위절제술 환자의 표준진료지침 개발 및 적용 효과

김은희,김철규,이순교,김순덕,이혜옥,권정순,이경미,이민미,심순미,유용만,신종식,강은희,이상일,김병식,오성태,육정환,박수길 한국의료QA학회 2003 한국의료질향상학회지 Vol.10 No.2

Background : Gastric cancer is the most common malignant tumor in Korea. surgical operation is one of the major treatment modalities for gastric cancer patients. Therefore, gastrectomy is one of the most common procedures in General Surgery. There were variation in length of hospital stay and medical treatment for gastrectomy between three surgeons at Asan Medical Center. Clinical pathways have received considerable attention as a tool for recucing the medical practice variation, increasing the efficiency of care process, and improving the quality of care. The aim of this study was to evaluate the effect of a clinical pathway for gastrectomy in gastric cancer patients. Methods : The clinical pathway for gastrectomy was developed and implemented by a multidisciplinary group in Asan Medical Center. A computerized clinical pathway program was developed and revised after a pilot test. A total of 145 patients underwent gastrectomy by three surgeons at Asan Medical Center. We compared the length of hospital stay, patient satisfaction, and unplanned readmission rate between the pre-pathway group(n=67) and the post-pathway group(n=78). We also investigated the degree of satisfaction among the physicians and nurses who were main end-users of the clinical pathway. Results : The clinical pathway was applied to all target patients. The average length of hospital stay was shortened from 12.7days to 10.6days(p<0.01). The degree of patient satisfaction with the care process changed from 90.3% to 89.2% after the implementation of the clinical pathway, but the difference was of satistically significant(p=0.761). Unplanned readmission rate was 2.9% in the pre-pathway group. More than 90% of physicians and nurses answered that the clinical pathway had been a useful tool in their medical practice. Conclusions : The findings of the study demonstrated that implementation of the clinical pathway for gastrectomy produced substantial reduction in the length of hospital stay while improving the quality of patient outcomes. The computerized clinical pathway program can be used as one of the powerful patient management tools for reducing the practice variations and increasing the efficiency of care process in Korea hospital settings.

Pollen Viability of Common Buckwheat (Fagopyrum esculentum Moench.) in in vitro Germination and its Application to Male Gametophyte Isolation

Woo, Sun-HeeㆍKeun-Yook ChungㆍHeung-Tae, KimㆍYong-Gu, ChoㆍHong-Sig, KimㆍBeom-Heon, Songㆍ Chul-Won, Lee and Seung-Keun Jong 忠北大學校 農業科學硏究所 2004 農業科學硏究 Vol.21 No.-

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STS 학습 지도법에 의한 유전공학 전공의 취업률 향상에 관한 연구

김대유,노용택,육철,이상희 永同大學校 1997 硏究論叢 Vol.3 No.1

STC 교육은 학생들이 학교를 떠나 장차 사회에서 유용하게 쓸 수 있는 경험을 쌓게 하는 방법으로서, 본 연구는 이와 같은 STC 학습법을 활용하여 생명공학부 유전공학전공 2, 3, 4학년 학생들을 대상으로 진행된 취업 대비 기사 자격증 취득을 위한 특별 학습 지도와 산업 현장 이해를 돕기 위한 현장 교육을 목적으로 추진되었다. 본 연구의 주요 추진 상황으로 정규 강의와 별도로 소규모 grouping을 통한 특별 학습 실시, 산업체 견학 및 대학원 실험실 실습, 기사 시험을 대비한 집중 학습 program실시, 하계 방학 특강, 취업에 필요한 제반 교육 들을 실시하였다. 주요 실적으로는 식품 제조 기사2급 2차 시험에 생명공학부 유전공학전공 4학년 학생 5명이 응시하여 5명 전원이 합격한 것을 비롯하여 총 8명이 기사 자격증을 취득하였고, 여러 차례 현장 학습을 통하여 현장에 대한 감각과 이해력을 높였던 점을 들 수 있다. 그리고 본 연구의 가장 중요한 성과로는 목표 설정과 동기 부여 및 목표달성을 통하여 학생들 스스로가 학습 성취도를 고취시킬 수 있었던 점이라 생각된다. STC program is a strategy of preparatory educations for students to gain useful experiences for social activities after graduation. In this STC study, special programs to pass the national technical qualification certification and field trips and practical experiments to understand the actual conditions of industry and society first-hand, are carried out through STS education method. This course included special programs besides the regular lectures such as special group study in small-sized group, tours at industrial plants and laboratories, practical experiments in graduate school, intensive study programs prepared for the national technical qualification examination, special lectures during the summer vacation and general educations for employment after graduation. In this program, it was achieved that 5 senior students passed the national technical qualification examination of food manufacturing, totally 8 students aquired the national technical qualification certification and students majoring in genetic engineering of the faculty of life science and engineering learned the feeling and appreciations of industry and society through several field learning. Conclusively, the main achievement of STS program is that students for themselves developed the learning activity through setting the goals, giving incentives, and reaching the goals voluntarily.

총체적 학습법을 통한 취업 대비 기사 자격증 취득을 위한 특별 학습 지도

육 철,노용택,김대유,이상희 永同工科大學校 1996 硏究論叢 Vol.2 No.1

본 연구는 생명공학부 유전공학전공 2, 3학년을 대상으로 진행된 특별 학습 program으로 취업 대비 목적의 국가 기술 자격증 취득을 위한 특별 학습 지도와 산업 현장 이해를 돕기 위한 현장 교육을 목적으로 추진되었다. 본 연구의 주요 추진 상황으로는 정규 강의와 별도로 소규모 grouping을 통한 특별 학습 실시, 산업체 현장 견학 및 실습, 기사 시험을 대비한 집중 학습 program실시, 하계 방학 특강, 취업에 필요한 제반 교육 등을 실시하였다. 주요 실적으로는 식품 제조 기사 1차시험에서 60%의 합격률을 보였으며 6회에 걸친 산업체 현장 견학과 1회의 산업체 실습을 통하여 현장에 대한 이해도를 높임과 동시에 관련 산업체에 영동공대의 인지도를 높여 주었다. 그리고 본 연구의 가장 중요한 성과로는 목표 설정과 동기 부여를 통하여 학생들 스스로가 학습 성취감을 느낄 수 있었던 점이라 생각된다. This research is of a special topics course(STC) prepared for the sophomore and junior students of the Faculty of Life Science and Engineering(majoring in genetic engineering). It consists of two major programs to improve opportunities for employment of students after graduation: one is a special study program for national technical qualification certification and the other is a field trip and practical experience to learn about industry firsthand. This course included special programs such as special group study in small-sized groups of 2-5 persons, tours and practice at industrial plants and laboratories, intensive study programs prepared for the national technical qualification examination, special lectures during the summer vacation and general education designed to increase opportunities for employment of the students after graduation, in addition to the normal lectures. With the fulfillment of this special topics course, 60% of students who participated in the program succeeded in the national technical qualification examination for food processing, and the students 'understanding about processing and facilities at plants was increased through a total of 7 plant tours and practice which also helped the acknowledgement of YIT to the relevant industries.

Combinatorial Activin Receptor-Like Kinase/Smad and Basic Fibroblast Growth Factor Signals Stimulate the Differentiation of Human Embryonic Stem Cells into the Cardiac Lineage

Yook, Jin-Yong,Kim, Min-Jeong,Son, Myung Jin,Lee, Seokyoung,Nam, Yoonkey,Han, Yong-Mahn,Cho, Yee Sook Mary Ann Liebert 2011 STEM CELLS AND DEVELOPMENT Vol.20 No.9

Analysis on the Effect of a Training System for Improving Equilibrium Sense Using an Unstable Platform

Yong-Jun Piao,Mi Yu,Yong-Yook Kim,Tae-Kyu Kwon,Chul-Un Hong,Nam-Gyun Kim 제어로봇시스템학회 2005 제어로봇시스템학회 국제학술대회 논문집 Vol.2005 No.6

점막 관련 림프조직에서 발생한 저등위 위 B - 림프절 림프종

김완수,김병식,김희철,유은실,박건춘,육정환,민영일,정훈용,김상희,오성태 대한소화기학회 1998 대한소화기학회지 Vol.31 No.6

Background/Aims: The great majority of primary gastric lymphomas are B-cell origin. Unlike nodal B-cell lymphomas, low-grade B-cell lymphomas of the stomach recapitulate the features of mucosa-associated lymphoid tissue (MALT) and are the paradigm for the MALT lymphoma group. This study was perfarmed to determine the clinical behaviors of gastric MALT lymphoma and to decide the optimal treatment modalities. Methods: The retrospective study and pathologic review of 18 patients with gastric MALT lymphomas were performed. Results: The rnedian age was 47 years (range, 33-63 years). There were 11 men and 7 women. Tumor stage of the patients were classified according to the Ann-Arbor staging system. The 72% of patients were in stage IE, 11% in IIE, 6% in IIIE and 11% in IVE. Eleven patients received resection. Among them, 7 patients received postoperative adjuvant chemotherapy and 2 patients received postoperative radiotherapy. Among the other 7 cases three patients received chemotherapy, only. One patient received chemotherapy combined with antibiotics far eradication of H. pylori and the remaining three patients received antibiotic therapy only. In the 11 resected cases, there were 8 cases in T1, 1 in T2, 2 in T3 and 8 in NO, 1 in N1, 2 in N2 according to the AJCC staging system for the gastric adenocarcinoma. The median of follow-up period was 16 months (range, 3-65 months). All cases except 1 case treated with the bone marrow permeation at initial diagnosis were survived. The recurrence occurred in one case that received antibiotic therapy, but complete remission was obtained after retrial of antibiotics. Conclusions: We conclude that the resection is considered for the treatment of MALT lymphomas especially with deep penetration of stomach wall and perigastric node metastasis.

Targeting mutant <i>KRAS</i> with CRISPR-Cas9 controls tumor growth

Kim, Wonjoo,Lee, Sangeun,Kim, Han Sang,Song, Minjung,Cha, Yong Hoon,Kim, Young-Hoon,Shin, Jeonghong,Lee, Eun-Seo,Joo, Yeonsoo,Song, Jae J.,Choi, Eun Ju,Choi, Jae W.,Lee, Jinu,Kang, Moonkyung,Yook, Jon Cold Spring Harbor Laboratory Press 2018 Genome Research Vol.28 No.3

<P>KRAS is the most frequently mutated oncogene in human tumors, and its activating mutations represent important therapeutic targets. The combination of Cas9 and guide RNA from the CRISPR-Cas system recognizes a specific DNA sequence and makes a double-strand break, which enables editing of the relevant genes. Here, we harnessed CRISPR to specifically target mutant KRAS alleles in cancer cells. We screened guide RNAs using a reporter system and validated them in cancer cells after lentiviral delivery of Cas9 and guide RNA. The survival, proliferation, and tumorigenicity of cancer cells in vitro and the growth of tumors in vivo were determined after delivery of Cas9 and guide RNA. We identified guide RNAs that efficiently target mutant OAS without significant alterations of the wild-type allele. Doxycycline-inducible expression of this guide RNA in KRAS-mutant cancer cells transduced with a lentiviral vector encoding Cas9 disrupted the mutant KRAS gene, leading to inhibition of cancer cell proliferation both in vitro and in vivo. Intra-tumoral injection of lentivirus and adeno-associated virus expressing Cas9 and sgRNA suppressed tumor growth in vivo, albeit incompletely, in immunodeficient mice. Expression of Cas9 and the guide RNA in cells containing wild-type KIZAS did not alter cell survival or proliferation either in vitro and in vivo. Our study provides a proof-of-concept that CRISPR can be utilized to target driver mutations of cancers in vitro and in vivo.</P>

<i>Sicyos angulatus</i> ameliorates acute liver injury by inhibiting oxidative stress via upregulation of anti-oxidant enzymes

Kim, Hyun-Yong,Noh, Jung-Ran,Moon, Sung-Je,Choi, Dong-Hee,Kim, Yong-Hoon,Kim, Kyoung-Shim,Yook, Hong-Sun,An, Jin-Pyo,Oh, Won-Keon,Hwang, Jung Hwan,Lee, Chul-Ho Informa UK (TaylorFrancis) 2018 Redox report Vol.23 No.1

출혈성 식도정맥류의 내시경적 경화요법 및 결찰요법시행후 위정맥류의 발생양상

김남재,김진희,서광식,김석현,이병석,이헌영,김성걸,육은주,정현용,임의혁 대한소화기내시경학회 1996 Clinical Endoscopy Vol.16 No.1

Background: Esophageal variceal hemorrhage is the most life threatening complication of portal hypertension secondary to chronic progressive liver disease such as liver cirrhosis. Recently, endoscopic injection sclerotherapy(EIS) and endoscopic variceal ligation(EVL) have been known to be the most effective, simple and safe methods. Gastric varices are sometimes associated with esophageal varices in patients with portal hypertension. However the role of endoscopic sclerotherapy in the treatment of gastric varices has not been adequately evaluated, and the fate of coexisting gastric varices after eradication of esophageal varices is not clearly known. Methods: EIS or EVL was preformed in 174 patients with variceal hemorrhage in CHUNG-NAM NATIONAL UNIVERSITY HOSPITAL from September 1990 to December 1993. Among the total 174 patients, 50 patients were followed for at least 1 year. Forty four patients were treated with EIS, and 6 witb EVL. We assesed the influence of EIS or EVL on coexisting gastric varices and the development of gastric varices after EIS or EVL in 50 patients. Results: 1) Primary(present at initial examination) gastric varices were seen I 40(23.0%) of 174 patients. 2) In 6(17.1%) of the 35 patients after sclerotherapy, secondary gastric varices developed. 3) In 2(22.2%) of 9 patients who diagnosed as coexisting gastric varices in early evaluation, gastric varices were reduced or disappered after EIS. 4) Six patients with ligation therapy were followed over 1 year, and the development of Secondary gastric varices were observed in 3(50%) patients. Coneluslon: These results show that the development and reduction of gastric varices after EIS or EVL in portal hypertension patients, however we think that further clinical studies with a large number of cases including control group should be undertaken to achieve statistical significance.