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마늘-죽염 제제가 위장 장애 유발 흰쥐의 항산화 효소활성에 미치는 영향
허근,김영희,김대경 영남대학교 약품개발연구소 2001 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-
Garlic has been known to be effective against the gastrointestinal diseases which can be induced by production of oxygen-derived free radical. It has been shown that bamboo salt is effective on the treatment and prevention of various gastrointestinal disorders. Bamboo salt is a processed salt invented by a Korean, ll-Hoon Kim. It has been reported that garlic and bamboo-salt are useful to the treatment of gastric disorders in Korea. To clarify the protective mechanism of the garlic-bamboo salt mixture, the gastropathy was induced in rats with alcohol-salicylate and the activities of the free radical scavenging enzymes were examined. In this study, we found that the garlic-bamboo salt mixture reduced the severity of hemorrhagic lesion in gastric mucosa in the rats. In addition, the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) were significnatly increased and the total content of GSH was recovered. From these results, we concluded that the protective effect of the garlicbamboo salt mixture on gastropathy in rats in its ability to recover the level of GSH and to increase the activities of the free radical scavenging enzymes (SOD. GPx. GR).
Bacillus lentimorbus WJ5의 감마선유도 돌연변이체들에서 공통으로 발현되는 방사선 관련 유전자의 microarray 분석
이영근,장화형,장유신,허재호,형석원,정혜영 한국환경생물학회 2004 환경생물 : 환경생물학회지 Vol.22 No.3
본 연구에서는 감마선으로 유도된 돌연변이체들에서 공통으로 발현되는 방사선 관련 유전자들의 발현을 연구하기 위하여, B. lentimorbus WJ5의 방사선 유도 돌연변이체에서 발현되는 유전자를 DNA microarray로 동시에 탐색하였다. DNA microarray는 B. lentimorbus WJ5 genome을 무작위로 절단하여 2,000단편으로 구성하였으며, 감마선 (^(60)Co)으로 유도된 7돌연변이체의 발현을 정량적으로 관찰하였다. 클러스터 분석결과 발현된 408 유전자 중 27개가 감마선 유도 돌연변이체 모두에서 유의하게 발현이 증가되었다. 특히, 복구(mutL, mutM)에너지 대사 (acsA, sdhB, p하, yhjB, citB), protease(npr), 산화자극에 대한 환원 (HMM)관련 유전자들이 동시에 증가되었다. 이는 감마선 유도 돌연변이체들에서 자발적인 직/간접 복구 관련 유전자의 발현 증가는 방사선 노출 직후 보이는 stress response와는 다른 현상임을 나타내는 것으로 생각된다. To study the radiation related gene expression in mutants of Bacillus lentimorbus WJ5 induced by gamm radiation, the simultaneous gene expression was analyzed by DNA microarray. We constructed DNA chips including two thousand randomly digested genome spots of B. lentimorbus WJ5 and compared its quantitative aspect with seven mutants induced by gamma radiation (^(60)Co). From the cluster analysis of gene expression pattern, totally 408 genes were expressed and 27 genes were significantly upregulated by the gamma radiation in all mutants. Especially, genes involved in repair (mutL, mutM), energy metabolism (acsA, sdhB, pgk, yhjB, citB), protease (npr), and reduction response to oxidative stress (HMM) were simultaneously upregulated. It seems that the induction of the direct and/or indirect repair related genes in mutants induced by gamma radiation could be remarkably different from the adaptive responses against acute exposure to radiation.
박영수,김창오,김영근,홍성관,장경희,허애정,염준섭,송영구,김준명 대한감염학회 2001 감염 Vol.33 No.5
The Korean hemorrhagic fever (KHF) is an acute febrile disease with characteristic of fever, bleeding tendency, and renal failure. There are many complications of Korean hemorrhagic fever such as infection, anemia, internal bleeding, hypopituitarism, respiratory, and neurologic complication. A few cases were reported on acute pancreatitis with hemorrhagic fever abroad, but there was no case about Korean hemorrhagic fever with acute pancreatitis in this country. We experienced a case of Korean hemorrhagic fever associated with suspected acute pancreatits. With review of articles, we report a case of 51 year-old woman with KHF, where acute pancreatitis developed during management, (Korean J Infect Dis 33:376∼379, 2001)
의사결정지원시스템에서 직관적이고 사용자 친숙한 모델 해결을 위한 모델과 솔버의 유연한 통합에 대한 연구
이근우,허순영 한국경영과학회 2005 韓國經營科學會誌 Vol.30 No.1
Research in the decision sciences has continued to develop a variety of mathematical models as well as software tools supporting corporate decision-making. Yet, in spite of their potential usefulness, the models are little used in real-world decision making since the model solution processes are too complex for ordinary users to get accustomed. This paper proposes an intelligent and flexible model-solver integration framework that enables the suer to solve decision problems using multiple models and solvers without having precise knowledge of the model-solution processes. Specifically, for intuitive model-solution, the framework enables a decision support system to suggest the compatible solvers of a model autonomously without direct user intervention and to solve the model by matching the model and solver parameters intelligently without any serious conflicts. Thus, the framework would improve the productivity of institutional model solving tasks by relieving the user from the burden of learning model and solver semantics requiring considerable time and efforts.
Keun Young Huh(Keun Young Huh),Hyuncheol Heo(Hyuncheol Heo),Hyunjong Jung(Hyunjong Jung),Inhea Kim(Inhea Kim) 인간식물환경학회 2022 인간식물환경학회지 Vol.25 No.5
Background and objective: This study was conducted to analyze users’ behavior, recognition, and satisfaction toward forest trails and exercise facilities in urban mountainous forests, Jinju City, South Korea. Methods: Users’ characteristics, visit motives, and satisfaction with forest trails and exercise facilities in three urban mountainous forests were surveyed from September to October 2020. The data of 300 respondents were analyzed using frequency, descriptive, and regression analysis. Results: There was a high percentage of users aged 51 or older (62.0%). Most users visited regardless of weekdays or weekends, every day or 2-3 times a week, and stayed for 1-2 hours. Most were using the forest trails and outdoor fitness facilities. Hiking or walking showed the highest frequency in visit motives, followed by using outdoor fitness facilities. Overall satisfaction with forest trails was high at 3.74-3.93 on a 5-point Likert scale, which was affected by the landscape and environment of small private arable lands around forest trails and convenient facilities such as handrails and information boards. Overall satisfaction with outdoor fitness facilities was 3.34-3.62, which was affected by harmony with forest landscape and facility maintenance. Overall satisfaction with indoor badminton courts was 3.01-3.08, which was affected by harmony with forest landscape. Conclusion: For improving overall satisfaction, it is crucial to maintain and repair the width and surface of forest trails, but renovating the landscape and environment of small private arable lands and exercise facilities may be more critical. It is desirable to improve and maintain the function and landscape of outdoor fitness facilities and to relocate indoor badminton courts to the outskirts or boundaries of the mountainous forests. To provide various leisure and recreation activities, the creation of a forest bathing place will be first necessary, followed by a family recreation place and outdoor learning classroom.