단백질 S 결핍증에 의한 장간막정맥혈전증 치험 1예

김용신,박창영,손정일,김병익,서원태,김명숙,전우규,정을순,김흥대 대한소화기학회 1999 대한소화기학회지 Vol.34 No.6

Mesenteric venous thrombosis is rare but clinically important because it can cause ischemia or infarction in the small intestine. Unless it is diagnosed in time, the patient die eventually. However, the diagnosis is difficult because patients often present with nonspecific abdominal symptoms. Furthermore, if it occurs in young individuals without any known predisposing factor, the diagnosis may become more difficult. Recently, the development of modern imaging techniques (particularly ultrasonography, duplex scanning, and computed tomography) have enabled early recognition of this disease. We report a case of mesenteric venous thrombosis and deep vein thrombosis of left lower extremity. A patient was admitted to our hospital due to continuous, dull abdominal pain. The simple abdomen examination showed abnormal gas pattern probably due to small bowel edema. Abdominal computerized tomography revealed mesenteric venous thrombosis with bowel wall thickenings. Bowel resection was performed and the patient was recovered soon. Mesenteric venous thrombosis was known to be secondary to protein S deficiency later.

베타-글루쿠로니다제에 의한 황련ㆍ황금 공침물의 가수분해 및 생체이용률 증가

김미정,김남순,김영일,김대근,양재헌 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2

During the preparation of decoction from the mixture of Coptidis Rhizoma and Scutellariae Radix, insoluble copreciptate was formed. The coprecipitated product(COP) was composed of berberine and baicalin which was the active ingredient of Coptidis Rhizoma and Scutellariae Radix, respectively. COP was slightly soluble in water and could not be well absorbed after oral administration. This poor bioavailibility might be associated with its poor aqueous solubility. With the purpose of increasing the solubility and bioavailibility of COP, hydrolysis of COP by β-glucuronidase was carried out. Hydrolyzed products (HOP) of COP were identified and assayed for active ingredients. The partition coefficient study, in situ absorption test, and pharmacokinetic study after oral administration were also performed. COP was found to be consisted of berberine and baicalin with molecular ratio or 1 to 1. This compound was hydrolyzed to berberine and baicalin by β-glucuronidase. The rate of hydrolysis was higher at higher temperature up to 50℃ and higher concentration of β-glucuronidase up to 2500 unit under our experimental conditions. Baicalein, which is more liphophilic than baicalin, showed greater absorption in small intestine than baicalin did. The plasma concentrations of berberine and baicalein after oral administration of HOP were significantly higher than those of COP. The possible mechanism of increased bioavailibility of berberine and baicalein could be the hydrolysis of COP by β-glucuronidase. On the basis of the above results, it might be said that HOP should be a suitable preparation for increasing the bioavailibility of Coptidis Rhizoma and Scutellariae Radix.

복발효 감식초의 품질

김미경,김미정,김소연,정대성,정용진,김순동 대구효성가톨릭대학교 식품과학연구소 1994 식품과학지 Vol.6 No.-

고품질의 감식초를 농가에서 자가생산하기 위한 기초적 자료를 마련할 목적으로 자연발효시킨 경우와 복발효시킨 경우의 품질을 비교하였다. 그 결과 복발효시킨 식초는 자연발효 식초에 비하여 초산농도가 1/2인 3%정도였다. 그리고 HPLC 법으로 측정한 유리당의 총함량은 자연발효 식초는 6%, 복발효시킨 것은 5%였다. 감식초내에 함유된 유기산류로는 oxalic acid, malic acid, lactic acid, citric acid, succinic acid, glutaric acid 등 이었으며 자연발효시킨 경우가 전반적으로 함량이 높았다. 특히 자연 발효시킨 경우 lactic acid함량이 높았다. 그러나 감과실의 flavour와 과실의 고유색상과 맛은 복발효시킨 경우가 강하게 나타났다. To prepare the basic information for the fermentation of high quality persimmon vinegar in the farm, the quality of the complex fermented persimmon vinegar(CFPV) was compared to that of naturally fermented persimmon vinegar(NFPV). The titratable acidity of the CFPV was 3% which was the half concentration of the NFPV. The content of total free sugar by HPLC was 6% in CFPV and NFPV was 5%. Organic acid compositions in persimmon vinegar were oxalic acid, malic acid, lactic acid, citric acid, succinic acid and glutaric acid in addition to acetic acid. Total content of the organic acids in NFPV was higer than that in CFPV. Especially, the content of latic acid in NFPV was very higher than that of CFPV. The flavour, color and taste of persimmon fruit itself in CFPV were stronger than those in NFPV.

8년간(1992~1999) 산업안전보건연구원에 의뢰된 직업병 심의 사례 분석

강성규,김규상,김양호,최정근,안연순,진영우,최병순,양정선,김은아,채창호,최용휴,김대성,박정선,정호근 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : Pneumoconisis and noise-induced hearing loss (NIHL) have been reported as main occupational diseases by the Special Health Examination. The Industrial Accident Compensation Insurance has reported various work-related diseases, however, these two diseases occupied almost a half of compensated cases. Therefore, it was not well known about the status of occupational diseases other than pneumoconiosis, NIHL, and cardio-cerebrovascular accident (CVA). This study was conducted to analyze claimed cases as an occupational disease, that was requested to the Korea Industrial Safety and Health Agency (KOSHA). Methods : The local office of the Korea Labor Welfare Corporation (KLWC) has asked the KOSHA for confirmation of claimed cases as an occupational disease. We analyzed 379 cases requested from KLWC, the Ministry of Labor, employers, unions and occupational health agencies from 1992 to 1999. Results : Male was 80.7 % of the requested cases. Their mean age was 42 years old and 75.5 % of them were more than 35 years old. The requested cases were increased rapidly from 25 cases in 1992 to 108 cases in 1999 and the accept rate was 50.7 %. The majority of requested cases were respiratory diseases(22.4%), cancers(18.5%), Neuropsychiatric problems(14.5%), and musculoskeletal problems(13.5%). The accept rate was high in reproductive, respiratory, musculoskeletal and digestive disorders and low in neuropsychiatric, renal and otologic problems and occupational cancers. 73.6% of them were caused by chemical agents, especially 28.5 % were by organic solvents. 67% of them were clinically confirmed at university hospitals. A half of the cases were from KyongIn area, even the request came from the whole country. Conclusions : A claim was common in workers whose age was over 35 years old and exposure history was over 10 years. The respiratory diseases and neuropsychiatric disorders were still main problems in occupational health and occupational cancers was increasing even though its accept rate was not high yet.

우리나라 長壽者의 生活 및 意識調査에 관한 硏究 - Ⅴ. 過去의 健康疾病 및 苦痛에 대한 態度 -

최진호(Jin-Ho Choi),변재형(Jae-Hyeung Pyeun),임채환(Chae-Hwan Rhim),양종순(Jong-Soon Yang),김수현(Soo-Hyun Kim),김정한(Jeung-Han Kim),이병호(Byeong-Ho Lee),우순임(Soon-Im Woo),최선남(Sun-Nam Choe),변대석(Dae-Seok Byun),김무남(Mu-Nam 군산대학교 수산과학연구소 1994 군산대학교 수산과학연구소 연구논문집 Vol.1 No.-

The present study was designed to be link a part of the research on the investigation on daily life and consciousness of the longevous people in Korea, and to investigate the health conditions, and the attitude on disease and suffering of longevous people in the past. 1. By the health conditions of longevous people between 40 and 60 years, ""very good"" showed the highest figure of 71.0%, followed by ""ordinary"" (21.6%). Consequently it is found that 92.6% of total longevous people surveyed maintained the good health conditions above ordinary. 2. Of the experiences of disease and/or injury after 60 years of longevous people, ""never"" showed the highest figure of 74.7%, while ""had"" showed the only 22.6% of total longevous people surveyed. 3. Of the details of disease and/or injury after 60 years of longevous people. ""digestive disease"" showed the highest figure of 32.6%. followed by ""apoplexia cerebri & hypertensions""(14.0%) and ""heart disease""(14.0%), and followed by ""respiratory disease""(12.3%). 4. Of the experiences of suffering between 40 and 60 years of longevous people, ""never"" showed 53.7% of total longevous people surveyed, while the frequency of suffering decreased in the order of ""once""(22.7%), ""2 times""(15.8%) and ""3 times""(4.7%). By the details of suffering between 40 and 60 years of longevous people. ""family life"" showed the highest figure of 85.1%, followed by ""business""(10.1%). 5. By the attitude on suffering of longevous people, ""tried to forget soon"" showed the highest figure of 54.2%, followed by ""continuous worried""(23.3%), and followed by ""not worried""(7.2%).

國內問題不干涉의 原則에 관한 硏究

金楨鍵,金大淳 연세대학교 행정대학원 1981 延世行政論叢 Vol.8 No.-

자연 교과 지도에 대한 초등 교사의 인식

김광명,신순임,강태완,이대형,장병기 춘천교육대학교 과학교육연구소 1995 과학교육연구 Vol.18 No.-

산업디자인 정책에 관한 연구 : 중소제조업을 중심으로 in Small & Medium Manufacturing Firm

김세훈,박대순 한국디자인과학학회 1998 디자인과학연구 Vol.1 No.-

정부가 4년여에 걸친 중소기업에 대한 산업디자인의 지원 노력에도 불구하고 디자인 인식기반은 여전히 취약하다. 따라서 중소기업의 산업디자인 육성에 관한 제반 법적, 제도적 문제점을 지적해보고 선진외국의 사례를 비교하여 한정된 자원으로 가급적 단기간내에 가시적 성과를 가져올 수 있는 정부의 산업디자인 지원 육성방안에 대하여 고찰하였다 중소기업의 디자인분야에 대한 정부의 강력한 의지의 표명으로 (가칭) 「중소기업 산업디자인육성법」제정을 제안하고, 향후 중소기업을 위한 새로운 패러다임에 입각한 정부의 시책추진체계 구축 및 정책수단에 대하여 제안하였다. 정부의 지속적이고 강력한 의지와 중소기업이 이를 수용하고 추진하려는 경영자의 의지가 편짜될 때 중소기업의 디자인육성에 관한 뚜렷한 성과가 기대된다. Public awareness of the importance of design is still poor in spite of the 4 years of effort of the government to foster the field of industrial design. The purpose of this thesis is to study the legal and systematic problems related to the development of the Industrial design and thus, to suggest effective policies which are expected to bear considerable fruits soon. The policies and tool suggested include the legislation of necessary laws and the making of new system of policies based upon new paradigm. Continued and sustained strong support of the government together with the will of the managers will bring about the stable growth of design industry.

체육교사 지식연구 고찰

김대진,문도순 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.2

A review literature has been done about teachers' knowledge research. Shulman (1987) outlined seven categories of knowledge that teachers should have in his article. Four knowledge domains of them have been reviewed; ⅰ) content knowledge, ⅱ) general pedagogical knowledge, ⅲ) pedagogical content knowledge, and ⅳ) curricular knowledge. Since Dunkin and Biddle's research model (1974)was developed, numerous process-product studies have been performed, and lots of useful information was acquired for effective teaching in this field. Fairly recently researchers took an interest in teachers knowledge, however. Most of teacher knowledge research have been performed using qualitative approach such as interview, participant and nonparticipant observation, field note, log etc. Especially special interests were taken in pedagogical content knowledge by researchers, for they thought the knowledge would be most important and influential for student learning. Mainly, qualitative research approach was adopted to perform research on teachers pedagogical content knowledge. Several suggestions have been made: ⅰ)teachers knowledge research should adopt both quantitative and qualitative methods, ⅱ) relationships among content knowledge, pedagogical knowledge, and pedagogical content knowledge should be revealed ⅲ) since students' maximal learning is the educators goal, the relationships between each knowledge domains and teaching performance should be found.

유럽共同體法 優位의 原則에 대한 會員國 裁判所의 反應에 關한 小考 : 西獨의 경우를 中心으로

金大淳 전북대학교 법학연구소 1985 法學硏究 Vol.12 No.-

In Case 6/64, Costa v. Enel, the European Court observed : ...By transferring to the Community legal order functions which hitherto were art of their internal legal order, the Member States have thus brought about a final limitation of their sovereign rights which cannot be revoked by means of subsequent unilateral measures which are incompatible with the concept of Community. ... By "transferring," not merely delegating, sovereign rights, of course albeit within limited fields, the Member States might be said to have lose power to violate EC law. Therefore, according to the idea of European Court, the supremacy of EC law is required on the national level as well as on the Community level. In this repect the relationship between EC law and municipal laws of Member States in fundamentally different from the hitherto established between international and municipal law. This paper shows how the German domestic courts have reacted to the principal of supremacy of EC law. Generally speaking, the German courts may be said to have, more or less willingly, accepted the principle save and except in the field of fundamental human rights.