Interferon-γ Inhibits in vitro Mobilization of Eosinophils by Interleukin-5

Park, Choon-Sik,Choi, Eun Nam,Kim, Jung Sun,Choi, Yun Sung,Rhim, Tai Youn,Chang, Hun Soo,Chung, Il Yup S. Karger AG 2005 International archives of allergy and immunology Vol.136 No.3

<P><I>Background:</I> Th2 cytokines play pivotal roles in allergic inflammation, including eosinophilia, and their actions are antagonized by Th1 cytokines, conferring them therapeutic potential. <I>Methods:</I> In this study, we examined the ability of a number of cytokines to suppress the activation of eosinophils that function as effector cells for allergic airway diseases. <I>Results:</I> Interleukin (IL)-5, IL-6, and tumor necrosis factor (TNF) induced an eosinophil shape change, whereas interferon (IFN)-γ significantly inhibited the shape change. Other cytokines, including IL-1β, IL-4, IL-10 and IL-13, had little or only slightly enhancing or reducing effects on the shape change. We further analyzed the IFN-γ effect, showing that pretreatment with IFN-γ strongly suppressed IL-5-induced eosinophil shape change, and cycloheximide (CHX) abrogated the suppression by IFN-γ, suggesting that new protein synthesis is required for the inhibitory effect by this cytokine. In agreement with these results, IFN-γ blocked the eosinophil migration and ERK phophorylation induced by IL-5, and the addition of CHX restored eosinophil chemotaxis. <I>Conclusions:</I> Collectively, IFN-γ may attenuate eosinophilic inflammation by directly negating eosinophil mobilization.</P><P>Copyright © 2005 S. Karger AG, Basel</P>

OVA로 유도된 생쥐 모델에서 EGCG의 천식 예방 효과

박성남,이찬우,이창민,정만홍,황순철,박영민 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Epigallocatechin-3-gallate (EGCG), a major form of tea epicatechin, has a variety of biological activities. It has recently been studied intensively as an antiallergic and anti-inflammatory agent. Thus we elucidated the anti-allergic effect of EGCG in the ovalbumin (OVA)-induced asthma model mice by examining the expression of matrix metalloproteinase (MMP)-9. Also airway reactivity to methacholine challenge and reactive oxygen species (ROS) generation in BAL fluid. mesured by the expression of iNOS mRNA in lung tissue and tumor necrosis factor (TNF) in BAL fluids. The OVA challenged mice showed allergic airway reactions, such as inflammatory chemokine (CCL5,CXCL10) in the airway and lung tissues. However mice administrated with EGCG had significantly reduced CCL5 and MMP-9 expression in lung tissues as well as TNF-α and IL-5 production in BAL fluid. these results suggest that EGCG regulate

조선대학교 의과대학 유급제도 개선을 위한 예비조사

박종,박상기,박상학,도남용,송창훈,이승일,임성철 朝鮮大學校 附設 醫學硏究所 1998 The Medical Journal of Chosun University Vol.23 No.1

This is a pilot study to improve the flunk system, a self-reported questionnaire survey was done by 58 professors among a total of 94 professors at Chosun University Medical School in December 1997. The results were as follows : 1. In regard to the student's residence, 69% of professors answered that the current system was appropriate. For a proper method of flunking. 46.6% of the professors agreed to the introduction of retesting by the Academic Affairs Department and 44.8% of the professors agreed to the evaluation of academic achievement of each subject. 2. Sixty-seven point two percents of professors agreed to the changing of time of flunk. 43.1% felt at the end of course, 24.1% felt at midterm, and 25.9% felt that the current system. 3. In regard to flunking, 34.5% of professors thought the current system-if a student receives an F grade in to be one subject, he/she was flunked-was sufficient, but 65.6% of the professors felt needed there improvement. The method of improvement was considered was losing more than two credits-fail(32.8%), and losing more than four credits-fail(10.3%). 4. Eighty-four point five percent of the professors agreed to the necessity of flunking by grade point average(GPA) and 77.6% of the professors answered that the students who must re-register should take all designated subjects. 5. Seventy-two point four percent of the professors opposed summer or winter courses for students who flunk and 51.7% of the professors opposed the necessity of a management system for students. In conclusion, the professors in Chosun University Medical College recognized the necessity of improving the flunk system, especially, the time, method and record keeping. So a concrete follow-up study needed to improve the flunk system.

高等學敎 學生들의 進路探索에 관한 硏究

朴昌南 건국대학교 교육대학원 1991 敎育論叢 Vol.15 No.-

1.Purpose of the study As a study of inquiry about the realites of cowse guidances are forcing in the liberal arts system high school the main purpose of this study is to experiment and to analyze what influence affects the selection of the system of school,as well as school subject by course guidance in time of the liberal arts system high school students who are going to enter the vocational field or continue into college in the future. 2.Method of the study I examined the theoretical background of course guidance through the study of documents and precedent study. The method of carrying out the study<see table 4-1> was the divide the questionnaire into 30questions, 9questions and 9uestions And I studied respectively as to the students consciousness of the course. The as to the parent's view of course the teacher's consciousness of course. The questionnaire about the student's consciousness of cowse was enfarced in advance(106), later(96), and it made parents(41), teacher(44) as on object study and (as in table 4-3) after the first students questionnaire, a second questionnaire was given to see what changes accured through course guidance and consel for the students and their parents. 3.Findings of the study If we examine the results through this experimentation and analysis, The next is : first: The students have formed a distinct self-concept toward their aptitude, capacity, physical peculiarity because they more correctly understood them. Second:The students have a high interest and knowledge of the Vocational world, the present condition of college curriculum and changeable view, they have a confidence in their desired occupation of School Subject, ultimately their attitude toward a vocation is changed affirmativly. Third:In the decision of wheather they go to college or not, when to enter the school propertime, the selection of school system and school subject are decided with wandering and conflict. They decided upon their think correctly and rationally and they propered their future coures with a sense of stability. fourth:Correct and various information concerning the direction of coures quidance was obtained from the questionnaire. it helped to establish future intentional contemplative ability and a distinctive life object. fifth:For teachers cognizance and aptitude about course education was changed affirmatively. The coures education ability has improved. sixth:The parents have had a higher understanding and recognition of the course, it helped them to from the right sense of direction. seventh:The need of documentation for course guidance is recognized in the liberal arts high school. According to the results of this study, I would like to propose the following: first:The course education must be put in force systematically from the elementary school to enlighten and stretched individual qualities, aptitudes second:In the light of the importance for course education if the text book revized so the contents of the course education should be establish in the educational cowse systematically. third:To diffuse and extend course education, we should in stall course education lectures and offer the chance of leadership technic's training to instill an upright understanding of course education. This can be done when training meetings are held for students. fourth:documetation for course education must be developed and earlier developed good documents should be supplied to the schools for the purpose of course education's inner-fertilization schools for the purpose of education's inner-fertilization and qualitative improvement. fifth:We Should consolidate course education public relations at the social and national levels in order to from a beffer sense of value among parents toward vocation and a right understanding about course education. sixth:We should strengthen the chance of study and training for teacher's in order to renew course education and to help them acqire expert knowledge.

How We Have Treated Severe to Critically Ill Patients With Coronavirus Disease 2019 in Korea

Park Do Hyeon,Kang Chang Kyung,Choe Pyoeng Gyun,Kim Nam Joong,Park Wan Beom,Oh Myoung-don 대한의학회 2022 Journal of Korean medical science Vol.37 No.49

Since 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide, and the coronavirus disease 2019 (COVID-19) pandemic currently continues. In response to this unprecedented pandemic, several researchers and medical staff have struggled to find appropriate treatments for COVID-19. Patients with mild symptoms can recuperate with symptomatic care, however establishing treatment for severe to critically ill patients who can have a high mortality has been essential. Accordingly, the guidelines for COVID-19 treatment have evolved through numerous trials and errors and have been relatively well established to date. In the Republic of Korea, several evidence-based guidelines for COVID-19 treatment were released and revised, reflecting various research and regional medical conditions. To date, approximately 3 years after the beginning of the COVID-19 pandemic, we are reflecting on the changes in the guidelines thus far and have summarized the treatment experience of severe to critically ill patients with COVID-19. The Korean guidelines for COVID-19 treatment have been updated continuously as the National Institutes of Health (NIH) guidelines have changed. Dexamethasone is currently used as the backbone for the treatment of severe to critically ill patients with COVID-19, and remdesivir, baricitinib, and tocilizumab can be added depending on a patient’s situation. In addition, venous thromboembolism prophylaxis is one of the important adjunctive therapies for patients with severe COVID-19. In the clinical field, treatment of severely ill patients with COVID-19 based on guidelines is widely practiced by medical staff and established currently.

Analysis of Genetic Diversity of Korean Wheat Cultivars Using Microsatellite DNA Polymorphisms

Park,Yong-Jin,Cho,Gyu-Taek,Ma,Kyung-Ho,Lee,Sok-Young,Lee,Jung-Ro,Kim,Young-Chang,Cho,Eun-Gi,Kim Chang-Yung,Nam,Jung-Hyun,Rao,V,Ramanatha,Kang,Hee-Kyoung 한국자원식물학회 2004 Plant Resources Vol.7 No.2

Genetic background and phylogenetic relationships among 20 Korean wheat cultivars were assessed using microsatellites after amplifying with 13 SSR primer pairs. Average allele number per primer pair was 3.36. Genetic similarities for every pair of cultivars ranged from 0.42 to 0.97, with 0.69 of overall average. Korean cultivars were divided into two major groups based on microsatellite DNA polymorphisms. Group I consisted of relatively old cultivars developed until 1970s, and group II contained the recent cultivars developed during 1980s and 1990s. Amongst old elite cultivars/lines, ‘Yukseung 3’, ‘Norin 12’ and ‘Norin 72’ contributed most to the genetic background of cultivars belonging to group I, and ‘Norin 4’, ‘Norin 12’, ‘Norin 43’ and ‘Norin 72’ to group II, respectively. The phylogenetic relationship of Korean wheat cultivars was in accordance with the genealogical data of each cultivar. The genetic background of each cultivar was assessed from the point of breeding and germplasm management such as variety identification and duplicated accessions for assisting in developing a system for the registration of new variety based on the molecular characterization in future.

Chunghyul-Dan(Qingxie-Dan) Improves Arterial Stiffness in Patients with Increased baPWV

Park, Seong Uk,June, Woo Sang,Moon, Sang Kwan,Ko, Chang Nam,Cho, Ki Ho,Kim, Young Suk,Bae, Hyung Sup 경희대학교 동서의학연구소 2006 東西醫學硏究所 論文集 Vol.2006 No.-

Arterial stiffness is an important, independent determinant of cardiovascular risk. Pulse wave velocity (PWV) has been used as a valuable index of arterial stiffness and as a surrogate marker for atherosclerosis. Chunghyul-dan (CHD) has anti-hyperlipidemic activity, anti-inflammatory activity and anti-atherogenic effects. To determine its clinical effect on increased arterial stiffness, we examined whether CHD improves arterial stiffness in patients with increased brachial-ankle PWV (baPWV). Thirty-five subjects with increased baPWV (> 1400 cm/sec) were recruited and randomized to a treatment group (20 subjects) or a control group (15 subjects). The treatment group was administered CHD at a dose of 600 mg three times a day for 8 weeks, and the control group received no medication (observation only). baPWV was assessed using a pulse pressure analyzer at baseline and after 8 weeks. Blood pressure and serum lipid profile were monitored in the treatment group. Our results indicate that baPWV was lowered significantly in the treatment group after 8 weeks of medication (p < 0.05), but not in the control group. Moreover, there were no significant changes in blood pressure and serum lipids profile except triglyceride level suggesting that the effect is largely independent of CHD's lipid-lowering effect or a blood pressure change. In conclusion, CHD appears to improve arterial stiffness in patients with increased PWV.

Three-dimensional analysis of soft and hard tissue changes after mandibular setback surgery in skeletal Class III patients

Park, Jae-Woo,Kim, Nam-Kug,Kim, Myung-Jin,Chang, Young-Il The Korean Association Of Orthodontists 2005 대한치과교정학회지 Vol.35 No.4

하악 수술로 치료한 골격성 3급 부정교합 환자의 연조직 변화를 3차원적으로 분석하였다. 수술전과 수술후에 CT를 촬영하고, 연조직과 경조직을 각각의 임계값에 따라 segmentation였다. FH.평면, 정중시상면, PNS를 포함하는 전두면을 기준으로 공통 좌표계를 구성하고, 이 좌표계를 기준으로 술전, 술후 영상을 위치시켰다. 술후의 변화를 측정하기 위해 각각의 모형에 대해 전두면에 평행한 grid를 형성하였다. Grid내의 교점에서 골조직과 연조직 모형에 투사하여 만나는 점의 좌표값을 구하고, 이를 바탕으로 술후의 변화를 측정하였다. 하악골 후퇴술시 안모의 변화는 하악골 부분에서만 발생한 것이 아니라, 구각부에서도 관찰되었다. 하악골 부위의 연조직 변화는 대응되는 골조직 이동량에 따른 상대적인 값으로 계산하였다. 정중시상면에서의 변화율은 $77\~102\%$로 나타났다. (p<0.05). 정중시상면 이외의 부분의 변화양상도 이와 유사하였다. 구각부에서의 변화는 하악골의 이동을 대표할 수 있는 점의 이동량에 대한 상대적인 값으로 계산하였다. 정중시상면에서의 변화는 B점을 기준으로 $14\~29\%$이고, Pog점을 기준으로 $17\~37\%$, grid상 83번째 점을 기준으로 $11\~22\%$로 관찰되었다.(p<0.05) The three-dimensional (3D) changes of bone, soft tissue and the ratio of soft tissue to bony movement was investigated in 8 skeletal Class III patients treated by mandibular setback surgery. CT scans of each patient at pre- and post-operative states were taken. Each scan was segmented by a threshold value and registered to a universal three-dimensional coordinate system, consisting of an FH plane, a mid-sagittal plane, and a coronal plane defined by PNS. In the study, the grid parallel to the coronal plane was proposed for the comparison of the changes. The bone or soft tissue was intersected by the projected line from each point on the gird. The coordinate values of intersected point were measured and compared between the pre- and post-operative models. The facial surface changes after setback surgery occurred not only in the mandible, but also in the mouth corner region. The soft tissue changes of the mandibular area were measured relatively by the proportional ratios to the bone changes. The ratios at the mid-sagittal plane were $77\~102\%(p<0.05)$. The ratios at all other sagittal planes had similar patterns to the mid-sagittal plane, but with decreased values. And, the changes in the maxillary region were calculated as a ratio, relative to the movement of a point representing a mandibular movement. When B point was used as a representative point, the ratios were $14\~29\%$, and when Pog was used, the ratios were $17\~37\%(9<0.05)$. In case of the 83rd point of the grid, the ratios were $11\~22\%(p<0.05)$.

私立大學生의 成長發育 및 營養狀態에 關한 硏究 : 中學校 入試有無過程을 通한 比較

朴淳永,具燾書,朴良元,金振浩,南炳執,朴昌植,朴喆斌 慶熙大學校 1980 論文集 Vol.10 No.-

In order to ascertain any possible changes in the physical and the nutritional status of Korean high school students before and after the abolishment of college entrance examination system, an intensive survey was conducted on the physical conditions of the incoming freshmen students (9532 males and 3428 females) of Kyung Hee University from 1972 to 1980. The finding are as below. 1. Physical growth conditions In each of the average physical dimensions of body height, body weight, chest girth and sitting height, a remarkable improvement was recorded for all age groups after the matriculation was abolished. 2. Physical and nutritional indices Relative body weight showed constant values of 35.0 in male and 32.0 in female. Relative chest girth showed the normal chest girth style in all age groups of both sexes. Relative sitting height showed a constant value of 54 for both sexes. The values of vervaeck index of th nutritional status were shown to be between 86-87 in male and 83-94 in female, Pelidisi index 91 and 92-93, Rohrer index of physical status 121-125 and 130-132, and Kaup index 206-211 and 202-210, respectively.

조선대학교 의과대학의 유급제도 개선을 위한 예비조사

박종,박상기,박상학,도남용,송창훈,이승일,임성철 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1