국산 Lidocaine 알칼리화를 위한 Bicarbonate 혼합시 침전유발 최소량에 대한 고찰

이선호,김현수,곽인숙,안원식,최관호,김광민,손민제 대한마취과학회 2000 Korean Journal of Anesthesiology Vol.39 No.5

Background : When local anesthetics for regional anesthesia is used, usually small amounts of bicar-bonate are added for rapid onset. This addition gives the mixed solution a more alkaline pH. The following result is an increased unionized form of the local anesthetic and rapid penetration of the drug into tiissue. Unfortunately, no data about adequate mixing volumes of domestic lidocaine and bicarbonate is available. Methods : We examined six mixing pairs of two kinds of 2% lidocaines and three kinds of 8.4% bicarbonates for minimum volumes of bicarbonate to cause a precipitation of 2% 20 ml lidocaine. Results : The mean volumes of bicarbonate to cause precipitation were 1.54 ml for Kwang-Myung lidocaine with Kwang-Myung bicarbonate, 2.90 ml for Kwang-Myung lidocaine with Dae-Won bicarbonate, 2.73 ml for Kwang-Myung lidocaine with Je-Il bicarbonate, 0.97 ml for Je-Il lidocaine with Kwang-Myung bicarbonate, 1.26ml for Je-Il lidocaine with Dae-Won bicarbonate and 1.39 ml for Je-Il lidocaine with Je-Il bicarbonate. Conclusions : We conclude that the Kwang-Myung lidocaine and the Je-Il lidocaine could cause precipitation when mixing with a smaller bicarbonate volume than foreign textbook recommended. (Korean J Anesthesiol 2000; 39: 726-729)

Hypoxia-Responsive MicroRNA-101 Promotes Angiogenesis <i>via</i> Heme Oxygenase-1/Vascular Endothelial Growth Factor Axis by Targeting Cullin 3

Kim, Ji-Hee,Lee, Kwang-Soon,Lee, Dong-Keon,Kim, Joohwan,Kwak, Su-Nam,Ha, Kwon-Soo,Choe, Jongseon,Won, Moo-Ho,Cho, Byung-Ryul,Jeoung, Dooil,Lee, Hansoo,Kwon, Young-Guen,Kim, Young-Myeong Mary Ann Liebert 2014 Antioxidants & redox signaling Vol.21 No.18

<P>Aims: Hypoxia induces expression of various genes and microRNAs (miRs) that regulate angiogenesis and vascular function. In this study, we investigated a new functional role of new hypoxia-responsive miR-101 in angiogenesis and its underlying mechanism for regulating heme oxygenase-1 (HO-1) and vascular endothelial growth factor (VEGF) expression. Results: We found that hypoxia induced miR-101, which binds to the 3 ' untranslated region of cullin 3 (Cul3) and stabilizes nuclear factor erythroid-derived 2-related factor 2 (Nrf2) via inhibition of the proteasomal degradation pathway. miR-101 overexpression promoted Nrf2 nuclear accumulation, which was accompanied with increases in HO-1 induction, VEGF expression, and endothelial nitric oxide synthase (eNOS)-derived nitric oxide (NO) production. The elevated NO-induced S-nitrosylation of Kelch-like ECH-associated protein 1 and subsequent induction of Nrf2-dependent HO-1 lead to further elevation of VEGF production via a positive feedback loop between the Nrf2/HO-1 and VEGF/eNOS axes. Moreover, miR-101 promoted angiogenic signals and angiogenesis both in vitro and in vivo, and these events were attenuated by inhibiting the biological activity of HO-1, VEGF, or eNOS. Moreover, these effects were also observed in aortic rings from HO-1(+/-) and eNOS(-/-) mice. Local overexpression of miR-101 improved therapeutic angiogenesis and perfusion recovery in the ischemic mouse hindlimb, whereas antagomiR-101 diminished regional blood flow. Innovation: Hypoxia-responsive miR-101 stimulates angiogenesis by activating the HO-1/VEGF/eNOS axis via Cul3 targeting. Thus, miR-101 is a novel angiomir. Conclusion: Our results provide new mechanistic insights into a functional role of miR-101 as a potential therapeutic target in angiogenesis and vascular remodeling. Antioxid. Redox Signal. 21, 2469-2482.</P>

사례보고 : 하수오 복용 후 발생한 재발성 독성 간염 1예

배상훈 ( Sang Hoon Bae ),김동현 ( Dong Hyun Kim ),배영석 ( Young Seok Bae ),이광재 ( Kwang Jae Lee ),김동완 ( Dong Wan Kim ),윤정빈 ( Jeoung Bin Yoon ),홍준호 ( Joon Ho Hong ),김상현 ( Sang Hyun Kim ) 대한간학회 2010 Clinical and Molecular Hepatology(대한간학회지) Vol.16 No.2

Toxic hepatitis has been reported as a major cause of acute hepatitis, but its potential induction by herbal remedies and/or health foods is usually neglected. We experienced a case of toxic hepatitis associated with Polygoni multiflori, a Chinese herb commonly known as Ho-Shou-Wu. A 54-year-old woman consumed Ho-Shou-Wu for 1 month, after which she experienced fatigue and overall weakness. A diagnosis of toxic hepatitis was made based on her clinical history, the findings for viral markers and other laboratory data, and ultrasonography. Her condition improved considerably after she stopped taking Ho-Shou-Wu. However, she resumed taking Ho-Shou-Wu immediately after discharge from hospital, which aggravated her symptoms and liver function. She was immediately readmitted and stopped taking Ho-Shou-Wu. Her relapse into hepatitis immediate after resuming consumption of the herb is strongly indicative of the validity of Koch`s postulate in this case.

운동강도의 차이가 대장에서의 Heme oxygenase-1 발현에 미치는 영향: Oligonucleotide chip microarray analysis

최은주 ( Eun Ju Choi ),류호영 ( Ho Young Ryu ),차광석 ( Kwang Suk Cha ) 한국운동생리학회(구-한국운동과학회) 2012 운동과학 Vol.21 No.1

이 연구의 목적은 운동강도 차이에 의한 대장조직이 Heme oxygenase-1(HO-1)의 mRNA 발현에 어떠한 영향을 미치는지 규명하기 위해, Sprage-Dawley계 흰쥐를 대상으로 통제그룹(CON)과 저강도 운동그룹(LIE), 고강도 운동그룹(HIE)으로 구분하여 4주 동안 트레드밀운동 후 48시간 이후에 High through-put microarray analysis방법으로 다음과 같은 실험을 실시하였다. 본 실험은 Rat ABI oligo chip 26,857 개의 유전자 중 filtering을 통하여 12.079개 유전지를 선택하였고, 이 중 유의성 있는(p<.05) 유전자 12,072개를 선별하였으며, clustering분석 방법과 면역조직화학염색법에서도 HO-l이 운동강도에 따라 유의하게 발현하였다(p<.05). Microarray분석 후 RT-PCR로 확인한 결과 HO-I의 유전자 발현양상이 일치하는 결과를 얻었다. 이 실험의 결과로서 운동이 대장에서 HO-1 발현에 영향을 주는 것을 알 수 있었다. 운동이 대장에서의 mRNA 발현이 저강도 운동그룹(LIE)보다 고강도 운동그룹(HIE)에서 더 많이 발현되어지는 것으로 보아 고강도 운동에 의해 발생되는 산소라디칼을 HO-l의 유도를 통하여 적절히 제거함으로써 스스로 항상성을 유지하고 있는 것으로 생각되어진다. The purpose of this study is to identify how large intestine tissue effects to mRNA expression in Heme oxygenase-l (HO-1) due to differences in exercise intensity. To perform this experiment we divided Sprage-Dawley rats into 3 groups (control group (CON). low-intensity exercise group (LIE) and high-intensity exercise group (HIE)), and in 48 hours after 4 weeks treadmill exercise. the following experiment was performed with "High through-put micro array analysis methods" . 12,079 genes were chosen by filtering of the Rat ASI oligo chip 26.857 genes in this experiment Among 12.079 genes, we selected significant genes (p<.05) that were also expressed in the ways of clustering analysis and immunohistochemistry. With results of RT-PCR confirming and microarray analyzing, we derived that gene expression profiles of HO-l had been consistent. As a result of this experiment, we certainly identified that exercise effects to HQ-l expression in large intestine. mRNA expression was more expressed in high-intensity exercise group CHIE) than low-intensity exercise group (LIE), it seems that homeostasis maintains itself by properly removing oxygen radical. caused by high intensity exercise. through reduction of HO-l.

개의 상후두신경 뇌간유발반응에 대한 실험적 연구

김광문,김영호,김광문,김영호 대한이비인후과학회 1998 대한이비인후과학회지 두경부외과학 Vol.41 No.4

簡易精神診斷檢査(SCL-90)의 韓國版 標準化 硏究Ⅰ : 正常人의 反應特性

金光日,元鎬澤,李正浩,金光潤 大韓神經精神醫學會 1978 신경정신의학 Vol.17 No.4

In recent years, community mental health and medical welfare programs have been gradually emphasized. Accordingly shortage of man power in psychiatric profession becomes an important issue. As an effort for resolution of it, psychiatric rating scales have been developed to provide the time saving device for psychiatric practice. Symptom Checklist-90, a self-report psychiatric rating scale, has been proved to be not only an efficient but also reliable and valid diagnostic tool in psychiatric practice. This scale, developed by Derogatis and his colleagues, consists of 90 symptomatic items which reflect 9 symptom dimensions; somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, and psychoticism dimension. The purposes of this study are to provide Korean version of the SCL-90 and investigate normal response characteristics for it's standardization in Korea. The scales were administered to 199 urban subjects from Seoul and 221 rural subjects from 2 villages of Kyung-Buk and Chun-Buk provinces. Data of 420 subjects were divided into dichotomous subgroups in respect to sex, age (30year and over, and under 30 years), education (6th grade and under, 12th grade and upper), and residency(Seoul and rural) respectively. Each pair of dichotomous subgroups was compared for scale scores by analysis of variance. The results were as follows; 1. Considering sex difference, female subjects revealed significantly higher scores on all scales except hostility scale. 2. In subgroup, dichotomized by education, signjficant differences are seen 6 scales as somatization, obsessive compulsive, interpersonal sensitivity, depression, hostility and paranoid ideation. Somatization score is higher in lower educated group, whereas 5 other scales scores are higher in high educated group. 3. There were no significant difference between age subgroups except somatization scale, in that older group obtained higher scores than the younger. 4. In regional comparison, Seoul subjects obtained significantly higher scores on 7 scales except anxiety phobia and psychoticism scales. The results have been discussed and the authors suggest to separate sex norms for standardization of SCL-90. Further detailed research for preperation of several norms differred by educational and regional backgrounds is recommended.

급성 뇌경색 환자에서 경색 위치가 심근 효소치 상승에 미치는 영향

윤경호,박현영,박성욱,장혁,김요식,조광호,유남진,김남호,오석규,정진원 圓光大學校 醫科學硏究所 2003 圓光醫科學 Vol.18 No.2

중 · 근세 척법 어휘의 단위 의미 분석

이광호(Lee, Kwang-Ho),도희금(Do, Hee-Geum) 한국어문학회 2018 語文學 Vol.0 No.141

Arch교의 橫桁連結部 局部應力과 疲勞擧動에 관한 硏究

최광순,조호근,손영호,최광규 東亞大學校 建設技術硏究所 1997 硏究論文集 Vol.21 No.2

In this paper, the relation between the local stress and the fatigue behavior at gusset plate connected with main girder and floor beam in arch bridges was obtained. The conclusion was as follows : (1) In-plane bending moment and out-of-plane bending moment are higher than other internal stress resultants. (2) When a vehicle crosses the bridges, the change of out-of-plane bending moment corresponds with the change of relative difference in displacement in the longitudinal direction between the tie-girder and stringer. (3) The change of in-plane bending moment corresponds with the change of the displacement in the transverse direction of arch-rib. (4) Fatigue crack can be initiated by in-plane bending stress that is produced by out-of-plane bending moment at the toe of gusset plate. (5) Fatigue crack can be initiated by tension stress that is produced by in-plane bending moment at the toe of gusset plate.

최승자 시의 애도 주체와 젠더 정치학

이광호(Lee, Kwang-Ho) 한국시학회 2016 한국시학연구 Vol.- No.45

본 논문은 최승자 초기 시에서의 ‘애도의 주체’를 분석하면서 그 미학적 특이성과 젠더 정치학의 문제를 제기하고자 한다. 최승자의 시는 애도의 주체가 ‘낳은 주체’ 즉 존재를 ‘생성’하고 ‘이행’시키는 존재가 되는 시적인 과정을 드러낸다. ‘너’와 함께 한 시간의 상실 앞에서 시적 주체는 기억을 보존하는 방식으로 ‘부재’속에 머문다. 기억은 몸에 새겨져 지워질 수 없는 것으로 재구성되고, 기억의 주체는 그 ‘주체화’의 자리에서 내려와 기억에 대해 수동적인 위치에 처하게 된다. 기억의 윤리학은 몸에 새겨진 시간을 ‘기억할 수밖에 없는’ 존재로서의 ‘이중 애도’의 주체가 된다. 기억의 주체가 ‘낳은 주체’로 전환될 때, 죽어 가는 ‘여성-몸’은 애도의 예외적인 형식을 드러낸다. 죽은 여성의 몸과 ‘사산’된 존재에 대한 애도는, ‘여성-몸’이 만드는 다른 생산의 ‘(불)가능성’으로 전환된다. 애도는 죽음을 넘어서는 ‘여성-몸’의 혁명적인 상상력과 조우한다. ‘낳는 주체’로서의 ‘여성-몸’의 잠재성은, 하나의 존재를 다른 존재로 ‘이행’시키는 것이며, 애도 주체로서의 여성 주체는 통과제의적인 장소가 된다. 최승자의 초기 시의 여성 주체는 시의 언어들 속에서 구성된 애도의 ‘수행자(遂行者)’로서의 시적 주체이다. 이 애도의 주체는 사랑과 기억의 대상을 포기하기를 거부하며, ‘죽은 몸’이 대상을 ‘다시 낳는’ 행위를 통해 대상을 ‘내’ 안에서 재생성한다. ‘낳은 주체’는 모성의 이데올로기로서의 여성을 규정하는 것이 아니라, ‘낳은 행위’ 자체를 통해 애도의 주체를 재구성한다. 정상적인 애도의 경제학이 애도를 탈정치화한다면, 최승자의 시적 주체는 제도화되고 권력화된 젠더 시스템을 파열시키고 애도를 재정치화 한다. This research aimed at re-contextualizing the problem of the esthetic specialty and gender politics while analyzing "the subject of condolence" in Choi, Seung-Ja"s early poem. Choi, Seung-Ja"s poem reveals the poetic process that becomes a being that "creates" and "transmits" the "born subject", i.e. the existence that the subject of condolence gave birth. At the loss of time with "you", poetic subject remains in "absence" in the method of preserving the memory. Memory is recomposed as something that cannot be erased by being carved in body, and the subject of memory stays in the passive position in memory by descending from the position of that "subjectivation". Ethics of memory becomes the subject of "double condolence" as the being that "cannot but remember" the time carved in body. When the subject of memory is changed to "the subject that gave birth", dying "woman-body" reveals the exceptional form of condolence. Condolences on dead woman"s body and "stillborn" being is changed to "(im)possibility" of another production and revolution that "woman-body" makes. Condolence encounters revolutionary imagination of "woman-body" beyond death. Potential of "woman-body" as "the subject that gives birth" "transmits" an existence to another one, and the woman subject as the subject of condolence becomes the place of passage offer. Woman subject in Choi, Seung-Ja"s early poem is the poetic subject as the "performer (遂行者)’ of condolence composed in poetic languages. Subject of this condolence refuses to give up the object of love and memory, and regenerate the object in "me" through the act of ‘giving birth to the object again’ of ‘dead body’. ‘Birth giving subject’ does not define woman category as the ideology of mother, but recomposes the subject of condolence through ‘birth giving act’ itself. If the economics of normal condolence ex-politicizes condolence, Choi, Seung-Ja"s poetic subject ruptures institutionalized and authorized gender system and re-politicizes condolence.