual, could be effectively used for intervening with memory of this population, which would support music therapists to make better decision with regard to song selection. Further studies would be needed to deepen the understanding of autobiographical memory in older population with cognitive impairment and to propose more effective music therapy strategies for intervening with memory. 본 연구의 목적은 초기 알츠하이머 치매환자를 대상으로 본인이 선곡한 노래 조건과 치료사가 선곡한 노래 조건에서 자서전적 기억 회상의 내용, 회상하는데 걸린 시간과 기분변화를 측정하여 자서전적 기억회상에 효과적인 노래조건을 알아보는 것이다. 실험 동안 각 피험자는 자신이 선곡한 친숙한 노래(M-AD)와 치료사가 선곡한 노래(M-MT) 조건에서 노래를 듣다가 자신이 직접 경험한 기억이 떠오르면 손을 들게 하였고, 노래가 끝나면 인출된 기억을 이야기하도록 하였다. 피험자가 이야기한 내용은 녹음 전사하였고, 기억의 주체성과 내용, 회상 시간과 기분 변화 등과 관련하여 분석하였다. 본 연구 결과 M-AD 조건이 M-MT 조건에서 제공된 노래에 대한 친숙도와 선호도가 높았으며, 회상한 기억과 노래의 밀접함의 정도가 높았다. 또한 구체적으로 기억을 회상할 수 있었으며, 회상하는 데 걸린 시간도 짧았다. 또한 실험 전후의 기분변화 폭이 컸으며, 회상한 기억과 기분의 관련성에도 영향을 미쳤다. 본 연구는 초기 알츠하이머 환자 본인이 선곡한 노래가 자서전적 기억을 회상하는 단서가 되어 구체적이고, 긍정적인 기억을 촉진하며 회상시간이 단축됨을 보여주어 임상에서 초기 알츠하이머 환자의 자서전적 기억을 회상할 때, 본인이 선곡한 친숙한 노래가 효과적으로 사용될 수 있음을 보여줄 수 있음을 시사한다.

Effects of lamotrigine on attention-deficit hyperactivity disorder in pediatric epilepsy patients

한승아,양유진,송미경,김선준 대한소아청소년과학회 2017 Clinical and Experimental Pediatrics (CEP) Vol.60 No.6

Purpose: The purpose of this study was to investigate the effects of lamotrigine for the treatment of attention-deficit hyperactivity disorder (ADHD) symptoms in children with epilepsy. Methods: Pediatric patients newly diagnosed with epilepsy (n=90 [61 boys and 29 girls]; mean age, 9.1±3.4 years) were enrolled. All patients were evaluated with the Korean ADHD rating scale (K-ARS)-IV before treatment with lamotrigine and after doses had been administered. The mean interval of ADHD testing was approximately 12.3 months. The initial dosage of lamotrigine was 1 mg/kg/day (maximum 25 mg/day for the first 2 weeks), and increased by 1 mg/kg every 2 weeks until titrated up to 7 mg/kg/day (or maximum 200 mg/day). Results: The mean ADHD test score of the 90 subjects was 17.0±1.8 at baseline. It was slightly reduced to 15.6±1.7 after lamotrigine monotherapy (P>0.01). Prior to treatment, a total of 31 patients (34.4%) met the diagnostic criteria for ADHD according to Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision, Of these 31 patients, 27 (87.1%) had significantly improved ADHD scores with lamotrigine monotherapy (28.0±1.6 reduced to 18.1±2.6, P<0.001). Among these 27 patients, 25 (92.6%) showed normalized electroencephalogram (EEG) and 26 (96.3%) achieved total freedom from seizures within 12 months of the initiation of lamotrigine monotherapy. Conclusion: The results from our study show that lamotrigine had a positive effect in pediatric epilepsy patients by reducing ADHD symptoms, preventing seizures, and normalizing EEG. However, further research is required to determine whether lamotrigine is efficacious against ADHD symptoms independent of its effects on epileptic seizures.

Effects of low-dose topiramate on language function in children with migraine

한승아,양유진,공영화,주찬웅,김선준 대한소아청소년과학회 2017 Clinical and Experimental Pediatrics (CEP) Vol.60 No.7

Purpose: This study aimed to verify the safety of low-dose topiramate on language development in pediatric patients with migraine. Methods: Thirty newly diagnosed pediatric patients with migraine who needed topiramate were enrolled and assessed twice with standard language tests, including the Test of Language Problem Solving Abilities (TOPs), Receptive and Expressive Vocabulary Test, Urimal Test of Articulation and Phonology, and computerized speech laboratory analysis. Data were collected before treatment, and topiramate as monotherapy was sustained for at least 3 months. The mean follow-up period was 4.3± 2.7 months. The mean topiramate dosage was 0.9 mg/kg/day. Results: The patient’s mean age was 144.1±42.3 months (male-to-female ratio, 9:21). The values of all the language parameters of the TOPs were not changed significantly after the topiramate treatment as follows: Determine cause, from 15.0±4.4 to 15.4±4.8 (P>0.05); making inference, from 17.6±5.6 to 17.5±6.6 (P>0.05); predicting, from 11.5±4.5 to 12.3±4.0 (P>0.05); and total TOPs score, from 44.1± 13.4 to 45.3±13.6 (P>0.05). The total mean length of utterance in words during the test decreased from 44.1±13.4 to 45.3±13.6 (P<0.05). The Receptive and Expressive Vocabulary Test results decreased from 97.7±22.1 to 96.3±19.9 months, and from 81.8±23.4 to 82.3±25.4 months, respectively (P>0.05). In the articulation and phonology validation in both groups, speech pitch and energy were not significant, and all the vowel test results showed no other significant values. Conclusion: No significant difference was found in the language-speaking ability between the patients; however, the number of vocabularies used decreased. Therefore, topiramate should be used cautiously for children with migraine.

COVID-19로 인한 노인의 신체활동, 사회참여 및 정신건강 변화 분석

한승아,김민준,감현준,박현미,김도희,허웅,이정훈,오태웅 한국체육학회 2023 한국체육학회지 Vol.62 No.4

The purpose of this study is to figure out a change in physical activity, social participation and mental health of the elderly caused by COVID-19 and to look into which influence this change has upon mental health of old people. Targeting 184 senior citizens aged 65 or older who are dwelling in Y city of Gyeonggi Province, who have no problem with cognitive function, and who are free to communicate, the offline questionnaire survey was conducted over a total of three months from August of 2022 to October. To examine a change due to COVID-19, the Paired samples T-test was carried out. To verify the relative influence among physical activity, social participation and mental health of the elderly, the correlation analysis was implemented. According to the research results, first, elderly people’s physical activity, social participation and mental health caused by COVID-19 appeared to have a statistically significant difference(p<.001). Second, the correlation was indicated to be r=0.302, p=.000 between physical activity and mental health and to be r=0.147, p=.046 between social participation and mental health. Thus, there was a low positive(+) correlation.

비타민 D 보충이 운동선수의 신체적 퍼포먼스에 미치는 영향 : 무작위 대조 연구에 대한 체계적 문헌고찰 및 메타분석

한승아,오태웅 한국체육과학회 2022 한국체육과학회지 Vol.31 No.1

Purpose: The recent observational study was clarified what the vitamin D supplementation is related to the physical performance of an athlete. However, RCTs, which have been reported so far, have not been concluded yet because every researcher shows a difference as for the impact of vitamin D supplementation on the physical performance. Also, there are many existing systematic considerations or meta analyses that were conducted targeting mainly the general public. Thus, there is a limit to evaluating the role of vitamin D as the improvement in physical performance of an athlete. Accordingly, this study is aimed to examine the influence of the Vitamin D supplement therapy in an athlete upon physical performance through meta analysis. Method: A literature search was carried out the comprehensive retrieval by using MEDLINE, EMBASE, Cochrane Library. The integrated effect size of the collected research was analyzed by using statistical program R version 4.0.4 (Feb. 15, 2021). The effect size was distinguished in accordance with the guideline in Cohen’s d. Results: Totally 7 RCTs were included in meta analysis. The effect size of physical performance in an athlete after vitamin D supplementation stood at 0.39, thereby having reflected the meaningful effect size. The significant effect size was shown in counter movement jump(0.89) and Peak Power(1.24) out of the muscle power in physical performance. Conclusion: This meta analysis can be considered that the vitamin D supplementation has the impact on the counter movement jump and the Peak Power in an athlete’s physical performance. Nevertheless, the outcome needs to be interpreted carefully due to few number of usable RCTs and to the restrictions such as the research-based heterogeneity and the potential publication bias.

Preparatory there 에 관한 고찰

한승 한국박문학회 1994 박문논집 Vol.1 No.1

‘씻다’류 동사의 통시적 고찰과 그 본질적 속성 연구

한승 중국어문학연구회 2023 중국어문학논집 Vol.- No.142

This paper analyzed the essential properties of the verbs of “wash” from a diachronic point of view. The verbs of “wash” was “洗(xi)”、“沐(mu)”、“浴(yu)”、“盥(guan)”、“澡(zao)”, “濯(zhuo)”. “滌(di)”. “洗(xi)” had turned into the dominant word from WeiJin Southern and Northern Dynasties till modern times. The author found out the main reason why “洗(xi)” replaced “浴(yu)”, because it had the most semantic features from WeiJin Southern and Northern Dynasties. This paper also described the formation of various disyllable compound words from monosyllabic verbs and their formation rules. Specifically, it is mentioned as follows. The author researched that how monosyllabic verb is developed to a compounded words composed of synonyms and also researched on the reason why “洗澡(xizao)”, “洗浴(xiyu)” had developed to Separable Word. In addition, this paper also with researched on the relationship of verbs of “wash” and “乾淨(ganjing)”,“淨(jing)” and found the reason why the verbs of “wash” often collocate with it. Finally, from the typology of view, it showed the reason why the verbs of “洗(xi)” to be an ergative verb. The author found out “洗(xi)” can be an ergative verb, because “洗(xi)” can induce a change in the state of the object, and can indicate the result of a change in the state of the object by action of wash.

退溪의 主賓觀과 民主主義

한승일 영남퇴계학연구원 2019 퇴계학논집 Vol.- No.25

A democratic society is a collection of citizens with diverse opinions. That is why the value of democracy shines when one's opinions are not considered unfair, that is, when they are right. The two impeachment trials in the history of the constitutional government of the Republic of Korea are a good example of how democracy is progressing. Democratia(δημοκρατία), the etymology of modern democracy, means that the people have sovereignty. In the Joseon Dynasty, however, the king is called a host of people. If the host can not the role of host, he or she is impeached. A host of people and Democratia seem to be different concepts, but they are certainly similar in their appearance. Mencius understood his host and guest as a matter of the proprieties. The aspect of host-guest is neither the host nor the guest. However, if the host fails to be the host, and when the guest tries to be the host, he or she quickly fails to be in a relationship with the host-slave, and eventually, there is a Gapjil(갑질) controversy over the issue. It is clear that in a democracy everyone is the host, so who are the guests? I would like to find a solution to this problem through the "Diagram of the heart-mind connecting nature and emotion" of Toegye. Toegye places the painting as the host and the king Seonjo as the guest, in the book "Diagram of the heart-mind connecting nature and emotion" that was given to King Seonjo. These problems cause that king always looks south, which faces the people, to be viewed north. Toegye means that even the king must learn from his guests’ seats. In particular, the Xingqinglun(性情論) of the "Second Diagram of the heart-mind connecting nature and emotion" is a form of the goodness of human nature, and it is said that king have to learn it. This learning position, the king who understood the position of guests, looks toward the people. Learning hosts do not judge their guests in their own way. In other words, they have the perception of the true host to understand the other person as he is. These hosts’ epistemology keeps an the proprieties of a all guest listening to all sounds. 민주주의 사회는 다양한 의견을 가진 시민들의 집합체이다. 그렇기 때문에 각자가 지닌 의견이 부당하다고 여겨지지 않을 때, 즉 그 의견이 올바를 때 민주주의의 가치는 빛이 난다. 대한민국 헌정 역사에서 겪었던 두 차례의 탄핵 심판은 민주주의가 얼마나 제대로 가고 있는지 살펴볼 수 있는 사례이다. 현대의 민주주의를 일컫는 어원인 데모크라티아는 국민에게 주권이 있다는 말이다. 그러나 조선시대에는 임금을 인주(人主)라고 부른다. 주인이 주인 노릇 못하면 탄핵을 당하고, 탄핵을 하는 주인은 국민이다. 인주와 데모크라티아는 다른 개념 같지만, 분명히 보여주고 있는 양상이 유사하다. 맹자는 주인[主]과 손님[賓]에 대해 예(禮)의 일로 보았다. 주빈의 양상은 언제나 주인이지도 않을 뿐더러, 언제나 손님이지도 않다. 그렇다고 주인이 주인 노릇 못하고, 손님이 주인 노릇하려하면 금세 인격적 주종 관계로 틀어지고 결국엔 갑질 논란이 일어나고 만다. 주인다운 주인, 손님다운 손님의 모습은 어떤 모습일까? 민주주의에서 모두가 주인인 것은 분명한데, 그렇다면 손님은 누구일까? 필자는 퇴계(李滉, 退溪, 1501~1570)의 「심통성정도」에 나타난 주빈관(主賓觀)을 통해 이 문제의 해결점을 찾아보고자 한다. 퇴계는 선조 임금에게 올린 「심통성정도」에서 그림을 주인의 자리에, 선조 임금을 독자, 즉 손님의 자리에 위치시킨다. 이러한 문제는 항상 백성을 향하는 남면(南面)의 자리에 위치하는 임금을 북향(北向)시키고 있다. 아무리 임금일지라도 손님의 자리에서 배우지 않으면 안된다는 퇴계의 뜻이 표현된다. 특히 「심통성정도-중도」의 성정론은 인간 본성의 선함을 간직한 형태로서, 아무리 임금일지라도 이것을 배우고, 확인할 것을 말하고 있다. 이같이 배우는 자리, 즉 손님의 자리를 이해한 임금은 백성들을 향해 남면한다. 배우는 주인의 특징은 손님을 자기만의 방식으로 재단하지 않는다. 즉 상대방을 있는 그대로 이해하려는 참된 주인의 인식론을 지닌다. 이러한 참된 주인의 인식론은 모든 소리에 경청하는 손님의 예(禮)를 지키게 된다.

스테레요 비전을 이용한 포인팅 디바이스에 관한 연구

한승일 ( Seung Il Han ),황용현 ( Yong Hyun Hwang ),이병국 ( Byung Gook Lee ),이준재 ( Joon Jae Lee ) 한국산업응용수학회(구 한국산업정보응용수학회) 2006 한국산업정보응용수학회 Vol.10 No.20

Selection of Resistant Varieties to Aspergillus flavus by Determination of Aflatoxin B1 Content in Korean Peanut (Arachis hypogaea L.) Accessions

한승아(Seungah Han),김병철(Byeong-Cheol Kim),하정민(Jungmin Ha),전태환(Tae-Hwan Jun) 한국작물학회 2023 한국작물학회지 Vol.68 No.3

Peanuts, also known as groundnuts (Arachis hypogaea L.), are globally recognized as a vital oilseed crop. Peanuts are rich in proteins (e.g., arginine), oils (e.g., oleic acid and linoleic acid), fiber, vitamins (e.g., niacin and tocopherol), and carbohydrates and are consumed worldwide. However, the presence of aflatoxin (AF) has garnered substantial attention since its initial discovery as the causative agent of Tukey’s X disease in the United Kingdom in 1960. Among the 18 aflatoxins identified, aflatoxin B1 (AFB1) has the highest toxic activity and causes hepatocellular carcinoma. It is classified as Group I by the International Agency for Research on Cancer (IARC) of the World Health Organization (WHO). The present study was conducted to evaluate aflatoxin B1 resistance of 102 peanut accessions and select putative aflatoxin B1-resistant peanut accessions to aflatoxin B1. One hundred and one Korean germplasms harvested in 2020 were inoculated with A. flavus to identify aflatoxin-resistant cultivars, and the aflatoxin B1 concentration was measured using an ultra-performance liquid chromatography-photodiode array detector. Twenty-six accessions with aflatoxin B1 concentrations lower than those of the check plant 55-437 were chosen for the development of aflatoxin-resistant varieties in Korea. As Korean aflatoxin-resistant varieties have not yet been developed, the findings of the present study are expected to provide useful information for the development of aflatoxin-resistant cultivars.