BCG 접종후의 결핵반응검사의 변화

김진경,김기홍,김행미,안두홍 慶北大學校 醫科大學 1991 慶北醫大誌 Vol.32 No.1

신생아 시기에 BCG를 접종받은 영아를 대상으로 3±개월, 7-8개월 및 15-16개월에 Mantoux 검사를 시행하여 다음과 같은 결과를 얻었다. 3-4개월째 측정한 결절의 크기는 5.8±4.5㎜, 7-8개월째 7.9±4.9㎜,15-16개월째 6.7±4.9㎜로서 7-8개월째 의의있게 (p<0.55)증가되어 있었다. Mantoux 검사상 결절의 크기가 5㎜미만인 경우를 음성으로 간주하였을대 3-4개월째 38.5%, 7-8개월째 26.0% 및 15-16개월째 35.2%가 음성이었으며 15㎜이상의 강양성은 3-4개월째 1.9%, 7-8개월째 12%, 15-16개월째 7.5%를 차지하였다. 33례의 미숙아에 있어서 BCG 접종후 18개월 동안 5㎜ 이상의 반응을 보인 양전례는 63.6%인 21례로 이들 양전군과 비양전군 사이에는 출생시 제태연령, 체중 및 BCG 접종시기에 유의한 차이를 보이지 않았으며 만삭아의 양전율과 비교 하였을 때 의의있는 차이를 보이지 않았다. We conducted this study to evaluate the change of tuberculin reaction after neonatal BCG vaccination in Korea. Seventy-four infants were followed for 15-16 month after birth. BCG vaccination were given within 4 weeks after birht and 3 times of Mantoux test were performed at 3-4 months, 7-8 months and 15-16 month after birth. During the same period, Mantoux test were done on 238 cases of 3-4 months-old infants, 107 cases of 7-8 months-old infants and 85 cases of 15-16 months-old infants who were given BCG vaccination within 4 week after birth. We evaluated the results without distinction of these infants because there was no statistically significant difference between two groups. The size of induration was significantly increased at 7-8 months(7.9±4.9㎜) compare to the size at 3-4 months (5.8±4.5㎜) and 15-16months(6.7±4.9㎜) (P<0.05). But 38.5%, 26.8% andn 32.5% of infants were not converted ( < 5㎜) at 3-4months, 7-8 months and 15-16 months after birth respectively. Thirty-three preterm infants were followed for 18 months after birth. Twenty-one out of 33 (63.6%) were converted during this period. There was no difference of gestational age, birth weight, age on BCG vaccination between converters and nonconverters. There was no difference of conversion rate compatre to full term infants.

The Effects of Microeconomic Fundamentals on the Korean Financial Crisis

Kim,Sunghwan,Kim,Hong Kee,Kim,Jin San 한국산업경영학회 2010 한국산업경영학회 발표논문집 Vol.2010 No.1

In this study, we assess the effects of default risks and financial performance of firms on the overall risk of Korea around its financial crisis in the late 1990s and on their market values, using firm-level data from 1991 to 2007. We develop default prediction models and calculate Altman’s K scores to measure the overall risks and quality of firms respectively. Based on our own default prediction models, we have shown that the default risks of firms were extremely high before the crisis and drastically declined after the crisis. We have also found that the default risks of chaebol firms were much lower before and after the financial crisis and that their market values were much higher after the crisis, compared with those of non-chaebol firms. This implies that the Korean economy with high sovereign risks for a long time experienced the crisis due to weak firm-level fundamentals, regained its vitality due to significant improvements made by chaebol firms through the crisis and has become much stronger than before.

이황화탄소 폭로가 혈압과 콜레스테롤치에 미치는 영향

洪起天,李恩一,金光鍾 고려대학교 의과대학 1994 고려대 의대 잡지 Vol.31 No.3

To study the effects of exposure to carbon disulfide on blood pressure and serum cholesterol level, we gathered the informations from file of the periodic health examination for occupational disease, the periodic health examination for general disease and medical records in, Wonjin factory clinic. The study subjects were 266 workers who had worked in spinning department as exposure group, and 207 male office workers and 59 female office workers as non-exposure group. The results are as follows; 1. The slope coefficients of systolic blood pressure(as dependent variable) and age and exposure duration(as independent variable) were 0.013 and 0.066 respectively in exposure group. And the slope coefficients of diastolic blood pressure(as dependent variable) and age and expoure duration(as independent variable) mere 0.010 and 0.051 respectively in expoure group. 2. The slope coefficients of systolic blood pressure(as dependent variable) and age and tenure duration(as independent variable) were 0.019 and 0.009 respectively in male unexposure group, and were 0.032 and 0.018 respectively in female unexposure group. And the slope coefficients of diastolic blood pressure(as dependent variable) and age and tenure duration(as independent variable) were 0.016 and 0.009 respectively in male unexposure group, and were 0.019 and 0.033 respectively in female unexposure group. 3. The slope coefficient of exposure duration was greater than that of age in exposure group and that of age was greater than that of tenure duration in male unexposure group. 4.There was no significant difference of blood pressure between the exposure and non-exposure group. 5.The slope coefficients of Serum cholesterol(as dependent variable) and age and exposure duration(as independent variable) were 0.03 and 0.035 respectively in exposure group. The slope coefficients of serum cholesterol(as dependent variable) and age and tenure duration(as independent variable) were 0.102 and -0.012 respectively in male unexposure group. And the slope coefficients was very low in female unexposure group. 6. The slope coefficient of exposure duration was similar to that of age in exposure group, and only age was positively related to serum cholesterol in male unexposure group.

초등학교용 웹 기반 교수-학습 자료 개발 전략

김홍래,정인기,신준식,이대형 춘천교육대학교 과학교육연구소 2001 과학교육연구 Vol.25 No.-

사고음 인식에 의한 교차로 교통사고 감지

김병철,박기현,한민홍 한국경영과학회 2001 한국경영과학회 학술대회논문집 Vol.- No.1(2)

This paper presents the detection-method of a traffic accident at a crossroads by the recognition of crash-sound. For the detection of crash-sound, the FFT algorithm is used and found characters of crash-sound. The result of using FFT algorithm is that crash-sound has a higher frequency than noise of roads. Then the using that result. We can detect the crush sound and know when the accident happen exactly. This method will be used the development of vision- blackbox.

Wilson θ 법에 의한 橋梁의 動的應答 解析

김기대,홍병희,박성규 大邱大學校 科學技術硏究所 2000 科學技術硏究 Vol.7 No.1

This study presents the use of transfer matrix method to determine the natural frequencies of bridges, and the application of Wilson B method to the analysis of dynamic response of the bridges caused by moving loads. To check the reliability of the theory introduced and the computer program developed, the dynamic responses of single-span and multi-span bridges subjected to moving vehicle loads with constant velocity were studied. The results obtained were compared with the field test results of existing information. It was found that good agreement was achieved, and the conclusions obtained from the observations of analysis inform that can use as rational approach to the dynamic analysis for these problems.

Bacillus subtilis JK-56이 생산하는 chitinase isozyme의 정제와 특성 규명

김낙원,정영기,전홍기 부산대학교 유전공학연구소 2002 분자생물학 연구보 Vol.18 No.-

토양으로부터 chitinase를 생성하는 균주를 분리하여 동정한 결과 Bacillus subtilis로 판명되었으며, 분리한 균주를 Bacillus subtilis JK-56이라 명명하였다. B. subtilis JK-56의 chitinase 생산 최적 조건을 검토한 결과 1% chitin, 0.5% polypeptone, 0.1% KCl, 0.05% MnSO_4 · 4H_2O이며 초발 pH 7.0, 배양온도 37℃에서 가장 많은 효소를 생산하였다. 본 균주가 생산하는 chitinase를 정제하기 위해서 native-PAGE를 이용해 효소활성 band를 확인한 결과, 1개의 강한 활성 band와 2개의 약한 활성 band를 가지는 isozyme중 1개의 강한 활성 band를 정제하였고 정제된 효소를 Chi-56A라고 명명하였다. Chi-56A의 효소 특성에 관해서 실험한 결과 분자량은 약 53kDa, pl는 4.3으로 확인되었다. 본 효소는 65℃까지 상당히 안정하였으며 효소의 최대활성 온도도 65℃로 확인되는 등 열에 대해 상당히 안정한 효소로 확인되었다. Collidal chitin에 대한 정제효소 Chi-56A의 K_m값은 17.33g/L였다. 그리고 pH 6.0에서 최대의 활성을 나타내었고, 산성범위보다 알칼리범위에서 안정한 것으로 나타났다. 또한 Mn^2+ 존재 하에서 높은 활성을 나타내었고 Co^2+와 Mg^2+ 존재 하에서도 활성이 약간 증가한 반면에 Hg^2+ 존재 하에서는 상당한 저해를 받았다. Chito 올리고당에 대한 분해 산물을 HPLC로 확인해 본 결과 짝수개의 올리고당의 분해산물은 (GlcNAc)_2만을 생산하였고 홀수개의 올리고당에 대해서는 GlcNAc와 (GlcNAc)_2를 생산하는 것으로 비환원성 말단으로부터 이당체인 diacetyl chitobiose ((GlcNAc)_2)를 생산하는 exo형 chitinase로 추정된다. Chitin, a β-1,4 polymer of N-acetyl-D-glucosamine, is one of the most abundant organic compounds in nature. Chitinase (EC 3.2.1.14) is an enzyme that degrades chitin to chito-oligosaccharides, diacetyl chitobiose and N-acetyl-D-glucosamine. An extracellular chitinase-producing bacterial strain was isolated from soil and named to as Bacillus subtilis JK-56. Optimum culture condition of B. subtilis JK-56 for the production of chitinase was 1% chitin, 0.5% polypepton, 0.1% KCl, 0.05% MnSO_4 · 4H_2O, 37℃, initial pH 7.0 and 40 hour culture time. When B. subtilis JK-56 was grown in the optimum medium, one major active band and two minor active bands were detected by native-PAGE and active staining of the gel. Among them, the major band was purified from the culture supernatant by 70% ammonium sulfate precipitation and native-PAGE with BIO-RAD Model 491 Prep-Cell and named as Chi-56A. Its molecular weight was estimated to be 53kDa monomer and the isoelectric point (pl) was pH 4.3. The pH and temperature for the optimum activity of Chi-56A were pH 6.0 and 65℃, respectively. Chi-56A was stable up to 65℃ and in alkaline region. Its K_m value for colloidal chitin was 17.33g/L. HPLC analysis of the reaction products confirmed that Chi-56A was an exo type chitinase.

유량측정기법에 관한 연구 : 실험수로에서 희석법을 중심으로 Dilution Method in Experimental Channel

김성원,지홍기,이순탁 嶺南大學校 環境問題硏究所 1996 環境硏究 Vol.16 No.1

실험수로에서 희석법을 이용한 유량측정의 기법은 일정량주입법과 일시주입법으로 나누어 진다. 본 연구에서는 일정량주입법에 의한 유량측정 결과치가 일시주입법보다 좀 더 실험유량값에 근접한 것으로 분석되었고, 만약 측정장치의 설치오차, 주입용액의 완전 혼합오차와 농도 측정오차 등을 최소로 한다면, 실험수로에서의 유량측정에 있어서 보다 정확한 유량측정을 할 수 있을 것이다. 이와같은 연구분석의 결과로서, 유속계를 사용할 수 없는 하천유역이나 다른수로에서는 희석법을 이용한 유량측정기법이 적용되어 높은 정밀도를 구할 수 있다고 고려된다. It is divided into constant-rate injection method and sudden-injection method in the technique of discharge measurement using the dilution method for experimental channel. It is analyzied that the value of constant-rate injection method is approached more exact than that of sudden-injection method in this research. In this study, if it is minimized for the exact installation error of the testing equipment, the perfect mixing error of the injection-solution and concentration measurement error and so on, It is measured the more exact discharge in this experimental channel. It is considered that the dilution method is applied for the river basin which in not used the current meter and another channel in this research.

웹 온톨로지를 이용한 공급자와 판매자의 데이터 통합 모델

김영근,김수경,안기홍 한밭대학교 정보통신전문대학원 2005 정보통신전문대학원 논문집 Vol.3 No.1

정보통신의 발전은 경제 구조에 많은 변화를 가져왔으며, 향후에도 많은 변화를 예고하고 있다. 가장 대표적인 것은 경제 흐름의 근간이라 할 수 있는 유통의 변화이다. 이것은 통신망 위에 구축되는 가상의 공간에서 이루어지는 유통을 지칭하는 것으로, 빠른 속도로 발전하고 있다. 이러한 빠른 발전에도 상품데이터베이스를 구성하는 것에는 매우 불합리한 비효율성이 존재한다. 상품데이터베이스 구성의 가장 큰 비효율은 싸이트들이 개별의 데이터베이스를 구성한다는 것이다. 이런 문제를 해결하기 위해 시멘틱웹의 RDF(Resource Description Framework)언어를 이용하여 웹 온톨로지를 구성하여 공급자와 판매자간 상품 데이터를 공유하게 된다면, 전자상거래에서 상품데이터베이스 구성의 비효율성을 제거 할 수 있다. 따라서 본 논문에서는 RDF의 소개와 RDF 웹 온톨로지 편집기를 제작하고, 구성된 RDF를 참조하여 간단한 쇼핑몰을 구성하여 온톨로지를 통한 데이터의 효율적 상호운영성(Interoperability)을 증명하여, 현재 제안되고 있는 상품 카탈로그 분야의 발전에 기여하고자 한다. IT development has brought about many changes in an economic structure, and will bring about many changes in the future. The most representative thing is the change of distribution which is a basis of the economic flow. It means a distribution an a virtual space built through communication network. It has rapidly developed. However, building the product database by each site for numberless products is very unreasonable simple repeating process. To solve this problem, if the product data is shared between a supplier and seller through the web ontology by using the Semantic Web RDF (Resource Description Framework) language, an efficiency of e-commerce will be created. Accordingly, the study is intended to prove an efficient interoperability of data through ontology by introducing the RDF, fabricating the RDF web ontology editor, and building a simple shopping mall through organized RDF, and to contribute to a development of currently-proposed product catalog field.

소아에서 발생한 골수이형성 증후군 2례

홍성진,윤석중,김성우,조형구,오명호,김기혁,이인성 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.5 No.-

Myelodysplastic syndrome(MDS) is a group of acquired conditions characterized by progressive bone marrow failure associated with normocellular or hypercellular bone marrow that cannot be attributed to nutritional deficiency, chronic infection, or other chronic systemic illness, and cannot be reversed by the successful treatment of those conditions. Whereas the cases of secondary MDS occur at all ages, primary MDS is essentially a disease of elderly, though no age group is exempt and predomonant in men. The MDS is fundamentally clonal disorders at the level of the haemopoietic totipotent stem cell. Clinically, they are characterized by varing degrees of peripheral cytopenia(s) with morphological and functional abnormalities of blood elements. We have experienced two unrelated pediatric cases, who showed pancytopenia on admission and the characteristic marrow findings of MDS. The first case, a 12 months-old girl, showed increased reticulin with abnormal localization of immature precursor cells(ALIP) in her bone marrow, in addition to dysplastic features such as bi-and multi-nucleation of late normoblasts and internuclear bridging. She also showed 22% of blasts in her bone marrow cells thus classified in the category of RAEB-t after FAB classification. Also found were a chromosomal abnormality namely 46 XX t(14q21q), which was an unusual one. Her family brought her home and, 4 month later, she deceased. The second case, a 12 year-old boy, showed pancytopenia with Pseudo-Pelger-Huet anomaly in neutrophils but no blasts in the peripheral blood. Bone marrow of this case also showed the picture of dyserythropoiesis with binuclearity, internuclear bridging, nuclear fragments, multinuclearity of late normoblasts, in addition to megaloblastoid change in the normoblasts and increased mitosis in granulocytic series. No chromosomal abnormality was found. Classified as RA after FAB classification of MDS. Showed good response to conservative management for anemia for more than one year.