Seltzer Model에서 인삼과 morphine의 공동투여가 통각행동에 미치는 영향

홍선미,강영님,김광진 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

The aim of this study was to compare the effects of the ginseng total saponin(100㎎/㎏, i.p., GTS), morphine(3㎎/㎏, i.v.) and the co-administration of the GTS and morphine at same time after the unilateral tight ligation of about half of the sciatic nerve in rats. This tight ligation evoked a markedly different responses of the neuropathic pain in both injured left sides and non-injured right side, which is representing the mirror effect in spite of the time courses of the various stimili; mechanical, chemical and cold, but exception of spontaneous. The maximal responses of each stimulus showed neuropathic pain evoked at the seventh day, and the values of the response were used as a indicater of the nerve injury group for drugs; GTS alone, morphine alone, and the co-administration of GTS and morphine at same time. The effect of the GTS was continued for approximate 48 hours and morphine for 2 hours, respectively. The co-administration of the GTS and morphine at same time, however, showed the no considerable antinociceptive effect at first injection, but the consideralble difference after injection of 24 hours of 48 hours. And also these responses showed the mirror-like response after the drug treatments. These results suggest that partially tight ligation evoked the neuropathic pain in the various stimuli showing the mirror-like effect, and the actions between GTS and morphine has the antagonistic relationship with each other, and the action mechanism is partly involved the non-opioid and opioid mechanisms.

유아특수교육 기관의 개별화교육프로그램 운영실태 및 개선 방안

조광순,전병운,박혜준,홍은숙 국립특수교육원 2005 특수교육연구 Vol.12 No.1

본 연구에서는 유아특수교육교사 8명과의 심층면담과 30개의 IEP 문서 분석을 통해, 특수교육진흥법 상의 규정과 유아특수교육 추천 실제에 따른 IEP의 질적 수준을 알아보았다. 연구결과 특수학급 교사의 경우 유치원 교육과정과의 연계가 부족한 IEP를 작성하여 운영하고 있으며, 개별화교육운영위원회는 실질적으로 소집되지 못하고 있고, IEP의과정에 보호자의 참여 정도는 미미한 것으로 나타났다. 대부분의 IEP 내용은 유아의 현 수행수준에 근거한 장 · 단기 목표의 기술을 제외하고는 상당히 형식적이고 제한적이어서 IEP 운영에 도움을 주지 못하고 있는 것으로 나타났다. 그러나 특수교육진흥법 상에 규정되어 있지는 않지만 실제 현장에서는 가족지원이 다양한 방식으로 이루어지고 있으며, 다학문적 팀의 구성과 구성원들 간의 협력은 교사에 따라, 또는 기관에 따라 큰 차이가 있는 것으로 나타났다. 일반 유치원 프로그램의 일일 계획안과 IEP와의 연계, 발달적 교육과정과 유치원 교육과정과의 연계, 목표의 수정, 개별화교육운영위원회의 협력적 참여, 객관성 있는 수행 평가 면에서 유아특수교육교사들은 어려움을 나타내 보였으며, IEP 작성과 운영에 따른 문제를 해결하기 위해서는 무엇보다도 표준화된 IEP 양식 또는 구조화된 IEP와 평가준거의 예가 제시된 IEP 모델이 필요한 것으로 교사들은 제안하고 있다. Various research has identified a number of problems with individualized education program (IEP) development and implementation among schools, including a lack of adequate teacher training, poorly developed team processes, minimal coordination with general education, and failure to develop measurable goals and objectives to evaluate child achievements. The purpose of this study was to evaluate the quality levels of IEPs implemented in early childhood special education (ECSE) settings based on recommended ECSE practices and requirements of the Korean Special Education Enhancement Act. Through an in-depth focus group interview with eight ECSE teachers from eight different programs and an analysis of 30 IEPs, the study investigated: 1) how regulations on IEP development and implementation of the Special Education Enhancement Act, specifically regulations on IEP team organization and implementation, parent participation, and IEP contents, are interpreted in ECSE programs; 2) how ECSE program professionals collaborate with families and how family supports are provided; 3) how a multidisciplinary approach is put into practice and effective levels of collaboration among IEP team members; 4) ECSE teacher suggestions for solving problems with IEP development and implementation, and for improving practices. The results indicate that special education classroom teachers of regular kindergarten programs develop and implement IEPs that are irrelevant to their curricular. IEP procedural deficits were found in the area of team process. It was found that the ECSE programs lack a multidisciplinary team approach when developing and implementing IEPs. Overall, parental participation was not ensured even though regulations require IEP teams to include parental requests in IEPs and implement their signed IEPs. Key personnel such as regular early childhood education teachers and therapists were found to be absent from IEP meetings. However, differences were found among the programs in the team process. Programs specialized only for young children with disabilities demonstrated higher levels of team approaches than those of ECSE programs in special schools and regular kindergartens. In this study, limited content of IEPs were found to be developed for young children with disabilities. IEP goals and objectives analyzed in this study were shown to be generally adequate, showing that children's levels of performance information and annual goals were congruent and that measurable goals and objectives were developed. During the in-depth interview, it was learned that ECSE teachers provide support to children and families, coordinating services in the community for children with disabilities. The results of this study also show that ECSE teachers in regular kindergarten programs have difficulties in linking IEP goals with their daily instructional plans as well as linking their general curriculum with developmental goals for young children with disabilities. Overall, teachers in this study demonstrated difficulties with modification of IEP goals, facilitating collaborative IEP team participation, and objective monitoring of IEP goals. They suggest that standards for IEP and structured IEP forms be developed. They also suggest that model IEPs be introduced by school districts. The findings of this study suggest that: 1) specific IEP procedures need to be mandated through special education laws and regulations in order to facilitate and monitor team approaches when developing and implementing IEPs in ECSE settings; 2) a coordinated service system is needed to provide comprehensive services to young children with special needs and their families; 3) there is an urgent need for comprehensive curriculum-based assessment tools that reflect various developmental aspects as well as diverse special needs and suggest assessment guidelines; 4) it is important to provide strong pre-service teacher education programs as well as in-service work shops for teachers in order to develope skills in developing meaningful IEP goals and objectives linked to curriculum and daily classroom routines; and 5) IEP model development research should be facilitated.

유색미에 관한 연구 : Ⅲ. 유색미 유망계통에 대한 주요 생육 특성

김광수,최윤표,김선택,최현구,정종태,김보경,유지홍,이희봉 충남대학교 농업과학연구소 2007 농업과학연구 Vol.34 No.2

국내외 유색미 수집종을 돌연변이원에 의해 유기된 우수 계통과 수집종간 상호교배에 의해 선발된 CNU 20계통을 파종하여 얻어진 주요 작물학적 특성을 살펴보면 다음과 같다. 1. 간장은 유색 메벼인 CNU126 계통이 대조품종인 동진벼와 같이 가장 컸고 메성인 CNU 128계통에서 가장 작았다. 2. 주당 분얼수는 CNU3, CNU50. CNU56, CNU112 계통에서 가장 많았고 대조품종과 CNU 128 계통에서 10개 미만으로 가장 적게 나타났다. 3. 수장은 육성 계통 중 CNU88 계통에서 가장 길었으나 대조구보다 짧고, 육성계통 중에서는 CNU 126 계통이 가장 짧았다. 4. 주당 영화수는 대조구인 동진벼보다 CNU50 계통에서 2배 이상 많았고, CNU158 계통에서 가장 적게 나타났다. 5. 천립중은 CNU113 계통에서 30g이상으로 대조구와 같이 가장 무거웠고, CNU128 계통에서 20g으로 가장 적었다. 6. 주당 수량은 대조구의 26.6g에 비해 CNU50, CNU112 계통에서 두배정도 높았고, CNU128, CNU158, CNU200 계통에서 가장 낮게 타나났다. Aims of this study were carried out to develop the useful lines induced from mutation and pedigree breeding methods among the collected genetic resources from national and domestic areas. In this study, Stem height of CNU126 line and check among them were high, while CNU128 was lower than other lines. Spiklet length of CNU88 was longer, but that of CNU126 was shorter than check. Number of spiklets per plant of CNU50 among lines have twice time than check. 1,000 grains weight of CNU113 was higher than check. In yield per plant, CNU50 and CNU112 were higher than check, Dongjinbyeo.

열처리된 AgInS₂박막의 defect 연구

박창선,김봉재,홍광준 조선대학교 에너지.자원신기술연구소 2002 에너지·자원신기술연구소 논문지 Vol.24 No.1

AgInS₂단결정 박막은 수평 전기로에서 합성한 AgInS₂다결정을 증발원으로하여, hot wall epitaxy(HWE) 방법으로 증발원과 기판(반절연성-GaAs(100))의 온도를 각각 680℃, 410℃로 고정하여 단결정 박막을 성장하였다. 이때 단결정 박막의 결정성은 광발광 스펙트럼과 이중결정 X-선 요동곡선(DCRC)으로부터 구하였다. Hall 효과는 van der Pauw 방법에 의해 측정되었으며, 293K에서 운반자 농도와 이동도는 각각 9.35×10^(16)/㎤, 294 ㎠/V·s였다. 또한 광흡수 spectra에서 energy band gap의 온도 의존성 E_(g)(T)는 2.3165eV-(9.89×10_(-3)eV/K)T² / (T+2930K)임을 확인하였다. 성장된 AgInS₂단결정 박막을 Ag, S, In 분위기에 열처리하여 10K에서 photoluminescience(PL) spectra를 측정하여 점 결함의 기원을 알아보았다. PL 측정으로부터 얻어진 V_(Ag), Vs, Ag_(int), 그리고 S_(int)는 주개와 받개로 분류되어졌다. AgInS₂단결정 박막을 S분위기에서 열처리하면 p형으로 변환됨을 알 수 있었고, In 분위기에서 열처리하면 열처리 이전의 PL spectra를 보이고 있어서 I₂, I₁ 및 S, A emission에 의한 PL peak에는 영향을 주지 않는다고 보았다. A stoichiometric mixture of evaporating materials for AgInS₂single crystal thin films was prepared from horizontal furnace. To obtain the single crystal thin films, AgInS₂ mixed crystal was deposited on thoroughly etched semi-insulating GaAs(100) substrate by the Hot Wall Epitaxy(HWE) system. Temperature of the source and substrate were 680℃ and 410℃, respectively. The crystalline structure of the single crystal thin films was investigated by the photoluminescence and double crystal X-ray diffraction (DCXD). The carrier density and mobility of AgInS₂single crystal thin films measured from Hall effect by van der Pauw method are 9.35×10^(16)cm^(-3) and 294 cm²/V·s at 293 K, respectively. From the optical absorption measurement, the temperature dependence of the energy band gap bn-AgInSz single crystal thin films was found to be E_(g)(T) = 2.1365 eV - (9.89 x10^(-3) eV) T²/(2930 + T). After the as-grown AgInS₂single crystal thin films was annealed in Ag-, S-, and In-atmospheres, the origin of point defects of AgInS₂single crystal thin films has been investigated by using the photoluminescence(PL) at 10 K. The native defects of V_(Ag), Vs, Ag_(int), and S_(int) obtained from PL measurements were classified as a donors or acceptors type. And we concluded that the heat-treatment in the S-atmosphere converted AgInS₂single crystal thin films to an optical p-type. Also, we confirmed that In in AgInS₂/GaAs did not form the native defects because In in AgInS₂single crystal thin films did exist in the form of stable bonds.

안인 군선강의 이화학적 수질

민선홍,최봉종,김한수,김영하,박광하 강릉대학교동해안지역연구소 1993 東海岸硏究 Vol.4 No.3

1993년 2월부터 9월까지 4회에 걸쳐 명주군 군선강의 8개 지점을 대상으로 하여 수질 조사를 하였다. 수질 평가를 위하여서는 수온, pH, 용존 산소량, 화학적 산소 요구량, 생물학적 산소 요구량, 부유 물질, 암모니아성 질소, 아질산성 질소, 질산성 질소, 인산염 인, 계면 활성제, 대장균등을 측정 하였다. 본 하천의 상류쪽은 산성을 나타냈으며 하류쪽으로 갈수록 알카리성으로 나타났다. 또한 대장균수는 상대적으로 작았다. 그 원인은 광산 폐수때문인 것으로 나타났으며 하류쪽으로 갈수록 해수와 혼합되기 때문인 것으로 나타났다. The water quality was monitored from February through September, 1993 for four times on the eight sites of Gunseon Stream, Myungju. To monitor the water quality, water temperature, pH, Dissolved oxygen, Chemical oxygen demand, Biochemical oxygen demand, Suspended solid, Ammonia-nitrogen. Nitrite-nitrogen, Nitrate-nitrogen, Inorganic phosphate, Sulfactant, and E. coli MPN were chosen as parameters. The upstream was more acidic; downstream was more alkalic. The E. coli MPN value was relatively low due to the mine pollutant and seawater mixture.

이차 전기영동을 이용한 프로테오믹 접근을 통한 정맥 압박이 혈장 프로테옴에 미치는 영향

양광익,박선아,오형근,정두신,박형국,성기범,안무영,홍세용 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

The human proteomics-based approaches, which examine the expressed proteins of a tissue or cell type, are increasingly being used. Venous occlusion is commonly employed for stimulating tissue-plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-l) release from venous endothelial cells, and this has been regarded as a parameter of the individual fibrinolytic capacity of plasma. The present work involved a detailed investigation of the plasma proteome and fibrinolytic activity in normal subjects, with the aim of determining whether correlations exist between various parameters of the fibhnolytic system before and after venous occlusion. We analyzed fibhnolytic parameters and plasma proteome before and after 15-min periods of venous occlusion in the forearm in 10 healthy 3rd-decade volunteers. Proteome analysis was performed using two-dimensional gels. The tryptic digests of some proteins were confirmed by MALDI-TOF and the MS-Fit algorithm. The fibrinolytic response as measured by the absolute amount of t-PA after venous occlusion was increased by venous occlusion (5.5 vs 9.6 ng/㎗, p<0.05), as was PAI-l (46.8 vs 56.1 ng/㎗, p<0.05). However, two-dimensional electrophoresis finding was virtually nonspecific and inconsistent after venous occlusion in healthy male subjects. Venous occlusion does not influence plasma proteome in healthy males. Although the fibhnolytic response to venous occlusion is attributed to an increase in free tUPA antigen, this change is not correlated with plasma proteome.

상피종양의 keratin 생성능에 대한 전자현미경적 연구

이길선,이명주,장정수,이민전,노광을,서재홍 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1

Keratins are characteristically present in all keratinizing and nonkeratinizing epithelial cells and their neoplasms. They consist of at least 19 different polypeptides ranging from 40 to 69 kilodaltons, which are developmentally related to specific epithelial cell types. Keratins of high and intermediate molecular weights are readily demonstrated in squamous cell carcinomas, which are characteristically rich in tonofilaments and tonofilament-desmosome complexes. Keratins of low molecular weights are expressed in adenocarcinoma including renal cell carinoma, hepatocellular carcinoma, small cell carcinoma, and carcinoid tumor. These tumors do not reveal any tonofilaments and sacrcely show discrete filaments on electron microscopy. An immunoperoxidase technique employing antibody to keratin was used to study distribution and staining pattern of keratin filaments in benign and malignant epithelial tumors (20 squamous cell carcinomas, 20 gastric adenocarcinomas, 20 transitional cell carcinomas and 15 non-neoplastic epithelia). These immunohistochemical results were compared with ultrastructural features of neoplastic diagnosis of squamous cell carcinoma, adenocarcinoma and transitional cell carcinoma, and estimation of degree of differentiation. The results are as follows : 1. The squamous epithelium, glandular epithelium and transitional epithelium disclosed the positive reaction for keratin. 2. Squamous cell carcinoma and transitional cell carcinoma exhibited positive reaction for keratin. 3. Gastric adenocarcinoma showed uniformly negative or weakly positive reaction for keratin. 4. On electron microscopy, heavy bundles of tonofilaments and desmosomes were more frequently encountered in well differentiated squamous cell carcinoma, In poorly differentiated squamous cell carcinoma, a few tonofibrils and desmosome were noted. 5. In the adenocarcinomas, the intermediate filaments were arranged randomly as nonaggregated, short filaments spread throughout the cytoplasm, although occasionally they formed a perinuclear whorl. These filaments did not become aggregated to form tonofilaments. 6. On the immunogold labeling for keratin of low molecular weight areas in gastric adenocinoma, in tense labeling of intermediate filaments for keratin was noted. From the above result, ultrastructural and immunohistochemical study on malignant epithelial cell were useful in differential diagnosis of squamous cell carcinoma, adenocarcinoma and transitional cell carcinoma, and estimation of degree of differentiation. It was also proved that immunogold labeling technique was especially valuable for diagnosis of vague case which showed negative or weakly positive reaction in immunohistochemical stain.

횡문근육종의 항암제-방사선치료 후 치아발육장애

고광준,홍성우,최선영 大韓口腔顎顔面 放射線學會 1998 Imaging Science in Dentistry Vol.28 No.1

This report details a case of 8-year-old girl showing failure of odontogenesis after chemo-radiation therapy for the rhabdomyosarcoma at the age of 4. The observed results were as follows: 1. Past history revealed that she had received for a total radiation dose of 4430cGy, 29 fractions in 6 weeks and chemotherapy with vincristine, actinomycin D and cytoxan, followed as maintenance phase for 2 years. 2. The patient was symptom-free and appointed for the treatment of multiple dental caries. 3. Oral examination showed hypoplastic enamel on whole erupted permanent teeth and showed retarded eruption. 4. Conventional radiograms showed failure of root development including abrupt cessation of root formation and root agenesis, and microdontia, missing teeth, irregular enamel, dislocation of the impacted teeth. Additional finding showed good healing bone pattern on the left mandibular ramus and angle area. 5. Cephalometric analysis revealed failure of bite raising due to incomplete eruption of all the first molars and made it possible to suspect entrapped mandibular growth and then Class Ⅱ tendency growth. 6. There was correlation between the time of chemo-radiation therapy and the damage of the teeth.

디밍 안정기를 이용한 형광등의 퍼지 제어기 설계

崔洪圭,全光鎬,姜太垠,崔琁雄 홍익대학교 산업기술연구소 1997 産業技術 Vol.7 No.-

This paper proposes Dimming Ballast illumination control method using fuzzy reasoning the proposed method has the following effects. First the power saving above 50% is accompanied by the automatic control of the illumination and the choice of a turn-on or -off of a fluorescent lamps that is accompanied by the number of person and working time and weather Second the maintainment of the best illumination in spite of time and weather variation. Third More simple establishment and low than BAS(Building Automation System) because need not main control unit or communication cable

영동지역 주요 3개 하천의 수질실태 및 관리에 관한 연구

박광하,민선홍,최봉종,전방욱 강릉대학교동해안지역연구소 1994 東海岸硏究 Vol.5 No.1

영동지방의 주요 3개 하천의 수질을 조사하고 QUAL-2E 모델을 적용하여 보았다. 강릉남대천은 각 수질항목에서 시기별, 정점별로 큰 차이를 보였으며, 일반적으로 상류의 수질은 하류로 갈수록 생활오수의 유입으로 수질이 악화되는 전형적인 양상을 나타내었다. 양양남대천은 강릉남대천 및 삼척오십천에 비하여 시기별 변이폭이 좁았으며 각 정점별의 수질도 양호한 것으로 나타났다. 삼척오십천은 시기별보다는 정점별 수질차이가 크게 나타났으며 오염된 상류의 수질이 자정작용에 의하여 개선되다가 다시 생활오수의 유입으로 인하여 악화되는 특이한 양상을 보였다. 모델링 결과 하천의 유속, 유량등의 실측 자료가 부족함에도 불구하고 강릉남대천과 양양남대천은 실측치와 예상치가 높은 상관관계를 나타내었다. 또한 이 모델을 사용하여 강릉남대천의 수질예측을 시도하였다. The water quality was monitored and QUAL-2E modelling was applied in three main stream of Youngdong area. Kangnung Namdaecheon was shown to be a typical stream that the downstream water quality was worse than in the upperstream. Water quality of Yangyang Namdaecheon was better than that of Kangnung Namdaecheon and Samchuk Osipcheon. The spatial variation of water quality was greater than the temporal variation in Samchuk Osipcheon: the polluted upperstream water got better in the midstream, but got worse gain in the downstream. Despite of the lack of suitable measurement data, Kangnung Namdaecheon and Ynagyang Namdaecheon showed good relationship between measured and obtained data: however Samchuk Osipcheon, which had many point sources and much pollution load, showed poor relationship. Based on this model, future water quality of Kangnung Namdaecheon was prospected.