Ionic & Electronic Conductive Polythiophene-based Polymer for Lithium-ion Battery Binder Applications

송인혜,이종찬,김진석,김나경,정다운 한국공업화학회 2021 한국공업화학회 연구논문 초록집 Vol.2021 No.0

The Association of Estrogen Receptor Activity, Interferon Signaling, and MHC Class I Expression in Breast Cancer

송인혜,김영애,허선희,방원선,박혜선,최연호,이희재,서정한,조영진,정성욱,김희정,안세현,이희진,공경엽 대한암학회 2022 Cancer Research and Treatment Vol.54 No.4

Purpose The expression of major histocompatibility complex class I (MHC I) has previously been reported to be negatively associated with estrogen receptor (ER) expression. Furthermore, MHC I expression, level of tumor-infiltrating lymphocytes (TILs), and expression of interferon (IFN) mediator MxA are positively associated with one another in human breast cancers. This study aimed to investigate the mechanisms of association of MHC I with ER and IFN signaling. Materials and Methods The human leukocyte antigen (HLA)-ABC protein expression was analyzed in breast cancer cell lines. The expressions of HLA-A and MxA mRNAs were analyzed in MCF-7 cells in Gene Expression Omnibus (GEO) data. ER and HLA-ABC expressions, Ki-67 labeling index and TIL levels in tumor tissue were also analyzed in ER+/human epidermal growth factor receptor 2– breast cancer patients who randomly received either neoadjuvant chemotherapy or estrogen modulator treatment followed by resection. Results HLA-ABC protein expression was decreased after β-estradiol treatment or hESR-GFP transfection and increased after fulvestrant or IFN-γ treatment in cell lines. In GEO data, HLA-A and MxA expression was increased after ESR1 shRNA transfection. In patients, ER Allred score was significantly lower and the HLA-ABC expression, TIL levels, and Ki-67 were significantly higher in the estrogen modulator treated group than the chemotherapy treated group. Conclusion MHC I expression and TIL levels might be affected by ER pathway modulation and IFN treatment. Further studies elucidating the mechanism of MHC I regulation could suggest a way to boost TIL influx in cancer in a clinical setting. PurposeThe expression of major histocompatibility complex class I (MHC I) has previously been reported to be negatively associated with estrogen receptor (ER) expression. Furthermore, MHC I expression, level of tumor-infiltrating lymphocytes (TILs), and expression of interferon (IFN) mediator MxA are positively associated with one another in human breast cancers. This study aimed to investigate the mechanisms of association of MHC I with ER and IFN signaling.Materials and MethodsThe human leukocyte antigen (HLA)-ABC protein expression was analyzed in breast cancer cell lines. The expressions of <i>HLA</i>-<i>A</i> and <i>MxA</i> mRNAs were analyzed in MCF-7 cells in Gene Expression Omnibus (GEO) data. ER and HLA-ABC expressions, Ki-67 labeling index and TIL levels in tumor tissue were also analyzed in ER+/ human epidermal growth factor receptor 2 (HER2)- breast cancer patients who randomly received either neoadjuvant chemotherapy or estrogen modulator treatment followed by resection.ResultsHLA-ABC protein expression was decreased after β-estradiol treatment or hESR-GFP transfection and increased after fulvestrant or IFN-γ treatment in cell lines. In GEO data, <i>HLA</i>-<i>A</i> and <i>MxA</i> expression was increased after ESR1 shRNA transfection. In patients, ER Allred score was significantly lower and the HLA-ABC expression, TIL levels, and Ki-67 were significantly higher in the estrogen modulator treated group than the chemotherapy treated group.ConclusionMHC I expression and TIL levels might be affected by ER pathway modulation and IFN treatment. Further studies elucidating the mechanism of MHC I regulation could suggest a way to boost TIL influx in cancer in a clinical setting.

읽기 목적에 대한 지시와 지연시간이 과제 기억과 추론에 미치는 영향

송인혜,최경숙 성균관대학교 생활과학연구소 2005 生活科學 Vol.8 No.-

Predictive Value of Tertiary Lymphoid Structures Assessed by High Endothelial Venule Counts in the Neoadjuvant Setting of Triple-Negative Breast Cancer

송인혜,허선희,방원선,박혜선,박인아,김영애,박석영,노진,공경엽,이희진 대한암학회 2017 Cancer Research and Treatment Vol.49 No.2

Purpose The tertiary lymphoid structure (TLS) is an important source of tumor-infiltrating lymphocytes (TILs), which have a strong prognostic and predictive value in triple-negative breast cancer (TNBC). A previous study reported that the levels of CXCL13 mRNA expression were associated with TLSs, but measuring the gene expression is challenging in routine practice. Therefore, this study evaluated the MECA79-positive high endothelial venule (HEV) densities and their association with the histopathologically assessed TLSs in biopsy samples. In addition, the relationship of TLSs with the CXCL13 transcript levels and clinical outcomes were examined. Materials and Methods A total of 108 TNBC patients treated with neoadjuvant chemotherapy (NAC) were studied. The amounts of TILs and TLSs were measured histopathologically using hematoxylin and eosin–stained slides. The HEV densities and TIL subpopulations were measured by immunohistochemistry for MECA79, CD3, CD8, and CD20. CXCL13mRNA expression levels using a NanoString assay (NanoString Technologies). Results The mean number of HEVs in pre-NAC biopsies was 12 (range, 0 to 72). The amounts of TILs and TLSs, HEV density, and CXCL13 expression showed robust correlations with each other. A lower pre-NAC clinical T stage, higher TIL and TLS levels, a higher HEV density, CD20- positive cell density, and CXCL13 expression were significant predictors of a pathologic complete response (pCR). Higher CD8-positive cell density and levels of CXCL13 expression were significantly associated with a better disease-free survival rate. Conclusion MECA79-positive HEV density in pre-NAC biopsies is an objective and quantitative surrogate marker of TLS and might be a valuable tool for predicting pCR of TNBC in routine pathology practice.

얼굴표정을 통한 정서읽기 능력의 성인기 발달

송인혜,김혜리,조경자,이수미 한국심리학회 산하 한국발달심리학회 2008 한국심리학회지 발달 Vol.21 No.3

In this study, it was tested whether the ability to recognize the emotional states through facial expression changes by age (university students, middle-aged, older adults), dimensions of emotion(pleasantness/unpleasantness dimensions), and face parts (whole face, eyes, mouth) during adulthood. A total 32 pictures of emotional facial expressions and emotion vocabularies were used as stimuli. In each trial, subjects were shown 4 pictures of emotional facial expressions and one emotion vocabulary. Subjects were told to choose one suitable facial expression which was matched to the emotion vocabulary. Older adults performed worse that the middle age. However, older adults' performances were not declined equal amount in all conditions: Older adults' performances were declined greater amount in reading the pleasant and unpleasant emotions from the eyes or mouth regions, but declined far less amount in reading the pleasant emotions from the whole face. The present results cannot be explained by the deterioration of cognitive abilities, but could be explained by the theory of affective optimization. 본 연구는 얼굴표정에서 정서를 읽는 능력이 성인기 이후에 어떠한 발달적 변화를 보이는지 알아보고자 수행되었다. 이를 위해 정서차원(쾌-불쾌)과 제시된 얼굴자극의 영역(얼굴, 눈, 입)을 달리하였을 때 정서읽기 정확률에 어떠한 변화가 나타나는지 살펴보았다. 114명의 참가자들(대학생 40명, 중년 39명, 노인 35명)에게 얼굴표정과 정서어휘 간의 연결이 비교적 분명하게 나타나는 32개의 정서어휘를 각각 제시하고 그 정서어휘에 맞는 표정자극을 네 개의 표정자극 중에서 선택하도록 하였다. 연구 결과 대학생과 중년의 정서읽기 능력의 차이는 유의미하지 않았으나 노인의 정서읽기 능력은 중년에 비해 떨어졌다. 그러나 노인의 정서읽기 능력이 중년에 비해 여러 조건에서 일관되게 저하되지는 않았다. 눈이나 입에서 쾌 정서와 불쾌 정서를 읽는 능력은 크게 저하되었으나 얼굴전체에서 쾌 정서를 읽는 능력은 저하되는 정도가 작았다. 이러한 결과는 성인기 이후에 나타나는 정서읽기 능력의 변화가 전반적인 인지 능력의 저하로 설명될 수 없으며, 정서최적화 이론으로 설명될 수 있음을 보여준다. 즉 정서최적화를 위해 부정적 정서에 덜 주의하게 되어서 부정적 정서를 읽는 능력이 상대적으로 크게 저하되었을 가능성을 시사한다.

Accuracy of Core Needle Biopsy Versus Fine Needle Aspiration Cytology for Diagnosing Salivary Gland Tumors

송인혜,조경자,송준선,성창옥,노종렬,최승호,남순열,김상윤,이정현,백정환 대한병리학회 2015 Journal of Pathology and Translational Medicine Vol.49 No.2

Background: Core needle biopsy is a relatively new technique used to diagnose salivary gland lesions, and its role in comparison with fine needle aspiration cytology needs to be refined. Methods: We compared the results of 228 ultrasound-guided core needle biopsy and 371 fine needle aspiration procedures performed on major salivary gland tumors with their postoperative histological diagnoses. Results: Core needle biopsy resulted in significantly higher sensitivity and more accurate tumor subtyping, especially for malignant tumors, than fine needle aspiration. No patient developed major complications after core needle biopsy. Conclusions: We recommend ultrasoundguided core needle biopsy as the primary diagnostic tool for the preoperative evaluation of patients with salivary gland lesions, especially when malignancy is suspected.

시각적 지원을 통한 이야기 읽기 교수가 자폐 스펙트럼 장애 아동의 기본 감정 이해 및 표현에 미치는 효과

송인혜,김은경 한국정서ㆍ행동장애아교육학회 2011 정서ㆍ행동장애연구 Vol.27 No.3

이 연구에서는 시각적 지원을 통한 이야기 읽기 교수가 자폐 스펙트럼 장애 아동의 자기 및 타인의 다섯 가지 기본 감정 이해에 미치는 효과와 감정 표현의 반응 일반화에 미치는 효과를 알아보았다. 일반 초등학교에 통합된 자폐 스펙트럼 장애 아동 2명을 대상으로 대상자간 중다 간헐 기초선 설계를 적용하여 기초선, 중재, 유지 순으로 실험을 실시하였다. 중재는 주 2회 국어 시간에 실시하였다. 그리고 중재의 반응 일반화를 알아보기 위하여 기초선부터 유지까지 총 4회 아동의 놀이 활동 중 언어·비언어 기본 감정 표현을 관찰하였다. 연구 결과, 첫째, 대상 장애 아동 모두 자기 및 타인의 기본 감정 이해가 향상되었다. 둘째, 대상 아동 모두 중재 효과가 기본 감정 표현으로 일반화 되었다. 이러한 연구 결과를 통해, 시각적 지원을 통한 이야기 읽기 교수는 자폐 스펙트럼 장애 아동의 기본 감정 이해를 향상 및 유지 시키는데 효과적이며, 기본 감정 표현에도 긍정적인 영향을 주는 것을 알 수 있었다. 이 연구는 자폐 스펙트럼 장애 아동의 특성을 고려하였으며 교과 학습과 감정 이해 중재를 함께 실시할 수 있도록 구성하였다는 점에 의의가 있다. The purpose of this study was to investigate the effects of story reading instruction using visual support on basic emotions of children with autistic spectrum disorder. The subjects were two children with autistic spectrum disorder in elementary schools. To demonstrate the functional relationship between the independent and dependent variables, a multiple prove baseline design across subjects was used. In addition, to understanding the response generalization of intervention, basic emotional expressions were observed. The results of the study were as follows: First, the story reading instruction using visual support were effective to increase the basic emotional understanding of themselves and others, and the effects was maintained after withdrawal of the intervention. Second, the response generalization was showed on the basic emotional expression. This study was significant in that the characteristics of children with autistic spectrum disorder were considered to conduct both textbook instruction and emotional understanding intervention simultaneously.

정서차원과 얼굴제시영역이 얼굴표정 인식에 미치는 영향: 성차를 중심으로

송인혜,김혜리,조경자 한국여성심리학회 2008 한국심리학회지 여성 Vol.13 No.2

In this study, we observed the abilities to recognize facial expressions between the genders, the different types of emotions (basic and complex emotions) and facial expression presenting areas (whole face and eyes). We also investigated whether there are differences in ability to recognize facial expressions according to dimensions of emotion(pleasantness/unpleasantness and awakening/relaxation dimension). A total of 32 types of emotional state facial expressions which are linked relatively strong with the emotional vocabularies were presented. In each trial, an emotional vocabulary and four facial expressions were shown to the subjects who were told to choose one suitable facial expression which was matched with the emotional vocabulary. The results showed that the subjects judged better on the condition of basic emotions more than complex emotions, the whole face more than eyes, the pleasantness dimension more than the unpleasantness dimension and the relaxation dimension more than the awakening dimension. Also, it was found that women were better at judging facial expressions than men. This study suggests that gender, types of emotion, facial presenting areas and dimension of emotion have effects on recognition of facial expressions.

마음이해 능력의 학습효과

송인혜 ( In Hye Song ),박은혜 ( Eun Hye Park ),차재연 ( Jae Yeon Cha ),이수미 ( Su Mi Yi ),조경자 ( Kyung Ja Cho ),김혜리 ( Hei Rhee Ghim ) 한국아동교육학회 2007 아동교육 Vol.16 No.3

Evaluation of TiO₂/SiO₂ Complex Oxide Particles for UV Blocking Effect by Ultrasonic Spray Pyrolysis

권오산,송인혜,장석근,이진화,이동규 한국공업화학회 2009 한국공업화학회 연구논문 초록집 Vol.2009 No.1