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Han, Minsoo,Hong, Kee-Jeung,Cho, Sung-Gook 한국지진공학회 2018 한국지진공학회논문집 Vol.22 No.2
This paper proposes extension of Latin Hypercube Sampling (LHS) to avoid the necessity of using intervals with the same probability area where intervals with different probability areas are used. This method is called Weighted Latin Hypercube Sampling (WLHS). This paper describes equations and detail procedure necessary to apply weight function to WLHS. WLHS is verified through numerical examples by comparing the estimated distribution parameters with those from other methods such as Random Sampling and Latin Hypercube Sampling. WLHS provides more flexible way on selecting samples than LHS. Accuracy of WLHS estimation on distribution parameters is depending on the selection of weight function. The proposed WLHS is applied to seismically isolated structures in nuclear power plants. In this application, clearance-to-stops (CSs) calculated using LHS proposed by Huang et al. [1] and WLHS proposed in this paper, respectively, are compared to investigate the effect of choosing different sampling techniques.
Exploration of Novel 2-Alkylimino-1,3-thiazolines: T-Type Calcium Channel Inhibitory Activity
Han, Minsoo,Nam, Kee Dal,Shin, Dongyun,Jeong, Nakcheol,Hahn, Hoh-Gyu American Chemical Society 2010 Journal of combinatorial chemistry Vol.12 No.4
<P>We have developed combinatorial libraries of new 2-alkylimino-1,3-thiazolines with four diversity points, consisting of more than 500 compounds, in a parallel synthetic fashion. The synthetic strategy was based on the construction of a large library aimed at the discovery of new compounds with T-type calcium channel inhibitory activity through structure modifications of hit compound <B>2</B>. The syntheses of the compounds of Chemset A with four diversity points were accomplished by the condensation of thioureas <B>5</B> with α-haloketones <B>6</B>{<I>1−66</I>} having two diversity points each. A library of phthalimidyl 1,3-thiazolines <B>24</B> was synthesized to provide Chemset B, which allowed the introduction of other diversity points through the nucleophilic character of the amino nitrogen. A sublibrary, Chemset C, was constructed from the libraries of Chemset A and Chemset B by functionalization of the C-4 position of the 1,3-thiazoline ring. The products containing ester or acid groups at the C-4 position of the 1,3-thiazoline ring were used in amide synthesis to give a new sublibrary within Chemset C. Deprotection of the phthalimidyl moiety of <B>24</B> followed by the reaction with benzoyl chloride gave the corresponding sublibrary in Chemset C. Another sublibrary which includes secondary amino derivatives was obtained by reduction of the amide moiety or reductive amination of <B>23</B> with phenyl aldehyde. The selected compounds from the generated libraries were evaluated with respect to inhibition of T-type calcium channels, where some of them have exhibited promising activity.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jcchff/2010/jcchff.2010.12.issue-4/cc100041m/production/images/medium/cc-2010-00041m_0022.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cc100041m'>ACS Electronic Supporting Info</A></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cc100041m'>ACS Electronic Supporting Info</A></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cc100041m'>ACS Electronic Supporting Info</A></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cc100041m'>ACS Electronic Supporting Info</A></P>
The Design and Synthesis of 1,4-Substituted Piperazine Derivatives as Triple Reuptake Inhibitors
Minsoo Han,Younghue Han,송치만,한호규 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.8
Novel 1,4-substituted piperazine derivatives 5, Series A and B were designed by fragment analysis and molecular modification of 4 selected piperazine-containing compounds which possess antidepressant activity. We synthesized new 39 analogues of Series A and 10 compounds of Series B, respectively. The antidepressant screening against DA, NE, and serotonin neurotransmitter uptake inhibition was carried out using the Neurotransmitter Transporter Uptake Assay Kit. The compounds in Series B showed relatively higher reuptake inhibitory activity for SERT, NET, and DAT than those in Series A. The length of spacer between the central piperazine core and the terminal phenyl ring substituted at the piperazine ring in Series B seems to exert an important role in the activity.
Robust Position Control of One DOF Mechanical Systems Using Dual PIOs Without Velocity Measurement
Han, Minsoo,Lee, Cho Won,Yook, Joo-Hyoung,Son, Young Ik The Korean Institute of Electrical Engineers 2017 Journal of Electrical Engineering & Technology Vol.12 No.1
This paper presents a robust position controller for a one degree-of-freedom (DOF) mechanical system using only position measurement. In order to alleviate the performance degradation owing to various uncertainties, a two-stage design method is studied by employing a proportional integral observer (PIO). In the first stage, a baseline backstepping controller is designed for a nominal system without accounting for uncertainties. The PIO is developed for estimating both the velocity information for the backstepping controller and an equivalent input disturbance for a feedforward compensation using the estimated uncertainty. It is shown that the estimation errors with the proposed PIO can be made arbitrarily small in a finite time. If the system suffers from undesirable actuator nonlinearities, however, it might be necessary to estimate the velocity and the disturbance with different rates of convergence. The proposed method combines the predesigned backstepping controller and dual PIOs to reduce mechanical vibrations as well as steady-state errors. The performance of the proposed method is tested through comparative computer simulations and experiments using a laboratory prototype.
Robust Position Control of One DOF Mechanical Systems Using Dual PIOs Without Velocity Measurement
Minsoo Han,Cho Won Lee,Joo-Hyoung Yook,Young Ik Son 대한전기학회 2017 Journal of Electrical Engineering & Technology Vol.12 No.1
This paper presents a robust position controller for a one degree-of-freedom (DOF) mechanical system using only position measurement. In order to alleviate the performance degradation owing to various uncertainties, a two-stage design method is studied by employing a proportional integral observer (PIO). In the first stage, a baseline backstepping controller is designed for a nominal system without accounting for uncertainties. The PIO is developed for estimating both the velocity information for the backstepping controller and an equivalent input disturbance for a feedforward compensation using the estimated uncertainty. It is shown that the estimation errors with the proposed PIO can be made arbitrarily small in a finite time. If the system suffers from undesirable actuator nonlinearities, however, it might be necessary to estimate the velocity and the disturbance with different rates of convergence. The proposed method combines the predesigned backstepping controller and dual PIOs to reduce mechanical vibrations as well as steady-state errors. The performance of the proposed method is tested through comparative computer simulations and experiments using a laboratory prototype.
( Minsoo Kim ),( Sanghyuk Han ),( Jiwoong Jeon ),( Sangwoon Woo ),( Jun Won Yang ),( Sungyoon Park ),( Yejee Lim ),( Nway Oo Khin ),( Jimin Yu ),( Han S. Kim ) 한국폐기물자원순환학회(구 한국폐기물학회) 2019 ISSE 초록집 Vol.2019 No.-
To date, demand for valuable metals continuously increasing due to electronic industries in Korea, and as a result, the generation of wastes are dramatically increasing. Along with aluminum, copper is one of the most demanding metals in most industries, and therefore, their recovery and recycling have received extensive interests. High-purity copper is critically required for electronic and electrical industries. A number of purification processes have been developed for the purity level-up of low-degree copper recycling resources. In this study, copper was recovered from acidic wastewaters generated in plating processes by electrolysis. Copper extraction was conducted in a 1.5L batch type reactor (90×120×170 mm, L×W×H) made of plexiglass. Cathode was made of a stainless-steel plate and anode was prepared by coating iridium/ruthenium onto a titanium plate (100×100×0.4 mm, L×W×T for both electrodes). The electronic wastewaters used in this study were highly acidic (mainly composed of sulfuric and nitric acids, respectively) and contained a considerable amount of copper. The metals contained in the sulfuric acid wastewater were 92.95% of copper, 2.89% of iron, 1.19% of lead, and 2.97% of other trace metals and those in the nitric acid wastewater were 49.87% of aluminum, 45.97% of copper, and 4.16% of other trace metals. Inductively coupled plasma-optical emission spectroscopy was used to determine the recovery rate and purity of copper during electrolysis. Recovery rate of copper from sulfuric acid wastewater and its purity were 99.98% and 99.47%, respectively. Recovered copper was obtained in the form of thin foil at the high recovery rate. Furthermore, it was found that the recovery rate of copper from the sulfuric acid wastewater can be effectively enhanced by optimizing reaction run time, current density, and chemical additives. On the contrary, copper in nitric acid wastewater was not recovered by electrolysis. Instead, a precipitation method was employed for the recovery, and 86.54% of recovery rate was achieved as a copper hydroxide form. This copper can be recovered by dissolving into sulfuric acid wastewater followed by electrolysis process. Voltage and temperature did not change significantly, and the pH was maintained at the low level due to the H+ formation in the electrolysis process. The results of this study will be useful for the development of a process that efficiently recovers high purity copper from waste acids and wastewaters of plating process.