http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
성낙도,유성재,남기달,장기혁,한호규 충남대학교 생물공학연구소 1999 생물공학연구지 Vol.7 No.-
기질(S) 화합물로 30종의 5,6-dihydro-2-trifluoromethyl-1,4-oxathiin carboxanilide 유도체들을 합성하고 벼 잎집무늬 마름병균(Rhizoctonia solani)과 밀 붉은 녹병균(Puccinia recondita)에 대한 항균활성(in vivo) 값(pI_50)을 측정하였다. (S)는 잘록병균보다 밀 붉은녹병균에 대하여 보다 큰 항균활성을 나타내었으며 두 종의 균에 대하여 3-methoxy, 11, 3-iso-propyloxy, 13 및 3-iso-propyl 치환체, 25가 제일 큰 활성을 보였다. 그리고 치환(X)-phenylcarbamoyl group의 변화에 따른 물리-화학 파라미터와 항균활성(pI_50)으로부터 구조-활성관계(SAR)를 검토 한 결과, 벼 잎집무늬 마름병균에 대하여는 공명효과에 따른 전자밀게(R<0)의 소수성이 큰(π>0) m-alkyl 치환기(X)가, 그리고 밀 붉은녹병균에 대하여는 분자 분극율(Sp.Po1.)과 분자의 음하전(ABSQ<0)을 위시하여 HOMO에너지(e.v.)가 클수록(HOMO<0) 높은 항균활성을 나타내었다. 또한, 전하-조절 반응에 의한 수용체-(S)간의 상호작용과 높은 활성발현 조건들이 검토되었다.(1998년 2월 3일 접수, 1998년 12월 1일 수리) New thirty derivatives of 5,6-dihydro-2-trifluoromethyl-1,4-oxathiin carboxanilide as substrate(S) were synthesized and their fungicidal activities in vivo against rice sheath blight(Rhizoctonia solani) and wheat leaf rust(Puccinia recondita) were examined. The structure activity relationships(SAR) between the activities(pI_50) and a physicochemical parameters of substituents(X) at the phenylcarbamoyl group were analyzed using the adaptive regression analysis method. The 3-methoxy, 11, 3-isopropyloxy, 13 and 3-isopropyl substituent, 25 as X on the phenylcarbamoyl group exhibited the most highest fungicidal activity against the two fungi. The fungicidal potency of the (S) against Puccinia recondita was higher than Rhizoctonia solani. In case of Rhizoctonia solani, the molecular hydrophobicity(π>0) and resonance effect(R<0) by meta-alkyl substitutents with electron donating were important factors in determining fungicidal activity. And the HOMO energy(HOMO>0), ABSQ, sum of absolute values of the atomic charges on each atom and specific polarizability(Sp.Pol<0) of (S) were significantly influential towards fungicidal activity against Puccinia recondita. The interaction between (S) and receptor against from the based on SAR studies proceeds through charge-control reaction, and conditions to show higher activity has been also discussed.
닭 성장 및 육질개선을 위한 수용성키토산의 사료첨가 급이효과
남기달 ( Kee Dal Nam ),한호규 ( Hoh Gyu Hahn ),조승주 ( Seung Joo Cho ),박길현 ( Gil Hyun Park ),김종태 ( Chong Tai Kim ) 한국키틴키토산학회 2008 한국키틴키토산학회지 Vol.13 No.1
The objectives of this study were (1) to investigate the effects of chitosan-based feed additive(CFA) on the growth performance, feed intake, feed conversion, carcass characteristics, and (2) to explore the composition of biochemical components and on the textural and microstructural properties growing-finishing broiler chickens. The body weight gain of chicken fed with CFA was increased about 18% when compared to than that of commercial feed group. The mortalities of chicken fed with CFA were reduced about 55% when compared to than that of commercial feed group. There were no differences between control and broiler chicken fed with CFA in chemical components. Among fatty acids, comparably higher contents of 16 : 0, 16 : 1, 18 : 1 ω9 and 18 : 1 ω7 were observed in broiler chicken fed with CFA. The texture of breast meat in broiler chicken fed CFA exhibited a higher value for storage modulus compared than that of control. The microstructure of breast muscle showed a great difference between control and broiler chicken fed with CFA. This result might be greatly related to the hardness of texture. As a result, this study may suggest that the CFA effectively increased the body weight and reduced the mortality of chicken, and the CFA may be useful in poultry industry as cost-effective and eco-friendly feed additives.
박경남(Kyung Nam Park),한동수(Dong Soo Han),민경랑(Kyung Ran Min),함준수(Joon Soo Hahm),이종철(Jong Chul Rhee),이민호(Min Ho Lee),기춘석(Choon Suhk Kee),이중달(Jung Dal Lee),원치규(Chi Kyooh Won) 대한내과학회 1988 대한내과학회지 Vol.34 No.6
N/A Stomach cancer is the most common malignancy and one of the leading causes of death in Korea. It is now an unchallanged concept that the only practical way of improving 5-year survival rate in patients with stomach cancer lies in the treatment in its early stage. Thus, tremendous efforts including mass survey and screening programs have been made for the early detection of stomach cancer, especially in the 1960s. The authors reviewed 96cases of early gastric cancer (EGC) which had been confirmed by surgery and pathologic examination from March 1974 to July 1986 in Hanyang University Hospital. 1) The incidence of early gastric cancer was 6.6% of all gastric cancer and 15.8% of gastric resection for stomach cancer, and there was no annual difference in incidence of EGC. 2) The greatest prevalence was in 4th decade (32.3%) and male to female ratio was 2.2:1 with male preponderance. 3) The common sites were gastric angle (47.9%) and antrum (36.4%), and along the lesser curvature (69.8%). 4) The most frequently encountered types by macroscopic classification were type IIc and its variants, accounting for over 60% of the cases. 5) In 52cases (54.2%), the lesions extended to submucosa, while 44cases (45.8%) were confined to mucosa. The metastases to regional lymph nodes were detected in 1cases of mucosal cancer and 11cas of patients with submucosal cancer. 6) The size of the lesions varied from smaller than 1.0cm to larger than 5 cm but there was no statiscally significant difference between the size of the lesion and the depth of invasion or the lymph node involvement. 7) According to the histopathologic type by WHO classification, tubuloadenocarcinoma was most common (53.7%). 8) The preoperative diagnostic rates for early gastric cancer was 63.5% by fiberoptic endoscopy and 57.1% by double contrast radiography. 9) Follow-up studies were possible in 43cases, and 5yr-survival rate was 93.0%.
박경남 ( Kyung Nam Park ),최호순 ( Ho Soon Choi ),기춘석 ( Choon Suhk Kee ),이중달 ( Jung Dal Lee ),박문향 ( Moon Hyang Park ),홍일 ( Il Hong ),차호진 ( Ho Jin Cha ) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2
A teratorna (C'reek teratos [):IonsterJ and onkoma [a swelling]) is a true tumor or neoplasm composed of multiple tissues of kinds foreign to the parts in which it arises, take different forms, either solid or cystic, and arise in an immediately prexial median or paramedian location. The retroperitoneal teratoma is a rare condition in only 10% of all retroperitoneal primary neoplasms. Among 10%, the incidence of malignant degeneration has been reported to be from 6 to 10 percent and mature solid retropertioneal teratoma is about 90 percent. About 200 cases has been recorded since Morgargnis first description in 1961. A 24-year-old woman complained left upper guadrant palpable mass. Roentgen study revealed typical conglomerated frame-like calcification in left abdomen. In addition to reporting a case of mature solid retroperioneal teratoma, we will present a review of the literature available on this subject.