벼 담수산파 재배시 파종량·질소분시·물관리 방법의 차이가 생육 및 수량성에 미치는 영향

권영립,권석주,조승현,최동철 원광대학교 2005 論文集 Vol.35 No.-

This study was carried out to investigate in connection with seeding rate according to the fertilizer application method and water management in direct seeding on flooded paddy surface. The total nitrogen and chlorophyll contents was decreased as increasing amount of seeding. The total nitrogen and chlorophyll contents were high in the strong drainage methods than the custom water management. LAI and dry mater recording where the seeding amount will increase to the fertilizer application method it increases consequently were low tendency from the site which omits the omitted the top dressing at tillering stage. The number of panicles per square metre was increased according to amount of seeding, but the number of spikelets per panicle was decreased. When omitted the top dressing at tillering stage and increasing the amount of seeding, the rice yield was high and amount of seeding was 89 kg per hectare. The results indicate that increasing of seeding rate and omission of fertilizer application with strong drainage at tillering stage was to reduce field lodging degree, to economy of water culture and to save labor for fertilization.

벼 상온 저장 시기별 쌀 품질 변화

권석주,송영은,권영립,이덕렬,조승현,최동철 원광대학교 2005 論文集 Vol.35 No.-

Increasing concern about a rice quality, it is considered postharvest technology as well as cultivation management as an important factor. Therefore it is necessary to find optimal drying, storage method that did not affected a rice quality. In order to find the optimum storage period of rice, the rice quality was investigated during storage period. The temperature and humidity of storage bin were greatly changed but those of rice were a little do. The germination rate was slowly decreased as the storage period is long. The content of moisture was affected by a room temperature, it was increased at stored rice in rainy season(10-Jul~20-Jul). As storage period is long, the content of amylose, fatty acidity were a just Little changed but did not showed a constant tendency to it. The content of protein was increased and mechanic palatability value was decreased during storage period. The chromaticity of milled rice showed a range of lightness(L); 75.15~71.75, redness(a); 0.21~0.91, yellowness(b); 16.78~19.28 during storage period.

조선시대 남자복식에 표현된 선(線)의 미(美)

都周衍,權瑛淑 服飾文化學會 2000 服飾文化硏究 Vol.8 No.4

The purpose of this study is to investigate the internal and extemal line beauty of men's dress of the Chosun period from the views of dress design and dress aesthetics. 1) External Line Beauty of Men's Dress of the Chosun Period ① Functional Beauty: Having the beauty of functional line in terms of convenience, notion, effectiveness, practice and sanitation. ② Structural Beauty: H77ing the beauty harmonizing between lines of internal and external structures. ③ Ornamental Beauty: Having the beauty of simple line by mashing accessories (gat, fan, sejodae, shoes) with a simple dress. ④ Wearing Beauty: Making tall-looking or expressing a mature masculine beauty by a visual mistake caused by a combination of internal and external structural beauty lines. 2) Internal Line Beauty of Men's Dress of the Chosun Period Including a simple but natural beauty based on natural philosophy, the beauty of courtesy emphasizing official hat and dress and the beauty of dress having aesthetic consciousness with which people enjoy an idyllic life.

조선복식에 표현된 선(線)의 미(美)에 대한 고찰

都周衍,權瑛淑 服飾文化學會 2000 服飾文化硏究 Vol.8 No.2

The study is on the beauty of the line in the Cho-sun Costume. In the aspect of the Costume Aesthetics and Study of Clothing Design, I try to find the beauty of the line in the external form and the immanent beauty of the external line in the Cho-sun Costume. The results of the study is that: 1) The beauty of the line external form have ① the functional beauty of the line ② the beauty of draped line ③ combination of the line of internal and external structure. ④ the beauty of wearing with the Chi-ma. ⑤ the beauty of sharp line in the ornamenats 2) The immanent beauty of the line in the Cho-sun Costume: There are a natural beauty found by the reason of nature, temperate beauty, simple beauty in the Cho-sun Costeme.

만성 간질환에서 혈중 Gelatinase (Matrix Metalloproteinase-2와 9)의 측정 의의

권오상,임도윤,권광안,정문기,박동균,김선숙,김연석,권소영,구양서,김유경,최덕주,김주현,황유진,변관수,이창홍 대한간학회 2003 Clinical and Molecular Hepatology(대한간학회지) Vol.9 No.3

목적: Gelatinase (MMP-2와 9)는 기저막의 주구성요인 type IV collagen을 분해하는 효소로, MMP-2는 간경변과 MMP-0은 간세포암의 진행과 연관이 있는 것으로 알려져 있다. 본 연구에서는 만성 간질환과 MMP-2와 9의 관계를 알아보고자 하였다. 대상과 방법: 간기능이 정상이고 간질환이 없는 건강 대조군 10예, 만성 간염 15예, 간경변 18예, 그리고 간세포암 25예를 대상으로 혈장을 채취하여 MMP-2와 9의 활성을 보기 위해 zymography를 시행하였다. 결과: 혈장 MMP-2의 활성은 간경변군에서 건강 대조군(p=0.009)과 만성 간염군(p=0.011)에 비해 증가되어 있었으나 간세포암군과는 차이가 없었다. 혈장 MMP-9의 활성은 간경변군에서 건강 대조군에 비해 증가되어 있었으나(p=0.035), 만성 간염군과 간세포암군과는 차이가 없었다. 간세포함이 없는 간경변군 15예와 간세포암을 동반한 간경변군 23예를 합친 총 간경변군 38예에서 MMP-2의 활성은 total bilirubin이 높을수록 (r=0.323, p=0.048) 그리고 Child-Pugh 점수가 높을수록(r=0.414, p=0.012) 증가되어 있었다. 총 간경변군에서 MMP-2와 MMP-9의 활성은 알코올 성 간경변군에서 HBV에 의한 간경변군 보다 현저히 증가되어 있었다(각각 p=0.009, p=0.002). 결론: 혈장 MMP-2의 활성은 간경변의 진단과 중증도에 유용한 표지자로 사용될 수 있을 것이다. 혈장 MMP-9의 활성은 간세포암에서의 유용성은 적으리라 생각되나 알코올성 간경변의 진단적 표지자로는 유용하리라 생각된다. MMP-2와 MMP-9의 활성은 간경변의 원인 별로 차이가 나는 것으로 생각되며 그 이유에 대한 연구가 필요하리라 생각된다. Background/Aims: Gelatinase (matrix metalloproteinase (MMP) -2 and 9) has an important role in the pathogenesis of liver cirrhosis (LC) and hepatocellular carcinoma (HCC). In this study, we evaluated the relationship of gelatinase to chronic liver disease. Methods: Four groups of subjects were examined; healthy control (10 cases), chronic hepatitis (18 cases), LC (15 cases), and HCC (28 cases). The plasma of each subject was obtained, and the equal quantification of plasma protein was done. The plasma activities of MMP-2 and 9 were measured by zymography. Results: The activities of plasma MMP-2 in patients with LC were significantly higher than those in controls (p=0.009) and in patients with chronic hepatitis (p=0.011), but not different from those in patients with HCC. The activities of plasma MMP-9 in patients with LC were significantly higher than those in controls, but not different from those in patients with chronic hepatitis or HCC. In patients with LC (regardless of having HCC), the activities of MMP-2 correlated with total bilirubin (r=0.323, p=0.048) and Child-Pugh score (r=0.414, p=0.012). The activities of MMP-2 and 0 were higher in patients with LC (regardless of having HCC) caused by alcohol than caused by HBV (p=0.009 and 0.0002 for each one). Conclusions: The plasma activity of MMP-2 may be a useful marker for the diagnosis and determination of the severity of LC. The plasma activity of MMP-9 was not useful for HCC, but may be a marker for alcoholic LC. Further study is needed to determine why the plasma activity of gelatinase was higher in patients with LC caused by alcohol than by HBV.(Korean J Hepatol 2003;9:222-230)

Comparison with cultivation area to the rice yield and quality to according to the ecological type and transplanting times

Kwon Suk-Ju,Kwon Young-Rip,Lee Deok-Ryeol,Choi Dong-Chil 한국작물학회 2005 한국작물학회 학술발표대회 논문집 Vol.2005 No.-

생명현상 관찰에서 나타나는 인과적 의문 생성의 ERF 특성: MEG 연구

권석원 ( Suk Won Kwon ),권용주 ( Yong Ju Kwon ) 경북대학교 과학교육연구소 2009 科學敎育硏究誌 Vol.33 No.2

이 연구의 목적은 생명현상 관찰에서 나타나는 인과적 의문 생성 ERF components를 개발하는 것이다. 이를 위해 우선 인지심리적 방법으로 생명현상 기반의 인과적 의문생성 유발 사진 과제를 개발하였다. 이를 활용해 전기생리적 방법인 MEG(Magnetoencephalography) 두뇌 영상 기기를 이용하여 시계열적 두뇌 처리과정에 기초한 인과적 의문의 ERF(Event Related Fields) 패턴을 확인할 수 있었다. 생명현상 기반의 인과적 의문생성 유발 사진은 과학교육 전문가와 과학교육연구진으로 구성된 인원의 R&D 방식으로 개발되었다. 과제는 생물군 유형에 따라 동물(A, animal), 미생물(M, microbe), 식물(P,plant)과제로 분류 형태를 나누고, 생물 개체 수준의 유형에 따라 개체간 상호작용(i, interaction), 단일개체(a, all), 개체 일부(p, part)로 구분하여 총 100장에 대한 인과적 의문 유발 사진을 완성하였다. 이후 서울대학병원 MEG 센터팀과의 세미나 과정을 통해MEG 과제용 패러다임을 개발하고, 과학교육 전공 여자 대학원생 5명(M=26.4, SD=2.30)을 대상으로 인과적 의문생성간 MEG data를 수집하였다. 이를 통해 인과적 의문 유형별 고유 특성을 확인하기 위해MEG ERF components 분석을 실시하였다. 인과적 의문 생성시 나타나는 ERF components분석 결과 M1(100~130ms), M2(220~280ms), M3(320~390ms), M4(460~520ms) 총 4개 components 패턴이 발견되었다. M1과 M2의 경우인과적 의문 사진 과제 제시에 따라 피험자가 관찰하는 동안 보고 되는 것으로 dipole fitting 과정을 통해 두뇌 활성 영역을 확인해 본 것처럼 시각령이 위치하는 후두엽에 걸쳐 확인되었다. M3 components의 경우 인과적 의문에 대한 불확실감을 해소하기 위해 장기기억 저장소로부터 경험 상황을 가지고 오는 귀추의 과정을 반영한다고 볼 수 있다. 이는 이전 경험상황을 분석하는 단계에 해당하며 학생들이 가설을 생성할 때 가장 큰 어려움을 경험하여 교사의 적절한 도움이 요구되는 부분이다. M4 components는 장기 기억 속의 경험 상황에서 인과적 의문에 대한 설명자를 표상하는 단계에 해당하는 것으로 인과적 의문 생성 후 가설을 만드는 전 단계에 해당 한다고 할 수 있다. 본 연구는 확인된 인과적 의문 생성시 나타나는 MEG ERF components와 latency 시간을 통해 인과적 의문 생성에 어려움을 호소하는 학생들에 대한 개별적 교수 처치와 더불어 고등인지 영역의 ERF 연구의 기초를 마련하였다는데 의의가 있다고 하겠다. The purpose of this study is to analysis ERF components patterns of causal questions generated during the observation of biological phenomenon. First, the system that shows pictures causing causal questions based on biological phenomenon (evoked picture system) was developed in a way of cognitive psychology. The ERF patterns of causal questions based on time-series brain processing was observed using MEG. The evoked picture system was developed by R&D method consisting of scientific education experts and researchers. Tasks were classified into animal (A), microbe (M), and plant (P) tasks according to biological species and into interaction (I), all (A), and part (P) based on the interaction between different species. According to the collaboration with MEG team in the hospital of Seoul National University, the paradigm of MEG task was developed. MEG data about the generation of scientific questions in 5 female graduate student were collected. For examining the unique characteristic of causal question, MEG ERF components were analyzed. As a result, total 100 pictures were produced by evoked picture and 4 ERF components, M1(100~130ms), M2(220~280ms), M3(320~390ms), M4(460~520ms). The present study could guide personalized teaching-learning method through the application and development of scientific question learning program.

Preclinical evaluation of the efficacy of an H5N8 vaccine candidate (IDCDC-RG43A) in mouse and ferret models for pandemic preparedness

Jeong, Ju Hwan,Kim, Eun-Ha,Lloren, Khristine Kaith S.,Kwon, Jin Jung,Kwon, Hyeok-il,Ahn, Su Jeong,Kim, Young-Il,Choi, Won-Suk,Si, Young-Jae,Lee, Ok-Jun,Han, Hae Jung,Baek, Yun Hee,Song, Min-Suk,Choi, Elsevier 2019 Vaccine Vol.37 No.3

<P><B>Abstract</B></P> <P>Because H5N1 influenza viruses continuously threaten the public health, the WHO has prepared various clades of H5N1 mock-up vaccines as one of the measures for pandemic preparedness. The recent worldwide outbreak of H5Nx virus which belongs to clade 2.3.4.4 and of which H5N6 subtype belongs and already caused human infection also increases the need of pandemic vaccine for such novel emerging viruses. In this study, we evaluated the protective efficacy and immunogenicity of an egg-based and inactivated whole-virus H5N8 (IDCDC-RG43A) developed by CDC containing HA and NA gene of the parent virus A/gyrfalcon/Washington/41088-6/2014. Mice vaccinated two times elicited low to moderate antibody titer in varying amount of antigen doses against the homologous H5N8 vaccine virus and heterologous intra–clade 2.3.4.4 H5N6 (A/Sichuan/26221/2014) virus. Mice immunized with at least 3.0 µg/dose of IDCDC-RG43A with aluminum hydroxide adjuvant were completely protected from lethal challenge with the mouse-adapted H5N8 (A/Environment/Korea/ma468/2015, maH5N8) as well as cleared the viral replication in tissues including lung, brain, spleen, and kidney. Vaccinated ferrets induced high antibody titers against clade 2.3.4.4 H5N8/H5N6 viruses and the antibody showed high cross-reactivity to clade 2.2 H5N1 but not to clade 1 and 2.3.4 viruses as measured by hemagglutinin inhibition and serum neutralization assays. Furthermore, administration of the vaccine in ferrets resulted in attenuation of clinical disease signs and virus spread to peripheral organs including lung, spleen, and kidney from high dose challenge with maH5N8 virus. The protective and immunogenic characteristic of the candidate vaccine are essential attributes to be considered for further clinical trials as a pre-pandemic vaccine for a potential pandemic virus.</P>

가상현실(VR) 기반 생명과학 콘텐츠의 뇌전도(EEG) 특성

권석원(Kwon, Suk-Won),권승혁(Kwon, Seung-Hyuk),권용주(Kwon, Yong-Ju) 학습자중심교과교육학회 2018 학습자중심교과교육연구 Vol.18 No.9

본 연구의 목적은 가상현실 기반 체험형 생명과학 콘텐츠 자료와 기존 교육현장에서 사용되던 동영상이나 사진 자료와 같은 교수학습매체가 학습자의 두뇌에서 어떤 차이를 보이는지 확인하고, 이를 통해 다양한 연구 가능성을 제안하는 것이다. 이 를 위해 가상현실, 동영상, 사진 과제를 각 3종씩 9종을 개발하여 과학교육 전공 여성 대상자 5명에게 투입하며 19채널 뇌전도 측정을 실시하였다. 연구 결과 동영상이나 사진 과제에 비해 가상현실 기반 생명과학 콘텐츠 과제를 수행할 때 델타 및 감 마 대역에서 유의하게 높은 두뇌 활성 차이가 확인되었고, 이러한 활성은 주로 하이감마대역으로 갈수록 우측 후두엽을 중심으로 편측되어 나타나는 경향이 주로 관찰되었다. 이는 가상현실기반 과제가 기존 교수학습방법보다 선택적 주의집중과 가치 연합 처리에 있어 상호보완적 역할을 수행하고 있음을 나타내는 것이라 볼 수 있다. 감마 대역 활성은 후두엽과 변연계 사이에서 발생되어 지며, 이로 미루어보아 가상현실 기반 생명과학 콘텐츠는 주로 기억 부호화 및 재인과 연관되어 있음을 확인할수 있었다. 본 연구는 가상현실기반 콘텐츠가 학습자에게 미칠 수 있는 다양한 영향 에 대한 뇌과학적 근거를 제시하였다는데 의의가 있다. The purpose of this study is to identify differences in the effects on learner’s brain between virtual reality-based biology contents and teaching-learning media such as video and picture materials used in the existing educational field, and to propose various research possibilities. For this purpose, we developed three kinds of 9 tasks of virtual reality, video, and picture type and applied them to 5 female participants in science education major with nineteen-channel EEG. Results showed that brain activity difference was significantly higher in delta and gamma band when during virtual reality-based biology contents tasks then video and photo tasks. These activities were observed mainly in the left side of the right occipital lobe. This suggests that the virtual reality-based tasks play a complementary role between selective attention process and value association processing compared to the existing teaching-learning tasks. In addition, gamma band activity occurs between the occipital lobe and the limbic system, suggesting that virtual reality contents are mainly related to memory coding and memory recognition. It is significant that this study presented the neuroscientific basis of various effects on learners using virtual reality-based contents.

디지털 교과서와 서책형 교과서 사용시 두뇌 활성 차이-EEG 연구

권석원(Kwon, Suk-Won),권용주(Kwon, Yong-Ju),양일호(Yang, Il-Ho),변정호(Byun, Jung-Ho),이일선(Lee, Il-Sun),권승혁(Kwon, Seung-Hyuk),김순미(Kim, Soon-Mi),박상희(Park, Sang-Hee),김윤영(Kim, Yoon-Young),계보경(Kye, Bo-Kyung),정광훈(Jung, 학습자중심교과교육학회 2014 학습자중심교과교육연구 Vol.14 No.5

정보통신 전자기술이 발달하고 확산됨에 이를 이용한 스마트 교육이 점점 확산되고 있다. 이에 스마트 기기를 이용한 디지털 교과서의 사용에 대한 우려가 증가하고 있다. 이 스마트 교육의 보급을 위해서 디지털 교과서 사용에 따른 역기능에 대한 체 계적인 진단 및 분석에 대한 요구의 목소리가 높아지고 있다. 이에 본 연구의 목적은 디지털 교과서 사용의 뇌기능에 대한 영향을 규명하고 안전하고 올바른 활용 방안을 제시하는 것이다. 이를 위해 먼저 디지털 교과서 활용 시 학습자의 두뇌 활성 영향분석을 위해 실험 연구를 진행하였다. 연구 결과, 디지털 교과서 사용시 서책형 사용에 비해 델타와 감마대역에서 우측 전두엽, 두정엽, 피질하 일부 영역과 변연계 중뇌섬엽에서 유의하게 두뇌 활성 및 강도가 높게 나타났다. 본 연구를 바탕으로 디지털 교과서의 안전하고 올바른 사용을 위해 관련 뇌과학연구의 확대와 가이드라인의 제작 및 제시, 교사와 함께하는 스마트 교육의 발전을 위한 추가 연구의 필요성을 제시하였다. The smart education is spreading to more and more according to development of information and communication technologies and the proliferation of electronic communication. It is increasing concerns about using digital device based on digital textbooks. The growing calls for systematic diagnosis and analysis about dysfunction of using digital textbooks for the proper prevalence of smart education. Therefore, the purpose of this research is to investigate the effect on brain function using digital textbooks and to propose ways to ensure safe and proper utilization. To reach the purpose, experimental research was conducted for analysis effect on brain activation of learner using digital textbooks. A comparative study of active region of the brain when students use digital textbook or paper textbook, this results of this study, we observed a significant delta and gamma power increase in right frontal, parietal and insula(Sub-lobar) in using the digital textbook. Though this research, It is revealed that using digital textbook effect especially on brain function. And we propose a enlargement of smart education related brian science research, manufacture and present guide-line and necessity of additional research for development smart education with teachers.