Nuss 방법에 의한 소아 오목가슴 수술 후 정맥 통증자가조절법을 사용한 Fentanyl 과 Fentanyl-Ketorolac의 진통효과 비교

안기량,서은정,김천숙,강규식,유시현,정진헌,정지원 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

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DCT 변환을 이용한 워터마킹 기법

박성훈,현기호 영산대학교 2002 영산논총 Vol.9 No.-

The proliferation of digitized media(audio, image and video) is creating a pressing need for copyright enforcement schemes that protect copyright ownership. We argue that a watermark must be placed in perceptually significant components of a signal if it is to be robust to signal distortions and malicious attack. In this paper, we studied the method of embedding the encrypted digital watermark in quantization coefficients of DCT when we encode the image data in the process of watermarking.

갑상선에 전이된 유방암 1예

장기훈,김준성,조현진,김권천 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.1

The thyroid gland has been considered as an infrequent metastasis site. However, the incidence of thyroid involvement in reported autopsy series varies from 1.25% to 24%. In most autopsy series, breast and lung cancers have been the most frequent metastatic diseases to the thyroid gland, In contrast, renal cell carcinoma is the most frequent source of metastasis in clinical series. Many reports suggested that ultrasonography and subsequent ultrasonography-guided FNAB are mostly best suited for diagnosis of thyroid metastasis. Metastasis to the thyroid gland is associated with a poor prognosis and the prognosis depends essentially on the primary cancer. Surgery may prolong survival in a patient in whom the thyroid metastasis isolated, and thus early diagnosis and aggressive treatment should be performed in patients with the history of cancer.

갑상선 기능항진증에 병발된 주기성 마비 3예

최지훈,최경숙,김기훈,박병현,조정구 圓光大學校 醫科學硏究所 2001 圓光醫科學 Vol.16 No.1-2

Thyrotoxic periodic paralysis is characterized by intermittent flaccid paralysis of skeletal muscle, lasting several hours. The underlying pathophysiology of the syndrome is not yet to be well characterized and remains controversal, but reflects altered potassium and calcium dynamics as well as certain morphologic characteristics within the muscle unit itself. It occurs primarily in Asian populations with an overwhelming male preponderance and a higher association of specific HLA antigens. Precipitating factors include high carbohydrate ingestion, exercise, trauma, infection, alcohol ingestion, administration of epinephrine, thyroid hormone, or corticosteroid. If hypokalemia is present, potassium administration may help abort the attack, but the only definitive treatment is formation of euthyroid state. We discribed two patients with hypokalemic thyrotoxic periodic paralysis and one patient with normokalemic thyrotoxic periodic paralysis.

Lymphangioma에 의한 거설증을 지닌 환자의 개교합 증례보고 : A CASE REPORT

윤희훈,이상대,김영재,장기택,한세현,이상훈 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.2

Lymphangioma는 림프관에 나타나는 양성종양으로 림프관의 증식을 특징으로 한다. 이 종양의 대부분은 출생 시에 나타나며 종양의 95%정도가 10세 이전에 나타난다. 구강 내에 발생하는 경우에는 혀에서 가장 호발하며 거설증을 야기한다. 대개 양측성으로 혀의 전방 2/3부위에 나타나며 불규칙한 회색과 핑크빛을 띤 소절형태를 보인다. 본 증례 모두에서 환아들은 출생당시 혀에 lymphangioma를 지니고 태어나 거설증을 보였으며 이로 인해 개교합과 하악과성장 양상을 나타내었다. Lymphangioma에 의한 비정상적인 혀의 비대에 의해 환아의 구강과 두개안면부의 주위조직에 대한 적응 결과로 나타난 소견을 관찰하고 관련문헌을 고찰하여 다소의 지견을 얻었기에 보고하는 바이다. Lymphangioma is a benign tumor of lymphatic vessels. The majority of cases are present at birth and 95% of the tumors aroused before the age of 10 years. Oral lymphangioma may occur at various sites but are most frequent on the anterior two thirds of the tongue, where they often result in macroglossia. The lesions present nodularity with gray and pink projections. In the present cases, all the patients who had the macroglossia combined with lymphangioma showed openbite and mandibular prognathism. The purpose of this paper was to report the dental and craniofacial findings of macroglossia combined with lymphangioma and review the pertinent literature through the cases.

흰쥐에서 에스트로젠 결핍이 하악골 골밀도에 미치는 영향

김기현,신상훈,김욱규,박봉수,정인교 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.2

The relationship between systemic bone loss(osteopenia) and loss of oral bone has been of considerable recent interest. In dentistry, some investigators have studied using human subjects, but no firm conclusion due to many obstacles have yet been obtained. From these obstacles in the assessment of human subjects, the significance of investigations with overiectomized rats has been proposed recently. Also, in ovariectomized rats, quantitative data on changes in the alveolar bone of mandible and basal bone of mandible using dual-energy x-ray absorptiometry(DEXA) were far fewer. The purposes of this study were to certify systemic estrogen deficiency-induced osteopenia by biochemical markers(serum osteocalcin(OC) & urinary deoxypyridinoline(DPD)) and bone mimeral density(BMD) of femur by DEXA and examine changes in BMD of the rat mandible by DEXA with 24-week-old female Sprague-Dawley rats. Forty eight rats were used in this study and twenty four rats were ovariectomized bilaterally(OVX) to induce systemic osteopenia and remainders were subjected to sham surgery(Sham). The experimental rats were killed at different time interval(1st, 2nd, 3rd, 4th, 6th, 8th, 12th and 16th week) for histologic examination, biochemistry analysis and BMD measurement. The results obtained from this study were as follows: On histological examination, in mandible, early degeneration of periodontal ligament, early bone resorption in alveolar bone and late bone resorption in basal bone were observed. On biochemical analysis, OC and DPD were observed statistically no significancy to predict systemic osteopenia. On DEXA measurement, in OVX group, we observed statistically significant decrease from 3rd week in distal metaphysis, statistically non-significant decrease from 2nd week in alveolar bone of mandible, and statistically significant decrease at 16th week in total mandible. From these results, it could be stated that systemic osteopenia by ovariectomy was early affected in the trabecular bone of femur and alveolar bone of the mandible whereas the total mandible was affected later.

Relationship Between Biological Marker Expression and Fluorine-18 Fluorodeoxyglucose Uptake in Incidentally Detected Thyroid Cancer

Kim, Bo Hyun,Kim, In Joo,Kim, Sang Soo,Kim, Seong-Jang,Lee, Chang Hun,Kim, Yong-Ki Mary Ann Liebert 2010 Cancer Biotherapy & Radiopharmaceuticals Vol.25 No.3

<P>The aim of this study was to investigate the underlying mechanisms associated with fluorine-18 fluorodeoxyglucose (F-18 FDG) uptake in an incidentally detected thyroid cancer during nonthyroid cancer evaluation. Among 92 patients (10 men and 82 women; mean age, 56.2 +/- 10.9 years; age range, 26-78 years) with focal thyroid FDG uptake during nonthyroid cancer evaluation, 14 patients with cytologically confirmed papillary thyroid cancer were included. For semiquantitative analysis, the maximal standardized uptake value was calculated. Immunohistochemical studies were performed for hypoxia inducible factor 1 alpha (HIF1alpha), HIF2alpha, glucose transporter 1 (GLUT1), GLUT3, carbonic anhydrase IX (CA-IX), hexokinase type II (HK II), and vascular endothelial growth factor (VEGF). The significant findings of this study were as follows: (1) a lack of HIF1alpha and HIF2alpha expression; (2) low-degree expression of GLUT1 (1 patient), GLUT3 (5 of 14 patients), HK II (3 of 14 patients), and CA-IX (1 patient); and (3) high degree expression of VEGF (all 14 patients). The data presented in this study indicate that F-18 FDG uptake in incidentally detected thyroid cancer was not related to hypoxia-induced upregulation of GLUT1, GLUT3, CA-IX, and HK II. Ki-67 expression was not associated with F-18 FDG uptake. However, all incidentally detected thyroid cancers showed a high degree of expression of VEGF.</P>

오존처리에 의한 하수슬러지의 감량화

권재현,류성호,박기영,안규홍,염익태,이용훈 대한상하수도학회 2002 상하수도학회지 Vol.16 No.2

The effects of ozone treatment on the dewaterability of activated sludge wasted from a sewage treatment plant were investigated in this study. Following ozone treatment, sludge was dewatered using a pressure fitter. The sludge filterability evaluated by SRF deteriorated with ozone dosage at relatively low ozone doses due to sludge solubilization and particle size decrease. However, at ozone doses higher than 0.6gO_3/gSS, the SRF of the ozone treated sludge became comparable with the value for the sludge without ozone treatment. It is suggested that the oxidation of the viscous, high molecule organics attached at cell surface reduces the surface charge of sludge particle and promotes flocculation at relatively high ozone doses. Ozone treatment also cause the release of bound water trapped inside cells or flocs, resulting in significant reduction of cake water content after dewatering. In terms of cake volume, more than 70% reduction was obtained at 0.6gO_3/gSS. These observations suggest that ozone treatment has potential to significantly enhance sludge dewaterability and to produce a more compact cake without severe deterioration of its filterability.

농촌지역 노인들의 우울증상에 관련된 요인들의 특성

송미숙,전기홍,송현종,김정은,박승구,신상건,이동훈,정성현,최연주,최완철,최민규,황재철,홍지만 아주대학교 1997 아주의학 Vol.2 No.2

This study was performed to identify risk factors for depression among the elderly in a rural area. A survey was done for the elderly living in Gosam-myenn, Ansung-kun during the period of July 28, 1997 and July 30, 1997. Demographic and sodoeconornic characteristics, and functional and health Status were assessed using a structured questionnaire, and the level of depression was measured by GDS score. The data obtained were analyzed by frequencies, percentage, t-test, ANOVA, and multiple regression, and the results were as follows: 1. The total sample consisted of 133 elderly. Of them, 47 elderly (35.4%) showed significant depressive Symptoms. 2. The GDS score was the highest for the group over 85 years of age (p < 0.05). Those living alone or widowed showed lower GDS score than those living with someone or married (p < 0.05). 3. The GDS score was the highest in the absolutely dependent group, followed by the partially dependent group, and the independent group (p < 0.01). The elderly who perceived their health Status as excellent showed the lowest GDS score. In contrast, those who had more than five chronic diseases showed the highest GDS score. 4. The elderly receiving financial and emotional support from their family or friends showed lower GDS score compared to those without any support. 5. The economically dependent group showed higher GDS score than that of independent group. 6. The elderly who involved in leisure activities showed lower GDS score than those without any involvement. 7. In terms of risk factors for depression, we found that perceived health Status, subjective economic Status, leisure activities, living arrangement and financial support were inversely associated with GDS score, whereas labor support was positively associated with GDS score. Based upon the above findings, this study suggests that these risk factors for depression in the elderly should be taken into consideration for a comprehensive mental health program for the elderly living in the rural area.

Mycophenolic Acid와 Rapamycin이 흰쥐 사구체 혈관간세포증식과 세포외기질 생성에 미치는 영향

김명수,박제현,하헌주,허규하,서지연,김유선,김혜진,박기일 이화여자대학교 약학연구소 2004 藥學硏究論文集 Vol.- No.14

Background: Excess proliferation and extracellular matrix (ECM) accumulation of mesenchymal cells such as vascular smooth muscle cells (VSMC) and glomerular mesangial cells cause chronic allograft nephropathy showing transplant vascular sclerosis and glomerulosclerosis. Mycophenolic acid (MPA) and rapamycin (RPM) are well known as strong inhibitors of VSMC proliferation, but their effects on the glomerular mesangial cells are not yet clearly understood. This study examined the effects of MPA or RPM on PDGF-induced proliferation and ECM accumulation in rat glomerular mesangial cells. Methods: Mesangial cells isolated from the glomeruli of Sprague-Dawley rats were cultured with DMEM containing 20% fetal bovine serum. Growth arrested and synchronized cells were administered with test drugs (MPA10 nM-10μM, RPM 0.1 nM-1μM) before the addition of PDGF 10 ng/mL. Cell proliferation was assessed by [³H]thymidine incorporation, collagen by [³H]proline incorporation, and fibronectin, ERK, and p38 MAPK by Western blot analysis. Results: PDGF increased mesangial cell proliferation by 4.64-fold. Compared to stimulated control, MPA above 500 nM and RPM above 10nM showed a significant inhibitory effect in a dose-dependent manner. The IC_(50) of MPA and RPM against PDGF-induced mesangial cell proliferation were around 500 nM and 100 nM, respectively. The collagen synthesis was also inhibited by MPA and RPM, but the fibronectin secretion was inhibited by MPA alone. The proliferation of mesangial cell correlated with activation of ERK and. p38 MAPK. MPA, but not RPM, inhibited ERK and p38 MAPK activation. Conclusion: This study demonstrated that MPA and RPM significantly inhibited PDGF-induced proliferation and ECM production in rat glomerular mesangial cells. The inhibitory effects of MPA, but not RPM, are correlated with ERK and p38 MAPK.