Slide Session : OS-IFD-07 ; Infectious Disease : In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus

( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.

Group Size And Measure Of Group-Level Properties

Kim,Kyoung-Su,Kim In-Sook,Jun,Gyung-Ju,Yang,Dong-Min 한국인적자원관리학회 2009 인적자원관리연구 Vol.16 No.4

Bliese와 Halverson(1998)은 집단수준의 효과를 분석하는데 있어서 기존에 사용되어 온 eta-squared 보다는 eta-squared 값이 사용되어야만 한다는 것을 주장하였다 그러나 이들이 제시한 수정된 eta-squared 접근은 다음과 같은 한계점을 가지게 되는 바 첫째, 이 접근법은 개인수준의 데이터를 집단 수준의 데이터로 만드는데 있어서의 정당성을 제공하는 기준을 구체적으로 제시하고 있지 못하다는 것을 들 수 있고, 둘째, 이 접근법은 또한 집단 내 효과를 용인하고 분석하는 기준을 제공하고 있지 못하다는 점을 들 수 있다 본 논문에서는 이러한 한계점을 극복할 수 있는 몇 가지의 대안을 제시하고 있으며, 이와 더불어 개인수준의 데이터를 집단 수준으로 만드는 것에 대한 정당성을 위한 또 하나의 추가적인 절차를 제시하였다 Bliese and Halverson(1998) argue that corrected eta-squared, rather than eta-squared, should be used for analyzing group-level effects However, their proposed corrected eta-squared approach has the following limitations (1) it fails to specify a criterion for justifying the aggregation of individual-level data to the group level and (2) it fails to specify a criterion for analyzing and allowing for within-group effects In this paper, we suggest several alternatives that overcome these limitations We suggest an additional procedure for justifying the aggregation of individual-level data to the group level

광주지역 소아에서 유행한 호흡기바이러스 유행양상 분석

서진종,김민지,김선희,기혜영,정재근,김은선,박종태,김경심,이수야,김명권,정윤석 대한감염학회 2008 감염과 화학요법 Vol.40 No.4

Background : This investigation was to perform the epidemiological surveillance and genetic analysis on respiratory viral agents from children with acute respiratory infections in Gwangju. Materials and Methods : For this study, 3,695 specimens obtained from patients with acute respiratory infections were collected by collaboration with pediatric hospitals in Gwangju between 2005 and 2007. Specimens were screened for 8 respiratory viruses including influenza viruses (IFV), human rhinoviruses (HRV), human coronaviruses (HCoV), adenoviruses (ADV), parainfluenza viruses (PIV), human enteroviruses (HEV), respiratory synthitial viruses (RSV) and human bocaviruses (HBoV). Respiratory viruses were detected using multiplex (RT) PCR with viral specific primers. Results : Out of 3,695 specimens, the ratio of virus detection was 24.9% (919). Overall, HRV (35.5%) and IFV (34.9%) were the most common viruses found, followed by HBoV (14.8%), HCoV (10.6%), RSV (3.7%), ADV (3.4%), PIV (3.2%) and HEV (3.0%). In addition, multiple infections were detected in 80 patients (8.7%). When the prevalence was analyzed according to season, HBoV, IFV and HCoV showed two epidemic points in late spring and early winter. ADV, HRV, RSV PIV and HEV, however, were all found to have only one epidemic point, with RSV being most common during winter and the others being most prominent during spring. Conclusions : Through this epidemiological surveillance, the respiratory viruses prevalent in children in Gwanaju area were investigated. We strongly recommend the development of nationwide policy for the management of prevalent respiratory virus that includes long term collection of data and samples, vaccine development and prevention education of the misuse of antibiotics.

부산지역 IT기업의 특성이 수출성과에 미치는 영향에 관한 연구

김미정,박경은,이춘수 한국관세학회 2009 관세학회지 Vol.10 No.1

According to the empirical results, it was found out that the R&D capability of a company's characteristics, overseas market experience and export immersion from the CEO's characteristics directly affected the qualitative export results. This study also found out that the R&D capability of a company's characteristics, export immersion from the CEO's characteristics and government overseas marketing support policy characteristics directly affected the qualitative export results. Therefore, a high R&D capability played a key role in quick market entrance and performance creation of technology oriented IT companies that have less market experience and insufficient business resources.

스키장의 서비스스케이프가 고객만족과 행동의도에 미치는 영향

김형섭,장경수,이귀옥 대한경영학회 2003 大韓經營學會誌 Vol.16 No.6

The purpose of this study is to develop scale items to measure servicescape of ski resort, to measure servicescape of ski resort to use them, and to find out relationships among servicescape, customer satisfaction and Behavioral intentions. Hypotheses were developed from reviewing the existing literature and tested empirically. The survey, based on questionnaire, was conducted in ski resort. The data were analyzed using SPSS 10.0 and structural equation model by LISREL 8.51. As a result of factor analysis on servicescape of ski resort, 6 factors were extracted and titled "lift", "ski slope", "facilities layout", "safety facilities", "other facilities", and "ski equipments". The results of the study show that servicescape of ski resort has a positive relationship with customer satisfaction, but has not relationship with behavioral intention. The customer satisfaction has a positive influence on behavioral intentions.

수도권 소재 산부인과의원의 제왕절개율과 관련 요인분석

김윤미,고수경 여성건강간호학회 2002 여성건강간호학회지 Vol.8 No.3

This study aims to find factors that affect variations in cesarean section frequency rates among OBGY clinics in Metropolitan areas. The factors include patient. medical supplier characteristics and economic factors. This study is a cross-sectional analysis using health insurance delivery claims from July to December 2000 and files of the NHIC(national health insurance corporation). Multiple regression was used to analyze the dependent variable of cesarean section frequency rate at each clinic. The results are as follows' Cesarean section frequency rate is increasing in proportion to the number of the following patients repeated caesarean section. disproportion. obstructed labour, fetal distress. emergency caesarean section and self-employed patients. There are geographic variations as well. Cesarean section frequency rates are higher in Inchon and Gyonggi province than in Seoul. The higher number of total delivery the clinic has. the lower rate of cesarean section it has. Clinics with high frequency rates in 1999 showed higher rates the next year. Further research is required to develop evidence based delivery modes and change strategies for increasing normal delivery and activating midwife clinics.

경력개발활동 유형이 성과에 미치는 영향

김경수,최광신,김봉광 全南大學校 企業經營硏究所 1997 産業經濟硏究 Vol.21 No.1

초록 본 연구의 목적은 조직 뿐만 아니라 개인 종업원들이 경력개발에 대한 책임을 느끼고 노력 을 하는 것이 그렇지 않을 때보다 효과적인지를 검증하는데 있다. 이를 위하여 길레이 (Gilley)가 주장한 경력개발활동을 기초로 개인개발활동과 조직의 경력개발활동의 시행여부, 활용정도, 파급효과 등에 대해 종업원이 지각하는 형태에 따라 경력개발유형을 부진 미흡형, 개별 분리형, 상호 보완형으로 분류하였으며, 이들 유형이 조직몰입과 이직의도, 주관적인 성과 등에 달리 영향을 미칠 것으로 보았다. 즉, 개인의 경력개발활동과 조직의 지원활동이 활발한 상호보완형의 경우 조직몰입도나 성과가 높게 나타날 것이고, 이직의도는 낮게 나타날 것이며, 이와 반대로 개인의 경력개발활동도 부진하고 조직의 지원활동도 미흡한 부진미 흡형의 경우 조직몰입과 성과는 낮게 나타날 것이고, 이직의도는 높게 나타날 것이란 가설 을 설정하였다. 12개의 금융회사의 직원들로부터 수집한 자료를 분석한 결과 경력개발활동 유형중 상호보완형에 속한 직원들은 높은 조직몰입과 주관적인 성과를 보였으며, 이직의도 는 낮은 것으로 나타났다. 반대로 부진미흡형에 속한 직원들은 낮은 조직몰입과 주관적인 성과를 보였으며, 높은 이직의도를 가지는 것으로 나타났다. 또한 개별분리형에 속한 직원들 은 중간 정도의 조직몰입과 성과를 보였으며, 이직의도 역시 중간 정도로 나타났다. 이러한 결과 결론부분에서 개인과 조직목표의 조화측면에서 논의되었다. <Abstract> The purpose of this study is to investigate the effects of Career Development Activites(CDA), which improves QWL and expedites the attainment of organizatonal goal, on performance. To accomplish this purpose, we classified CDA types into three dimentions(stagnation type, separation type, integration type) according to the employees perception regarding personal and organizational activities and analyzed the effects of CDA on performance such as organizational commitment, subjective outcome, and turnover intention. The results from 12 financial company showed that1) with regard to the level of organizational commitment and subjective outcome, employees in the separation type among CDA significantly and lowly differd from those in the stagnation type, 2) as for the level of turnover intention, employees in the separation type significantly and highly differed from thise in the integration type and significantly and lowly differed from those in the stagnation type. These results were discussed in terms of the fit between person and organizational goals.

3D Dental-CT를 이용한 상악 매복 과잉치의 진단 : 증례보고

김재곤,김수경,양연미,백병주,김성희 大韓小兒齒科學會 2006 大韓小兒齒科學會誌 Vol.33 No.1

과잉치는 법랑기(enamel organ)가 치배형성을 지속하거나 과도한 세포증식을 함으로써 발생한다. 과잉치는 상악 전방부에서 종종 발견되며, 유치열기와 혼합치열기에서 다양한 문제를 야기한다. 과잉치는 형태에 따라서 보충치(supplemental tooth)와 흔적치(rudimental tooth)로 나눌 수 있다. 보충치는 정상 절치와 크기 및 형태가 유사하나, 흔적치는 비정삭적인 형태와 작은 크기를 갖고 있다. 보충치는 영구 측절치 부위에서 호발하며 정상 전치와 유사한 형태와 크기를 갖고 있으므로, 발치시 주의를 기울여야 한다. 본 3증례는 상악 전방부에 정상 전치 형태의 과잉치를 갖는 증례들이다. 모든 증례에서, 치근단, 교합, 파노라마 방사선 사진 등의 기존 방사선 사진 촬영 외에 3Dimensional Dental-Computed Tomography(3D Dental-CT)를 촬영하여 진단하였다. 기존 일반 방사선 사진들(conventional radiographs)과 3D Dental-CT를 비교시, 일반 방사선 사진들은 2차원적인 영상만을 제공하여 상의 해석에 있어서 술자의 주관이 개입되는 한계가 있다. 반면 3D Dental-CT는 과잉치의 정확한 위치와 형태에 대한 객관적인 정보를 제공하며, 좀 더 보존적인 수술을 시행하고, 수술 시간과 스트레스를 줄이는데 유용하다. 그러므로 일반 방사선 사진 촬영 후 과잉치의 위치가 불분명하고 인접 영구치의 손상이 의심되는 경우 3D Dental-CT를 이용한 진단이 고려된다. Supernumerary teeth are teeth which result from the continued budding of the enamel organ of the preceding tooth or from excessive proliferation of cells. They are most often found in the maxillary anterior region. And they can be responsible for a variey of irregularities in the primary and transitional dentition. There are two morphological types of supernumerary teeth: supplemental and rudimentary. Supplemental teeth have normal shape and size. In contrast, rudimental teeth have abnormal shape and smaller size. Supplemental supernumerary teeth are most common in permanent lateral incisor area. Its extration must be decided more carefully with differential diagnosis between normal teeth, because it has nomal shape and size. We reports 3 cases of the normal incisor shaped teeth in the maxillary anterior region. In all cases, we used the 3D Dental-CT as well as the conventionl plain film such as periapical, occlusal, and panoramic ridiograph. Consequently, 3D Dental-CT was valualble to figure out the exact position and morphology of supernumerary teeth, to do more conservative surgery, and to reduce surgery stress and time.

학교 직업교육이 장애인의 취업 및 임금에 미치는 영향

김동일,김수정,김경선 한국장애인고용공단 고용개발원 2012 장애와 고용 Vol.22 No.3

본 연구는 학교에서 제공하는 직업교육 프로그램이 실제 장애인의 졸업 후 취업과 임 금에 영향을 미치는지 여부를 탐색하였다. 이를 위해 장애인고용패널 2008년도 데이터 를 사용하여 분석을 수행하였다. 장애인의 특성을 인구학적 변인, 노동환경 변인, 인적자 원변인으로 나누어 학교 직업교육여부에 따른 취업효과와 임금효과를 로지스틱 회귀분석 과 다중회귀분석을 통해 수행하였으며, 그 결과 학교 직업교육의 취업효과와 임금효과는 나타나지 않는 것으로 확인되었다. 통제변수의 경우 남성이며 기혼이고 청각장애일수록, 장애가 경증일수록, 건강상태가 좋으며, 중소도시와 농어촌에 거주할 경우 취업률이 높아 지는 것으로 나타났다. 반면 장애정도에 따라 직업교육의 효과가 다르게 나타날 수 있으 므로 직업교육 및 장애유형과 장애정도의 상호작용항을 삽입한 결과 직업교육과 장애등 급과의 상호작용항이 취업여부에 유의한 영향을 미치는 것으로 나타났다. 임금효과를 알 아보기 위한 다중회귀분석에서도 학교 직업교육 이수 여부에 따른 임금효과는 유의미하 지 않은 것으로 나타났다. 통제변수의 경우 인구학적 특성으로는 성별, 결혼여부, 장애등 급, 건강상태가, 노동환경 특성으로는 사업체 근로자수와 정규직 여부가, 인적자본 특성 으로는 경력과 자격증보유여부가 임금에 유의미한 영향력이 있는 변인으로 나타났다. This study examined the effect of the vocational Education on the probability of obtaining job and the amount of salary for individual with disabilities. The data analyzed was extracted from Panel Survey of Employment for the Disabled and released by Korean Employment Agency for the Disabled. Logistic regression and multiple linear regressions were used to analyze the effectiveness of vocational education. The results of this study are as follows; First of all, the vocational education experience has no statistical significant impact on both the probability of obtaining job and the amount of salary. For control variables, males, individuals who has hearing impairment rather than physical disability and visual impairment, individuals with mild disability compare to those who have severe disability, individuals with good health, individuals who lived in small city compare to those in big cities has more probability of obtaining job. Control variables such as gender, marital status, disability level, work conditions, working experience, and license or certification were the variables which had casual effect on the amount of salary.

시멘틱 웹 기반의 비교구매 에이전트를 위한 동적 웹 온톨로지 시스템에 대한 연구

김수경,안기홍 한밭대학교 정보통신전문대학원 2005 정보통신전문대학원 논문집 Vol.3 No.1

기존 전자상거래 플랫폼과 컨텐츠는 데이터의 확장 및 통합이 고려되지 않은 HTML을 중심으로 한 표현 기반 기술로 되어 있고, 특히 전자상거래 사이트별로 상품 정보에 대한 분류체계가 상이함으로 인해 구매자에게 상품별 비교와 검색에 있어서 많은 시간이 낭비되고 또한 정보의 공유가 어려운 기술로 인하여 판매자와 구매자 모두의 요구를 만족시키지 못하고 있다. 본 논문에서는 최근 차세대 웹 기술로 각광받고 있는 시맨틱 웹 기반 기술인 RDF/RDFS를 이승하여 기존 이종의 상점에 제시된 상품 정보를 RDF 문서로 생성하고, Web Ontology Language(OWL)를 사용하여 상품 지식 기반 온톨로지를 구축한 뒤, RDF 문서와의 분석과 매칭을 통하여 이종의 상점에 표현된 상품을 실시간으로 비교 검색하고 동적으로 상품에 대한 지식 기반 온톨로지를 생성하는 웹 온톨로지 시스템을 설계 제안하였다. The existing e-commerce platform and contents are made of expression-based technology HTML that expansion and integration of data weren't considered. Besides, a lot of time is wasted in comparison and a retrieval of product to a buyer, because a classification System about product information is different every electronic commerce site, and cannot satisfy demand of seller and buyer all by trouble of information sharing an technology. In this paper, use the RDF/RDFS which is Semantic Web-based technology to get attention with next generation Web technology recently and it generates product information of the existing store in a RDF document, and after use OWL, and establishing product knowledge-based ontology, and through analysis and matching with a RDF document, A design proposed a System that compare a product expressed to an each e-commerce site by real time, and to retrieval and redefine product knowledge-based ontology as dynamic.