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개의 신장기능(腎臟機能)에 대(對)한 Serotonin의 작용(作用)
서병철,Sub, Byoung-Chul 대한약리학회 1966 대한약리학잡지 Vol.2 No.1
The action of serotonin (5-Hydroxytryptamine) on the excretory function of the kidney was investigated in the dog, utilizing the clearance method and the stop-flow technique. It was shown that serotonin, $10{\mu}g/kg/min$, i. v., exerts a marked antidiuretic effects and elicits a marked hemodynamic changes in the kidney: a highly significant decrease of the glomerular filtration rate and a tendency of decrement in the renal plasma flow. Little change in the systemic blood pressure was noted, and the participation of the antidiuretic hormone in the antidiuretic action was ruled out by adding vasopressin to the infusion fluid. The stop-flow analysis showed that there is no evidence of altered activity in the tubules by serotonin. It was thus concluded that serotonin elicits anti diuresis in the dog by decreasing glomerular filtration rate, which results from the constriction of Vas afferens in the glomeruli.
신세뇨관기능(腎細尿管機能)에 미치는 Bradykinin의 영향(影響)
서병철,Sub, Byoung-Chul 대한약리학회 1966 대한약리학잡지 Vol.2 No.1
In this study the influence of Bradykinin, a biogenic polypeptide, on the excretory function of the dog kidney was investigated, utilizing the clearance and stop-flow method. The results are summarized as follows; 1) Bradykinin administered intravenously elicited a marked antidiuresis. 2) When given into the renal artery, however, prompt increase of the urine flow, sodium excretion and free water clearance without significant change in the glomerular filtration rate ensued. 3) It was also effective during an osmotic diuresis with 10% Mannitol infusion, though the response was not so marked. 4) The stop-flow experiment showed that sodium reabsorption in the proximal tubules is inhibited by the infusion of bradykinin into the renal artery. It was thus concluded that the diuretic effect of bradykinin given intra-arterially results from the inhibition of sodium transport in the proximal tubules.
C. S. 루이스의 『사자, 마녀 그리고 옷장』: 판타지 공간의 구조
서병철 한국중앙영어영문학회 2015 영어영문학연구 Vol.57 No.4
The purpose of this paper is to examine the fantastic space in The Lion, the Witch and the Wardrobe and to investigate its narrative strategy accordingly. The fantastic space means the relationship between the real world and the fantastic world. The real world and the fantastic world present in The Lion, the Witch and the Wardrobe are separated, in which characters leave from their real world and pass through a passage into the fantastic world. The portrayal of the setting tends to be delicate and elaborate, because the fantastic world and the real world are kept strictly demarcated. The fantastic space of The Lion, the Witch and the Wardrobe can affect the narrative strategy and also be a form from which ideological messages emerge. The structure of the fantastic space of The Lion, the Witch and the Wardrobe can determines the implementation of the story elements such as setting, magic and time. In light of children’s literature, the structure of fantastic space in The Lion, the Witch and the Wardrobe can provide literary pleasure and include some moral messages to the child readers. Through the adventure which the characters experience, the child readers could have the ability that they could deal with their realistic problems encountered in their life.