Diagnostic Performance of the Modified Korean Thyroid Imaging Reporting and Data System for Thyroid Malignancy: A Multicenter Validation Study

Chung Sae Rom,Ahn Hye Shin,Choi Young Jun,Lee Ji Ye,Yoo Roh-Eul,Lee Yoo Jin,Kim Jee Young,Sung Jin Yong,김지훈,Baek Jung Hwan 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.9

Objective: To evaluate the diagnostic performance of the modified Korean Thyroid Imaging Reporting and Data System (K-TIRADS), and compare it with the 2016 version of K-TIRADS using the Thyroid Imaging Network of Korea. Materials and Methods: Between June and September 2015, 5708 thyroid nodules (≥ 1.0 cm) from 5081 consecutive patients who had undergone thyroid ultrasonography at 26 institutions were retrospectively evaluated. We used a biopsy size threshold of 2 cm for K-TIRADS 3 and 1 cm for K-TIRADS 4 (modified K-TIRADS 1) or 1.5 cm for K-TIRADS 4 (modified K-TIRADS 3). The modified K-TIRADS 2 subcategorized the K-TIRADS 4 into 4A and 4B, and the cutoff sizes for the biopsies were defined as 1 cm for K-TIRADS 4B and 1.5 cm for K-TIRADS 4A. The diagnostic performance and the rate of unnecessary biopsies of the modified K-TIRADS for detecting malignancy were compared with those of the 2016 K-TIRAD, which were stratified by nodule size (with a threshold of 2 cm). Results: A total of 1111 malignant nodules and 4597 benign nodules were included. The sensitivity, specificity, and unnecessary biopsy rate of the benign nodules were 94.9%, 24.4%, and 60.9% for the 2016 K-TIRADS; 91.0%, 39.7%, and 48.6% for the modified K-TIRADS 1; 84.9%, 45.9%, and 43.5% for the modified K-TIRADS 2; and 76.1%, 50.2%, and 40.1% for the modified K-TIRADS 3. For small nodules (1–2 cm), the diagnostic sensitivity of the modified K-TIRADS decreased by 5.2–25.6% and the rate of unnecessary biopsies reduced by 19.2–32.8% compared with those of the 2016 K-TIRADS (p < 0.001). For large nodules (> 2 cm), the modified K-TIRADSs maintained a very high sensitivity for detecting malignancy (98%). Conclusion: The modified K-TIRADSs significantly reduced the rate of unnecessary biopsies for small (1–2 cm) nodules while maintaining a very high sensitivity for malignancy for large (> 2 cm) nodules.

Sonographic Diagnosis of Cervical Lymph Node Metastasis in Patients with Thyroid Cancer and Comparison of European and Korean Guidelines for Stratifying the Risk of Malignant Lymph Node

Chung Sae Rom,Baek Jung Hwan,Rho Yun Hwa,Choi Young Jun,Sung Tae-Yon,Song Dong Eun,Kim Tae Yong,Lee Jeong Hyun 대한영상의학회 2022 Korean Journal of Radiology Vol.23 No.11

Objective: To evaluate the ultrasonography (US) features for diagnosing metastasis in cervical lymph nodes (LNs) in patients with thyroid cancer and compare the US classification of risk of LN metastasis between European and Korean guidelines. Materials and Methods: From January 2014 to December 2018, US-guided fine-needle aspiration was performed on 836 LNs from 714 patients for the preoperative nodal staging of thyroid cancer. The US features of LNs were retrospectively reviewed for the following features: size, presence of hilum, margin, orientation, cystic change, punctate echogenic foci (PEF), large echogenic foci, eccentric cortical thickening, abnormal vascularity, and cortical hyperechogenicity. A multiple logistic regression analysis was performed to identify the independent US features for the diagnosis of metastatic LNs. The diagnostic performance of independent US features was subsequently evaluated. LNs were categorized according to the Korean Thyroid Imaging Reporting and Data System (K-TIRADS) and European Thyroid Association (ETA) guidelines, and the correlation between the two sets of classifications was assessed. Results: Absence of the hilum, presence of cystic changes, PEF, abnormal vascularity, and cortical hyperechogenicity were independent US features of metastatic LNs. Cystic changes, PEF, abnormal vascularity, and cortical hyperechogenicity showed high specificity (86.8%–99.6%). The absence of the hilum had the highest sensitivity yet low specificity (66.4%). When LNs were classified according to the ETA guidelines and K-TIRADS, they yielded similar categorizations of malignancy risks and were strongly correlated (Spearman coefficient, 0.9766 [95% confidence interval, 0.973–0.979]). According to the ETA guidelines, 9.8% (82/836) of LNs were classified as “not specified.” Conclusion: Absence of hilum, cystic changes, PEF, abnormal vascularity, and cortical hyperechogenicity were independent US features suggestive of metastatic LNs in thyroid cancer. Both K-TIRADS and the ETA guidelines provided similar risk stratification for metastatic LNs with a high correlation; however, the ETA guidelines failed to classify 9.8% of LNs into a specific risk stratum. These results may provide a basis for revising LN classification in future guidelines.

Tumor Vascular Permeability Pattern Is Associated With Complete Response in Immunocompetent Patients With Newly Diagnosed Primary Central Nervous System Lymphoma : Retrospective Cohort Study

Chung, Sae Rom,Choi, Young Jun,Kim, Ho Sung,Park, Ji Eun,Shim, Woo Hyun,Kim, Sang Joon Williams & Wilkins Co 2016 Medicine Vol.95 No.6

<P><B>Abstract</B></P><P>A dynamic contrast-enhanced MR imaging (DCE-MRI) could provide the information about tumor drug delivery efficacy. We investigated the potential utility of the permeability pattern of DCE-MRI for predicting tumor response to high dose-methotrexate treatment and progression-free survival (PFS) in patients with primary CNS lymphoma (PCNSL). Clinical and conventional imaging parameters were assessed as potential predictors of tumor response in 48 immunocompetent PCNSL patients in a preliminary study. Fifty additional immunocompetent patients (27 men and 23 women; mean age, 60.6 years) with PCNSL underwent DCE-MRI before starting first-line treatment with high dose-methotrexate. The DCE-MRI pattern was categorized as diffuse or nondiffuse. After 4 courses of high dose methotrexate, patients underwent follow-up brain MR imaging to identify their complete response (CR). Predictors of CR and PFS were analyzed using clinical parameters, conventional MRI, and DCE-MRI. CR was noted in 20 (74.1%) of 27 patients with diffuse DCE-MRI pattern and in 4 (17.4%) of 23 patients with nondiffuse DCE-MRI pattern. The diffuse DCE-MRI pattern showed a significantly higher association with CR than the nondiffuse pattern (<I>P</I> < 0.001). Multivariate Cox proportional hazards model revealed that the DCE-MRI pattern (hazard ratio = 0.70; <I>P</I> = 0.045), age (hazard ratio = 1.47; <I>P</I> = 0.041), and adjuvant autologous stem-cell transplantation (hazard ratio = 6.97; <I>P</I> = 0.003) tended to be associated with a PFS. The pretreatment diffuse DCE-MRI pattern can be used as a potential imaging biomarker for predicting CR and a longer PFS in patients with newly diagnosed PCNSLs.</P>

Sonographic Assessment of the Extent of Extrathyroidal Extension in Thyroid Cancer

Chung Sae Rom,Baek Jung Hwan,Choi Young Jun,Sung Tae-Yon,Song Dong Eun,Kim Tae Yong,Lee Jeong Hyun 대한영상의학회 2020 Korean Journal of Radiology Vol.21 No.10

Objective: This study aimed to determine the sonographic features suggestive of extrathyroidal extension (ETE) of thyroid cancers. Materials and Methods: We retrospectively reviewed the sonographic images of 1656 consecutive patients who had undergone thyroidectomy in 2017. The diagnostic performance of sonographic features suggestive of ETE was evaluated using operation and histopathologic reports. Sonographic features for gross ETE to the strap muscle and minor ETE were assessed for thyroid cancer abutting the anterolateral thyroid capsule. Sonographic features for tracheal invasion were assessed according to whether the angle between the tumor and the trachea was an acute, right, or obtuse angle. Sonographic features for recurrent laryngeal nerve (RLN) invasion were assessed based on the association between the tumor and tracheoesophageal groove (TEG) as preserved normal tissue, abutting or protruding into the TEG. Results: ETE was observed in 783 patients (47.3%), including 123 patients with gross ETE (7.4% [strap muscle, n = 97; RLN, n = 24; and trachea, n = 14]) and 660 patients with minor ETE (39.9%). Regarding the diagnosis of gross and minor ETE to the strap muscle, sonographic features of replacement of the strap muscle and capsular disruption showed the highest positive predictive value (75.9% and 58.5%, respectively). Thyroid cancer forming an obtuse angle with the trachea had the highest sensitivity for the diagnosis of tracheal invasion (85.7%), and thyroid cancer protrusion into the TEG showed the highest sensitivity for the diagnosis of RLN (83.3%). Conclusion: Sonography is considered beneficial in the diagnosis of ETE to the strap muscle, trachea, and RLN. Assessment of ETE is important for the accurate staging of thyroid cancer, which in turn determines the extent of surgery or whether active surveillance is appropriate or not.

Clinical and Radiological Features of Diffuse Lacrimal Gland Enlargement: Comparisons among Various Etiologies in 91 Biopsy-Confirmed Patients

Chung Sae Rom,Kim Gye Jung,Choi Young Jun,Cho Kyung-Ja,Suh Chong Hyun,Kim Soo Chin,Baek Jung Hwan,Lee Jeong Hyun,Yang Min Kyu,Sa Ho-Seok 대한영상의학회 2022 Korean Journal of Radiology Vol.23 No.10

Objective: To compare the clinical and radiological features of various etiologies of chronic diffuse lacrimal gland enlargement. Materials and Methods: We retrospectively reviewed 91 consecutive patients who underwent surgical biopsy for chronic diffuse lacrimal gland enlargement and were diagnosed with non-specific dacryoadenitis (DA) (n = 42), immunoglobulin G4-related dacryoadenitis (IgG4-RD) (n = 33), and lymphoma (n = 16). Data on patient demographics, clinical presentation, and CT imaging findings (n = 73) and MRI (n = 43) were collected. The following radiologic features of lacrimal gland enlargement were evaluated: size, unilaterality, wedge sign, angle with the orbital wall, heterogeneity, signal intensity, degree of enhancement, patterns of dynamic contrast-enhanced, and apparent diffusion coefficient value. Radiological features outside the lacrimal glands, such as extra-lacrimal orbital involvement and extra-orbital head and neck involvement, were also evaluated. The clinical and radiological findings were compared among the three diseases. Results: Compared to the DA and IgG4-RD groups, the lymphoma group was significantly older (mean 59.9 vs. 46.0 and 49.4 years, respectively; p = 0.001) and had a higher frequency of unilateral involvement (62.5% vs. 31.0% and 15.2%, respectively; p = 0.004). Compared to the IgG4-RD and lymphoma groups, the DA group had significantly smaller lacrimal glands (2.3 vs. 2.8 and 3.3 cm, respectively; p < 0.001) and a lower proportion of cases with a wedge sign (54.8% vs. 84.8% and 87.5%, respectively; p = 0.005). The IgG4-RD group showed more frequent involvement of the extra-orbital head and neck structures, including the infraorbital nerve (36.4%), paranasal sinus (72.7%), and salivary gland (58.6%) compared to the DA and lymphoma groups (4.8%–28.6%) (all p < 0.005). Conclusion: Patient age, unilaterality, lacrimal gland size, wedge sign, and extra-orbital head and neck involvement differed significantly different between lymphoma, DA, and IgG4-RD. Our results will be useful for the differential diagnosis and proper management of chronic lacrimal gland enlargement.

항공기 중량관리 데이터베이스 개발

정새롬(Sae-Rom Chung),배경문(Kyung-Mun Bae),강민성(Min-Seong Kang) 한국항공우주학회 2019 한국항공우주학회 학술발표회 논문집 Vol.2019 No.11

양안 외직근후전술 후 재발한 간헐외사시에서 양안 내직근절제술의 효과

정새롬(Sae Rom Chung),이태은(Tae Eun Lee),유인천(In Cheon You),조남천(Nam Chun Cho),안 민(Min Ahn) 대한안과학회 2018 대한안과학회지 Vol.59 No.6

목적: 간헐외사시로 양안 외직근후전술을 받은 후 재발한 환자에서 양안 내직근절제술의 효과를 알아본다. 대상과 방법: 2009년 1월부터 2015년 8월까지 간헐외사시로 외직근후전술을 받은 후 20프리즘디옵터(prism diopters, PD) 이상 외사시가 재발한 환자 중 양안 내직근절제술을 시행한 25명을 대상으로 의무기록을 후향적으로 조사하였다. 내직근절제는 원거리 사시각을 기준으로 4.0-6.5 mm까지 0.5 mm 단위로 시행하였고 수술 후 경과관찰은 1일, 1주일, 3개월, 6개월, 1년에 사시각을 측정하여 내직근절제량에 따른 사시각 교정 정도를 조사하였다. 결과: 재수술 전 사시각은 27.20 ± 5.02 PD의 외편위였고, 재수술 시 시행한 양안 내직근절제술의 양은 평균 5.10 ± 0.79 mm였다. 재수술 후 원거리 사시각은 수술 직후 10.68 ± 5.50 PD 내편위각을 보이다 시간이 지남에 따라 과교정된 내편위각이 줄어들고 수술 1년 후에는 1.16 ± 7.54 PD의 내편위각을 보였다. 수술 직후에는 84%에서 과교정 소견을 보였으나 1년이 지난 후에는 24%로 줄어들었고 수술 성공률은 68%였다. mm당 교정량은 재수술 후 1일, 1주일, 3개월, 6개월, 1년에서 각각 7.53 ± 1.22, 7.75 ± 2.16, 6.27 ± 1.74, 5.50 ± 1.54, 5.56 ± 1.58 PD/mm였으며, 시간이 지남에 따라 교정 효과가 감소하는 경향을 보였다. 수술 1년째 mm당 교정량은 내직근 절제량과 관계없이 일정하게 유지되었다(p=0.939). 결론: 양안 외직근후전술 후 20 PD 이상 재발한 외사시에서 양안 내직근절제술 시 처음에는 과교정되나 시간이 경과함에 따라 수술 후 1년에는 1.16 ± 7.54 PD 내편위각으로 정위에 가까운 소견을 보인다. 20 PD 이상의 외사시에서 양안 내직근절제술은 유용한 수술방법이다. Purpose: The purpose of this study was to investigate the effect of bilateral medial rectus muscle resection on the treatment of recurrent intermittent exotropia. Methods: A retrospective chart analysis was conducted for 25 patients who underwent bilateral medial rectus resection for recurrent exotropia over 20 prism diopters (PD) between January 2009 and August 2015. The medial rectus was resected from 4.0 to 6.5 mm by 0.5 mm according to the deviation angle. The postoperative angle of deviation was checked at 1 day, 1 week, 3 months, 6 months, and 1 year postoperatively to investigate the amount of corrected deviation per resected muscle. Results: The average preoperative deviation angle was 27.20 ± 5.02 PD exodeviation and the mean resection was 5.10 ± 0.79 mm of the medial rectus. The postoperative angle deviation was 10.68 ± 5.50 PD esodeviation at 1 day. The incidence of esodeviation tended to decrease over time. At 1 year, the postoperative angle deviation was 1.16 ± 7.54 PD esodeviation. The overcorrection rate was 84% at 1 day postoperatively but decreased to 24% at 1 year with a success rate of 68%. The corrected deviation angle per millimeter was 7.53 ± 1.22, 7.75 ± 2.16, 6.27 ± 1.74, 5.50 ± 1.54, and 5.56 ± 1.58 PD/mm at 1 day, 1 week, 3 months, 6 months, and 1 year after surgery, respectively. The dose effect per millimeter decreased over time. The corrected deviated angle per millimeter remained constant regardless of the amount of medial rectus muscle resection at 1 year postoperatively(p=0.939). Conclusions: Bilateral medial rectus resection for recurrent exotropia over 20 PD tended to overcorrect at first; however, after 1 year, the mean angle of deviation was 1.16 ± 7.54 PD esodeviation. Bilateral medial rectus resection is an effective surgical method for the treatment of recurrent exotropia over 20 PD.

비디오안구운동도를 이용한 상사근 근파동의 진단

정새롬(Sae Rom Chung),이태은(Tae Eun Lee),유인천(In Cheon You),조남천(Nam Chun Cho),안민(Min Ahn) 대한안과학회 2016 대한안과학회지 Vol.57 No.8

목적: 상사근 근파동은 간헐적이고 불수의적인 상사근의 수축에 의해 한쪽 눈에서 빠르고 작은 진폭의 내회선과 하전을 보이는 질환으로, 세극등현미경검사와 비디오안구운동도를 이용하여 상사근 근파동을 객관적이고 정량적으로 진단하였고, 치료하여 이를 보고하고자 한다. 증례요약: 44세 여자가 7년 전부터 간헐적으로 갑자기 발생하여 수초 지속되는 진동시를 주소로 내원하였다. 과거 두부 외상은 없었고, 전신질환 및 안과적 질환 치료 기왕력도 없었다. 전안부 및 안저검사에서 정상소견 관찰되었고, 세극등현미경검사에서 수 초간지속되는 내회선을 측정할 수 있었으며, 비디오안구운동도로 5-10o 반시계방향 회전성 운동과 2-5o 하전을 확인하고 상사근 근파동으로 진단하였다. Timolol을 하루 두 번 점안하였으나 증상 호전이 없었고, Timolol 중단 후 carbamazepine 400 mg/day를 사용한 뒤 증상의 호전이 나타났다. 결론: 세극등현미경검사와 비디오안구운동도를 이용하여 상사근 근파동을 객관적이고 정량적으로 진단할 수 있고, 적절한 치료를 할 수 있다. Purpose: Superior oblique myokymia is intermittent spontaneous contractions of the superior oblique muscle presenting as rapid and small-amplitude intorsions and depressions of the eye. The authors report a case of superior oblique myokymia that was objectively and quantitatively diagnosed with slit lamp examination and video-oculography and completely resolved with medical treatment. Case summary: A 44-year-old woman presented with a seven-year history of intermittent oscillopsia which continued for few seconds. She had no history of head trauma or systemic ocular disease, and the anterior segment and fundus examination were unremarkable. Right eye intorsion lasting for a few seconds as detected by slit lamp examination. Eye movements were recorded using video-oculography, which showed a torsional nystagmus of 5 to 10 degrees with 2 to 5 vertical components in the right eye. Based on these findings, the patient was diagnosed with superior oblique myokymia. The patient was prescribed topical timolol ophthalmic solution, one drop twice per day, but the symptoms persisted. Timolol ophthalmic solution was stopped and replaced with carbamazepine, 200 mg twice a day, which resolved her symptoms. Conclusions: Slit lamp examination and video-oculography can be used as objective and quantitative diagnostic tools in order to confirmed a diagnosis and lead to proper treatment.

패실로마이세스 각막염: 국내 증례 보고 및 해외 문헌 고찰

정새롬(Sae Rom Chung),유인천(In Cheon You),조남천(Nam Chun Cho),안민(Min Ahn) 대한안과학회 2016 대한안과학회지 Vol.57 No.3

목적: 패실로마이세스 각막염으로 확진된 본원 및 국내 사례를 종합하여 알아보고, 이를 외국에서 보고된 증례와 비교해 보고자 하였다. 대상과 방법: 본원 안과를 방문하여 패실로마이세스가 검출된 환자 3예와 국내에 보고된 증례를 종합하여 각막염 발생의 위험인자, 초기 임상양상, 수술적 처치 여부, 치료 후 시력에 대해 알아보고, 이를 외국에서 발표된 패실로마이세스 각막염 환자의 논문들을 정리하여 비교하였다. 결과: 국내 사례 중 자연적으로 발생한 1예의 여성을 제외하고 모두 남성이었으며 외상, 수술과 같은 위험인자가 있었다. 5예 모두 초기시력이 손가락세기 이하였으며 각막의 중심부위에 깊게 침범된 소견을 보였다. 전방 내 및 각막기질 내 보리코나졸 주사 등의 약물치료 외에도 안구내용제거술, 각막이식술을 시행 받았으며 1예는 안구위축 상태가 되는 등 시력이 불량한 경우가 많았다. 외국사례들도 과거 안수술, 외상, 콘택트렌즈 착용과 같은 위험인자가 존재하는 경우가 많았으며, 약물치료에 호전되지 않아 각막이식술과 같은 수술적 처치가 필요한 경우가 많았고, 최종 시력이 낮다는 점에서 국내와 비슷한 임상양상을 보였다. 결론: 패실로마이세스 각막염은 국내외에서 모두 직접적인 위험인자를 갖는 경우가 많고, 심한 임상 경과를 보이며 기존의 약물치료에 잘 호전되지 않고, 수술적 처치가 필요한 경우가 많았다. 패실로마이세스 각막염이 의심되는 경우에는 처음부터 전방내주사, 안내주사와 같은 적극적인 치료가 필요하다. Purpose: To analyze the Paecilomyces keratitis cases in Korea and compare cases from foreign literature. Methods: The records of 3 patients diagnosed with Paecilomyces keratitis at our hospital and other reported cases in Korea were evaluated to examine the predisposing factors, clinical aspects, antifungal therapy, therapeutic surgery, and visual outcome and compared with previously reported foreign cases. Results: In Korea, 1 patient was female, 4 patients were male and had predisposing factors including prior corneal trauma or surgery, except 1 spontaneous occurrence. All 5 eyes of 5 patients had poor initial visual acuity, less than finger count, and deep corneal infiltration. The patients were treated with multiple topical and systemic antifungal treatments such as intracameral or intrastromal voriconazole injections and required evisceration and penetrating keratoplasty. However, the final outcomes were unsatisfactory. Previously reported cases from foreign literature also had predisposing factors such as corneal surgery, trauma, and soft contact lens use. They were resistant to antifungal therapy and eventually led to surgeries such as penetrating keratoplasty and the final outcomes were poor. Conclusions: Frequently, Paecilomyces keratitis has direct risk factors and is resistant to many topical and systemic antifungal agents. In the majority of cases, therapeutic surgery was required and the final visual outcomes were poor. When Paecilomyces keratitis is suspected, we suggest aggressive therapy including intracameral and intravitreal injections of voriconazole in the initial treatment.

만성 중심장액맥락망막병증에서 경구 스피로놀락톤의 효과

정새롬(Sae Rom Chung),정진구(Jin Gu Jeong),이태은(Tae Eun Lee),유인천(In Cheon You),안 민(Min Ahn),⋅,조남천(Nam Chun Cho) 대한안과학회 2020 대한안과학회지 Vol.61 No.3

목적: 만성 중심장액맥락망막병증 중 유리체강내 베바시주맙주입술 시행에도 호전이 없는 환자에서 경구 스피로놀락톤 치료의 효과를 알아본다. 대상과 방법: 2017년 9월부터 2018년 12월까지, 만성 중심장액맥락망막병증으로 유리체강내 베바시주맙주입술 시행에도 호전이 없는 환자에서 6개월동안 경구 스피로놀락톤 치료를 시행한 17명, 17안을 대상으로 중심황반두께, 망막하액의 높이, 최대교정시력의 변화를 후향적으로 분석하였다. 결과: 17명의 환자가 6개월동안 경구 스피로놀락톤을 복용하였다. 중심황반두께는 치료 전 309.94 ± 105.20 μm에서 3개월째 259.76 ± 81.83 μm, 6개월째 243.11 ± 61.98 μm로 통계학적으로 유의하게 감소하였다(Wilcoxon signed-rank test p=0.016, p=0.001). 망막하액의 높이는 치료 전 138.05 ± 95.69 μm에서 3개월째 70.88 ± 83.13 μm, 6개월째 54.00 ± 56.25 μm로 유의하게 감소하였다(Wilcoxon signed-rank test p=0.002, p=0.000). 최대교정시력(logMAR)은 치료 전 0.30 ± 0.38에서 1개월째 0.35 ± 0.43, 3개월째 0.29 ± 0.43, 6개월째 0.26 ± 0.40이었고 6개월째 치료 전에 비해 유의하게 감소하였다(Wilcoxon signed-rank test p=0.033). 경과 관찰 중 약물 부작용을 보인 환자는 없었다. 결론: 만성 중심장액맥락망막병증환자에서 6개월간 경구 스피로놀락톤 치료는 중심황반두께, 망막하액의 높이 감소, 시력개선에 효과가 있었으며 부작용은 관찰되지 않았다. Purpose: To evaluate the effect of oral spironolactone for non-resolving chronic central serous chorioretinopathy after intravitreal bevacizumab injection. Methods: Seventeen eyes of 17 patients with non-resolving chronic central serous chorioretinopathy after intravitreal bevacizumab injection from September 2017 to December 2018 were treated with oral spironolactone for 6 months, and changes in central macular thickness, subretinal fluid height, and best-corrected visual acuity (BCVA) were analyzed retrospectively. Results: The central macular thickness decreased from 309.94 ± 105.20 μm at baseline to 259.76 ± 81.83 μm at 3 months, and 243.11 ± 61.98 μm at 6 months, which were both statistically significant (Wilcoxon signed-rank test, p = 0.016 and p = 0.001, respectively). The subretinal fluid height decreased from 138.05 ± 95.69 μm at baseline to 70.88 ± 83.13 μm at 3 months, and 54.00 ± 56.25 μm at 6 months, which were both statistically significant (Wilcoxon signed-rank test, p = 0.002 and p = 0.000, respectively). The BCVA (LogMAR) changed from 0.30 ± 0.38 at baseline to 0.35 ± 0.43 at 1 month, 0.29 ± 0.43 at 3 months, and 0.26 ± 0.40 at 6 months. The results at 6 months were statistically significant (Wilcoxon signed-rank test, p = 0.033). There were no side effects in patients treated with oral spironolactone. Conclusions: In chronic central serous chorioretinopathy, treatment with oral spironolactone significantly reduced the central macular thickness, subretinal fluid height, and the BCVA, without side effects.