개에 있어서 耳根部의 Lidocaine 水針에 의한 全身 無痛覺의 誘發

권현주,유건주,이상은,이정연,송근호,김명철,정성목,박성준,김덕환 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

Twelve clinically healthy mongrel dogs were used to clarify the possibility of general analgesia induction by lidocaine aquapuncture to auricular root area in the present study. The experimental animals were devided into control (6 heads) and experimental groups (6 heads), respectively. Physiological salines (3 ml/kg) were injected into both auricular root areas in control group. Lidocaine hydrochlorides (3 ml/kg) were injected into both auricular root areas in experimental group. Superficial pain, the changes of vital signs and blood leukocytes, and PCV were examined on pre, 5 min., 15 min., 30 min, and 60 min. after injection in control and experimental groups, respectively. Analgesia was not detected at all in control group, however, all experimental animals were recumbent and analgesia was generally detected in the auricles, noses, dorsal parts, ventral areas, limbs and tails from 5 to 30 minutes after injection with lidocaine hydrochloride into auricular root areas in experimental group. As for the change of vital signs, body temperature showed decreasing tendency from 5 minutes after lidocaine injection in experimental group. Heart rates and respiration rates were increased on 5 minutes after lidocaine injection and then they showed decreasing tendency in experimental group. No significant difference were found among groups. As for the changes of hematological findings, the numbers of blood leukocytes were increased till 15 minutes after lidocaine injection and then they showed decreasing tendency. PCV values were increased on 5 minutes after lidocaine injection, and then they showed decreasing tendency. However, no significant differences were observed among groups. Considering the above findings, it was thought that general analgesia was possible by aquapuncture with lidocaine hydrochloride into auricular root areas and lidocaine aquapuncture didn’t affect so much to the changes of vital signs and blood.

임신 생식관련인자와 비만위험

장기홍,권혁찬,이득주,유희석,이은주,한인권 대한비만학회 1995 The Korean journal of obesity Vol.4 No.1

It is thought Omt there is a close relationship between obesity and pregnancy, but there are not any concrete studies in Korea. Therefore, a retrospective study was conducted to evaluate how factors surrounding pregnancies affect the body mass index. 385 women who had no history of disease or medication as a cause of obesity were randomly selected, and factors vlated to pregnancy vi ere compared between a normal body mass index group and a group where the body mass index was more thsn one standard deviation from the average. The average age of the study group was 44,25 years(S.SS) and the average body mass index was 23.09 kg/m2(3.00). 4 the obese group the average age was statistically higher, the level of education was statistically lower, but there was no statistica] difference with regard to smoking, alcohol consumption and exercise. Age showed to be statistically significant positive correiation with body mass index, but the level of education showed negative correlation. The age of first pregnancy, age of first delivery, and the mterval between menarche and first pregnancy showed statistieally significant negative correlation with the body mass index, whereas the duration of lactation, total number of pregnancies showed statistically significant positive correlation with body mass index. There was statistical1y significant more deliveries in the group where the body mass index was more than one standard deviation frvm the average, the risk for obesity was 2.5 times higher in women who had three or more deliveries compared to those who had less than three deliveries, and the risk was 1.5 times higher in women who had their first delivery before the age of 25 years compared to those over the age of 25 years. But other factors were found not to be different between the two study group and were independent of age, level of education, aleohol consumption and smoking. It can be seen from these results that pregnancy related factors are related to obesity, and that especially age, level of education, alcohol consumption and smoking independantly increase the risk for obesity. Also those women who have had more than three deliveries or who had their first pregnancy before the age of 25 years were at risk, and there should be a formulative plan for these women. It is hoped that in-depth study of pregnancy factors contributing to obesity be determined with further study and research.

근위 대퇴정을 이용한 대퇴 전자부 골절의 치료

문영완,서동현,강신택,권덕주,지용남,이기병 대한골절학회 2003 대한골절학회지 Vol.16 No.1

목 적 : 근위 대퇴정을 이용한 고령 환자의 대퇴전자간 골절의 치료결과에 대해 보고하고자 한다. 대상 및 방법 : 2001년 4월부터 2002년 2월까지 대전자부에서 소전자에 이르는 횡선골절 및 소전자 주위 분쇄골절로 압박고 나사 고정이 용이하지 않은 전자간 골절, 일반적인 전자간 골절에 대해 근위 대퇴정을 사용해 치료한 80례 중 추시가 가능했던 71례를 대상으로 하였으며, 추시과정 중 골유합 시기, 대퇴경간각, 지연나사의 활강, 수술시간 및 출혈량, 술중 및 술후 합병증 수술시 주의사항을 조사하였다. 결 과 : 평균연령은 77.5세, 평균추시기간은 9개월이었다. Evans의 분류법으로 골절을 분류하여 안정성, 불안정성 골절은 30례, 41례였다. 평균 골 유합 시비는 13.8주였고, 대퇴경간각은 수술직후 131.9 ± 5.21˚, 129.9 ± 6.04˚ 였으며 평균지연나사의 활강은 4.21±4.13㎜였다. 수술시간은 평균 61분, 출혈량은 평균 0.67pint(134cc)였다. 술중 합병증으로는 정복 실패 1례, 원위고정나사 삽입시 피질골 골절 1례, drill bit 파손 1례가 있었으며, 술후 합병증으로는 대퇴 경간각 소실(5도이상) 12례, 경부골절의 발생이 2례, 지연나사의 관절내 돌출 1례였다. 결 론 : 대퇴골 전자부 골절의 치료로 근위 대퇴정은 정확한 삽입 위치, 삽입시의 조심스러운 확공, 지연나사의 연골하 골에 단단하게 고정시키는 등의 주의를 한다면 수술시간, 출혈량 감소 등의 술중 합병증을 줄이고, 견고한 내고정을 통한 조기 보행을 가능하게 하며, 좋은 골유합 등이 기대되므로, 특히 고령, 분쇄골절, 역행성 골절, 골다공증이 심한 경우에서 바람직한 수술방법으로 사료된다. Purpose : To evaluate the treatment results of geriatric intertochanteric fractures using a proximal femoral nail. Materials and Methods : From April 2001 to February 2002, 71 cases of the intertrochanteric fractures involving lesser trochanter, transverse or reverse oblique intertrochanteric fracture. We evaluated the bone union time, neck-shaft angle, lag screw sliding by follow up radiographs, operation time, blood loss and complications. Results : The average age was 77.5 years old, the mean duration of follow-up was 9 months and the mean duration of bone union was 13.8 weeks. The average neck-shaft angle on immediate postop. x-ray was 131.9 ± 5.21˚ and 129.9 ± 6.04˚ at last follow up and the average lag screw sliding was 4.21 ± 4.13㎜. The average operation time was 61 minutes and blood loss was 0.67 pints(134cc). Intraoperative complications were inadequate reduction in one case, difficulty in distal transfixing in one case and drill bit failure in one case and postoperative complications were loss of neck-shaft angle(more than 5 degree) in 12 cases, femur neck fracture in 2 cases and intraarticular cutting out of femur neck screw in one case. Conclusions : The use of the proximal femoral nail could be appropriate for the fixation of communited or reverse oblique intertrochanteric fracture in elderly, osteroporotic patients for early ambulation, preventing shortening and rotation deformity, and reducing operation time and blood loss.

여성호르몬 대체요법후 체중변화와 베타3 아드레날린 수용체 유전자형의 연관성에 관한 연구

이기호,김상만,이득주,최희정,한인권 대한비만학회 2003 The Korean journal of obesity Vol.12 No.3

연구배경: 폐경 전후에서의 체중 증가와 여성호르몬과의 연관성이 지속적으로 논의되어왔다 교감 신경계는 지방대사를 촉진하여 대사적 열생산을 증가시키는 작용을 가지고 있으므로 이와 관련하여 베타3아드레날린 수용체의 유전자형이 폐경여성에서 여성호르몬 대체요법 이후의 체중증가와 연관이 있는지를 밝히고자 본 연구를 시행하였다. 방법: 1995년부터 2002년 5월까지 삼성제일병윈 비만클리닉 및 갱년기 클리닉에 방문하여 여성 호르몬 대체요법을 시행 받았으며, 폐경에 관련한 과거력, 여성 호르몬 투여 전후의 체중, 체질량 지수에 대한 자료를 확보할 수 있곤, 베타3 아드레날린 수용체 유전자의 다형성을 분석한 92명을 최종 연구 대상자로 하였다. 결과: 베타3 아드레날린 수용체 유전자 다형성 분포는 Trp64Trp형 39.1%, Trp64Arg형 25.0%,Arg64Arg형 34.8%,로 나타났다 여성호르몬 투여 전 체중의 평균은 61.07±7.06이었으며, 여성 호르몬대체요법 후 체중 변화의 평균은 1.28±3.20 증가로 나타났으나, 통계적으로 유의하지 않았다 β3 아드레날린 수용체 유전자 아형에 따른 체중의 평균 변화는 Trp64Trp형에서 1.86±2.94 증가, Trp64Arg형 0.74±2.97 증가, Arg64Arg형 1,00±3.61 증가로 나타났으나 이들 모두 통계적 유의성은 없었으며, 세 아형간의 변화량도 유의하지 않았다. 결론: 폐경여성에서 여성호르몬 대체요법 후 체중이 증가하였으나 통계적으로 유의하지 않았으며, β3아드레날린 수용체 유전자 아형에 따른 차이를 관찰할 수 없었다. Background: The study results to determine the relationship between postmenopausal estrogen use and weight gain have not been consistent. Genetic studies have reported the association of BMI with the beta3-adrenergic receptor gene polymorhism. This study as designed to indentify association of beta3-adrenergic receptor gene polymorhism with weight gain related to HRT in postmenopausal women. Methods: 192 postmenopausal women at a general hospital, Bariatric and climacteric clinic have been collected. Subtypes of beta3 adrenergic receptors were measured and physical, anthropomeric data including body fat and BMI was obtained before and after HRT. Results: Arg/Arg group was 34.8%, Trp/Arg group was 25.0%, Trp/Trp group was 39.1%. Mean weight gain in 192 postmenopausal women was 1.28±3.20 kg and the percent changes in weight gain between initial and final point was 2.32±5.66% but these resulst had no statistical significance (p>0.05). Weight gain(%) were 2.24%(95% C.I 0.35~4.13) in Arg/Arg group, 1.08%(-1.17~3.29) in Trp/Arg group and 3.18%(1.49~4.92) in Trp/Trp, but these results did not show statistical significance(F=1.13, p=0.03). Conclusion: Polymorphism of beta3 adrenergic receptor gene was not associated with weight gain after HRT in postmenopausal women. From these results, we may conclude that polymorhism of beta3 adrenergic receptor may not be the predicting factor to understand the weight gain after HRT in postmenopausal women.

Original Article : Factors influencing the severity of acute viral hepatitis A

( Joo Il Kim ),( Yun Soo Kim ),( Young Kul Jung ),( Oh Sang Kwon ),( Yeon Suk Kim ),( Yang Suh Ku ),( Duck Joo Choi ),( Ju Hyun Kim ) 대한간학회 2010 Clinical and Molecular Hepatology(대한간학회지) Vol.16 No.3

Background/Aims: Most patients with acute viral hepatitis A have a favorable course, but a few of them suffer from severe forms of hepatitis such as fulminant hepatitis. This study was carried out to identify the factors influencing the severity of acute viral hepatitis A. Methods: We retrospectively reviewed the medical records of 713 patients with acute hepatitis A, who were divided into two groups: severe hepatitis A (N=87) and non-severe hepatitis A (N=626). Severe hepatitis was defined as fulminant hepatitis or prolongation of prothrombin time (INR≥1.5). Clinical variables were compared between the two groups. Results: The incidence of fulminant hepatitis was 1.4 % (10/713) in patients with acute hepatitis A. Thirty-three (4.6 %) cases exhibited HBsAg positivity. In multivariate analyses, significant alcohol intake and the presence of HBsAg were significant predictive factors of fulminant hepatitis A, and significant alcohol intake and age were significant predictive factors of severe hepatitis A. HBeAg and HBV-DNA status did not affect the clinical course of hepatitis A in chronic hepatitis B carriers. Conclusions: While most patients with acute hepatitis A have an uncomplicated clinical course, our data suggest that a more-severe clinical course is correlated with being older, significant alcohol intake, and chronic hepatitis-B-virus infection. (Korean J Hepatol 2010;16:295-300)

만성 간질환에서 혈중 Gelatinase (Matrix Metalloproteinase-2와 9)의 측정 의의

권오상,임도윤,권광안,정문기,박동균,김선숙,김연석,권소영,구양서,김유경,최덕주,김주현,황유진,변관수,이창홍 대한간학회 2003 Clinical and Molecular Hepatology(대한간학회지) Vol.9 No.3

목적: Gelatinase (MMP-2와 9)는 기저막의 주구성요인 type IV collagen을 분해하는 효소로, MMP-2는 간경변과 MMP-0은 간세포암의 진행과 연관이 있는 것으로 알려져 있다. 본 연구에서는 만성 간질환과 MMP-2와 9의 관계를 알아보고자 하였다. 대상과 방법: 간기능이 정상이고 간질환이 없는 건강 대조군 10예, 만성 간염 15예, 간경변 18예, 그리고 간세포암 25예를 대상으로 혈장을 채취하여 MMP-2와 9의 활성을 보기 위해 zymography를 시행하였다. 결과: 혈장 MMP-2의 활성은 간경변군에서 건강 대조군(p=0.009)과 만성 간염군(p=0.011)에 비해 증가되어 있었으나 간세포암군과는 차이가 없었다. 혈장 MMP-9의 활성은 간경변군에서 건강 대조군에 비해 증가되어 있었으나(p=0.035), 만성 간염군과 간세포암군과는 차이가 없었다. 간세포함이 없는 간경변군 15예와 간세포암을 동반한 간경변군 23예를 합친 총 간경변군 38예에서 MMP-2의 활성은 total bilirubin이 높을수록 (r=0.323, p=0.048) 그리고 Child-Pugh 점수가 높을수록(r=0.414, p=0.012) 증가되어 있었다. 총 간경변군에서 MMP-2와 MMP-9의 활성은 알코올 성 간경변군에서 HBV에 의한 간경변군 보다 현저히 증가되어 있었다(각각 p=0.009, p=0.002). 결론: 혈장 MMP-2의 활성은 간경변의 진단과 중증도에 유용한 표지자로 사용될 수 있을 것이다. 혈장 MMP-9의 활성은 간세포암에서의 유용성은 적으리라 생각되나 알코올성 간경변의 진단적 표지자로는 유용하리라 생각된다. MMP-2와 MMP-9의 활성은 간경변의 원인 별로 차이가 나는 것으로 생각되며 그 이유에 대한 연구가 필요하리라 생각된다. Background/Aims: Gelatinase (matrix metalloproteinase (MMP) -2 and 9) has an important role in the pathogenesis of liver cirrhosis (LC) and hepatocellular carcinoma (HCC). In this study, we evaluated the relationship of gelatinase to chronic liver disease. Methods: Four groups of subjects were examined; healthy control (10 cases), chronic hepatitis (18 cases), LC (15 cases), and HCC (28 cases). The plasma of each subject was obtained, and the equal quantification of plasma protein was done. The plasma activities of MMP-2 and 9 were measured by zymography. Results: The activities of plasma MMP-2 in patients with LC were significantly higher than those in controls (p=0.009) and in patients with chronic hepatitis (p=0.011), but not different from those in patients with HCC. The activities of plasma MMP-9 in patients with LC were significantly higher than those in controls, but not different from those in patients with chronic hepatitis or HCC. In patients with LC (regardless of having HCC), the activities of MMP-2 correlated with total bilirubin (r=0.323, p=0.048) and Child-Pugh score (r=0.414, p=0.012). The activities of MMP-2 and 0 were higher in patients with LC (regardless of having HCC) caused by alcohol than caused by HBV (p=0.009 and 0.0002 for each one). Conclusions: The plasma activity of MMP-2 may be a useful marker for the diagnosis and determination of the severity of LC. The plasma activity of MMP-9 was not useful for HCC, but may be a marker for alcoholic LC. Further study is needed to determine why the plasma activity of gelatinase was higher in patients with LC caused by alcohol than by HBV.(Korean J Hepatol 2003;9:222-230)

Poster Exhibition : Influence of Chronic Hepatitis B on the Severity of Acute Hepatitis A (초)

Joo Il Kim,Yun Soo Kim,Oh Sang Kwon,Duck Joo Choi,Ju Hyun Kim 대한간학회 2009 Clinical and Molecular Hepatology(대한간학회지) Vol.15 No.4(S)

White-Light-Emitting Materials for Organic Electroluminescent Devices

Kim, Duck-Young,Kwon, Oh-Kwan,Kwon, Hyuck-Joo,Kim, Young-Kwan,Sohn, Byoung-Chung,Ha, Yun-Kyoung The Korean Society of Applied Science and Technolo 2001 한국응용과학기술학회지 Vol.18 No.1

White emission is important for applying organic EL devices to full-color flat panel display and backlight for liquid crystal display. In order to obtain white emission, the use of a light-emitting material which shows the white emission by itself is advantageous for these applications because of its high reliability and productivity. A chelate-metal complex such as zinc bis(2-(2-hydroxyphenyl) benzothiazolate) ($Zn(BTZ)_{2}$ was known to emit white light with a broad electroluminescence. In this study, the electroluminescent characteristics of $Be(BTZ)_{2}$ and $Mg(BTZ)_{2}$, as well as $Zn(BTS)_2$ were investigated using organic electroluminescent devices with the structure of ITO/TPD/ $Be(BTZ)_{2}$, $Mg(BTZ)_{2}$, or $Zn(BTZ)_{2}/Al$. It was found that the device containing $Be(BTZ)_{2}$ showed the highest power efficiency.

White - Light - Emitting Materials for Organic Electroluminescent Devices

김덕영(Duck Young Kim),권오관(Oh Kwan Kwon),권혁주(Hyuck Joo Kwon),김영관(Young Kwan Kim),손병청(Byoung Chung Sohn),하윤경(Yun Kyoung Ha) 한국유화학회 2001 한국응용과학기술학회지 Vol.18 No.1

N/A White emission is important for applying organic EL devices to full-color flat panel display and backlight for liquid crystal display. In order to obtain white emission, the use of a light-emitting material which shows the white emission by itself is advantageous for these applications because of its high reliability and productivity. A chelate-metal complex such as zinc bis(2-(2-hydroxyphenyl) benzothiazolate) (Zn(BTZ)_2 was known to emit white light with a broad electroluminescence. In this study, the electroluminescent characteristics of Be(BTZ)_2 and Mg(BTZ)_2, as well as Zn(BTS)_2 were investigated using organic electroluminescent devices with the structure of ITO/TPD/ Be(BTZ)_2, Mg(BTZ)_2, or Zn(BTZ)_2/Al. It was found that the device containing Be(BTZ)_2 showed the highest power efficiency.

Processing and quality properties of olive flounder Paralichthys olivaceus balls product

Moon-Joo Yoon,Jae-Dong Lee,Si-Young Park,Soon-Jae Kwon,Jin-Hyo Park,Hee-Bum Jung,Cheung-Sik Kong,Jong-Duck Choi,Jong-Chan Joo,Jeong-Gyun Kim 한국수산해양기술학회(구 한국어업기술학회) 2015 한국수산해양기술학회 학술발표대회 Vol.2015 No.10