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Total Knee Arthroplasty: Is It Safe? A Single-Center Study of 4,124 Patients in South Korea
Kyunga Ko,Kee Hyun Kim,Sunho Ko,Changwung Jo,Hyuk-Soo Han,Myung Chul Lee,Du Hyun Ro 대한정형외과학회 2023 Clinics in Orthopedic Surgery Vol.15 No.6
Background: Although total knee arthroplasty (TKA) is considered an effective treatment for knee osteoarthritis, it carries risks of complications. With a growing number of TKAs performed on older patients, understanding the cause of mortality is crucial to enhance the safety of TKA. This study aimed to identify the major causes of short- and long-term mortality after TKA and report mortality trends for major causes of death. Methods: A total of 4,124 patients who underwent TKA were analyzed. The average age at surgery was 70.7 years. The average follow-up time was 73.5 months. The causes of death were retrospectively collected through Korean Statistical Information Service and classified into 13 subgroups based on the International Classification of Diseases-10 code. The short- and long-term causes of death were identified within the time-to-death intervals of 30, 60, 90, 180, 180 days, and > 180 days. Standard mortality ratios (SMRs) and cumulative incidence of deaths were computed to examine mortality trends after TKA. Results: The short-term mortality rate was 0.07% for 30 days, 0.1% for 60 days, 0.2% for 90 days, and 0.2% for 180 days. Malignant neoplasm and cardiovascular disease were the main short-term causes of death. The long-term (> 180 days) mortality rate was 6.2%. Malignant neoplasm (35%), others (11.7%), and respiratory disease (10.1%) were the major long-term causes of death. Men had a higher cumulative risk of death for respiratory, metabolic, and cardiovascular diseases. Age-adjusted mortality was significantly higher in TKA patients aged 70 years (SMR, 4.3; 95% confidence interval [CI], 3.3–5.4) and between 70 and 79 years (SMR 2.9; 95% CI, 2.5–3.5) than that in the general population. Conclusions: The short-term mortality rate after TKA was low, and most of the causes were unrelated to TKA. The major causes of long-term death were consistent with previous findings. Our findings can be used as counseling data to understand the survival and mortality of TKA patients.
사료내 쑥 첨가가 육체의 성장률, 영양소 이용율, 복강내 지방에 미치는 영향
Lee Sung-Jin,Song Ki-Duk,Ko Yung-Du,Kim Chang-Hyun 한국유기농업학회 2010 韓國有機農業學會誌 Vol.18 No.3
This study was carried out to investigate the effects of wormwood (Artemisia sp.) addition on the growth performance, nutrients utilization and abdominal fat deposition of broiler chickens. Two hundred twenty five and two-day old Arboracre strain male commercial broiler chicks were distributed to 5 treatments with wormwood supplementation levels; C(0%), T₁ (1%), T₂ (3%), T₃ (5%), and T₄ (10%) and with 3 replications each with 5 birds for five weeks. Body weight gain during the experiment was improved in T₁ (1723.0g) compared with that of T₃ (1557.7g) and T₄ (1450.7g) (P<0.05). Feed intake was significantly (P<0.05) increased as the levels of wormwood addition increased (C: 2653.8g, T₁: 2852.0, T₂: 2900.3, T₃: 2900.7g, T₄: 2954.7g). Feed conversion rate (feed/gain) was significantly (P<0.05) increased as the levels of wormwood addition increased (C: 1.55, T₁: 1.66, T₂: 1.70, T₃: 1.86, T₄: 2.04). The days reaching to 2.0㎏ of body weight were expected to be 43.2 days in control, whereas those of group T₁ were reduced to 42.6 days by 0.6 day from control. Nutrient utilization and abdominal fat deposition in the experiment were significantly decreased (P<0.05) and small intestine contents in the broilers was significantly increased (P<0.05) as the levels of wormwood addition increased. Therefore, although there was no significant improvement for the performance of broiler chickens with the dietary supplementation of wormwood meal, less than 1% addition of wormwood to broiler diets might have beneficial for human health by reducing the abdominal fat deposition of the broiler chickens.
증례 : 호흡기 ; 아시트레틴 투여로 발생한 간질성 폐렴 1예
김성두 ( Sung Du Kim ),김윤정 ( Yoon Jeong Kim ),고석찬 ( Seouk Chan Ko ),이호준 ( Ho Jun Lee ),최재필 ( Jae Phil Choi ),이헌 ( Heon Lee ),김수현 ( Su Hyun Kim ) 대한내과학회 2011 대한내과학회지 Vol.80 No.2S
저자들은 농포성 건선으로 아시트레틴 투여 후 발생한 간질성 폐렴 환자를 경험하여 문헌고찰과 함께 보고하는 바이다. Retinoids are effective systemic agents in the treatment of psoriasis. Acitretin, a synthetic aromatic derivative of retinoic acid, has replaced etretinate in retinoid therapy of psoriasis because of its more favorable pharmacokinetic profile, including a significantly shorter half-life. Most of the adverse effects associated with acitretin are teratogenicity, hepatotoxicity, pseudotumor cerebri, pancreatitis, hyperlipidemia, hyperostosis, and mucocutaneous side effects. There are two reports worldwide describing patients who developed acute respiratory distress syndrome associated with acitretin. This suggests the possibility of serious lung complications associated with acitretin. We report a case of a 61-year-old man who developed interstitial pneumonitis that might have been induced by acitretin during the treatment of pustular psoriasis. In these cases, immediate withdrawal of retinoic acid is necessary, and corticosteroid therapy should be considered. (Korean J Med 2011;80:S183-S187)
A New Malting Barley Variety with Early Maturity, Lodging Resistance, and Good Quality "Daeabori"
Jong Nae Hyun,Sang Ik Han,Dong Su Park,Jong Min Ko,Duck Yong Suh,Soon Jong Kweon,Sae Jung Suh,Du Chul Shin,Huhn Pal Moon 한국육종학회 2002 한국육종학회지 Vol.34 No.4
A new malting barley variety, 'Daeabori', was developed from cross between Jinkwangbori/Milyang 46 and Mihogolden, a good quality, by the barley breeding team in the National Yeongnam Agricultural Experiment Station(NYAES) in 2001. An elite line, YMB1503
Kim, Hae An,Lee, Hyun Jung,Hong, Ja Hye,Moon, Hyo Jung,Ko, Du Young,Jeong, Byeongmoon AMERICAN CHEMICAL SOCIETY 2017 Biomacromolecules Vol. No.
<P>Pluronics F127 (P, PEG-PPG-PEG triblock copolymer) was coupled with diphenylalanine (FF) to prepare FF-end-capped Pluronics (FFPFF). With increasing temperature from 10 to 60 degrees C, the FFPFF self-assembled to vesicles in water. The unimer-tovesicle transition accompanies endothermic enthalpy of 53.9 kcal/mol. Aqueous P and FFPFF solutions exhibited thermogelation in 15.0-24.0 wt %. The gel phase of FFPFF was stable up to 90 degrees C, whereas that of P turned into a sol again at 55-86 degrees C, indicating that end-capping with FF improved the gel stability against heat. In addition, the carboxylic acids of the FF end-groups can form coordination bonds with metal ions, and the gel modulus at 37 degrees C increased from 1521 KPa (P) to 20-25 KPa (FFPFF) to 24-28 KPa (FFPFF-Zn), and the duration of gel against water-erosion increased from 24 h (P) to 60 h (FFPFF-Zn), leading to a useful biomaterial for sustained drug delivery. The FFPFF-Zn gels implanted in the rats' subcutaneous layer induced a mild inflammatory responses. Contrary to the previous end-capping of Pluronics by poly(lactic acid), polycarprolactone, carboxylic acid, and so on that weakened the gel stability, the diphenylalanine end-capping strengthened the stability of Pluronics gel against heat and water erosion. This paper suggests that the control of polymer nanoassemblies directed by FF end-groups improves the mechanical properties and stability of the resulting thermogel and, thus, provides a useful drug delivery carrier with prolonged durability.</P>
ELS: 유비쿼터스 센서 네트워크를 위한 GPS 기반의 효율적인 위치인지 기법
윤재근(Jae Keun Yun),고두현(Du Hyun Ko),김범진(Bum Jin Kim),안순신(Sun Shin Ahn) 대한전기학회 2010 전기학회논문지 Vol.59 No.1
The problem of location awareness in wireless sensor networks where nodes use GPS (Global Positioning System), remains challenging problem, when considering the required large energy consumption during the localization phase. In this paper we designed hardware for GPS based localization and propose a framework, called ELS, to consume low cost energy. In the ELS framework, sensor nodes are equipped with GPS. Because GPS spends large energy for position awareness, conventional localization algorithms cannot use GPS-device. We try to find a solution for efficient energy expenditure of GPS. Finally, we derive optimal transmission power of GPS data and a scheme of localization through experiment and simulation.
KSNR Clinical Consensus Statements: Rehabilitation of Patients with Parkinson's Disease
KSNR PD Writing Group,김두영,Hyun Mi Oh,복수경,장우혁,최용민,전민호,한수정,한태륜,Sungju Jee,정세희,정한영,Tae-Du Jung,김민욱,Eun Joo Kim,김형섭,김연희,김용욱,김덕용,Dae Yul Kim,김돈규,고성화,Myoung-Hwan Ko,이주강,이종민,이성재,이삼규,임성훈,오병모,백남종,박기덕,박시운,박근영,박 대한뇌신경재활학회 2020 뇌신경재활 Vol.13 No.2
Clinical consensus statements (CCSs) aim to improve care for patients with Parkinson's disease (PD) and reduce the variability of rehabilitation methods in clinical practice. A literature search was conducted to find available evidence on the rehabilitation of patients with PD and to determine the scope of CCSs. The selection of PD rehabilitation domains and key questions was done using the modified Delphi method in 43 expert panels. These panels achieved a consensus on 11 key questions regarding rehabilitation assessment and goal setting, gait and balance, activities of daily living, and swallowing and communication disorders. After the completion of an agreement procedure, 11 key consensus statements were developed by the consensus panel. These statements addressed the needs of rehabilitation as a continuum in patients with PD. They included the appropriate rehabilitation initiation time, assessment items, rehabilitation contents, and complication management. This agreement can be used by physiatrists, rehabilitation therapists, and other practitioners who take care of patients with PD. The consensus panel also highlighted areas where a consensus could not be reached. The development of more focused CCS or clinical practice guidelines that target specific rehabilitation approaches is considered the next needed step.