Mouse에서의 Deoxynivalenol이 면역글로브린에 미치는 영향

이국천 ( Kuk Cheon Lee ),이주홍 ( Ju Hong Lee ),손성기 ( Sung Gi Son ),주영국 ( Young Kuk Joo ) 한국가축위생학회 1992 韓國家畜衛生學會誌 Vol.15 No.2

Mice were fed semi-purified diets containing 0, 2, 10 and 25 ppm(mg/kg) deoxynivalenol over 8 weeks and were assessed for effects on bodyweight gain, serum immunolgiobulin levels and surface immunoglobulin bearing lymphocyte ratio. 1. The rate of body-weight gain was significantly reduced (p<0.05) at the 10 and 25 ppm of DON, whereas the mice ingesting the diet containing 2 ppm DON was not. 2. IgA in serum immunolgiobulin was significantly increased (P<0.05) at the 10 and 25 ppm of DON, but IgG, IgM were decreased, whereas exposure to 2 ppm DON was not change. 3. Concentration of IgA from Peyer`s patch of mice fed DON exhibited increased at 10, 25 ppm. 4. Lymphocytes surface marker studies revealed that IgA, IgG and IgM were 2.2%, 0.4% and 1.5% respectively. These results suggest that dietary exposure to DON alters regulation of IgA production.

정상안에서 우세안과 비우세안 사이의 시신경유두주위 빛간섭단층혈관조영 측정치의 대칭성

류천국(Cheon Kuk Ryu),임형빈(Hyung Bin Lim),김정열(Jung Yeul Kim) 대한안과학회 2021 대한안과학회지 Vol.62 No.11

목적: 주시안과 비주시안이 빛간섭단층촬영 및 시신경유두주위 빛간섭단층혈관조영술 측정치에 미치는 영향을 분석해보고자 하였다. 대상과 방법: 안과 질환이 없는 성인을 대상으로 촬영한 빛간섭단층촬영 및 빛간섭단층혈관조영술을 분석하였다. ‘Hole-in-the-card test’를 시행하여 주시안을 확인하였다. 시신경유두주위에 4.5 x 4.5 mm scan을 시행하여 시신경유두주위 관류밀도 및 플럭스 지수를 측정하였으며, 중심황반두께 및 신경절세포층 및 내망상층, 망막신경섬유층 두께 역시 측정하였다. 주시안과 비주시안의 빛간섭단층촬영, 빛간섭단층혈관조영술 측정값을 비교 분석하였다. 결과: 42명 84안이 포함되었다. 대상군의 평균 나이는 27.3 ± 5.63세였으며, 주시안은 우안 28안(66.7%), 좌안이 14안(33.3%)이었다. 빛간섭단층촬영검사에서 주시안과 비주시안 간의 중심황반두께(260.00 ± 14.16 μm, 258.71 ± 15.18 μm, p=0.183), 신경절세포층 및내망상층 복합체두께(82.02 ± 5.07 μm, 82.43 ± 5.60 μm, p=0.460), 망막신경섬유층 두께(99.36 ± 9.27 μm, 97.90 ± 9.46 μm, p=0.091)에 유의한 차이가 없었다. 또한, 빛간섭단층혈관조영술검사의 시신경 주위 표층모세혈관망의 관류 밀도(44.62 ± 5.25%, 45.60 ± 2.27%, p=0.221), 플럭스 지수(0.455 ± 0.020, 0.449 ± 0.028, p=0.060)에서도 통계적인 차이는 확인되지 않았다. 결론: 빛간섭단층촬영 및 빛간섭단층혈관조영술의 측정치는 주시안과 비주시안 사이에 유의한 차이를 보이지 않았으며 따라서 주시안을 확인하는 데 이용할 수 있는 인자로서의 의미는 찾을 수 없었다. Purpose: To assess whether optical coherence tomography (OCT) measurements and peripapillary microvascular parameters measured via optical coherence tomography angiography (OCTA) were similar between the dominant and non-dominant eyes of normal subjects. Methods: We retrospectively analyzed spectral domain OCT and OCTA data on healthy Koreans. The “hole-in-the-card” technique was used to determine ocular dominance. The perfusion density (PD) and flux index (FI) of the peripapillary 4.5 × 4.5-mm area were measured via OCTA. Central macular, peripapillary retinal nerve fiber layer, and macular ganglion cell-inner plexiform layer thicknesses were measured with the aid of spectral-domain OCT. The OCT and OCTA data of dominant and non-dominant eyes were compared. Results: A total of 84 eyes of 42 healthy subjects were analyzed. The average age was 27.3 ± 5.63 years. Twenty-eight subjects (66.7%) were right eye-dominant and 14 (33.3%) left eye-dominant. None of the central macular (260.00 ± 14.16 μm, 258.71 ± 15.18 μm, p = 0.183), macular ganglion cell-inner plexiform layer (82.02 ± 5.07 μm, 82.43 ± 5.60 μm, p = 0.460), or peripapillary retinal nerve fiber layer thickness (99.36 ± 9.27 μm, 97.90 ± 9.46 μm, p = 0.091) differed between the eyes; neither did any OCTA-assessed microvascular parameter. Conclusions: No OCT or OCTA parameter differed between dominant and non-dominant eyes. No parameter identified ocular dominance.

Prevalence and Infection Intensity of Zoonotic Trematode Metacercariae in Fish from Soyang-cheon (Stream), in Wanju-gun, Jeollabuk-do, Korea

Woon-Mok Sohn,Byoung-Kuk Na,Shin-Hyeong Cho,Jung-Won Ju,Cheon-Hyeon Kim,Min-Ah Hwang,Kyeong-Woo No,Jong-Ho Park 대한기생충학열대의학회 2021 The Korean Journal of Parasitology Vol.59 No.3

Fabrication and Characterization of Alumina/Silver Nanocomposites

Cheon, Seung-Ho,Han, In-Sub,Woo, Sang-Kuk The Korean Ceramic Society 2007 한국세라믹학회지 Vol.44 No.7

Alumina/silver nanocomposites were fabricated using a soaking method through a sol-gel route to construct an intra-type nanostructure. The pulse electric-current sintering (PECS) technique was used to sinter the nanocomposites. Several specimens were annealed after sintering. The microstructure, mechanical properties, critical frontal process zone (FPZ) size, and thermo-mechanical properties of the nanocomposites were estimated. The relative densities of the specimens sintered at 1350 and $1450^{\circ}C$ were 95% and 99%, respectively. The maximum value of the three-point bending strength was found to be 780 MPa for the $2{\times}2{\times}10 mm$ specimen sintered at $1350^{\circ}C$. The fracture toughness of the specimen sintered at $1350^{\circ}C$ was measured to be $3.60 MPa{\cdot}m^{1/2}$ using the single-edge V-notched beam (SEVNB) technique. The fracture mode of the nanocomposites was transgranular, in contrast to the intergranular mode of monolithic alumina. The fracture morphology suggested that dislocations were generated around the silver nanoparticles dispersed within the alumina matrix. The specimens sintered at $1350^{\circ}C$ were annealed at $800^{\circ}C$ for 5 min, following which the maximum fracture strength became 810 MPa and the fracture toughness improved to $4.21 MPam^{1/2}$. The critical FPZ size was the largest for the specimen annealed at $800^{\circ}C$ for 5 min. Thermal conductivity of the alumina/silver nanocomposites sintered at $1350^{\circ}C$ was 38 W/mK at room temperature, which was higher than the value obtained with the law of mixture.

재순환에 의한 한국형 Biofilter System의 질소ㆍ인 제거

전기설 ( Cheon Gi-seol ),권순국 ( Kwun Soon-kuk ) 한국농공학회 2003 한국농공학회 학술대회초록집 Vol.2003 No.-

A Korean Type Biofilter system combined with a conventional anoxic tank(septic tank) process was investigated in regard to its feasibility for removing organic as well as nutrients from the rural wastewater in Korea. At recirculation, the removal rate in BOO and SS increased slightly as much as 93 and 95% compared with nonrecirculation system. On the other hand, removal rates of the total nitrogen(T-N) and total phosphorous(T-P) in recirculation system increased significantly as much as 62 and 57%, respectively compared with non-recirculation system. The recirculation system provides sufficient treatment to improve the removal rate in T-N and T-P.

만경수역의 해수유통으로 인한 조간대 면적변화 추정

전기설 ( Cheon Gi-seol ),박영욱 ( Park Yeong-wook ),권순국 ( Kwun Soon-kuk ) 한국농공학회 2002 한국농공학회 학술대회초록집 Vol.2002 No.-

A simulation by the TOPAS model, two dimensional finite difference model was performed on the flows through drainage lock gate for the Saemangeum tidal reclamation project. Analysis focus on the changes of intertidal zone areas according to the operation scheme of the gate. The intertidal zone areas were analyzed as 66~70㎢ when the opening of the gate was 300 m. It occupied about 85~90% of intertidal zone areas compared to that the Mangyung sea basin was opened without sea-dike. It appeared to be the most effective in terms of securing enough intertidal zone areas when the gate was operated as inflowing sea-water after 2 day's drainage.

Bacillus sp. E1이 생성하는 Cytlodextrin Glucanotransferase의 정제 및 특성

박천석,우의전,국승욱,서병철,박관화,임훈 한국산업미생물학회 1992 한국미생물·생명공학회지 Vol.20 No.2

Cyclodextrin glucanotransferase 생성균주 선발배지를 이용하여 국내 토양으로부터 CGTase 활성이 우수한 Bacillus sp. E1 균주를 분리하였다. FPLC를 이용하여 gel filtration과 anion exchange column chromatography를 한 결과 순수 정제된 단일 단백질을 얻을 수 있었으며, 정제된 효소의 최적 작용 pH 범위는 6에서 8까지였고, 온도는 60℃에서 최적을 나타냈다. 정제된 단백질의 분자량은 114,000, 등전점은 4.3이었다. 생성된 cyclodextrin은 β-와 γ-cyclodextrin이 주였으며, 특이하게도 α-cyclodextrin은 거의 생성되지 않았다. 작용 후 25시간 후 최대의 β-cyclodextrin이 생성되었으며, 이때 β-cyclodextrin과 γ-cyclodextrin의 생성비율은 7:1이었다. Bacillus sp. was isolated from soil for its strong activity of cyclodextrin glucanotransferase (CGTase, EC 2.4.1.19). The enzyme was purified by gel filtration and anion exchange column chromatography using FPLC. The purified enzyme exhibited its maximum CGTase activity in the pH range of 6∼8 and the temperature range of 5O∼70℃ The molecular weight was estimated as 114,000 by SDS-PAGE. The isoelectric point of the enzyme was 4.3. The CGTase of Bacillus sp. El produced β-cyclodextrin mainly and did not produce α-cyclodextrin. The product ratio of β-cyclodextrin to γ-cyclodextrin was 7:1.

Effectiveness of [124I]-PET/CT and [18F]-FDG-PET/CT for Localizing Recurrence in Patients with Differentiated Thyroid Carcinoma

이잔디,Kuk Young Nah,Ra Mi Kim,Yeon-Ju Oh,Young-Sil An,Joon-Kee Yoon,Gwang Il An,최태현,Gi Jeong Cheon,Euy-Young Soh,정웅윤 대한의학회 2012 Journal of Korean medical science Vol.27 No.9

Although the prognosis of patients with differentiated thyroid carcinoma (DTC) is generally encouraging, a diagnostic dilemma is posed when an increasing level of serum thyroglobulin (Tg) is noted, without detection of a recurrent tumor using conventional imaging tools such as the iodine-131 whole-body scanning (the [131I] scan) or neck ultrasonography (US). The objective of the present study was to evaluate the diagnostic value of [124I]-PET/CT and [18F]-FDG-PET/CT in terms of accurate detection of both iodineand non-iodine-avid recurrence, compared with that of conventional imaging such as the [131I] scan or neck ultrasonography (US). Between July 2009 and June 2010, we prospectively studied 19 DTC patients with elevated thyroglobulin levels but who do not show pathological lesions when conventional imaging modalities are used. All involved patients had undergone total thyroidectomy and radioiodine (RI) treatment, and who had been followed-up for a mean of 13 months (range, 6-21 months) after the last RI session. Combined [18F]-FDG-PET/CT and [124I]-PET/CT data were evaluated for detecting recurrent DTC lesions in study patients and compared with those of other radiological and/or cytological investigations. Nine of 19 patients (47.4%) showed pathological [18F]-FDG (5/19, 26.3%) or [124I]-PET (4/19, 21.1%) uptake, and were classed as true-positives. Among such patients, disease management was modified in six (66.7%) and disease was restaged in seven (77.8%). In particular, the use of the described imaging combination optimized planning of surgical resection to deal with locoregional recurrence in 21.1%(4/19) of patients, who were shown to be disease-free during follow-up after surgery. Our results indicate that combination of [18F]-FDG-PET/CT and [124I]-PET/CT affords a valuable diagnostic method that can be used to make therapeutic decisions in patients with DTC who are tumor-free on conventional imaging studies but who have high Tg levels.

소규모 오수처리 시스템에서의 제올라이트에 의한 질소 제거

방천희 ( Bang Cheon Hee ),권순국 ( Kwun Soon Kuk ) 한국농공학회 2002 韓國農工學會誌 : 전원과 자원 Vol.44 No.2

Recently, absorbent biofilters, which are inexpensive and easy to manacle, have been supplied to the rural areas, but have limitations in removing the nutrients effectively. Accordingly, as an alternative plan. natural zeolites were arranged in front or at the rear of the absorbent biofilters, and their removal efficiency for nitrogen and, ultimately, their applicability to the on-site wastewater treatment system were studied. Furthermore, the same experiments were carried out on artificial zeolites, made from coal ashes at National Honam Agricultural Experiment Station, to compare natural zeolites with artificial ones. Treated wastewater through the Absorbent Biofilter showed 22.6% nitrogen removal efficiency, while 64.6% was attained when natural Zeolites were placed in front of the absorbent biofilters (Zeolite-Aerobic process). As an addition, phosphorus was also efficiently removed. On the other hand, Aerobic-Zeolite process, which arranged natural zeolites at the rear of the biofilters, did not have significantly higher nitrogen removal as compared to the treatment using only the absorbent biofilters. Furthermore, upon regeneration of the natural zeolite, the ion exchange rate was fecund to increase over 10% as compared to before regeneration. Our results show that natural zeolites, applied to the on-site wastewater treatment system through the Zeolite-Aerobic process, not only increase the removal efficiency of nutrients, but, by choosing the appropriate regeneration time, can also be cast-effective. Artificial zeolites, on the other hand, though more efficient in removing nutrients, cannot be regenerated and, therefore, are not cost-effective.

식도이물에 의한 식도천공 및 식도주위농양의 1례

김일국,장천기,김형훈,조중환 釜算慶南耳鼻咽喉科學會 1991 임상이비인후과 Vol.2 No.1