Original Article : Geographic difference of epidemiological features of HCV infection in Korea

( Kyung Ah Kim ),( Sook Hyang Jeong ),( Eun Sun Jang ),( Young Seok Kim3 ),( Youn Jae Lee ),( Eun Uk Jung ),( In Hee Kim ),( Sung Bum Cho ),( Mee Kyung Kee ),( Chun Kang ) 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.4

Background/Aims: The prevalence of hepatitis C virus (HCV) infection in Korea exhibits significant geographic variation, with it being higher in Busan and Jeonam than in other areas. The reason for this intranational geographic difference was investigated in this study by conducting a comparative analysis of the risk factors related to HCV infection among three geographic areas: the capital (Seoul), Busan, and the province of Jeolla. Methods: In total, 990 patients with chronic HCV infection were prospectively enrolled at 5 university hospitals located in Seoul (n=374), Busan (n=264), and Jeolla (n=352). A standardized questionnaire survey on the risk factors for HCV infection was administered to these three groups of patients, and a comparative analysis of the findings was performed. Results: The analysis revealed significant regional differences in exposure to the risk factors of HCV infection. By comparison with patients in Seoul as a control group in the multivariate analysis, patients in Busan had significantly more experience of invasive medical procedures, acupuncture, cosmetic procedures, and multiple sex partners. In contrast, patients in Jeolla were significantly older, and they had a higher prevalence of hepatocellular carcinoma, a lower prevalence of multiple sex partners, and had experienced fewer invasive procedures. Conclusions: There was a significant geographic difference in the exposure to potential risk factors of HCV infection between patients from the three studied regions. This may explain the regional variation of the prevalence of HCV infection in Korea, and should be taken into account when planning strategies for the prevention and management of HCV infection. (Clin Mol Hepatol 2014;20:361-367)

Validity and Reliability of Cognitive Assessment Using Virtual Environment Technology in Patients with Stroke

Ku, Jeonghun,Lee, Jang Han,Han, Kiwan,Kim, Sun I.,Kang, Youn Joo,Park, Eun Sook Wolters Kluwer Health, Inc. All rights reserved. 2009 AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITA Vol.88 No.9

Ku J, Lee JH, Han K, Kim SI, Kang YJ, Park ES: Validity and reliability of cognitive assessment using virtual environment technology in patients with stroke. OBJECTIVES:: We assessed the validity and reliability of a virtual environment technology (VET)-based cognitive assessment program that was developed as a measurement tool of cognitive abilities in patients after a stroke. DESIGN:: Twenty participants diagnosed with stroke caused by unilateral brain lesions were enrolled to assess the VET program’s validity and test-retest reliability. Participants underwent evaluation by paper-based neuropsychological tests including the Korean Mini-Mental Status Examination, the Korean-Wechsler Adult Intelligence Scale, the Motor Free Visual Perception Test, Rey-Kim Memory Test, and Kim’s Frontal-Executive Neuropsychologic Test as well as the VET-based cognitive assessment. Major variables and indices of the VET program were calculated. The VET program validity was evaluated using a simple correlation analysis between variables from the VET program and conventional paper-based neuropsychological measurements, and the reliability was evaluated by investigating the test-retest correlation coefficients. RESULTS:: Major variables and indices of the VET program in patients with stroke correlated significantly with the related scores of paper-based neuropsychological tests. In addition, the test-retest reliability analysis revealed that the correlation coefficients ranged from 0.528 to 0.926. CONCLUSION:: The VET-based cognitive assessment program showed adequate reliability and validity as a method of cognitive assessment in patients after stroke.

관동맥 우회로술 중 경식도 심초음파도로 관찰한 도부타민 투여후와 우회로술후의 좌심실 국소벽운동

김희열,김종진,윤호중,유기동,박지원,이길환,노태호,채장성,김재형,홍순조,최규보 대한순환기학회 1997 Korean Circulation Journal Vol.27 No.8

접경지역의 법적,제도적 관리방안 : 강원도를 중심으로 focusing on Gangwondo

김장기,신윤창 한국정책학회 2004 韓國政策學會報 Vol.13 No.1

본 연구는 접경지역의 낙후현상에 대한 법적·제도적 차원의 정책적 해법을 취급하고 있다. 구체적으로 접경지역의 낙후현상은 단편적 규제주의, 국가안보의 특수성과 생태환경의 보존성에 대한 결과로서 검토된다. 이와 같은 점에서 본 연구의 주된 관심은 규제와 개발의 상호주의 관점에서, 접경지역의 낙후현상에 대한 원인규명과 해결책을 제시하였다. 특히 이론적 시각에서 접경지역의 낙후현상에 대한 분석모형을 설계하였으며, 이를 토대로 실증적 차원에서 접경지역의 낙후현상을 분석하였다. 연구결과는 접경지역의 사회적 가치상승에 따른 새로운 시각에서 접경지역의 낙후현상을 해결하기 위한 법적·제도적 차원의 개선방안이 필요하다는 주장이다. 특히 본 연구는 강원도 접경지역을 대상으로 수행하였고, 그 결과 접경지역에 대한 새로운 발전시각의 정립, 법·제도적 차원의 종합적인 관리대책, 지역낙후성 문제의 원인과 해결방안 등을 제안하였다.

만성 C형 간염 환자에서 페그인터페론 알파2a와 리바비린 병합 치료중 발생한 벨마비 1예

김일환,장제혁,유충헌,최규남,고정해,김윤정,서광원,김지현,박성재,박은택,이연재,이상혁,설상영 인제대학교 2008 仁濟醫學 Vol.29 No.-

페그인터페론과 리바비린 병합요법은 만성 C형 간염의 일차 치료법이다. 저자들은 만성 C형 간염 환자에서 페그인터페론 과 리바비린 병합 요법 중에 발생한 벨마비 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. 환자는 5년 전부터 만성 C형 간염을 앓아온 48세 남자이며, PEG-IFN α-2a 135μgm 피하주사 주1회와 하루 1200㎎의 리바비린을 투여하였다. 치료시작 후 9개월째 환자는 오른쪽 안면의 근력약화를 호소하였으며 벨마비로 진단되었다. 페그인터페론과 리바비린 병합요법을 지속하면서 관찰하였다. 환자의 벨마비는 페그인터페론 치료를 중단하지 않았음에도 3개월후 증상이 회복되고 이후 벨마비 재발 없이 현재 경과관찰 중이다. 만성 C형 간염에서 페그인터페론과 리바비린 병합 요법시 벨마비의 발생 가능성을 염두에 두어야 하겠다. A Case of Bell's Palsy Associated with Combination Therapy of Pegylated Interferon Alfa-2a (PEG-IFN) and Ribavirin for Chronic Hepatitis C Virus Infection Pegylated interferon alfa(PEG-IFN α) and ribavirin therapy is the first line treatment for chronic hepatitis C. Mild complications of the therapy are common, but more serious complications are rare. We report here a case of Bell's palsy that occurred in a patient with chronic hepatitis C virus infection during combination therapy of PEG-IFN α-2a and ribavirin. The patient was 49-year-old man with chronic hepatitis C (genotype 1b) for 8 years. He had compensated liver cirrhosis with splenomegaly. Therapy with PEG-IFN α- 2a 135mcg/week and ribavirin 1200mg/day was initiated. After 9 months of the therapy, the patient showed a loss of muscular tone on the right side of his face. A diagnosis of Bell's palsy was made. The Bell's palsy resolved over 3 months despite continuation of the combination therapy.

자동차 밸브바디 중간플레이트 성형해석에 관한 연구

장훈,성백섭,차용훈,김덕중,이연신 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

In the super slow speed die casting process, the casting defects due to melt flow should be controlled in order to obtain sound casting products. The casting defects that are caused by molten metal were cold shut formation, entrapment of air, gas, and inclusion. But the control of casting defects has been based on the experience of the foundry engineers. The calculation of simulation can produce very useful and important results. The calculation data of die casting process condition from the computer simulation by the Z-CAST is made to insure that the liquid metal is injected at the right velocity range and that the filling time is small enough to prevent premature solidification. The parameters of runner shape that affected on the optimized conditions that was calculated with simple equation were investigated. These die casting process control techniques of automobile valve body mid-plate have achieved good agreement with the experimental data of tensile strength, hardness test, and material structure photographies satisfactory results

아급성 Ethanol 중독시 고뇨산혈증에 미치는 Pyrazinamide의 영향

장윤경,강우규,김동훈,최종원 慶星大學校 環境問題硏究所 1992 環境硏報 Vol.2 No.1

Ethanol 투여후 pyrazinamide 처리로 유도되어지는고 뇨산혈증의 발생 기전과 규명하고자 ethanol을 rat에 아급성적으로 투여하고 pyrazinoic acid의 대사 과정, 뇨산의 혈증 농도, 뇨산의 생합성 및 분해과정에 관여하는 효소의 활성 변화를 비교검토하였을 때 pyrazina-mide의 대사산물인 pyazinoic acid의 생성과정은 증가되었으나 pyrazinoic acid의 분해과정은 영향이 없었다. Ethanol 아급성 중독상태에 pyrazinamide를 투여하였을 때 혈액중의 뇨산 농도는 대조군에 비해 약 123% 정도현저히 증가되었다. 뇨산의 분해 효소인 urixase의 활성변화와 생합성에 관여하는 adenosine deaminase, purine nucleoside phos-phorylase 및 guanine deaminase의 활성변화에는 별다른 관련성이 없었으며 선책적으로 xanthine oxidase 활성만이 유도되어 나타나는 결과였다. In the present work, the purpose was to onbserve the effect of subacute ethanol intoxication on the changes of purine metabnolic pathway after pyraxzinamide administration in rats. In vitro test, it was observed that pyrazinamide deaminasing-enzyme activity was significantly increased and pyrazinoic acid oxidizing-enzyme activity was not affected by ethanol-administrated rat's cytosolic liver. When uric acid level in blood was estimated after pyrazinamide treatment, the blood level was increased in comparison to control group of subacute ethanol intoxication. Ethanol administration did not affect activities of guanine deaminase, adenosine deaminase, purine nucleoside phosphorylase and uricase, on the other hand, xanthing oxidase activity was significantly increased as compared with control. These results suggest that hyperuricemia incuced by the administration of pyrazinamide after subacute ethanol intoxication may be result from the selective increase of xanthine oxidase activity.

대구지역 특수업태부의 성병에 대한 지각 및 지식과 검진, 이환정도

김연화,권경남,장은희 영남이공대학 산업기술연구소 1988 産業技術硏究 Vol.2 No.-

The objective of this study is to identify perception, knowledge, test and infection about VD for prostitutes. The subject of this study consisted of 343 prostitutes who were registered in 2 community health centers in Taegu and data was collected from January 12th to 17th, 1987. The results were as follow. 1. Mean of STD test was 22.37 and VDRL test was 1.63 during 6 months. Mean number of infection of VD was 2.82 during 6 months. 2. In the perception about VD, the majority of the subjects perceived VD as some susceptibility, low potential for mortality and often thought and discussed. Regarding public concern about VD, the majority perceived VD as non-socially acceptable disease. In the knowledge about VD, all most of the subjects had relatively high level of knowledge. 3. As the level of STD test according to the general characteristics, high group received more test than lower group in age. As the number of infection, below 1 year and alien group were higher than above 1 year in prostitution period and Korean in partener of prostitution. There were no differences in other characterristics. 4. As the level of perception according to general characteristics, high group was higher level of susceptibility than low group in age. Below middle school group was higher level of potential for recovery and mortality than above high school group in education. Also above 1 year group in duration of prostitution perceived VD as dirty but acceptable disease and alien group perceived more painful disease than Korean group in partener of prostitution. As the level of knowledge, above high school group and alien group were higher level in reason of need for regular VD test than below middle school in education and Korean group in partener of prostitution. In the VD itself and test method, below 1 year group was higher level than above 1 year group in period of prostitution. 5. As the level of perception according to STD level high group perceived VD as more painful disease, and less public concern than low group in STD test. But there were no differences in general.

유치열기 정상교합아동의 측모두부방사선 계측연구

김지연,권장혁,김경호,박기태 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.4

본 연구의 목적은 유치열기 부정교합의 진단자료로 사용할 수 있는 정상 계측치를 알아보는 것이다. 4세에서 6세 사이 유치열기 정상교합아동 32명의 측모두부방사선 계측사진 및 안모사진을 이용하여 악골 및 연조직의 전후방적, 수직적 관계를 분석하였다. 수평적인 골격성 계측항목 중 SNA는 83°,SNB는 78.72°,ANB는 5.28°를 나타내어 하악골이 상악골에 비해 후방에 위치하고 있었으며 수직적인 골격성 계측항목 중 Gonial angle은 127°를 나타내어 성인에 비하여 High angle pattern을 보였다. 연조직 분석에서는 성인에 비해 convex한 soft tissue profile이 관찰되었다. 치성 계측항목 중 U1 to SN은 91.04°, IMPA는 86.57°를 나타내어 성인에 비해 reteroclination된 상하악 유중절치가 관찰되었다. 정상교합아동의 골격성분석에서 여자가 남자에 비하여 평균 나이가 많음에도 불구하고 linear measurement는 전제적으로 남자가 여자보다 큰 수치를 보였다. The present study was designed to formulate cephalometric norms of normal occlusion for usage in orthodontic diagnosis of malocclusion in Korean children. Thirty two children, aged 4 to 6. with normal occlusion were chosen for this study. Sagittal and vertical relations were analyzed using lateral cephapogram and clinical photos and the measurements were compared with those of adults. On skeletal sagittal analysis, the mean values of the SNA and SNB angles were 83°and 78.72°. It showed that the mandible was retrognathic and retropositioned in comparison to those angle pattern in children and reduction of gonial angle due to counterclockwise rotation of the mandible. On dental analysis. the mean values of the U1 to SN and IMPA were 91.04° and 86.57°, This showed retroclined upper and lower deciduous teeth in comparison to adults. For values. the linear values were generally greater in males than females.

80세 이상의 허혈성 뇌졸중 환자의 임상적 특성 -병원 중심 연구-

오윤민,김장성 대한신경과학회 1999 대한신경과학회지 Vol.17 No.5