Roxythromycin-tylosin-furaltadone 합제의 닭 유래 세균에 대한 시험관내 항균효과

김지영,채미경,윤효인,서상희,박배근,김현수,전무형 충남대학교 수의과대학 동물의과학연구소 2003 動物醫科學硏究誌 Vol.11 No.-

In vitro antimicrobial susceptibility of roxythromycin (Rx), tylosin (Tyl), erythromycin (EM) and furaltadone (Fur) was studied, either by the single type or the combinated type of Rx-Tyl-Fur (RTF) against E. co1i (30 strains), Staph. aureus (20 strains) and Mycoplasma gallisepticum (5 strains) that are the major pathogens in poultry farm. The paper disk diffusion and MIC tests were applied. In screening test by paper disk diffusion method, the single types of antibiotics showed the sensitivity against 55 strains of bacteria in order of Fur, EM, Rx and Tyl. The combinated RTF showed the higher rate of sensitivity (80∼83.3% at 64㎍/disk, 60-75% at 32㎍/disk) and wider range of growth inhibiting zone (19.6±3.7-24.8±4.7mm) than those of the single drugs. In MIC test, the sensitivity against the 55 strains appeared in order of Fur. EM, Rx and Tyl as similar to those of paper disk diffusion method. The MIC ranges of RTF were 0.125∼16㎍/ml for E. coli, 0.25∼16㎍/ml for Staph. aureus and 1-8㎍/ml for Myco. gallisepticum, showing evidently lower than those of the single types. The MIC_(50) and MIC_(90) of RTF were estimated l∼4㎍/ml and 8∼16㎍/ml, respectively, and remarkably lower than those of the single drugs.

프랑스어 및 한국어 구강모음의 비교연구 : 컴퓨터 단층 촬영 및 디지틀 음향분광기를 사용하여 by means of Computed Tomography and High-speech Analysis System

김찬양,신효근,홍기환,김연희,김현기 全北大學校 語學硏究所 1994 어학 Vol.21 No.-

The methods of the Computed Tomograph and the High-speed Speech analysis system were used for the comparative study of French and Korean oral vowels. Three male native speackers of French and three Korean speakers were selected for these articulatory and acoustic characteristics. The speech materials were the simple French oral vowels / i, e, ε, a, u, o, ??, a / and the Korean oral vovels / i, e, ε, a, w, u, o /, respectively. The results of these studies are as follows : (1) In the case of articulation, the aperture of Korean closed front unrounded vowels is larger than that of French vowels and the Korean back closed vowel /u/ and the half-closed vowel /o/ did not show significant differences with the corresponding French high vowel /i/. But the aperture of the Korean half-open vowel /??/ is smaller than that of French vowel and in this case, the place of articulation for Korean vowel /??/ is more advanced than that of French vowel /??/ (2) By means of spectrographic analysis of the French and Korean vowels, the first formant of the Korean high vowel /i/ is higher than that of French high vowel /i/. This means that the aperture of the Korean high vowel is larger than that of French high vowel. The second formant of French back vowels are lower than those of Korean back vowels. This result shows that the projection of French back vowels is greater than that of Korean back vowels.

심근침범을 동반한 Becker형 근이영양증 환자에서 확인한 Dystrophin 유전자 Exon결실

김광일,오병희,이무용,채인호,신수,박성섭,김효수,손대원,이명묵,박영배,최윤식,이영우 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.5

경상북도의 교통사고 잦은 곳 개선사례분석

김효진,이상윤 경운대학교 산업기술연구소 2002 産業技術硏究論文誌 Vol.5 No.1(A)

The construction work, make up as follows are traffic safety equipment improvement, road appurtenant equipment improvement, traffic employ system improvement, road structure improvement, crossroads complex improvement etc. at improvement project of traffic accidents frequency spot. The center of such improvement project, we will select the representative point this while improvement construction work get accomplished in kyungsangbukdo. Accordingly, we first have to examine and compare the front with the after of accident type about construction work and then look into the problems and a reform measure. Through these ways, we will be able to analysis, what extent improvement effect is affected on accident type and diminution.

Enrofloxacin과 colistin의 복합제(Enroco)의 아급성 독성시험

윤효인,김민규,박승춘,장범수,이내경,최양웅 충남대학교 수의과대학 동물의과학연구소 1997 動物醫科學硏究誌 Vol.5 No.-

The study was carried out to evaluate toxicity of enrofloxacin and colistin complex (Enroco) with a dose of 10 ㎎/㎏/day, 20 ㎎/㎏/day and 40 ㎎/㎏/day via oral administration for 3 weeks in ICR mice. All procedures of the test were performed by the established regulation of Korean National Institute of Safety Research (1994. 4. 14). Appearance, behavior, mortality and food consumption of treated groups were not affected during the experimental periods. No significant does-related changes of the combined antibacterials were found in urinalysis, eye examination, hematology, serum chemistry, and organ weight. No histopathological lesions were observed in both control and treatment groups. Our results strongly suggested that no toxic changes were found in mice treated orally with enrofloxacin-colistin complex for 3 weeks.

경주마에서 Naproxen 및 대사산물의 검출

윤효인,박승춘,이관복,김창식 충남대학교 수의과대학 동물의과학연구소 1994 動物醫科學硏究誌 Vol.1 No.-

Naproxen(NPX) was administrered to a throrougbred mare in a single oral does. Plasma and urine samples were collected from 1 hour to 144 hours after administration, at varying intervals. The alkali hydrolysis was used for the seperation of glucuronide from the conjugated naproxen and its metabolite in urine. Naproxen and its metabolite desmethylnaproxen (DesNPX) were extracted at pH 4.0 with DCM/ETHETR/HEXAN(1/1/1, v/v/v) and quantitated by HPLC with diode-array-detector. The wavelength of ultraviolet was 235, 254 and 264 nm. The qulification of NPX and DesNPX was performed by gas-chromatograph-mass spectrometry using DB-1 column. Silylation (BSTFA including 1% TMCS) before the analysis of the extracted residue with GC/MSD was carried out for the detection of this drug and its metabolite. The characteristic ions (m/e) of trimethyl Silyated NPX and DesNPX were 73, 185, 302 and 73, 243, 360, respectively.

노인 환자에서 경피적 관동맥 중재술 후 조영제 유발 신부전의 발생률, 위험인자와 임상적 의의

김광일,배장환,강현재,채인호,김효수,손대원,김철호,오병희,이명묵,박영배,최윤식 대한노인병학회 2004 대한노인병학회지 Vol.8 No.1

인삼 재배토양에서의 Procymidone 흡착 및 분해

김효근,이윤환,이규승 한국환경농학회 2002 한국환경농학회지 Vol.21 No.4

인삼재배환경에서의 농약의 동태를 구명하기 위하여 살균제 procymidone을 공시하여 인삼 재배토양을 대상으로 흡착실험을 수행하였다. 또한 procymidone을 처리한 인삼재배토양을 10℃ 및 25℃의 항온에서 배양하면서 토양중 잔류성을 조사하였다. 흡착실험을 통하여 구한 procymidone의 유기탄소기준 흡착분배계수(K_(oc))는 531~743 수준으로서 토양 중 procymidone의 이동성은 낮을 것으로 판단되었다. 실내 항온배양 실험결과로부터 계산된 procymidone의 반감기는 248일(25%) 및 330일(10%)로서 포장실험결과에 비해 현저히 길어졌으며, 이는 procymidone이 가수분해 또는 미생물에 의한 분해 등에 안정한 화합물임을 시사하였다. This work has been conducted to investigate the behavior of pesticides in ginseng(Panax ginseng C. A. Meyer) cultivation environment, with a fungicide procymidone as a model pesticide. Procymidone adsorption on ginseng cultivating soil was studied and persistency of procymidone in soil was monitored in indoor incubation experiments at 25℃ and 10℃. The soil adsorption coefficients(K-(oc)) of procymidone were in the range of 513~743 suggesting the mobility of procymidone in soil is relatively low. Procymidone showed higher persistency in soil under indoor incubation condition than outdoor field condition. The half lives estimated from the first order reaction kinetics were 248 days and 330 days at 25℃ and 10℃, respectively.

TGA 방법을 이용한 플라스틱과 하수·분뇨슬러지의 열분해 반응속도 연구

윤효숙,최성필,김성탁,원양수,신부영 嶺南大學校 環境問題硏究所 1997 環境硏究 Vol.16 No.2

요약문 도시 고형폐기물의 열분해 특성에 대한 기초 자료를 제시하고자 열중량분석기를 이용하여 가열속도를 실험변수로 하여 하수 및 분뇨슬러지와 5대 범용 플라스틱인 LDPE, HDPE, PP, PS 와 PVC의 열분해 반응속도인자 및 분해특성을 파악하였다. 활성화에너지는 가열속도에 상관없이 일정한 값을 나타내었으며 분해속도가 최고일때의 온도는 가열속도가 증가함에 따라 증가하였다. LDPE, HDPE, PP와 PS는 1단계 분해반응으로 350∼520 ℃에서 대부분이 완전분해되었으며, PVC는 2단계 분해반응으로 250∼550 ℃에서 분해가 진행되었다. 슬러지는 여러 단계의 분해반응으로 특정한 분해구간이 없이 전구간에 걸쳐서 분해가 진행되었다. PVC를 제외한 플라스틱은 완전분해되었으며, PVC는 약 10%의 잔류량이 있었고, 슬러지의 잔류량은 D 하수, S 하수, T 분뇨 슬러지의 순으로 43, 70, 28.5%를 나타내었다.Abstract The thermal decomposition of sewage/night soil sludge and LDPE, HDPE, PP, PS and PVC was studied by using a conventional dynamic thermogravimetric analyzer (TGA) in a flowing nitrogen environment at several heating rates between 5 ℃ and 40 ℃/min. The dynamic thermogravimetric analysis curve was analyzed to obtain the information on the kinetic parameters such as activation energy, reaction order, and Arrhenius preexponential factor. The activation energy keeps constant regardless of heating rates, and the temperature of he fastest decomposition increases with the heating rate. LDPE, HDPE, PP and PS were completely decomposed in the temperature range of 350∼520 ℃ including as the first step decomposition and PVC was decomposed in the temperature range of 250∼550 ℃ including the second step decomposition. Sludge was decomposed without specific temperature range as several decomposition step. Except of PVC, all plastics were decomposed completely. PVC keeps the remains of about 10%, and sludge keeps the remains of 43% for D sewage sludge, 70% for S sewage sludge, 28.5% for T night soil sludge.

엔로플록사신 액제의 닭 호흡기 및 소화기 감염증에 대한 예방 및 치료효과

윤효인,박병권,조준형,정상희,박경환,장범수,김종춘,황윤환,임종환,이내경,박승춘 충남대학교 수의과대학 동물의과학연구소 2000 動物醫科學硏究誌 Vol.8 No.-

We evaluated the efficacy of the liquid form of enrofloxacin against poultry respiratory and digestive infections, the major problems in the poultry industry, from diverse diagnosis viewpoints. Results obtained through this study were as follows: 1. The liquid form of enrofloxacin showed good acceptability to poultry owing to no abhorrence to the drug by chickens, which indicated its suitability for mixing in drinking water. 2. The application of the enrofloxacin formulation improved the productivity of the chicken farm to a great extent by lowering the death toll of chicken raised in the farm. 3. The use of the drug shortened the days to the market, and increased the body weight at the time of marketing. 4. Preventive and therapeutic effects of the liquid enrofloxacin were observed higher than ampicillin, a major antibiotic used in poultry farming. From above results, the liquid form of enrofloxacin would find its use for the prevention and treatment of digestive and respiratory infections, let alone the growth promotion and feed efficiency, especially in the chicken farming practice.