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P247 : A study on use of complementary and alternative medicine for acne
( Sook Kyung Lee ),( Taek Geun Lee ),( Hyun Hwang Bo ),( Tae Gwang Kwon ),( Se Won Jung ),( Young Seok Lee ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Complementary and alternative medicine (CAM) is any practice that has healing effects, but is not based on evidence demonstrated by scientific method. Recently, CAM has been used in various diseases including acne. However, there have been no studies on CAM for acne in Korea. Objectives: The purpose of this study was to analyze the use of CAM in acne patients. Methods: A total of 159 patients with acne were enrolled on the study, and filled out a questionnaire about use of CAM. Results: Overall 87.4% (139/159) of the patients reported the previous or current use of at least one more type of CAM. Cosmetics for acne (100, 22.9%) was most frequently used, followed by diet therapy (81, 18.5%), spa and bath therapies (77, 17.6%), health food supplement (67, 15.3%), skin care shop (64, 14.6%), oriental medicine (38, 8.7%), and aromatherapy (9, 2.1%). The most common reason for using CAM was ``wish to try everything`` (28.6%), and the most common source of information was internet (40.5%). The therapeutic effect of CAM was best with diet therapy (32.1%). The most common side effect of CAM was aggravation of symptoms. The most common monthly cost for CAM was between 50,000 and 100,000 won/person. Conclusion: As our results, we can predict that the use of various types of CAM for acne will become more common. Therefore, dermatologists need to study about benefits and adverse effects of CAM for acne.
Tae-Bong Hur,김형국,Dae-Young Kwon,Se-Jeong Park,Soo-Won Hwang,황윤회 한국물리학회 2007 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.51 No.2I
We grew self-assembled ZnO nanocrystals on metal Pt(111) substrates by using two RF sputtering methods, a one-sided magnetron sputtering system (OMS) and a faced magnetron sputtering system (FMS), in order to study the growth dynamics. The growth rate of the FMS was much higher than that of the OMS due to the additional magnetic field. As the deposition time increased, the density and size of the Volmer-Weber type self-assembled ZnO nanocrystals also increased; in addition, the Ostwald ripening effect was observed between the nearest neighbors in both the OMS and the FMS. We fitted the size distribution of ZnO nanocrystals to Lifshitz-Slyozov and Gaussian functions. Before the ZnO nanocrystals were in a coalescence process with neighboring crystallites, the size distribution was well-explained by the Gaussian function.
Hepatoprotective effect of sodium hydrosulfide on hepatic encephalopathy in rats
Kwon, Kyoung Wan,Nam, Yoonjin,Choi, Won Seok,Kim, Tae Wook,Kim, Geon Min,Sohn, Uy Dong The Korean Society of Pharmacology 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.4
Hydrogen sulfide is well-known to exhibit anti-inflammatory and cytoprotective activities, and also has protective effects in the liver. This study aimed to examine the protective effect of hydrogen sulfide in rats with hepatic encephalopathy, which was induced by mild bile duct ligation. In this rat model, bile ducts were mildly ligated for 26 days. Rats were treated for the final 5 days with sodium hydrosulfide (NaHS). NaHS ($25{\mu}mol/kg$), 0.5% sodium carboxymethyl cellulose, or silymarin (100 mg/kg) was administered intraperitoneally once per day for 5 consecutive days. Mild bile duct ligation caused hepatotoxicity and inflammation in rats. Intraperitoneal NaHS administration reduced levels of aspartate aminotransferase and alanine aminotransferase, which are indicators of liver disease, compared to levels in the control mild bile duct ligation group. Levels of ammonia, a major causative factor of hepatic encephalopathy, were also significantly decreased. Malondialdehyde, myeloperoxidase, catalase, and tumor necrosis factor-${\alpha}$ levels were measured to confirm antioxidative and anti-inflammatory effects. N-Methyl-D-aspartic acid (NMDA) receptors with neurotoxic activity were assessed for subunit NMDA receptor subtype 2B. Based on these data, NaHS is suggested to exhibit hepatoprotective effects and guard against neurotoxicity through antioxidant and anti-inflammatory actions.
( Tae Seok Kim ),( Hyung Hwan Moon ),( Sang Hoon Lee ),( Sang Hyun Song ),( Mill Jae Shin ),( Jong Man Kim ),( Choon Hyuck David Kwon ),( Sung Joo Kim ),( Suk Koo Lee ),( Jae Won Joh ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: The prognosis of FHF depends on the etiology and reversibility. Although the King`s College Hospital (KCH) criteria and Clichy/Villejuif criteria remain the most widely used prognostic criteria of FHF, there are also limitations due to geographically various and different causes of disease. Furthermore it is difficult to estimate prognosis after liver transplantation (LT) according to these criteria. Therefore, we identified the etiologic difference of FHF in Korea, and analyzed the prognostic factors after LT for FHF. Methods: We retrospectively reviewed medical records of 42 patients diagnosed with FHF and underwent LT from April 1999 to April 2011 at Samsung Medical Center, Seoul, Korea. We evaluated the etiologic change and difference compared with western countries. The patients were categorized into two groups according to the in-hospital result of LT; survival group (n=35) and mortality group (n=7). Perioperative profiles were compared between groups to identify the in-hospital poor prognostic factors after LT for FHF. Results: The most common cause of FHF underwent LT was toxic hepatitis (45.2%). Unlike western countries, there was no paracetamol-related FHF but herbal medication or folk remedies are the most frequent causes of toxic hepatitis (58%). There was no patient underwent LT due to HAV-related FHF until 2005, however HAV-related FHF increased significantly and comprised the main portion of FHF (34.5%) after 2005. Encephalopathy grade, onset time, pre-transplantation need of renal replacement and ventilator treatment were significant prognostic factors after LT for FHF in univariate analysis. In multivariate analysis, pre-transplantation renal replacement treatment was the independent prognostic factor after LT for FHF. Conclusions: In this study, we showed the different etiology of FHF in Korea and identified the renal replacement treatment as an independent prognostic factor after LT for FHF. In order to confirm the prognostic factors after LT for FHF, large size of studies are needed.
Risk factors for recurrence of node-negative breast cancer with less than 1cm (초)
( Kwon Ji Hyun ),( Kim Yu Jung ),( Oh Do Youn ),( Park So Yeon ),( Kim Jee Hyun ),( Chie Eui Kyu ),( Kim Sung Won ),( Won Shik Han ),( Im Seock Ah ),( Kim In Ah ),( Kim Tae You ),( Park In Ae ),( Noh 대한내과학회 2008 대한내과학회 추계학술대회 Vol.2008 No.-
Forced Expression of Programmed Death-1 Gene on T Cell Decreased the Incidence of Type 1 Diabetes
Won, Tae-Joon,Jung, Yu-Jin,Kwon, Seok-Joong,Lee, Yoon-Jeong,Lee, Do-Ik,Min, Hye-Young,Park, Eon-Sub,Joo, Seong-Soo,Hwang, Kwang-Woo 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.11
Programmed death-1 (PD-1) is a co-inhibitory receptor of the CD28/CTLA-4 family which is expressed on activated T cells and inhibits T cell activation after binding to PD-1 ligands. In animal models, PD-1 regulates autoimmune disease and induces tolerance in pancreas. In this study the effects of PD-1 on type 1 diabetes were examined using PD-1 transgenic mice (Tg). The incidence of autoimmune diabetes induced by multiple low dose of streptozotocin (STZ) was reduced in PD-1 Tg mice. Although the expression of CTLA-4, PD-1 and FoxP3, which are inhibitory molecules of activated T cells, is reduced only on STZ injected wild type (WT) mice, CD4, CD8 and regulatory T cell populations were not changed in all experimental groups. When splenocytes were re-stimulated in ex vivo, the production of IL-2 and IFN-${\gamma}$ and the T cell proliferation were increased in all STZ injected mice, but the increment rate was less in PD-1 Tg groups. Interestingly, macrophages were observed in splenocytes of STZ injected PD-1 Tg at somewhat lower level than macrophage in diabetic wild type mice. In this research, we found out that total numbers of T cell in the experimental groups are not changed, but T cell function is changed, and FoxP3 expression is decreased in pancreas and spleen of diabetesinduced groups. Macrophage frequency might also affects on type 1 diabetes. Although more experimental evidence needs to be provided, these results suggest that ligation of PD-1 and PD-L1/2 may have an effect on macrophages as well as does T cells.
Won-Sik Shim,최민구,김인화,Tae-Sik Kwon,송임숙,Liwei Han,Dae-Duk Kim,정석재,심창구 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.5
The effect of organic anionic (OA) fractions of various rat organ tissues on the apparent partition coefficients (APC) of quarternary ammoniums (QAs) between n-octanol and phosphate buffer (pH 7.4) and QAs transport across the LLC-PK1 cell monolayer was examined. The OA fraction was prepared by filtering the aqueous extract of each tissue through an ion-exchange cartridge (Bond Elut C18). In the presence of OA fractions of liver and kidney extracts, substantial increase in APC was observed for tributylmethylammonium (TBuMA, Mw 200) and berberine (Mw 335), but not for triethylmethylammonium (TEMA, Mw 116) and tetraethylammonium (TEA, Mw 130). Because only QAs with higher Mw than a threshold (i.e., > 200) are known to form lipophilic ion-pair complexes with certain organic anions (e.g., bile salts such as taurodeoxycholate), above results are consistent with the hypothesis that only larger Mw QAs form lipophilic ion-pair complexes with endogenous organic anionic components of the liver and kidney extracts. Considering the comparable effect between the liver and kidney extracts on the APC of TBuMA regardless of far less (1/5) content of bile salts in the kidney extract, OAs other than bile salts in the kidney appear to contribute to the formation of lipophilic ion-pair complexes. Most interestingly, the secretory (i.e., basolateral to apical direction) transport of TBuMA and berberine across the LLC-PK1 cell monolayer was decreased by the cis-presence of the kidney extract, while remained unchanged for the transport of TEMA and TEA. The kidney extract had no effect on the absorptive (i.e., apical to basolateral direction) transport and cellular (LLC-PK1) accumulation of all of these QAs. Regardless of underlying mechanisms, it is notable that OA components of liver and kidney extracts influence the APC and secretory transport of QAs with Mw >200.