Development and Validation of a Model Using Radiomics Features from an Apparent Diffusion Coefficient Map to Diagnose Local Tumor Recurrence in Patients Treated for Head and Neck Squamous Cell Carcinoma

Kim Minjae,Lee Jeong Hyun,Joo Leehi,Jeong Boryeong,Kim Seonok,Ham Sungwon,Yun Jihye,Kim NamKug,Chung Sae Rom,Choi Young Jun,Baek Jung Hwan,Lee Ji Ye,Kim Ji-Hoon 대한영상의학회 2022 Korean Journal of Radiology Vol.23 No.11

Objective: To develop and validate a model using radiomics features from apparent diffusion coefficient (ADC) map to diagnose local tumor recurrence in head and neck squamous cell carcinoma (HNSCC). Materials and Methods: This retrospective study included 285 patients (mean age ± standard deviation, 62 ± 12 years; 220 male, 77.2%), including 215 for training (n = 161) and internal validation (n = 54) and 70 others for external validation, with newly developed contrast-enhancing lesions at the primary cancer site on the surveillance MRI following definitive treatment of HNSCC between January 2014 and October 2019. Of the 215 and 70 patients, 127 and 34, respectively, had local tumor recurrence. Radiomics models using radiomics scores were created separately for T2-weighted imaging (T2WI), contrast-enhanced T1-weighted imaging (CE-T1WI), and ADC maps using non-zero coefficients from the least absolute shrinkage and selection operator in the training set. Receiver operating characteristic (ROC) analysis was used to evaluate the diagnostic performance of each radiomics score and known clinical parameter (age, sex, and clinical stage) in the internal and external validation sets. Results: Five radiomics features from T2WI, six from CE-T1WI, and nine from ADC maps were selected and used to develop the respective radiomics models. The area under ROC curve (AUROC) of ADC radiomics score was 0.76 (95% confidence interval [CI], 0.62–0.89) and 0.77 (95% CI, 0.65–0.88) in the internal and external validation sets, respectively. These were significantly higher than the AUROC values of T2WI (0.53 [95% CI, 0.40–0.67], p = 0.006), CE-T1WI (0.53 [95% CI, 0.40– 0.67], p = 0.012), and clinical parameters (0.53 [95% CI, 0.39–0.67], p = 0.021) in the external validation set. Conclusion: The radiomics model using ADC maps exhibited higher diagnostic performance than those of the radiomics models using T2WI or CE-T1WI and clinical parameters in the diagnosis of local tumor recurrence in HNSCC following definitive treatment.

Treatment Outcomes of Patients With Ruptured Abdominal Aortic Aneurysms

Kim Hyangkyoung,Kwon Tae-Won,Cho Yong-Pil,Gwon Jun Gyo,Han Youngjin,Lee Sang Ah,Kim Ye-Jee,Kim Seonok 대한의학회 2023 Journal of Korean medical science Vol.38 No.39

Background: Ruptured abdominal aortic aneurysm (rAAA) is a serious complication of abdominal aortic aneurysm associated with high operative mortality and morbidity rates. The present study evaluated the perioperative and long-term outcomes of Korean patients with rAAA based on national health insurance claims data. Methods: The National Health Insurance Service (NHIS) database was searched retrospectively to identify patients with rAAA who underwent endovascular aneurysm repair (EVAR) and open surgical repair (OSR) from 2009 to 2018. Perioperative (≤ 30 days), early postoperative (≤ 3 month), and long-term (> 3 month) survival, reinterventions, and complications were assessed. Results: The search identified 1,034 patients with rAAA, including 594 who underwent EVAR and 440 who underwent OSR. When the study period was divided into two, the total numbers of patients with rAAA, patients who underwent EVAR, and octogenarians were higher during the second half. The perioperative mortality rate was 29.8% in the EVAR and 35.0% in the OSR group (P = 0.028). Hartmann’s procedure for bowel infarction was performed more frequently in the OSR than in the EVAR group (adjusted odds ratio, 6.28; 95% confidence interval [CI], 2.33–21.84; P = 0.001), but other complication rates did not differ significantly. All-cause mortality during the entire observation period did not differ significantly in the EVAR and OSR groups (adjusted hazard ratio, 1.17; 95% CI, 0.98–1.41; P = 0.087). Abdominal aortic aneurysm-related reintervention rate was significantly lower in the OSR group (adjusted hazard ratio, 0.31; 95% CI, 0.14–0.70; P = 0.005). Conclusion: Although EVAR showed somewhat superior perioperative outcomes for rAAA, the long-term outcomes of EVAR after excluding initial 3 months were significantly worse than OSR. When anatomically feasible for both treatments, the perioperative mortality risk and reasonable prospects of long-term survival should be considered in rAAA.

Outcomes of Surgery for Colorectal Cancer in Nonagenarian Patients

Seonok Oh,Chang Sik Yu,Jong Lyul Lee,Chan Wook Kim,Young Sik Yoon,In Ja Park,Jin Cheon Kim 대한종양외과학회 2014 대한임상종양학회 학술대회지 Vol.2014 No.3

Oncologic Safety of Gonadotropin-Releasing Hormone Agonist for Ovarian Function Protection During Breast Cancer Chemotherapy

Kim, Hee Jeong,Lee, Moo Hyun,Lee, Jeong Eon,Park, Seho,Lee, Eun Sook,Kang, Yong Joon,Shin, Hae Na,Kim, Seung Il,Lee, Jun Ho,Im, Seock Ah,Ahn, Sei Hyun,Lee, Keun Seok,Sohn, Joohyuk,Kim, Seonok,Nam, Seo Elsevier 2018 Clinical breast cancer Vol.18 No.5

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Receipt of a gonadotropin-releasing hormone (GnRH) agonist has been reported to protect against ovarian failure. We sought to determine the oncologic effect of a GnRH agonist with chemotherapy for breast cancer patients.</P> <P><B>Patients and Methods</B></P> <P>Data from 1160 patients aged 20 to 40 years with stage I to III breast cancer who received chemotherapy from 5 hospitals in Korea from 2002 to 2012 were reviewed. A GnRH agonist was provided to 406 patients for ovarian protection during chemotherapy, and 754 patients received chemotherapy without ovarian protection. An individual score-matching strategy was used to create sets matched by age, tumor stage, hormone receptor status, neoadjuvant or adjuvant chemotherapy, and institute.</P> <P><B>Results</B></P> <P>Survival analysis by Cox regression showed that the GnRH agonist group had better distant metastasis-free survival (hazard ratio [HR], 0.59; 95% confidence interval [CI], 0.39-0.89) and disease-free survival (HR, 0.72; 95% CI, 0.52-0.99) than the chemotherapy-alone group. Among patients with hormone receptor–positive breast cancer, the benefit was significant for distant metastasis-free survival (HR, 0.53; 95% CI, 0.29-0.99) and disease-free survival (HR, 0.58; 95% CI, 0.35-0.96).</P> <P><B>Conclusion</B></P> <P>Ovarian protection using a GnRH agonist can be safely considered for premenopausal breast cancer patients for whom chemotherapy is planned.</P>

Outcomes of Surgery for Colorectal Cancer in Nonagenarian Patients

Seonok Oh,Chang Sik Yu,Jong Lyul Lee,Chan Wook Kim,Yong Sik Yoon,In Ja Park,Jin Cheon Kim 대한종양외과학회 2013 대한임상종양학회 학술대회지 Vol.2013 No.10

기획논문-주제 : 지역 민속연희와 공연문화유산 ; 제천의 봉양 파대 놀이의 전승과파대(破帶)놀이의 전승과 특성

김선옥 ( Seonok Kim ) 한국공연문화학회(구 한국고전희곡학회) 2015 공연문화연구 Vol.0 No.31

‘파대(破帶)’는 가을철 논과 밭으로 몰려드는 새를 쫓기 위한 도구이다. 파대는 전국적인 분포를 보이고 있으며, 태백산맥을 중심으로 인접해 있는 지역에서 주로 사용된 흔적을 찾아볼 수 있다. 현재 제천시 봉양읍 구곡리.마곡리.삼거리 일대에서는 원형이 전승되고 있으며, 전국에서는 처음으로 2006년 제13회 충북 민속예술축제에서 ‘봉양읍 파대놀이’를 민속놀이로 재현하였다. 2007년에는 의림지 겨울 페스티벌 등에서 축제항목으로 재현하였으며, 2007년 9월 11일에는 서울 충정로에 있는 농업박물관 앞에 조성된 논에서 ‘파대놀이’ 재현 행사를 하기도 했다. 2007년 제14회 충북 민속예술축제에 참가하여 파대놀이를 9마당으로 구성하여 재현하였으며, 2008년 제15회 충북 민속예술축제에서는 ‘파대놀이’ 재현으로 단체부문 대상을 수상하기도 하였다. 파대는 지역별로 부르는 호칭이 다르게 나타나기도 하는데, 제천지역이나 경상북도 북부지역에서는 ‘태기’라고 부르기도 한다. 파대에 대한 원형은 2005년도 제천시 노인복지관에서 봉양읍 구곡리에 사시는 임대순 어르신이 만든 파대를 접하게 되면서부터 봉양읍 일대를 조사하여 파대의 원형이 전승된다는 것을 확인하게 되었다. 그러나 파대가 새를 쫓기 위한 도구로만 전승된 것이 아니라 봉양읍 구곡리.마곡리.삼거리 등에 풍물이 유명했으며, 절기별로 마을 행사 때마다 풍물을 친다는 것을 보면, 파대와 풍물이 어우러지는 파대놀이가 전승되었음을 짐작할 수 있다. 파대는 개인별로 만들어 사용하기도 하였지만, 매년 음력 칠월칠석날 마을 사람들이 모두 모여 공동 작업으로 만들고 난 후, 같이 음식을 해서 나누어 먹고, 파대가 잘 만들어졌는가 휘둘러보기도 하면서 본인이 만든 파대에 대한 기능도 시험해 보았을 것이다. 이 때 암묵적인 경쟁심으로 인해 파대에 대한 놀이를 즐기며 풍물도 함께했을 것으로 본다. 또한, 구술 조사 중에 한 사람의 기억으로 ‘쳐라, 내쳐라’라는 대목을 듣고, 파대를 가지고 놀이를 했었다고 본다. Sideband(破帶)``is a tool for chasing bird flock in autumn paddy field. Sideband has seen a nationwide distributions, the Taebaek mountain range can be found mainly used trail in the area adjacent to the center. Current Jecheon bongyangeup gugokri. Magokri In a circular intersection and one is handed down, the nation was the first time in 2006 to reproduce the ``bongyangeup Sideband play`` in the 13th Chungbuk National Folk Arts Festival in folk games. In 2007, the festival was reproduced by items, etc. uirimji Winter Festival, September 11, 2007 there was also a ``Sideband play`` reproduction event in front of a composition rice fields Agricultural Museum in Seoul Chungjeongro. 2007 participated in the 14th Chungbuk National Folk Arts Festival was reproduced by configuring the Sideband play in the yard 9, 2008 The 15th Chungbuk National Folk Arts Festival, the organization was awarded the Grand Prize in the ``Sideband play`` reproduction. Sideband also appear in the title is called differently by region, in Jecheon, North Gyeongsang Province and northern areas is also called ``taegi. Round about the Sideband has encountered a Sideband made Imdaesun seniors live in bongyangeup gugokri in 2005 from Jecheon elderly welfare as one examines the bongyangeup was confirmed that the prototype of the Sideband transmission. However, the transmission Sideband is not only a tool for chasing Bird bongyangeup gugokri. Magokri. This intersection was famous and Pungmul, look at that Pungmul strikes whenever Village event each season, the sideband with this Pungmul sideband play in harmony a guess that tradition can. Although Sideband is also used individual basis to create, collaborate, create together after the lunar calendar every year in July chilseoknal all the people of the village, divided by eating food such, the Sideband will also try to feature your Sideband is made while wielding it Was also made great viewIt is seen. Due to the implicit competition this time for the Sideband to play and enjoy together also deemed to have Pungmul. In addition, the Beat, Beat my ``in memory of a man during an oral hearing to investigate passage called, have a look They placed a Sideband play.

조선어 조류명칭어의 어형변화에 대한 고찰

김일(Kim Il),김선옥(Kim Seonok) 길림성민족사무위원회 2009 중국조선어문 Vol.160 No.-

Region Proposal Network를 이용한 의류 탐지 연구

김선옥(Seonok Kim),김현우(Hyunwoo Kim) 한국정보과학회 2021 한국정보과학회 학술발표논문집 Vol.2021 No.6

산재지구 학생들의 조선어 사용정황 분석

김선옥(Kim Seonok) 길림성민족사무위원회 2018 중국조선어문 Vol.216 No.-

Treatment of abdominal aortic aneurysms in Korea: a nationwide study

Hyangkyoung Kim,Tae-Won Kwon,Yong-Pil Cho,Jun Gyo Gwon,Youngjin Han,Sang Ah Lee,Ye-Jee Kim,Seonok Kim 대한외과학회 2023 Annals of Surgical Treatment and Research(ASRT) Vol.105 No.1

Purpose: Although endovascular aneurysm repair (EVAR) has been shown to be superior to open surgical repair (OSR) for abdominal aortic aneurysm (AAA) treatment, no large-scale studies in the Korean population have compared outcomes and costs. Methods: The National Health Insurance Service database in Korea was screened to identify AAA patients treated with EVAR or OSR from 2008 to 2019. Perioperative, early postoperative, and long-term survival were compared, as were reinterventions and complications. Patients were followed-up through 2020. Results: Of the 13,631 patients identified, 2,935 underwent OSR and 10,696 underwent EVAR. Perioperative mortality rate was lower in the EVAR group (4.2% vs . 8.0%, P < 0.001) even after excluding patients with ruptured AAA (2.7% vs . 3.3%, P = 0.003). However, long-term mortality rate per 100 person-years was significantly higher in the EVAR than in the OSR group (9.0 vs . 6.4, P < 0.001), and all-cause mortality was lower in the OSR group (hazard ratio, 0.9; 95% confidence interval, 0.87–0.97, P = 0.008). EVAR had a higher AAA-related reintervention rate per 100 person-years (1.75 vs . 0.52), and AAA-related reintervention costs were almost 10-fold higher with EVAR (US dollar [USD] 6,153,463) than with OSR (USD 624,216). Conclusion: While EVAR may have short-term advantages, OSR may provide better long-term outcomes and cost- effectiveness for AAA treatment in the Korean population, under the medical expense system in Korea.