사립체 DNA 뉴클레오타이드 3243 A→G 돌연변이 [MTTL1^*MELAS3243G]에 의한 MELAS 증후군

박기형,김승현,이영주,김희태,김주한,김명호,박성섭 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

간 세포암에서 VEGF, TGF-β1, b-FGF 발현의 의의

김성용,남충현,주종우,채만규,백무준,이문수,김형철,안현철,김홍수,김창진,김창호 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Purpose: Angiogenesis is important for the proliferation and the metastasis of solid tumors. The growth of a solid tumor is widely recognized to depend on the process of neovascularrozation. Without angiogenesis, tumors cease to grow beyond even a few milimeters in diameter. It has been shown that tumor vascular density is an independent prognostic marker in several types of human tumors and is known to correlate with poor prognosis. To date, many angiogenic factors have been identified, such as transforming growth factor-α(TGF-α), transforming growth factor-β(TGF-β), fibroblast growth factor family(FGF), vascular endothelial growth factor(VEGF), platelet derived endothelial cell growth factor(PD-ECGF), tumor necrosis factor-α(TNF-α), and angiogenin. Hepatocellular carcinoma(HCC) is the second most common tumor in Korean males and is known as a typical hypervascular tumor with frequent portal vein invastion. The authors identified the expreesion of VEGF, TGF-β1, and b-FGF in HCC specimens and evaluated the relationship between these growth factors and the clinicopathologic characteristics of HCC. Method: We reviewed the medical records of 30 patients who were diagnosed as hepatocellular carinoma treated with hepatic resection between January 1994 and December 1998 in Soonchunhyang University Chunan Hospital. The selection of the cases was decided according to the condition of paraffin block fixation. The prognostic factors such as age, sex, tumor size, concentration of serum α-fetoprotein, presence of liver cirrhosis, presence of tumor emboli in portal vein, TMN stage, amount of transfusion during the operation, hepatitis B virus(HBV) infection, and Edmonson-Steiner(E-S) grade were investigated. Relationship between the prognostic factors and the immunopathologic expression of the TGF-β1, b-FGF, and VEGF was examined. Result: Thirty patients (24 males, 6 females) were included in the current study. The patient's mean age was 50.6 years and the age ranged from 36 to 65 years. The mean size of the tumor was found to be 5.2cm. All the patients were follewed up for 7 to 63 months. Child's classification A patients were 23(76.7%)cases, B patients were 7(23.3%)cases, and C was none. Immunohistochemical staining of HCC tumor mass in VEGF expression patients were 17(56.7%), b-FGF expression patients were 10(33.3%), and TGF-β1 expression patients were 10(33.3%). VEGF expression or more than one positive expression among the three factors correlated with tumor size and the stage of HCC but did not correlated with other clinicopathological characteristics. TGF-β1 and b-FGF did not correlate with any clinicopathological characteristics. Conclusion: The results suggest that the expression of VEGF or more than one positive expression among the three factors in HCC cells may be a significant prognostic factor of HCC.

性別 및 年齡에 따른 體格과 體力의 特性과 變化에 關한 縱斷的 硏究Ⅱ : Emphasised on College Men of Department of Physical Education 體育專功 大學生을 中心으로

金尙國,姜東洹,張周鎬,金昇一,徐再均,金耕知,孫斗玉,鮮于攝,崔榮烈,尹宇相,金亨燉,方永鎭,朴英震,柳在忠 慶熙大學校 體育科學大學 1989 體育科學論叢 Vol.- No.2

The purpose of this study was to compare the characteristics, change in physique and physical function of college students majoring physical education and Taekwondo (454 males and 64 females of age groups ranging from 18 to 26). The results are as following: 1. The male group of 23yrs old in physical education showed highest values in 7 items(Weight, Chest Girth, Fore Arm Girth, Thigh Girth, Calf Girth, Scapular Skinfold Thickness and Suprailiac Skinfold Thickness). 2. In the Physical function, the male group of 18yrs old showed highest values in Power, Flexibility, and then 21yrs old at Back Strength, Vital Capacity, and 23yrs old at Grip Strength, and 25yrs old at Blood Pressure, respectively. 3. In the physique, the male group of 22yrs old showed highest values in Weight, Chest Girth, Thigh Girth, Calf Girth, and then 24yrs old Upper Arm Girth, Fore Arm Girth, and 19yrs old at Height, Upper Limb Length, respectively. 4. In Physical Function, the 22yrs old showed highest values in Back Strength, Vital Capacity, and then 23yrs old at Side Step, Trunk Extension, but 18yrs old showed lower Values in Grip Strength, Side Step, Vital Capacity and Blood Pressure. 5. The female group of 22yrs old showed highest values in 8 items(Height, Sitting Height, Waist Girth, Upper Limb Length, Lower Limb Length, Skinfold Thickness), and then 18yrs old at 5 items (Weight, Upper Arm Girth, Fore Arm Girth, Thigh Girth, Calf Girth), respectively. 6. In the physical function, the 22yrs old showed highest Values in Grip strength, Back Strength, Power, 5 Minute Run, and 18yrs old at flexibility, Harvard Step Test, respectively. 7. In the change of the physique for two years(1988-1989) in the male group, majoring Physical education the 22yrs old showed increase in 4 items, and the 20yrs old in 3 items, but 18yrs old showed decrease in 3 items. 8. In the change of the physical function for two years in the male group, the 20yrs old showed increase in 4 items, and the 21, 25, 26yrs old in 3 items, but the 19yrs old showed decrease in 6 items, and 18, 22 yrs old in 5 items, respectively. 9. The change of the physique for two years in all female group, of 18, 19, 20, 21yrs old showed increase in 11 items except Skinfold Thickness. 10. In the change of physical function for two years in female group, the 18yrs old showed increase in 3 items, and then 20yrs old in 5 items, but 19, 22yrs old decreased 12 items, respectively. 11. The highest significant difference in physique between male and female was found in weight(mean Value 17.5%), and the lowest difference was found Thigh Girth, Calf Girth(1,3%), Upper Limb Length, Lower Limb Length(2.5%). 12. The Highest difference in physical function was Strength (mean Value 40%), Vital Capacity (33%), Power(22%), but Lower Trunk Flexion, Foot Balance(3.4%). 13. In the difference of Physique and physical function between physical education major and taekwondo major, the physical education showed higher values in skinfold Thickines (mean Value 16.5%), Weight, Waist Girth(4.7%) and Strength(33%), Endurance(5.6%), but subjects majoring Taekwondo showed higher values in Flexibility and Foot Balance. 14. In all male groups, Waist Girth, Scapular Skinfold Thickness, Back Strength, Sargent Jump, Trunk Extension and Diastolic Blood Pressure were showed a significantly related at 0.001 level.

Effects of Phenytoin and Diazepam on the Seizure Activity in the Cortical Dysplasia Animal Models

Kim, Si-Hyung,Choi, In-Sun,Cho, Jin-Hwa,Park, Eun-Ju,Jang, Il-Sung,Choi, Byung-Ju,Kim, Hyun-Jung,Kim, Young-Jin,Nam, Soon-Hyeun The Korean Academy of Oral Biology 2006 International Journal of Oral Biology Vol.31 No.2

Dysplasia-associated seizure disorders are markedly resistant to pharmacological intervention. Relatively little research has been conducted studying the effects of antiepileptic drugs(AEDs) on seizure activity in a rat model of dysplasia. We have used rats exposed to methylazoxymethanol acetate(MAM) in utero, an animal model featuring nodular heterotopia, to investigate the effects of AEDs in the dysplastic brain. Pilocarpine was used to induce acute seizure in MAM-exposed and age-matched vehicle-injucted control animals. Field potential recordings were used to monitor amplitude and numbers population spikes, and paired pulse inhibition in response to stimulation of commissural pathway. Two commonly used AEDs were tested: diazepam 5, 2.5mg/kg;phenytoin 40, 60mg/kg. Diazepam(DZP) and phenytoin(PHT) reduced the amplitude of population spike in control and MAM-exposed rats. However, the amplitude of population spike was nearly eliminated in control rats as compared to the MAM-exposed rats. Pharmaco-resistance was tested by measuring seizure latencies in awake rats after pilocarpine administration(320mg/kg, i.p.) with and without pretreatment with AEDs. Pre-treatment with PHT 60 mg prolonged seizure latency in control rats, but not in MAM-exposed animals. The main findings of this study are that acute seizures initiated in MAM-exposed rats are relatively resistant to standard AEDs assessed in vivo. These data suggest that animal model with cortical dysplasia can be used to screen the effects of potential AEDs.

원위 대퇴골의 고립성 골연골종에서 발생한 속발성 연골 육종 1례 보고

정필현,황장수,강석,김용민,오형호,채동주,김종필 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

연골육종은 비교적 서서히 자라며 늦게 전이하는 악성 연골 종양으로 알려져 있다. 골 연골종에서 발생한 속발성 연골육종은 발생빈도는 드물며 타부위로의 전이가 적고 악성도가 낮은 경우가 많아 적합한 수술적 치료로서 좋은 예후를 보이는 것으로 보고되고 있다. 본 동국대학교 정형외과학 교실에서는 우측 대퇴골 원위부 골간단부에 생긴 고립성 골 연골종에서 이차적으로 발생한 연골육종을 치험한 바 문헌고찰과 함께 보고하는 바이다. A case of Secondary Chondrosarcoma Arising from Solitary Osteochondroma of the Distal Femur Department of Orthopaedic Surgery, College of Medicine, DongGuk University Phil Hyun Chung M.D., Jung Su Hwang M.D., Suk Kang M.D., Yang Mln Kim M.D., Hyung Ho Oh M.D., Dong Ju Chae M.D., Jong Pil Kim M.D. Chondrpsarcoma is a malignant cartilage-forming tumor that grows slowly and metastasis of this tumor occurs in late stage. Secondary chondrosarcomas arising from a solitary osteocartilaginous exostosis are rare and those have a better prognosis than other chondrosarcomas, and they rarely metastasize. We present our experience with a case of secondary chondrpsarcoma arising in solitary osteochondroma of distal metaphysis of right femur with clinical details.

축압축을 받는 CFRP 적층부재의 에너지흡수특성과 파괴모드에 관한 연구

김정호,정회범,전형주 한국산업안전학회 2002 한국안전학회지 Vol.17 No.3

The object of this paper is to investigate collapse characteristics of CF/Epoxy(Carbon Fiber/Epoxy resin)composite tubes on the change of interlaminar number and fiber orientation angle of outer and to evaluate reappearance of collapse characteristics on the change of tension strength of fibers under static and impact axial compression loads. When a CF/Epoxy composite tube is crushed, static/impact energy is consumed by friction between the loading plate and the splayed fronds of the tube, by fracture of the fibers, matrix and their interface. In general, CF/Epoxy tube with 6 interlaminar number(C-type) absorbed more energy than other tubes(A, B, D-types). The maximum collapse load seemed to increase as the interlaminar number of such tubes increases. The collapse mode depended upon orientation angle of outer of CF/Epoxy tubes and loading status(static/impact). Typical collapse modes of CF/Epoxy tubes are wedge collapse mode, splaying collapse mode and fragmentation collapse mode. The wedge collapse mode was shown in case of CF/Epoxy tubes with 0˚ orientation angle of outer under static and impact loadings. The splaying collapse mode was shown in only case of CF/Epoxy tubes with 90˚ orientation angle of outer under static loadings, however in impact tests those were collapsed in fragmentation mode. So that, CF/Epoxy tube with 6 interlaminar number and 90˚ outer orientation angle presented to the optimal collapse characteristics.

Binding Energy of Oxigen and Methane Adsorbed on Bundles of Open-Ended Single-Wall Carbon Nanotubes

서주연,유대황,곽진성,황윤회,김형국 부산대학교 유전체물성연구소 2004 유전체 논문집 Vol.3 No.

The adsorption of oxygen and methane on the bundles of open-ended single wall carbon nanotube(SWNT) was studied using the volumetric adsorption qst was obtained from the adsorption isotherm measurements performed at different temperatures. The trend in the values of the methane isosteric heat of adsorption showed three regions, representative of the adsorption on the different types of adsorption sites. In case of oxygen, on the other hand, such distinguishable regions were not appeared in the N-qst graph. From the results of qst the binding energies of oxygen and methane adsorbed on open-ended SWITs were estimated.

자동차 타이어의 진동특성에 관한 실험적 연구

김병삼,전형주 순천대학교 공업기술연구소 1997 工業技術硏究所論文集 Vol.11 No.-

The vibration characteristics of automobile tire is studied experimentally. In order to obtain the theoretical values of natural frequency and mode shape, the plane vibration of a tire is modeled as a circular beam. Theoretical results are determined by using the Tielking method which considers tension force due to tire inflation pressure, rotational velocity, tangential and radial stiffness. Modal parameters by the inflation pressure, load and rotational velocity are experimentally determined by using frequency response function method. Results show that material property and tire wear are parameters for shift the natural frequency and the increase of sidewall stiffness caused by the load on a tire results in the increase of natural frequency of the tire, and rotational velocity of the tire has no influence on the natural frequency.

석유류 저장 탱크에서의 액면 및 유출화재에 대한 복사열의 실험적 연구

김홍,박형주 한국안전학회 2004 한국안전학회지 Vol.19 No.1

This experimental study was carried out to evaluate effect of the radiation heat flux for the pool and spill fire in petroleum storage tanks, which were made form steel. Each of them had the capacity of 250, 2500 and 25000 liter, respectively. The effects of the radiation heat flux are as follows; 1) The intensity of radiation heat flux from a flame decreased exponentially with increasing distance from outside wall of tanks, and increased significantly with surface area of tank and dyke. 2) In the case of 25000L tank, the radiation heat flux was about max. 98.9 kW/m' in lm from wall of tank. 3) The distance, that was able to ignite wood or plastics by radiation heat flux of approximately 12.5kW/m², was about 3.14m from wall of 25000L tank.

韓國語와 滿洲語와의 接尾辭 比較硏究

金亨柱 東亞大學校 1984 東亞論叢 Vol.21 No.1

The Korean language belongs to the Altaic family which has a member of the Manchu-Tungus subfamily. Linguistically, both Korean and Manchurian seem to have much similarity in from and function, especially in regard to suffixes. Therefore, this thesis concentrates on the study of fourteen kinds of suffixes which are widely and frequently used in both languages. The result of this study shows the formal and functional similarity and correspondence of suffixes between two languages. The examples are as follows: The Korean subject suffix(이/가) similarly corresponds to the Manchurian suffix(i/ni/be), the possessive suffix (의) to (i/ni), the place-prepositional suffix (에) to (de), the predicative suffix (-??, -마, -??라) to (-mi/m??), the question-word suffix (-니/느니, -오/-고, -뇨) to (-ni, -o, -nio), the pre-nominal suffix (-ㄹ) to (-ra, -re, -ro), the enumerative suffix (-며) to (-me), the arriving-adverbial suffix (-도록) to (-tolo, -tele), the causative verbal suffix (부, 우) to (bu), the personal pronominal suffix (치, 씨) to (ci, si), the instrumental suffix (-개) to (-ku/-k??), the ordinal number suffix (째, 차이, 자이,찻) to (ci), etc.