유성견에서 교정적 치아이동에 따른 치주조직 변화에 관한 연구

강남용,윤영주,김광원 대한치과교정학회 1997 대한치과교정학회지 Vol.27 No.4

교정력에 의한 치주조직의 변화를 알아보기 위해 성장중인 유성견에서 단기간의 교정력이 가해진 직후와 보정기간 동안 일어나는 치아와 골조직의 변화양상을 조직학적으로 관찰하였다. 본 연구에서는 생후 4-6개월된 유성견 3마리를 이용하여, 각 실험동물의 하악 좌측 견치와 제1대구치는 실험군으로, 우측 견치와 제1대구치는 대조군으로 하였다. 하악견치와 제1대구치에 치관사이에서 최초 교정력이 200mg이 되도록 0.018"X0.022" S.S closed coil spring(Dentarum Co)의 길이를 조절하여 치아에 결찰시키고 장치는 1주간 활성화기간을 갖는 후 14일, 28일의 보정기간을 거쳐 희생시켜 하악골을 절제하여 통법에 따라 H-E염색군, 연마표본군, ALP염색군, TRAP염색군등으로 나누어 염색을 시행하여 다음과 같은 결과를 얻었다. 1. 교정력을 종료한 직후 견인측 치주인대 폭경이 대조군보다 더 증가된 상을 보이고, 반대로 압박측은 폭경이 감소된 소견을 보이며 치주인대의 섬유들이 치축에 수직으로 압축되며 초자양 변성이 관찰되었다. 대조군에서 관찰되는 다수의 규칙적인 배열을 보였던 조골세포가 견인측에서는 간혹 관찰되었다. 2. 교정력 종료후 14일 보정기간 경과군 치주인대내 섬유아세포들이 증식되어 초자지질대가 회복되는 소견이 관찰되었고 견인측 치주인대의 폭경이 교정력을 종료한 직후군보다 감소하였으며, 소수의 ALP(+) 조골세포와 함께 신생골형성도 관찰되었다. 압박측 치주인대의 폭경은 교정력을 종료한 직후군보다 다소 증가하였으며 골흡수도 증가되었다. 3. 교정력 종료후 28일 보정기간 경과군 치주인대섬유는 정상적으로 회복되어 대조군과 유사한 양상을 보였고 견인측 치조골내 다수의 ALP(+)조골세포와 활발한 신생골형성이 관찰됨과 더불어 압박측 치조골은 다수의 TRAP(+)파골세포와 왕성한 골흡수양상을 보였다. 이상의 결과를 종합해 볼때 교정력을 7일간 가한 직후 유리질화가 관찰되었고 교정력을 종료후 28일 보정기간 경과군에서 압박측에서는 파골세포 견인측에서는 조골세포의 활성과 함께 각각에서 왕성한 골 흡수와 신생골형성이 관찰됨을 알 수 있다. For orthodontic tooth movement, optimal orthodontic force should be maintained without periodontal breakdown and alveolar bone should be remodeled physiologically. Therefore, To obtain proper occlusion through tooth movement within alveolar bone, we should know the biomechanics of teeth and supporting tissues. The present study was performed to observe histologic changes of periodontal tissue immediately after application of orthodontic force and during the retention period in growing young adult dogs. In this study, of same animal. The 0.18"X0.22" stainless steel closed coil spring(Dentaurum Co.) was ligated on the experimental teeth at initial 200gm-force from mandibular canine to 1st molar. The animals(4 to 6 months aged young adult dogs)were sacrificed on 0, 14, 28 days after the finish of appliance activation, and the tissue samples were divided into himatoxylin-eosin(HE) staining section, groud section, alkaline phosphatase(ALP) staining section, and tartrate-resistant acid phosphatase(TRAP) staining section. Thereafter, the proparations were examined under light microscopy. The following results were obtained: 1. Immediately after the finish of appliance activation, the periodontal space was increased in tension side, but decreased in pressure side compared to that of control. The hyalinized zone was also observed in the periodontium. 2. After the 14-day retention, peridontal space was decreased in tension side ans slightly increased in pressure side compared to that of immediately after the finish of appliance activation. The hyalinized zone was repaired and a few osteoblasts showing slightly new bone formation were seen. Osteoblasts were scarcely observed along the alveolar bone. 3. After the 28-day retention, peridontal fibers are normally repaired. A lot of TRAP(+) osteoclasts and increased alveolar bone resorption were observed in pressure side, and AP(+) osteoblast and increased new bone formation were observed in tension side.

40세 이하 관상동맥 질환자에서 장기적 임상 관찰

이승욱,정명호,박종철,박형욱,조상희,김원,김계훈,이상현,강경태,조장현,김남호,김건형,안영근,조정관,박종춘,강정채 全南大醫大 2001 전남의대학술지 Vol.37 No.2

남성화를 보이는 여성에서 발견된 난소의 Steroid Cell Tumor 1예

조인호,정대훈,박영미,서영진,손영실,정철회,강영미,정수전,김영남,이경복,성문수,김기태 인제대학교 2006 仁濟醫學 Vol.27 No.-

Steroid cell tumor is a rare ovarian sex cord-stromal tumor which accounts for 0.1% of all ovarian tumors. Until now, only 4 cases have been reported in domestic literatures. Steroid cell tumor often secrets testosterone and presents virilization in adult women or precocious puberty in children. Treatment is often performed by surgical removal, adjuvant chemotherapy and radiation, but completely accepted treatment was not existed. We experienced a case of steroid cell tumor, which was manifested by typical virilization in a 43-year old patient, who was previously performed hysterectomy and unilateral oophorectomy. So, we present with a brief review of the literatures.

기관지천식 환자에서 Furosemide, Disodium cromoglycate 및 Heparin 흡입이 고장액 식염수 기관지유발검사에 미치는 영향

강천일,현상훈,남언정,김건우,윤종수,서영익,이종명,김능수 慶北大學校 醫科大學 1996 慶北醫大誌 Vol.37 No.3

목적 : 기관지천식 환자에서 고장액 식염수의 흡입은 기도수축을 유발할 수 있으며 이는 운동유발성 천식반응과 밀접한 관계가 있는 것으로 알려져 있다. 저자들은 알레르겐 흡입이나 운동에 의해 유발되는 천식에 예방효과가 있는 것으로 알려진 disodium cromoglycate(DSCG), furosemide 및 heparin 흡입이 4.5% NaCl 기관지유발검사(BPT)에 미치는 영향을 조사하였다. 대상 및 방법 : 4.5% NaCl BPT에서 양성반응을 보이는 기관지천식 환자 13명을 대상으로 하였으며 사용된 약물은 furosemide 40㎎, DSCG 40㎎ 및 heparin 1,000μ/㎏이었다. 먼저baseline 4.5% NaCl BPT를 시행한 다음 이들 약물로 전처치후 다시 4.5% NaCl BPT를 시행하여 약물의 효과를 관찰하였다. 결과 : Furosemide 40㎎, DSCG 40㎎및 heparin 1,000μ/㎏의 흡입 전처치는 고장액 식염수에 의한 기도수축 반응에 뚜렷한 예방효과를 보였다. Furosemide와 DSCG로 전처치한 군(n=6)에서 이들의 기도수축 방어율은 각각 100.6±6.6%, 91.1±17.2%였으며 furosemide와 heparin으로 전처치한 군(n=7)에서는 각각 58.7±29.2%, 59.0±51.1%로서 각 군에서 이들 약제간의 방어율에는 유의한 차이가 없었다. 결론 : Furosemide(40㎎), DSCG(40㎎) 및 heparin(1000μ/㎏)의 흡입 전처치는 고장액 식염수에 의한 기도수축 반응에 뚜렷한 예방효과를 보였으며, 적어도 이 용량에서 기도수축 예방 정도에는 유의한 차이가 없음을 알 수 있었다. Background: Hypertonic saline (4.5% NaCl) inhalation is known to induce broncho-constriction by affecting mast cell, epithelial cell and vagal afferent pathway in some asthmatics. Disodium cromoglycate (DSCG) is known to have a preventive effect on allergic asthma and exercise induced asthma, and recently it was reported that furosemide and heparin had similar effect. The purpose of this study was to evaluate the effects of furosemide, DSCG and heparin on hypertonic saline provocation test in asthmatics. Methods: Thirteen asthmatics with a positive response to hypertonic saline challenge were enrolled. Hypertonic saline and test drugs were generated by ultrasonic nebulizer. After taking baseline 4.5% NaCl challenge, subjects were rechallenged with 4.5% NaCl after inhalation of furosemide 40㎎, DSCG 40㎎ or heparin 1,000μ/㎏. Results: 1. There was a significant positive relationship between PC_20-methacholine and PTM-4.5% NaCl(r=0.5575, p = 0.024). 2. Furosemide, DSCG and heparin had no direct bronchodilating effects. 3. Premedication of furosemide and DSCG(n=6) showed significant protective effects on 4.5% NaCl induced broncho-constriction. The average protection rate were 100.6±6.6% and 91.1±17.2%, respectively. 4. Premedication of furosemide and heparin(n=7) showed significant protective effects on 4.5% NaCl induced broncho-constriction. The average protection rate were 58.7±29.2% and 59.0±51.1%. respectively. Conclusions: Furosemide(40㎎), DSCG(40㎎) and heparin(1.000μ/㎏) had significant protective effects on hypertonic saline induced broncho-constriction in asthmatics, and there were no significant differences in their potency of protection rate.

전국 단위 감시체계의 현황과 전망

강성규,안연순,지영구,김형옥,하미나,권호장,백남종,김성아,홍윤철,김재용,강대희,정혜선,하은희 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.2

Mobile IPv6 환경에서 신뢰성 있는 TCP 프로토콜의 성능향상에 관한 연구

姜昊錫,金南昌,沈永喆 弘益大學校 科學技術硏究所 2003 科學技術硏究論文集 Vol.14 No.-

There are three methods for improving performance of TCP Protocol in the Mobile IPv6 Environment. Those methods are link layer protocol method, end-to-end protocol method and split-connection method. It's a link layer protocol method among these to be applied without any changes of wired network environment. Snoop module is one of link layer protocol methods for improving performance of TCP Protocol. We apply snoop module to Mobile IPv6 and improve Mobile IPv6 with snoop module by changing some feature of Mobile IPv6 which reduces its performance. Based on these improvement of Mobile IPv6, We simulate it by ns2 and mobiwan comparing original Mobile IPv6 and our Mobile IPv6 with snoop module. Simulation of ours is better than original.

암남공원의 식물상과 삼림식생에 관한 연구

남정칠,박승범,김승환,강영조,이기철,이정아 동아대학교 환경문제연구소 1999 硏究報告 Vol.22 No.1

The objective of this study is to analyze the flora and forest vegetation of Amnam urban natural Park. 10 transects of quadrat of 10×10m were selected for the experiment. They were surveyed from January to October 1997. The obtained results were summerized as follows ; 1. The flora of plants distributed in Amnam Park was 88 families, 245 genus, 374 species. Dicotyledom in an angiosperm was 81.3% of total percentage was 73 families, 194 genus, 304 species, Monocotyledonous plant was 13.9% of total percentage was 7 families, 38 genus, 52 species, Gymnospermous plant was 2.1% of total percentage was 4 families, 5 genus, 8 species. Pteridophyta was 2.4% of total percentage was 3 families. 7 genus, 9 species, Shave grass was 0.3% of total percentage was 1 family, 1 genus, 1 species. 2. The representative wood plants of Amnam Park were Pinus thunbergii, Machilus thunbergii, Camellia japonica, Quercus spp., Celtis sinensis, Morus bombysis, Prunus sangentii, Sorbus alnifolia, Albizzia julibrissin, Juniperus rigida, Platycaya strobilacea, Lespedeza spp., Zanthoxylum piperitum, Zanthoxylum schinifolium, Rhus spp., Carpinus coreana, Mallotus japonicus. Ficus erecta, Pittosporum tobira, Eurya japonica. Elaeagnus macrophylla. 3. The area of plant community in Amnam Park was 84.29% in Pinus thunbergii community. 6.7% in Quercus dentata-Celtis sinensis community, 1.5% in Pittosporum tobira-Eurya japonica community, 1.4% in Quercus aliena-Prunus sargentii community, 1.29% in Pinus thunbergii-Pittosporum tobira community, 1.27% in Pinus thunbergii-Eurya japonica community.

상악 협측 치은에 발생한 모세혈관종 치험례 : A CASE REPORT

강근영,양규호,최남기,김선미 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.4

혈관종은 혈관의 증식에 의해 발생하는 양성 종양으로 유아와 어린이에서 호발한다. 대부분 진성종양으로 보다는 과오종(hamartoma)으로 보며 구강내 호발부위는 입술, 혀, 협점막 구개부 등이다. 임상소견은 편평하거나 융기된 적청색 병소로 보통 단발성이다. 조직학적 소견을 통해 모세혈관성(capillary), 해면상(cavernous), 혼합성(mixed), 경화성(sclerosing)등으로 분류되며 확진된다. 본 증례는 6세 남자 환아가 치은에 뭐가 났다는 것을 주소로 전남대학교 병원 소아치과에 내원하였다. 임상검사 결과 #62, 63 부위의 부착치은에 딸기모양 종물(mass)이 관찰되었다. 조직검사 시행 결과 모세혈관종으로 확진되었으며 외과적 절제로 양호한 결과를 얻었기에 보고하는 바이다. 혈관종은 재발이 드물며 악성전환이 없지만 출혈 경향이 높으므로 임상적 시술시 주의가 요구된다. The hemangioma, a benign proliferation of blood vessel, is the most common tumor of infancy and childhood. In many instances, the lesion probably represents a hamartoma or malformation rather than a true neoplasm. In the oral cavity, common sites are lips, followed by tongue, buccal mucosa and palate. Clinical characteristics appear as a flat or raised reddish-blue lesion and are generally solitary. They are classified on the basis of their histological appearance into capillary, mixed, cavernous or a sclerosing variety. A 6-year-old male of this case was referred to the Department of Pediatric Dentistry, Chonnam National University with a chief complaint of swelling lesion on gingiva. The strawberry appearance mass was detected by clinical examination on attached gingiva at the upper left primary lateral incisor and canine. Surgical excision and biopsy were carried out for histological examination and the lesion was diagnosed with a capillary hemangioma. The risk of recurrence after this therapy is rare, and there is no malignant transformation. Despite their benign origins and behaviour, hemangiomas in the region of oral cavity are always clinically important to the dental profession because of bleeding tendency.

III급 부정교합 어린이의 수완부 골성숙과 하악 3대구치 발육에 대한 연구

강근영,양규호,최남기,김선미 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.2

본 연구는 I급 부정교합과 III급 부정교합 어린이의 수완부 골성숙 단계와 하악 제3대구치 발육을 비교 · 평가하고자 하였다. 이를 위해 전남대학교병원 소아치과에 내원한 환자들로 8세부터 15세 사이의 Angle I급 부정교합을 지난 남자 149명,여자 155명 그리고 Angle III급 부정교합을 지닌 남자 153명,여자 155명,총 612명을 대상으로 하였으며 골성숙 단계 평가를 위해 수완부 사진을 이용한 Fishman의 방법을 사용하였고 하악 제3대구치의 발육 단계를 평가하기 위해 Orthopantomogram을 이용한 Gat 등의 New Six-Developmental-Stage 방법으로 판독하여 다음과 같은 결과를 얻었다. 1. 골성숙 단계는 I급 부정교합과 III급 부정교합군 모두 전반적으로 여자가 남자보다 빠르나(p<O.05) 하악 제3대구치의 석회화 단계는 성별 차이가 없었다. 2. 남녀별 골성숙 단계와 하악 제3대구치의 석회화 단계는 I급과 III급 부정교합군 간에서 유의한 차이가 없었다. 3. I급 부정교합과 III급 부정교합군의 수완부 골성숙 단계와 하악 제3대구치 석회화 단계 사이의 상관관계는 두 군 모두 높은 상관성을 보였다(p<O.O1). 4. I급 부정교합과 III급 부정교합군의 하악 제3대구치 석회화 단계와 연령사이의 상관관계는 두 군 모두 높은 상관성을 보였다(p<O.O1). 이상의 결과로 수완부 골성숙도와 하악 제3대구치 발육은 I급 부정교합과 III급 부정교합군 간에 차이가 없었다. The purpose of this study was to investigate the relationship of the skeletal maturity of hand-wrist and the development of mandibular third molar in subjects with class I and class III malocclusion. The subjects used in this study were 304 children(149 boys, 155 girls) with class I malocclusions and 308 children(153 boys, 155 girls) with class III malocclusions, ranged from 8 to 15 years of age. Hand-wrist radiographs and panoramic radiographs were used to evaluate the stage of skeletal maturity and teeth development. Fishman s method for the skeletal maturity stages of the hand-wrist and new six-developmental-stage method for the calcification stages of mandibular third molars were analyzed. The results were as follows: 1. In subjects with class I and class III malocclusion, skeletal maturity of the hand-wrist occured earlier in females than in ma1es(p<0.05), while the calcification stages of mandibular third molars were no significant gender differences. 2. There were no significant differences between the groups, when comparing the skeletal maturity stages of the hand-wrist and the calcification stages of mandibular third molars between subjects with the class I and the class III malocclusion. 3. The correlation coefficients between the calcification stages of mandibular third molars and the skeletal maturity stages of the hand-wrist in subjects with class I and class III malocclusion showed a high interrelationship(p<0.01). 4. The correlation coefficients between the calcification stages of mandibular third molars and chronological age in subjects with class I and class III malocclusion showed a high interrelationship (p<0.01). As a result, there were no significant differences between class I and class III malocclusion group for skeletal maturity of the hand-wrist and third molar development.

돌발성 난청의 임상적 분석

남부현,강갑진,성열웅,송영복 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

Sudden hearing loss is an abrupt onset of sensorineural hearing loss over a period of hours or a few days without definite cause. The cause and its pathophysiology have not been fully determined, and the treatmnet is controversial at present. The purpose of this study is to seek the best modality of treatment by clinical and stastical analysis of 48 patients (28 male and 20 female) diagnosed as a sudden hearing loss from January 1993 to October 1995. The therapeutic results of the 48 patients were 20 cases (41.7%) of complete recovery, 3 cases (6.2%) of partial recovery, 4 cases (8.3%) of slight recovery and 21 cases (43.8%) of no improvement. Early treatment within a week of onset, ascending or flat types of audiogram, and normal ABR were favorable prognostic factors in recovery of hearing. The presence of accompanying vestibular symptom (ie, vertigo) and profound hearing loss on initial audiogram were poor prognostic factors. However, the gender and the age of the patients did not affect on the hearing result.