馬山港 活成化方案에 관한 硏究

姜龍洙,河文植,李相斗,朴起東 昌原大學校 産業經濟硏究所 1984 産經硏究 Vol.1 No.-

마우스 肝 Alkaline Phosphatase의 分離 및 特性

琴技洙,姜信誠 慶北大學校 自然科學大學 1986 自然科學論文集 Vol.4 No.-

Alkaline phosphatase was purified from mouse liver tissues through the procedures of homogenation, butanol solublization, acetone extraction, Sephadex G-200 and concanavalin A-Sepharose chromatography, and its molecular and kinetic properties were characterized with the following results. The specific activity of liver alkaline phosphatase after affinity chromatography was found to be 11.7 unit/mg of protein with purification factor of 195-fold. The molecular weight of this enzyme was estimated to be about 120,000 composed of two identical subunits. The liver alkaline phosphatase had an optimum pH of 9.6∼10.0, and showed similar thermostability to that of the the other mammalian alkaline phosphatase. The Mg^2+ and Mn^2+ activated the enzyme activity and Ca^2+ showed little effect, whereas Co^2+, Zn^2+ and Cu^2+ decreased the activity. The liver enzyme was competitively inhibited by phosphate ion, but was uncompetitively inhibited by L-phenylalanine and L-homoarginine. Moreover, the inhibitory effect by homoarginine on the liver enzyme was much stronger.

혈관외피종 -1증례 보고-

강유미,지미경,양기화,강석진,김병기,김선무,정수일 대한병리학회 1990 Journal of Pathology and Translational Medicine Vol.25 No.5

기존 Shade guide의 변화 처리에 따른 색 재현성에 관한 실험적 연구

계기성,임수령,강용구 大韓齒科器材學會 1991 대한치과재료학회지 Vol.18 No.1

The purpose of this study was to evaluate the color differences that can exist between the #67 Trubyte Bioform shade guide of the full thickness, the half thickness, the full thickness with silver color die spacer and the half thickness with silver color die spacer and the sample fabricated by the laboratory made with the identical shade designation in the dental laboratory using colorimeter (TC-6FX, Tokyo Denshoku Co., Ltd., Japan). The four kinds of the full thickness, the half thickness, the full thickness with silver die spacer, the half thickness with silver color die spacer of #67 Trubyte Bioform shade guide were made. The sample fabricated by the laboratory were made according to the firing schedules for Ceramco opaque and body porcelain out of #67 Ceramco porcelain powders with the backing of the nonprecious Vera Bond metal plate of the round form with the thickness of 0.5mm. The color of the four kinds of #67 Trubyte Bioform shade guide and the sample fabricated by the laboratory was expressed in terms of CIE L*a*b* color coordinates by means of a colorimeter. Color differences(△E*ab) for each paired comparison within each shade group were calculated from the color data. The results were as follows: 1. The means of L*, a*, b* of the sample fabricated by the laboratory and full thickness, the half thickness, the full thickness with silver color die spacer, and the half thickness with silver color die spacer of #67 Trubyte Bioform shade guide were measured(Table 2). 2. There were not statistically significant difference at a* and b* except L* at L*a*b* color coordinates between the full thickness of #67 Trubyte Bioform shade guide and the sample fabricated by the laboratory and there were statistically significant difference between the half thickness of #67 Trubyte Bioform shade guide and the sample fabricated by the laboratory. 3. There were not statistically significant difference except b* of the half thickness with silver color die spacer of #67 Trubyte Boform shade guide at L*a*b*color coordinates between the full thickness and half thickness with silver color die spacer of #67 Trubyte Bioform shade guide and the sample fabricated by the laboratory. 4. As the color difference (△E*ab) between the sample fabricated by the laboratory and the #67 Trubyte Bioform shade guide by the modification increased in the order of the half thickness with silver color die spacer (0.991), the full thickness with silver color die spacer (1.157), the full thickness (2.399) and the half thickness (7.732), the color of the sample fabricated by the laboratory were to copy more easily the full thickness and half thickness with silver color die spacer of #67 Trubyte Bioform shade guide (Table 4).

高速道路 터널區間에서의 運轉者 視覺情報 特性에 관한 硏究

金明洙,延基錫,姜宗實 大田産業大學校 2001 한밭대학교 논문집 Vol.18 No.-

It is very important to analyse drivers' visual behavior because visual information accounts for more than 90 percent of information for driving. There is a research that adjustment factor a tunnel is 0.95 and for a continuous tunnel is 0.09. The reason is that a vehicle slowed down for visual trouble in the tunnel section of highway. This problem usually happens but there has never been studied of human factor which is operated as causes. Therefore the importance of researches on stable driving, smooth travel and coping with traffic safety is increasing day by day. In this regard, this study has an eye to visual aspect among things which influence drives' activity.

혈관외피종 -1증례 보고-

강유미,지미경,양기화,강석진,김병기,김선무,정수일 대한병리학회 1990 Journal of Pathology and Translational Medicine Vol.24 No.2

이담자균 효모의 성분화 과정중 인지질의 작용과 배지조성의 제한이 성분화에 미치는 영향

정영기,강원대,남수완 동의대학교 기초과학연구소 1997 基礎科學硏究論文集 Vol.7 No.1

The action of phospholipid on the rhodotorucine A(Rh.A) acceptance by heterobasidiomyceteous yeast Rhodospori-dium toruloides mating type a cells and the effect of medium composition during sexual differentiation were investigated. Activation of trigger peptidase(TPase) was very sensitive to the originated phospholipid from R. toruloides and was more sensitive to phospholipid liposome made up of phospholipid. Phospholipid present on the membrane of mating type a cells consists of phospatidylglycerol(PG), phosphatidylethanolamine(PE), phospatidylcholine(PC), phospatidylinositol(PI), and phosphatidylserine(PS) of 12.9, suprisingly 45.4, 11.0, and 13.9%, respectively. As the result of using C-1 and N-1 mediums which limited C and N sources capable of inhibiting the synthesis of phospholipid. it resulted inhibiting sexual differentiation and production of Rh.A from mating type A cells.

주요우울증에 대한 Milnacipran의 효과 및 안정성 : Fluoxetine과의 비교

이민수,함병주,기백석,김정범,연병길,오강섭,오병훈,이철,정한용,지익성,최병무,백인호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This 6-week, open label randomized, multicenter study was conducted to evaluate the antidepressant effect and safety of milnacipran and fluoxetine in patients with major depression. Methods : The study was done in patients with major depression diagnosed by DSM-IV who score ≥17 in 17 items Hamilton Rating Scale for Depression (17-item HAM-D) and score ≥25 in Montgomery and Asberg Depression Rating Scale (MADRS). A total of 87 patients were randomized to milnacipran group and fluoxetine group. In cases of the patients taking other antidepressants, 6 weeks of each medication was administered after 7 days of drug excretion period. The evaluation was done using 17 item HAM-D, MADRS, Clinical Global Impression Scale (CGI), and COVI scale after baseline, 1 week, 2 weeks, 4 weeks, and 6 weeks. The side effects that had occurred during the period of our study were put in records by developed/disappeared time, severities, incidences, managements and results. Results : A total of 87 patients were enrolled. 70 (mitnacipran group 39 ; fluoxetine group 31) of them were included for the 6 weeks of research and 17 of them dropped out with in the first week, not due to adverse reactions or deficiency of effects. Total 17 item HAM-D scores, total points of MADRS, and CGI showed significant decrease after 1 week in each treatment group and continued decrease after 2 weeks and 4, 6 weeks. But there was no difference between milnacipran group and fluoxetine group in the antidepressant effect. There were no significant changes in vital sign, CBC, chemistry, and EKG in each treatment group. The commonly reported side elfects of minlacipran were nausea (25.0%), headache (10.7%), vomiting (7.1%),constipation (7.1%), dizziness (7.1%) and those of fluoxetne were GI trouble (11.1%), diarrhea (11.1%), insomnia (11.1%),agitation (5.6%), and dizziness (5.6%). Conclusion : Milnacipran was effective for the improvement of depressive symptoms and was well tolerated and safe in patients with depression.

정신분열병 환자에서 자기공명영상 구획화를 이용한 전두엽 하위구조와 구조적 이상 관찰

김재진,권준수,강도형,윤탁,한문희,장기현 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.6

연구목적 : 정신분열병 환자를 대상으로 한 구조적 뇌영상 연구들은 국소적 전두피질(prefrontal cortex)의 이상에 대하여 상당히 다양한 결과들을 보고하였다. 본 연구는 정확한 해부학적 구획화를 바탕으로 한 관심영역 체계를 통해 정신분열병에서 전두피질의 구조적 이상 유무를 탐색하고자 시행되었다. 방 법 : 12명의 정신분열병 환자와 12명의 나이 및 성별 분포가 동일한 정상인들을 대상으로 뇌 자기공명 영상을 획득한 후, 지형학적 표지물을 이용하여 8개의 전두엽 하위구조 구획 작업을 실시하였다. 구획된 전두엽 하위구조들의 용적을 측정하여 두 군간에 차이가 있는가 관찰하였고, 하위구조 용적과 정신분열 증상의 심각도 간의 상관관계를 살펴보았다. 결 과 : 상당 수의 전두엽 하위구조들의 용적이 정상인에 비해 정신분열병 환자들에서 작은 경향을 보였고, 특히 우측 부운동영역(supplementary motor area)이 통계적으로 유의하게 작은 용적을 보였다(p<0.003). 또 이러한 전두엽 하위구조들의 용적 감소는 정신분열병 음성 증상의 심각도와 밀접한 상관성을 보였고, 이러한 현상은 우측 상전두이랑(superior frontal gyrus)에서 가장 대표적이었다(γ=-0.704, p=0.01). 결 론 : 이러한 결과는 정신분열병에서 전두엽기능저하의 바탕이 되는 구조적 결함의 존재 가능성을 시사한다. 이러한 전두피질의 구조적 결함은 정신분열병에서의 인지기능결핍과 신경회로의 장애 소견과 연결될 수 있다. Objectives : Although most of the functional and structural neuroimaging studies have reported the association of the that cognitive deficits in patients with schizophrenia with the pathophysiology of the prefrontal cortex, their findings vary considerably. Based on the precise parcellation methods, this study was designed to investigate substructural abnormalities of the prefrontal cortex in patients with schizophrenia. Methods : The subjects consisted of twelve patients with schizophrenia and 12 age- and sex-matched normal volunteers. Magnetic resonance images were obtained in all subjects, and parceled into 8 frontal substructures using the topographic landmarks. The frontal substructural volumes were compared between the two groups, and their correlations with the schizophrenic symptom severity were analysed in the patient group. Results : In the comparison of substructural volumes, most frontal substructures of the patient group tended to be smaller than those of the normal comparison group ; particularly the right supplementary motor area was significantly smaller(p<0.003). Negative symptoms tended to be inversely correlated with the frontal substructural volumes, particularly with the right superior frontal gyral volume(γ=-0.70, p=0.01). Conclusion : These findings suggest the possibility of structural defects related to 'hypofrontality' in schizophrenia. These frontal structural defects may be the basis of neurocognitive deficits and neural circuital dysfunction in schizophrenia.

조기 양막 파수 신생아에 대한 임상적 연구

양은석,김강호,박상기,나창수 朝鮮大學校 附設 醫學硏究所 1989 The Medical Journal of Chosun University Vol.14 No.1

A clinical study was made on 157 newborns of mothers with premature rupture of membranes (study group) and 916 newborns of mothers without rupture of membranes (control group) at Chosun University Hospital from Jaunary 1987 to Decembcr 1988. The results were as follows: 1) The incidence of PROM was 14.6%. 2) 10.2% of all babies with PROM were born prematurely, significantly higher than the incidence of PROM in all newborn cases with 4.8% (P<0.005). 3) The incidence of neonatal sepsis in the PROM group (4.5%) was four times higher than in the normal group(1.1%) (P<0.005). The incidience was related to the gestational age at birth, and also increased with increasing time interval after PROM. 4) The incidence of neonatal asphyxia in PROM group (7.6%) was twice the normal group (3.6%) (P<0.025). The premature babies had greater incidence in both groups. Also, a positive correlation was found with increasing time interval PROM. 5) Neonatal respiratory distress syndrome(RDS) was found in 1.3% of babies with PROM, whereas 1.4% of babies in the normal group had the syndrome. Premature babies had higher incidence of RDS in both normal and PROM groups, but the latter had an incidence amounting the only 1/5 of the former. And it tended to diminish with creasing time interval after PROM.