위궤양의 발생기전에 대한 시험적 및 임상적연구 - Prednisolone 투여 백서의 위 Pepsin 의 성상에 관한 연구 -

박경남,기춘석,장호연,고재경 ( Kyung Nam Park,Choon Suhk Kee,Ho Yun Chang,Jai Kyung Koh ) 대한소화기학회 1980 대한소화기학회지 Vol.12 No.1

Because of its potent proteolytic nature, pepsin has been known to play an important role 'in ulcerogenesis of the stomach '>. The rate of pepsin secretion by stomach was reported to be stimulated by histamine'>, gastrin', pentagastrin >, caerulein >, secretin >, cholecystokinin> and glucocorticoids >, and inhibited by vagotomy>, histamin antag- .onists> and prostaglandins . It has been suggested that compounds which can timulate pepsin output may cause gastric ulcer and that drugs which exhibit antipeptic activity could be used as therapeutic agents for gastric ulcer. The introduction of glucocorticoids into medical practice with concomitant increase in the incidence of gastric ulcer made it clear that the adrenal glucocorticoids had a good deal to do with pepsin output and its activity-. However, no definite evidence for that tle pepsin secretion and its activity are affected by acute or chronic administration of glucocorticoids has been obtained in both experimental and clinical studies. In order to investigate the effect of glucocorticoids on pepsin activity in gastric juice, changes in the activity of pepsin vere observed in both basal a.nd gastopsin stimulated gastric juice collected from rats treated with prednisolone for fifteen days. Also studied were properties of pepsin in gastric juice to screen the compounds which specifically activate or inhibit the enzyme through the in vitro experiment .

위 (胃) 십이지장궤양환자에서 (十二指腸潰瘍患者) Madecassol ( centella asiatica ) 의 사용경험

박경남(Kyung Nam Park),신현성(Hyun Sung Shin),최일균(Il Gyun Choi),이민호(Min Ho Lee) 대한소화기학회 1982 대한소화기학회지 Vol.14 No.1

N/A In order to elucidate the effect of titrated extract of Centella Asiatica(TECA) on peptic ulcer, the drug was given to a total of 40 patients with peptic ulcer including 25 cases of gastric ulcer and 15 cases of duodenal ulcer. The results obtained were as follows: Of 15 patients with peptic ulcer including 9 cases of gastric ulcer and 6 cases of duodenal ulcer who received TECA alone, 14 cases(93%) exhibited a definite improvement in subjective symptoms and 11 cases(73%) showed healing of the ulcer under endoscopic and radiological observations. 2) Of 14 patients of peptic ulcer who received TECA along with antacid, 13 cases showed an improvement in subjective symptoms and 11 cases(78%) exhibited healing of the ulcer. 3) Of 11 patients with peptic ulcer who served as control, 5 cases exhibited an improvement in subjective symptoms, but there were no sign of healing in observation. 4) Activities of serum transaminases, content of blood urea nitrogen and concentrations of serum electrolytes in patients ivith peptic ulcer were determined before and after administration of the drugs and were observed to be unchanged.

Mallory - Weiss 증후군 32예 내시경적 관찰

박경남(Kyung Nam Park),이민호(Min Ho Lee),신동호(Dong Ho Shin),진봉재(Bong Jae Shin),신성현(Sung Hyun Yoon),기춘석(Choon Seok Kee) 대한소화기학회 1982 대한소화기학회지 Vol.14 No.1

N/A Hemorrhages from laceration of upper gastrointestinal mucosa after severe vomiting has been frequently reported as an important cause of UGI bleeding. For previous two decades, the Mallory-Weiss Syndrome has become more easily and accurately diagnosed together with the development of endoscope. A clinical observation of endoscopically proven Mallory-Weiss syndrome during 4 years from 1978 to 1981 was performed. The results were as follows; 1) The incidence of Mallory-Weiss syndrome was 7. 6% (32 cases) of 421 cases with upper gastrointestinal bleeding. 2) Male to female ratio was 2.6:1 and the average age of patients was 44. 3) The main predisposing factor was alcohol drinking(56.3%) and the antecedent symptoms were belching, nausea, and vomiting and the summated frequency of above three symtoms was 18.75% Patients without any previous symptoms occupied 18. 8%. 4) Frequency of identificaion of active bleeding was 80% when endoscopic examination was performed within 12 hrs from bleeding and the frequency was decreased together with long duration from the bleeding. And so there was no identifiable active bleeding when examination was performed after 48 hrs from bleeding 5) Cases of single laceration were 25 cases(78.1%) and the bleeding site was predominently esophagogastric junction 18(56%) and the side of laceration was mainly posterior wall (50%). G) Associated lesions were detected in 21 cases; gastritis, gastric ulcer, esophagitis, duodenal ulcer, esophageal varix, and duodenitis in order of frequency. 7) All patients were well treated only with conservative treatment; ice water irrigation, pitressin, and transfusion, etc.

Peutz - Jeghers 증후군에서 병발한 대장 선암종 1예

박경남(Kyung Nam Park),전규영(Kyu Young Jun),이성구(Sung Koo Lee),이종철(Jong Chul Rhee),박문향(Moon Hyang Park),이중달(Jung Dal Lee) 대한소화기학회 1985 대한소화기학회지 Vol.17 No.1

N/A The Peutz-Jeghers syndrome, characterized by pigmentation of the skin and mucous membranes and gastrointestinal polyposis of hamartomatous variety, has been well documented. There have been conflicting views, however, as to the frequency with which malignant change occurs in the polyp. There are insufficient data to establish this syndrome as a precancerous condition but documented cases of gastrointestinal cancer arising in this syndrome have been reported with an incidence of 2~3%. A case of Peutz-Jeghers syndrome with two descrete invasive adenocarcinom as arising in colonic polyps is reported with pertinent literature review. The patient was a 42 year old male admitted with symptoms of intestinal obstruction. He was found to have numerous polyps of variable size throughout the entire length of the colon and in part in the small intestine. He also had pigmentation of oral mucosa. Histologically the polyps were mostly hamartomatous and some were transformed into adenomatous in type with considerable cellular atypia. There were two descrete invasive Duke C adenocarcinomas arising in polyps on colectomy specimen.

구연발표 : 간세포암종과 위암환자의 암조직 , 혈청 및 복수에서 핵산분해 효소활성과 뇨중 핵산분해산물의 배설량 변동에 관한 연구

박경남(Kyung Nam Park),한동수(Dong Soo Han),함준수(Jun Soo Ham),이민호(Min Ho Lee),기춘석(Choon Suck Kee),고재경(Jai Kyung Koh) 대한소화기학회 1987 대한소화기학회 추계학술대회 Vol.1987 No.-

일반연제 : 위질환 800례에 대한 임상적 고찰

박경남(Kyung Nam Park) 대한소화기학회 1974 대한소화기학회지 Vol.6 No.1

간농양 (肝膿瘍) 19예의 초음파상에 (超音波像) 관한 연구

박경남 ( Kyung Nam Park ),이동후 ( Dong Hoo Lee ),이재익 ( Jea Ik Lee ),최웅환 ( Oung Whan Choi ) 대한소화기학회 1981 대한소화기학회지 Vol.13 No.2

N/A With newly available means of diagnostic imaging, liver abscess, a potentially fatal disease, has been known to show a tendency of decreasing in incidence and its mortality by the advanced development of chemotherapy. By virtue of no-invasiveness and possibility to determine whether a lesion is cystic, complex or solid, ultrasonography has recently been advocated as a useful, safe and rapid diagnostic device for detection of liver abscess. The objective of this study was to evaluate ultrasonography in the diagncsis of liver abscess, including the visualization of site of the abscess and its characteristically diagnostic appearance. Ultrasonography of nireteen patients with proven intrahepatic abscesses seen in the past a couple of year were retrospectively investigated. Of these 19 patients, 9 were pyogenic and 8 were of amebic origin but remaining 2 were of mixed nature. Solitary lesion was notable in the majority of patients but 3 of 19 patients had multiple lesions. Ten of these 19 patients showed the lesion on the right lobe and 7 were of the left lobe; remaining 2, on the both lobes of liver. Space occupying lesion was noticed in 94.7% of ultrasonogaphy and 80% of Au-198 colloid, scans. Diagnostic accuracy by ultrasonographic examination was 78.9%. In four cases ultrasonographic diagnosis could be made in follow-up examination at two-four days intervals. In three cases the reported ultrasound diagnosis was that of hepatoma, where the final diagnosis was liver abscess. One cases were ultrasonically misinterpreted as parenchymal liver disease the multiple microabsceses of the liver did not show a remarkable evidence of abscess but diffuse alteration in hepatic texture of ultrasonogram. In an attempt to find helpful or even diagnostic pitfalls, we have demonstrated certain characteristics which could be defined as ultrasonographic features of liver abscess. Hypoechoic internal echo, poorly defined abscess wall rather than well defined one, distal acoustic reinforcement in post-posterior wall aspect of abscess and peripheral echo-free halo with accentuated echoic center so called target configuration representative conceivably of necrotic tissue debris frequently mistaken as hepatoma, were diagnostic stigma of liver abscess which revealed variable shapes of round, ovoid, ellipsoid and irregular character,

조기위암의 임상적 관찰

박경남(Kyung Nam Park),한동수(Dong Soo Han),민경랑(Kyung Ran Min),함준수(Joon Soo Hahm),이종철(Jong Chul Rhee),이민호(Min Ho Lee),기춘석(Choon Suhk Kee),이중달(Jung Dal Lee),원치규(Chi Kyooh Won) 대한내과학회 1988 대한내과학회지 Vol.34 No.6

N/A Stomach cancer is the most common malignancy and one of the leading causes of death in Korea. It is now an unchallanged concept that the only practical way of improving 5-year survival rate in patients with stomach cancer lies in the treatment in its early stage. Thus, tremendous efforts including mass survey and screening programs have been made for the early detection of stomach cancer, especially in the 1960s. The authors reviewed 96cases of early gastric cancer (EGC) which had been confirmed by surgery and pathologic examination from March 1974 to July 1986 in Hanyang University Hospital. 1) The incidence of early gastric cancer was 6.6% of all gastric cancer and 15.8% of gastric resection for stomach cancer, and there was no annual difference in incidence of EGC. 2) The greatest prevalence was in 4th decade (32.3%) and male to female ratio was 2.2:1 with male preponderance. 3) The common sites were gastric angle (47.9%) and antrum (36.4%), and along the lesser curvature (69.8%). 4) The most frequently encountered types by macroscopic classification were type IIc and its variants, accounting for over 60% of the cases. 5) In 52cases (54.2%), the lesions extended to submucosa, while 44cases (45.8%) were confined to mucosa. The metastases to regional lymph nodes were detected in 1cases of mucosal cancer and 11cas of patients with submucosal cancer. 6) The size of the lesions varied from smaller than 1.0cm to larger than 5 cm but there was no statiscally significant difference between the size of the lesion and the depth of invasion or the lymph node involvement. 7) According to the histopathologic type by WHO classification, tubuloadenocarcinoma was most common (53.7%). 8) The preoperative diagnostic rates for early gastric cancer was 63.5% by fiberoptic endoscopy and 57.1% by double contrast radiography. 9) Follow-up studies were possible in 43cases, and 5yr-survival rate was 93.0%.

HPLC 에 의한 암의 지표로서의 뇨중 Ribonucleoside 의 분리 및 정량에 대한 연구

박경남(Kyung Nam Park),한중수(Joong Soo Han),고재경(Jai Kyung Koh) 대한내과학회 1987 대한내과학회지 Vol.33 No.2

N/A Urine contains certain metabolic end products of nucleic acid metabolism including sma1l amounts of modified nucleosides. They are methylated or otherwise structurally transformed ribosyl purines and pyrimidines and are not recycled through the salvage pathway but are excreted in urine. Their measurement in urine provides an accurate indicatar of the metabolism of RNA, especially transfer RNA. Altered patterns of excretion of these compounds might offer a sensitive biomarker for diagnosis and treatment of cancer. In order to find out whether the urinary ribonucleosides could be used as tumor markers for the hepatocellular carcinoma or stomach cancer, analysis of urine samples from normal controls and patients with hepatocellular carcinoma and stomach cancer was performed using reversed-phase HPLC. For this study, a rapid and precise chromatographic method for the determination of ribonucleosides in urine by high-performance liquid chromatography has been developed, The ribonucleosides were first isolated with an affinity gel containing immobilized phenylboronic acid. Contents of pseudouridine, 5-methylcytidine, 1-methyladenosine, 7-methylguanosine, guanosine, 1-methylinosine and 1-methylguanosine were significantly increased in urine of patients with hepatocellular carcinoma. Among these elevated ribonucleosides, excretions of pseudouridine, 5-methylcytidine, 1-methylinosine and 1-methylguanosine were higher than the upper limits (mean+2SD) in control group providing positive rates above 78% (positive rates for the excretions of 5-methylcytidine and 1-methylinosine were 100 %). In patients with stomach cancer, urinary excretions of pseudauridine, cytidine, 5-methylcytidine, 7-methylguanosine and adenosine were significantly in- creased. Positive rates for those of pseudouridine and 5-methylcytidine were above 50o. The results suggest that urinary levels of pseudouridine, 5-methylcytidine, 1-methylinosine and 1-methylguaaosine for the hepatocellular carcinoma and those of pseudouridine and 5-methylcytidine for the stomach cancer are useful as diagnostic tumor markers.

적응적 필터링과 보간법을 이용한 블록기반 압축영상의 효율적인 후처리 알고리듬

박경남(Kyung-Nam Park) 한국산업정보학회 2007 한국산업정보학회논문지 Vol.12 No.1